Safe doubling of ventilator capacity: a last resort proposal for last resorts
(Source: Critical Care)
Source: Critical Care - May 14, 2020 Category: Intensive Care Authors: J. Geoffrey Chase, Yeong Shiong Chiew, Bernard Lambermont, Philippe Morimont, Geoffrey M. Shaw and Thomas Desaive Tags: Research Letter Source Type: research

The use of a neuromuscular blocking agent could significantly decrease mortality in moderate-to-severe ARDS patients: is moderate ARDS the best indication for neuromuscular blocking agents
(Source: Critical Care)
Source: Critical Care - May 13, 2020 Category: Intensive Care Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review
Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possib... (Source: Critical Care)
Source: Critical Care - May 13, 2020 Category: Intensive Care Authors: Matthijs M. den Os, Charissa E. van den Brom, Anoek L. I. van Leeuwen and Nicole A. M. Dekker Tags: Research Source Type: research

A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury
(Source: Critical Care)
Source: Critical Care - May 12, 2020 Category: Intensive Care Authors: Rapha ël Cinotti, Thierry Le Tourneau, Kalyane Bach-Ngohou, Maxime Le Courtois du Manoir, Bertrand Rozec and Karim Asehnoune Tags: Research Letter Source Type: research

Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory ca... (Source: Critical Care)
Source: Critical Care - May 11, 2020 Category: Intensive Care Authors: Aur élien Roumy, Lucas Liaudet, Marco Rusca, Carlo Marcucci and Matthias Kirsch Tags: Review Source Type: research

Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis
Predicting successful liberation from mechanical ventilation (MV) in critically ill patients is challenging. Brain natriuretic peptide (BNP) has been proposed to help guide decision-making for readiness to lib... (Source: Critical Care)
Source: Critical Care - May 11, 2020 Category: Intensive Care Authors: Jean Deschamps, Sarah K. Andersen, Jordan Webber, Robin Featherstone, Meghan Sebastianski, Ben Vandermeer, Janek Senaratne and Sean M. Bagshaw Tags: Research Source Type: research

Simultaneous ventilation of two simulated ARDS patients in COVID-19 pandemic
(Source: Critical Care)
Source: Critical Care - May 11, 2020 Category: Intensive Care Authors: Danny Epstein, Yoav Hoffman, George Dahoud, Aeyal Raz and Asaf Miller Tags: Research Letter Source Type: research

Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies
The coronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic. Preparing intensive care units (ICU) is an integral part of any pandemic response. In this review, we discuss the key prin... (Source: Critical Care)
Source: Critical Care - May 11, 2020 Category: Intensive Care Authors: Ken Junyang Goh, Jolin Wong, Jong-Chie Claudia Tien, Shin Yi Ng, Sewa Duu Wen, Ghee Chee Phua and Carrie Kah-Lai Leong Tags: Review Source Type: research

Austrian recommendations for best clinical practice in case of haemorrhagic traumatic brain injury under platelet inhibitors or non-vitamin K antagonist oral anticoagulants: an additional therapeutic option to consider
(Source: Critical Care)
Source: Critical Care - May 8, 2020 Category: Intensive Care Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Our recommendations for acute management of COVID-19
(Source: Critical Care)
Source: Critical Care - May 8, 2020 Category: Intensive Care Authors: Francesco Mojoli, Silvia Mongodi, Anita Orlando, Eric Arisi, Marco Pozzi, Luca Civardi, Guido Tavazzi, Fausto Baldanti, Raffaele Bruno and Giorgio Antonio Iotti Tags: Editorial Source Type: research

Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial
(Source: Critical Care)
Source: Critical Care - May 8, 2020 Category: Intensive Care Authors: Constantinos Pantos, Ioulia Tseti and Iordanis Mourouzis Tags: Research Letter Source Type: research

Chloroquine for COVID-19: rationale, facts, hopes
(Source: Critical Care)
Source: Critical Care - May 8, 2020 Category: Intensive Care Authors: Andrea Cortegiani, Mariachiara Ippolito, Giulia Ingoglia and Sharon Einav Tags: Editorial Source Type: research

Students Supporting Critical Care – A contention plan to prevent the decompensation of ICUs in the COVID-19 pandemic:Translating Bjorn Ibsens’ polio-lessons to modern times
(Source: Critical Care)
Source: Critical Care - May 8, 2020 Category: Intensive Care Authors: Pedro David Wendel Garcia, Paola Massarotto, Katja Auinger, Reto Andreas Schuepbach and Stephanie Klinzing Tags: Letter Source Type: research

Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis
The use of the furosemide stress test (FST) as an acute kidney injury (AKI) severity marker has been described in several trials. However, the diagnostic performance of the FST in predicting AKI progression ha... (Source: Critical Care)
Source: Critical Care - May 7, 2020 Category: Intensive Care Authors: Jia-Jin Chen, Chih-Hsiang Chang, Yen-Ta Huang and George Kuo Tags: Research Source Type: research

Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study
The role of site of infection in sepsis has been poorly characterized. Additionally, sepsis epidemiology has evolved. Early mortality has decreased, but many survivors now progress into chronic critical illnes... (Source: Critical Care)
Source: Critical Care - May 7, 2020 Category: Intensive Care Authors: Julie A. Stortz, Michael C. Cox, Russell B. Hawkins, Gabriela L. Ghita, Babette A. Brumback, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron, Scott C. Brakenridge and Frederick A. Moore Tags: Research Source Type: research

Intensive care for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a makeshift ICU in Wuhan
(Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Xiao Lu and Shanxiang Xu Tags: Research Letter Source Type: research

Psychological stress of ICU nurses in the time of COVID-19
(Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Xin Shen, Xiaoyue Zou, Xiaofeng Zhong, Jing Yan and Li Li Tags: Editorial Source Type: research

Can computed tomography be a primary tool for COVID-19 detection? Evidence appraisal through meta-analysis
(Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Edward Pei-Chuan Huang, Chih-Wei Sung, Chi-Hsin Chen, Cheng-Yi Fan, Pei-Chun Lai and Yen-Ta Huang Tags: Research Letter Source Type: research

Heating, ventilation and air conditioning (HVAC) in intensive care unit
The aim of this review is to describe variation in standards and guidelines on ‘heating, ventilation and air-conditioning (HVAC)’ system maintenance in the intensive care units, across the world, which is requ... (Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Sai Saran, Mohan Gurjar, Arvind Baronia, Vijayalakshmi Sivapurapu, Pralay S. Ghosh, Gautham M. Raju and Indubala Maurya Tags: Review Source Type: research

Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics
In order to assess the significance of drug/substance levels measured in intensive care medicine and clinical and forensic toxicology as well as for therapeutic drug monitoring, it is essential that a comprehe... (Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Martin Schulz, Achim Schmoldt, Hilke Andresen-Streichert and Stefanie Iwersen-Bergmann Tags: Review Source Type: research

Response to “Association between metformin use prior to admission and lower mortality in septic adult patients with diabetes mellitus: beware of potential confounders”
(Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Huoyan Liang, Xianfei Ding and Tongwen Sun Tags: Letter Source Type: research

Efficacy of ultrasound-guided technique for radial artery catheterization in pediatric populations: a systematic review and meta-analysis of randomized controlled trials
The use of an ultrasound-guided technique for radial arterial catheterization has not been well established in pediatric patients. We conducted a systematic review and meta-analysis to evaluate the efficacy of... (Source: Critical Care)
Source: Critical Care - May 6, 2020 Category: Intensive Care Authors: Wen Zhang, Kunpeng Li, Hui Xu, Dawei Luo, Changbin Ji, Keshi Yang and Qinghua Zhao Tags: Research Source Type: research

Liver injury in critically ill patients with COVID-19: a case series
(Source: Critical Care)
Source: Critical Care - May 5, 2020 Category: Intensive Care Authors: Filipe S. Cardoso, Rui Pereira and Nuno Germano Tags: Research Letter Source Type: research

Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers
Burn injury is associated with a long-standing inflammatory reaction. The use of albumin solutions for plasma volume support is controversial because of concerns of increased capillary leakage, which could agg... (Source: Critical Care)
Source: Critical Care - May 5, 2020 Category: Intensive Care Authors: Markus Zdolsek, Robert G. Hahn, Folke Sj öberg and Joachim H. Zdolsek Tags: Research Source Type: research

Meropenem: continuous or extended infusion?
(Source: Critical Care)
Source: Critical Care - May 5, 2020 Category: Intensive Care Authors: Fr édéric Frippiat, Christelle Vercheval and Nathalie Layios Tags: Letter Source Type: research

Structural equation modeling the “control of gut overgrowth” in the prevention of ICU-acquired Gram-negative infection
Conceptually, the “control of gut overgrowth” (COGO) is key in mediating prevention against infection with Gram-negative bacilli by topical antibiotic prophylaxis, a common constituent of selective digestive d... (Source: Critical Care)
Source: Critical Care - May 4, 2020 Category: Intensive Care Authors: James C. Hurley Tags: Research Source Type: research

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia
(Source: Critical Care)
Source: Critical Care - April 30, 2020 Category: Intensive Care Authors: Nikoletta Rovina, Karolina Akinosoglou, Jesper Eugen-Olsen, Salim Hayek, Jochen Reiser and Evangelos J. Giamarellos-Bourboulis Tags: Research Letter Source Type: research

Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China
We described the clinic... (Source: Critical Care)
Source: Critical Care - April 30, 2020 Category: Intensive Care Authors: Dawei Wang, Yimei Yin, Chang Hu, Xing Liu, Xingguo Zhang, Shuliang Zhou, Mingzhi Jian, Haibo Xu, John Prowle, Bo Hu, Yirong Li and Zhiyong Peng Tags: Research Source Type: research

Correction to: International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe
In the publication of this article [1], there was an error in Fig. 1 which caused that the a, b were switched and ‘b’ was missing as a caption on Fig. 1b. (Source: Critical Care)
Source: Critical Care - April 29, 2020 Category: Intensive Care Authors: Karin Thevissen, Cato Jacobs, Michelle Holtappels, Mitsuru Toda, Paul Verweij and Joost Wauters Tags: Correction Source Type: research

Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study
(Source: Critical Care)
Source: Critical Care - April 28, 2020 Category: Intensive Care Authors: Hidehiko Nakano, Tsunehiro Matsubara, Kazuma Yamakawa and Kensuke Nakamura Tags: Research Letter Source Type: research

Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy
(Source: Critical Care)
Source: Critical Care - April 28, 2020 Category: Intensive Care Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2
(Source: Critical Care)
Source: Critical Care - April 28, 2020 Category: Intensive Care Authors: Nicholas E. Ingraham, David Boulware, Matthew A. Sparks, Timothy Schacker, Bradley Benson, Jeffrey A. Sparks, Thomas Murray, John Connett, Jeffrey G. Chipman, Anthony Charles and Christopher J. Tignanelli Tags: Commentary Source Type: research

Association between metformin use prior to admission and lower mortality in septic adult patients with diabetes mellitus: beware of potential confounders
(Source: Critical Care)
Source: Critical Care - April 28, 2020 Category: Intensive Care Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Is the effect of a high-flow nasal cannula after extubation evaluated by electrical impedance tomography applicable to clinical practice?
(Source: Critical Care)
Source: Critical Care - April 28, 2020 Category: Intensive Care Authors: Wataru Matsuda Tags: Letter Source Type: research

How to measure blood pressure using an arterial catheter: a systematic 5-step approach
Arterial blood pressure (BP) is a fundamental cardiovascular variable, is routinely measured in perioperative and intensive care medicine, and has a significant impact on patient management. The clinical refer... (Source: Critical Care)
Source: Critical Care - April 24, 2020 Category: Intensive Care Authors: Bernd Saugel, Karim Kouz, Agnes S. Meidert, Leonie Schulte-Uentrop and Stefano Romagnoli Tags: Review Source Type: research

High-flow nasal cannula may be no safer than non-invasive positive pressure ventilation for COVID-19 patients
(Source: Critical Care)
Source: Critical Care - April 23, 2020 Category: Intensive Care Authors: Kenneth E. Remy, John C. Lin and Philip A. Verhoef Tags: Research Letter Source Type: research

SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression
(Source: Critical Care)
Source: Critical Care - April 23, 2020 Category: Intensive Care Authors: Xia Yu, Shanshan Sun, Yu Shi, Hao Wang, Ruihong Zhao and Jifang Sheng Tags: Research Letter Source Type: research

The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or ou... (Source: Critical Care)
Source: Critical Care - April 23, 2020 Category: Intensive Care Authors: Jean-Louis Vincent, Andrew Ferguson, Peter Pickkers, Stephan M. Jakob, Ulrich Jaschinski, Ghaleb A. Almekhlafi, Marc Leone, Majid Mokhtari, Luis E. Fontes, Philippe R. Bauer and Yasser Sakr Tags: Research Source Type: research

Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic
(Source: Critical Care)
Source: Critical Care - April 22, 2020 Category: Intensive Care Authors: Marco Vergano, Guido Bertolini, Alberto Giannini, Giuseppe R. Gristina, Sergio Livigni, Giovanni Mistraletti, Luigi Riccioni and Flavia Petrini Tags: Editorial Source Type: research

IL6-R blocking with tocilizumab in critically ill patients with hemophagocytic syndrome
(Source: Critical Care)
Source: Critical Care - April 22, 2020 Category: Intensive Care Authors: Etienne Dufranc, Arnaud Del Bello, Julie Belliere, Nassim Kamar and Stanislas Faguer Tags: Research Letter Source Type: research

Managing COVID-19 in resource-limited settings: critical care considerations
(Source: Critical Care)
Source: Critical Care - April 22, 2020 Category: Intensive Care Authors: Wen Ting Siow, Mei Fong Liew, Babu Raja Shrestha, Faisal Muchtar and Kay Choong See Tags: Editorial Source Type: research

Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients
Dipeptidyl peptidase-3 (DPP3) is a metallopeptidase which cleaves bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 has been proposed to be a myocardial depressant fa... (Source: Critical Care)
Source: Critical Care - April 22, 2020 Category: Intensive Care Authors: Fran çois Dépret, Juliette Amzallag, Adrien Pollina, Laure Fayolle-Pivot, Maxime Coutrot, Maïté Chaussard, Karine Santos, Oliver Hartmann, Marion Jully, Alexandre Fratani, Haikel Oueslati, Alexandru Cupaciu, Mourad Benyamina, Lucie Guillemet, Benjamin Tags: Research Source Type: research

The value of plasma pro-enkephalin and adrenomedullin for the prediction of sepsis-associated acute kidney injury in critically ill patients
(Source: Critical Care)
Source: Critical Care - April 21, 2020 Category: Intensive Care Authors: Ruijin Liu, Xiaoya Zheng, Hongliang Wang, Sicong Wang, Kaijiang Yu and Changsong Wang Tags: Research Letter Source Type: research

Using arterial-venous oxygen difference to guide red blood cell transfusion strategy
Guidelines recommend a restrictive red blood cell transfusion strategy based on hemoglobin (Hb) concentrations in critically ill patients. We hypothesized that the arterial-venous oxygen difference (A-V O2diff), ... (Source: Critical Care)
Source: Critical Care - April 20, 2020 Category: Intensive Care Authors: Alberto Fogagnolo, Fabio Silvio Taccone, Jean Louis Vincent, Giulia Benetto, Elaine Cavalcante, Elisabetta Marangoni, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta and Savino Spadaro Tags: Research Source Type: research

Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis
While delirium prevalence and duration are each associated with increased 30-day, 6-month, and 1-year mortality, the association between incident ICU delirium and mortality remains unclear. We evaluated the as... (Source: Critical Care)
Source: Critical Care - April 20, 2020 Category: Intensive Care Authors: Matthew S. Duprey, Mark van den Boogaard, Johannes G. van der Hoeven, Peter Pickkers, Becky A. Briesacher, Jane S. Saczynski, John L. Griffith and John W. Devlin Tags: Research Source Type: research

Whether the GFR measured by renal scintigraphy under non-steady state conditions for critically ill patients with AKI can be used as a predictive parameter for clinical events
(Source: Critical Care)
Source: Critical Care - April 19, 2020 Category: Intensive Care Authors: Guang-wen Zhu, Zhou Gao, Abdoul Rachid and Hui Liu Tags: Letter Source Type: research

The application of strong matrix management and PDCA cycle in the management of severe COVID-19 patients
(Source: Critical Care)
Source: Critical Care - April 17, 2020 Category: Intensive Care Authors: Yuanchao Li, Hongliang Wang and Jundong Jiao Tags: Editorial Source Type: research

VENTILatOry strategies in patients with severe traumatic brain injury: the VENTILO Survey of the European Society of Intensive Care Medicine (ESICM)
Severe traumatic brain injury (TBI) patients often develop acute respiratory failure. Optimal ventilator strategies in this setting are not well established. We performed an international survey to investigate... (Source: Critical Care)
Source: Critical Care - April 17, 2020 Category: Intensive Care Authors: Edoardo Picetti, Paolo Pelosi, Fabio Silvio Taccone, Giuseppe Citerio, Jordi Mancebo and Chiara Robba Tags: Research Source Type: research

A case of a readmitted patient who recovered from COVID-19 in Chengdu, China
(Source: Critical Care)
Source: Critical Care - April 16, 2020 Category: Intensive Care Authors: Xiao-jin Li, Zhong-wei Zhang and Zhi-yong Zong Tags: Research Letter Source Type: research

Interfacility helicopter transfers for critically ill patients: always the right choice?
(Source: Critical Care)
Source: Critical Care - April 16, 2020 Category: Intensive Care Authors: Hasan Hawilo and Ravi Taneja Tags: Editorial Source Type: research