Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock
This study investigated compliance rates with the Surviving Sepsis Campaign (SSC) 3-h bundle for daytime and ... (Source: Critical Care)
Source: Critical Care - February 11, 2022 Category: Intensive Care Authors: Je Sung You, Yoo Seok Park, Sung Phil Chung, Hye Sun Lee, Soyoung Jeon, Won Young Kim, Tae Gun Shin, You Hwan Jo, Gu Hyun Kang, Sung Hyuk Choi, Gil Joon Suh, Byuk Sung Ko, Kap Su Han, Jong Hwan Shin and Taeyoung Kong Tags: Research Source Type: research

Study find that COVID ARDS was associated with a low risk for possible or proven PCP: still true after dexamethasone use
(Source: Critical Care)
Source: Critical Care - February 10, 2022 Category: Intensive Care Authors: Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study
Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been ... (Source: Critical Care)
Source: Critical Care - February 8, 2022 Category: Intensive Care Authors: Pedro David Wendel-Garcia, Arantxa Mas, Cristina Gonz ález-Isern, Ricard Ferrer, Rafael Máñez, Joan-Ramon Masclans, Elena Sandoval, Paula Vera, Josep Trenado, Rafael Fernández, Josep-Maria Sirvent, Melcior Martínez, Mercedes Ibarz, Pau Garro, José L Tags: Research Source Type: research

The physiological foundations of critical care medicine: the contribution of Joseph Milic-Emili, a physiologist “by hook or by crook”
(Source: Critical Care)
Source: Critical Care - February 8, 2022 Category: Intensive Care Authors: V. Marco Ranieri and Claude Gu érin Tags: Obituary Source Type: research

Prone position during venovenous extracorporeal membrane oxygenation: survival analysis needed for a time-dependent intervention
(Source: Critical Care)
Source: Critical Care - February 8, 2022 Category: Intensive Care Authors: Akram M. Zaaqoq, Adrian G. Barnett, Silver Heinsar, Matthew J. Griffee, Graeme MacLaren, Jeffrey P. Jacobs, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Heidi J. Dalton and Giles J. Peek Tags: Comment Source Type: research

Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis
The association of tracheostomy timing and clinical outcomes in ventilated COVID-19 patients remains controversial. We performed a meta-analysis to evaluate the impact of early tracheostomy compared to late tr... (Source: Critical Care)
Source: Critical Care - February 8, 2022 Category: Intensive Care Authors: Yun Ji, Yumin Fang, Baoli Cheng, Libin Li and Xiangming Fang Tags: Research Source Type: research

Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda
The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and high-burden pathogens are unique. In this context, poor under... (Source: Critical Care)
Source: Critical Care - February 8, 2022 Category: Intensive Care Authors: Matthew J. Cummings, Barnabas Bakamutumaho, Adam Price, Nicholas Owor, John Kayiwa, Joyce Namulondo, Timothy Byaruhanga, Moses Muwanga, Christopher Nsereko, Stephen Sameroff, Rafal Tokarz, Wai Wong, Shivang S. Shah, Michelle H. Larsen, W. Ian Lipkin, Juli Tags: Research Source Type: research

Detection of cerebral hypoperfusion with a dynamic hyperoxia test using brain oxygenation pressure monitoring
Brain multimodal monitoring including intracranial pressure (ICP) and brain tissue oxygen pressure (PbtO2) is more accurate than ICP alone in detecting cerebral hypoperfusion after traumatic brain injury (TBI). N... (Source: Critical Care)
Source: Critical Care - February 7, 2022 Category: Intensive Care Authors: Thomas Gargadennec, Gioconda Ferraro, Rudy Chapusette, Xavier Chapalain, Elisa Bogossian, Morgane Van Wettere, Lorenzo Peluso, Jacques Creteur, Olivier Huet, Niloufar Sadeghi and Fabio Silvio Taccone Tags: Research Source Type: research

Extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study
Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit... (Source: Critical Care)
Source: Critical Care - February 5, 2022 Category: Intensive Care Authors: Vito Fanelli, Marco Giani, Giacomo Grasselli, Francesco Mojoli, Gennaro Martucci, Lorenzo Grazioli, Francesco Alessandri, Silvia Mongodi, Gabriele Sales, Giorgia Montrucchio, Costanza Pizzi, Lorenzo Richiardi, Luca Lorini, Antonio Arcadipane, Antonio Pese Tags: Research Source Type: research

Timing of inspiratory muscle activity detected from airway pressure and flow during pressure support ventilation: the waveform method
Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve p... (Source: Critical Care)
Source: Critical Care - January 30, 2022 Category: Intensive Care Authors: Francesco Mojoli, Marco Pozzi, Anita Orlando, Isabella M. Bianchi, Eric Arisi, Giorgio A. Iotti, Antonio Braschi and Laurent Brochard Tags: Research Source Type: research

Endotheliopathy is associated with slower liberation from mechanical ventilation: a cohort study
Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined. We investigated if endotheliopathy biomar... (Source: Critical Care)
Source: Critical Care - January 30, 2022 Category: Intensive Care Authors: Martin Sch ønemann-Lund, Theis S. Itenov, Johan E. Larsson, Birgitte Lindegaard, Pär I. Johansson and Morten H. Bestle Tags: Research Source Type: research

Immune effects of PI3K/Akt/HIF-1 α-regulated glycolysis in polymorphonuclear neutrophils during sepsis
Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in ... (Source: Critical Care)
Source: Critical Care - January 28, 2022 Category: Intensive Care Authors: Tingting Pan, Shaoqiong Sun, Yang Chen, Rui Tian, Erzhen Chen, Ruoming Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu and Hongping Qu Tags: Research Source Type: research

Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients
Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there are a growing number of cases that involve COVID-19-associated pulmon... (Source: Critical Care)
Source: Critical Care - January 28, 2022 Category: Intensive Care Authors: Rasmus Leistner, Lisa Schroeter, Thomas Adam, Denis Poddubnyy, Miriam Stegemann, Britta Siegmund, Friederike Maechler, Christine Geffers, Frank Schwab, Petra Gastmeier, Sascha Treskatsch, Stefan Angermair and Thomas Schneider Tags: Research Source Type: research

Effects of positive end-expiratory pressure on lung ultrasound patterns and their correlation with intracranial pressure in mechanically ventilated brain injured patients
The effects of positive end-expiratory pressure (PEEP) on lung ultrasound (LUS) patterns, and their relationship with intracranial pressure (ICP) in brain injured patients have not been completely clarified. T... (Source: Critical Care)
Source: Critical Care - January 28, 2022 Category: Intensive Care Authors: Chiara Robba, Lorenzo Ball, Denise Battaglini, Francesca Iannuzzi, Iole Brunetti, Pietro Fiaschi, Gianluigi Zona, Fabio Silvio Taccone, Antonio Messina, Silvia Mongodi and Paolo Pelosi Tags: Research Source Type: research

Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial
Intravenous vitamin C administration in septic shock may have a sparing effect on vasopressor requirements, and vitamin C ’s enzyme cofactor functions provide a mechanistic rationale. Our study aimed to determi... (Source: Critical Care)
Source: Critical Care - January 25, 2022 Category: Intensive Care Authors: Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee Van Der Heyden, Anna Morris, Geoff Shaw and Anitra C. Carr Tags: Research Source Type: research