Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study
Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this... (Source: Critical Care)
Source: Critical Care - November 22, 2018 Category: Intensive Care Authors: Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sak Tags: Research Source Type: research

How to improve worldwide early enteral nutrition performance in intensive care units?
(Source: Critical Care)
Source: Critical Care - November 21, 2018 Category: Intensive Care Authors: Arthur Raymond Hubert van Zanten Tags: Editorial Source Type: research

Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus
Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor ou... (Source: Critical Care)
Source: Critical Care - November 21, 2018 Category: Intensive Care Authors: Dominik Mad žar, Caroline Reindl, Antje Giede-Jeppe, Tobias Bobinger, Maximilian I. Sprügel, Ruben U. Knappe, Hajo M. Hamer and Hagen B. Huttner Tags: Research Source Type: research

When and how to use predictive biomarkers for corticosteroid treatment of septic shock
(Source: Critical Care)
Source: Critical Care - November 21, 2018 Category: Intensive Care Authors: James A. Russell Tags: Editorial Source Type: research

Letter on “Pre-hospital transthoracic echocardiography for early identification of non-ST-elevation myocardial infarction in patients with acute coronary syndrome”
(Source: Critical Care)
Source: Critical Care - November 21, 2018 Category: Intensive Care Authors: Guido Tavazzi, Aleksandar N Neskovic, Bogdan A Popescu and Gabriele Via Tags: Letter Source Type: research

The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review
Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. (Source: Critical Care)
Source: Critical Care - November 21, 2018 Category: Intensive Care Authors: Lin Ruan, Guan-Yu Chen, Zhen Liu, Yun Zhao, Guang-Yu Xu, Shu-Fang Li, Chun-Ni Li, Lin-Shan Chen and Zheng Tao Tags: Research Source Type: research

Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study
Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa... (Source: Critical Care)
Source: Critical Care - November 20, 2018 Category: Intensive Care Authors: Erwin Ista, Babette van Beusekom, Joost van Rosmalen, Martin C. J. Kneyber, Joris Lemson, Arno Brouwers, Gwen C. Dieleman, Bram Dierckx, Matthijs de Hoog, Dick Tibboel and Monique van Dijk Tags: Research Source Type: research

Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial
We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. (Source: Critical Care)
Source: Critical Care - November 20, 2018 Category: Intensive Care Authors: Michael J. Massey, Peter C. Hou, Michael Filbin, Henry Wang, Long Ngo, David T. Huang, William C. Aird, Victor Novack, Stephen Trzeciak, Donald M. Yealy, John A. Kellum, Derek C. Angus and Nathan I. Shapiro Tags: Research Source Type: research

Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years
Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we ... (Source: Critical Care)
Source: Critical Care - November 19, 2018 Category: Intensive Care Authors: Julius J. Schmidt, Catherina Lueck, Stefan Ziesing, Matthias Stoll, Hermann Haller, Jens Gottlieb, Matthias Eder, Tobias Welte, Marius M. Hoeper, Andr é Scherag and Sascha David Tags: Research Source Type: research

Prediction of acute kidney injury in intensive care unit patients
(Source: Critical Care)
Source: Critical Care - November 16, 2018 Category: Intensive Care Authors: Rui-Juan Guo, Fu-Shan Xue and Liu-Jia-Zi Shao Tags: Letter Source Type: research

Treatment of central line-associated bloodstream infections
(Source: Critical Care)
Source: Critical Care - November 16, 2018 Category: Intensive Care Authors: J érémy Guenezan, Bertrand Drugeon, Nicolas Marjanovic and Olivier Mimoz Tags: Editorial Source Type: research

Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study
We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. (Source: Critical Care)
Source: Critical Care - November 16, 2018 Category: Intensive Care Authors: Ernest van Veen, Mathieu van der Jagt, Maryse C. Cnossen, Andrew I. R. Maas, Inez D. de Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J. R. Rietdijk, Jeroen T. J. M. van Dijck and Erwin J. O. Kompanje Tags: Research Source Type: research

Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1 –αvβ5 integrin pathway in TLR4-mediated inflammation and injury
High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whethe... (Source: Critical Care)
Source: Critical Care - November 16, 2018 Category: Intensive Care Authors: Xibing Ding, Yao Tong, Shuqing Jin, Zhixia Chen, Tunliang Li, Timothy R. Billiar, Bruce R. Pitt, Quan Li and Li-Ming Zhang Tags: Research Source Type: research

Derivation and validation of plasma endostatin for predicting renal recovery from acute kidney injury: a prospective validation study
Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcome... (Source: Critical Care)
Source: Critical Care - November 16, 2018 Category: Intensive Care Authors: Hui-Miao Jia, Yue Zheng, Li-Feng Huang, Xin Xin, Wen-Liang Ma, Yi-Jia Jiang, Xi Zheng, Shu-Yan Guo and Wen-Xiong Li Tags: Research Source Type: research

Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis
Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the optimum aerosolized antibiotics for VAP remain unce... (Source: Critical Care)
Source: Critical Care - November 15, 2018 Category: Intensive Care Authors: Feng Xu, Lu-Lu He, Luan-Qing Che, Wen Li, Song-Min Ying, Zhi-Hua Chen and Hua-Hao Shen Tags: Review Source Type: research

Selective decontamination of the digestive tract in critical care: a teenage angst or coming of age issue?
Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range... (Source: Critical Care)
Source: Critical Care - November 14, 2018 Category: Intensive Care Authors: Brian H. Cuthbertson Tags: Editorial Source Type: research

“Think. Check. Submit.” to avoid predatory publishing
(Source: Critical Care)
Source: Critical Care - November 14, 2018 Category: Intensive Care Authors: Andrea Cortegiani and Steven L. Shafer Tags: Letter Source Type: research

Comparison between surgical and percutaneous tracheostomy effects on procalcitonin kinetics in critically ill patients
Available evidence from randomized controlled trials including adult critically ill patients tends to show that percutaneous dilatational tracheostomy (PDT) techniques are performed faster and reduce stoma inf... (Source: Critical Care)
Source: Critical Care - November 14, 2018 Category: Intensive Care Authors: Maria Vargas, Pasquale Buonanno, Lina Giorgiano, Giovanna Sorriento, Carmine Iacovazzo and Giuseppe Servillo Tags: Letter Source Type: research

Is goal-directed fluid therapy based on dynamic variables alone sufficient to improve clinical outcomes among patients undergoing surgery? A meta-analysis
Whether goal-directed fluid therapy based on dynamic predictors of fluid responsiveness (GDFTdyn) alone improves clinical outcomes in comparison with standard fluid therapy among patients undergoing surgery re... (Source: Critical Care)
Source: Critical Care - November 14, 2018 Category: Intensive Care Authors: Qi-Wen Deng, Wen-Cheng Tan, Bing-Cheng Zhao, Shi-Hong Wen, Jian-Tong Shen and Miao Xu Tags: Research Source Type: research

Systematic review of incretin therapy during peri-operative and intensive care
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering blood glucose in a glucose-dependent manner, incretin-based therapies represent a novel and... (Source: Critical Care)
Source: Critical Care - November 14, 2018 Category: Intensive Care Authors: Abraham H Hulst, Mark P Plummer, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Adam M Deane and Jeroen Hermanides Tags: Research Source Type: research

A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock
(Source: Critical Care)
Source: Critical Care - November 13, 2018 Category: Intensive Care Authors: Xu Li and Xiaochun Ma Tags: Letter Source Type: research

Bright environmental light improves the sleepiness of nightshift ICU nurses
Shift work can disturb circadian homeostasis and result in fatigue, excessive sleepiness, and reduced quality of life. Light therapy has been shown to impart positive effects in night shift workers. We sought ... (Source: Critical Care)
Source: Critical Care - November 13, 2018 Category: Intensive Care Authors: John E. Griepentrog, Hanna E. Labiner, Scott R. Gunn and Matthew R. Rosengart Tags: Research Source Type: research

Cost-effectiveness of procalcitonin testing to guide antibiotic treatment duration in critically ill patients: results from a randomised controlled multicentre trial in the Netherlands
Procalcitonin (PCT) testing can help in safely reducing antibiotic treatment duration in intensive care patients with sepsis. However, the cost-effectiveness of such PCT guidance is not yet known. (Source: Critical Care)
Source: Critical Care - November 13, 2018 Category: Intensive Care Authors: Michelle M. A. Kip, Jos A. van Oers, Arezoo Shajiei, Albertus Beishuizen, A. M. Sofie Berghuis, Armand R. Girbes, Evelien de Jong, Dylan W. de Lange, Maarten W. N. Nijsten, Maarten J. IJzerman, Hendrik Koffijberg and Ron Kusters Tags: Research Source Type: research

Ultrasound-guided vessel puncture: calling for Pythagoras ’ help
(Source: Critical Care)
Source: Critical Care - November 8, 2018 Category: Intensive Care Authors: Ga ël Piton, Gilles Capellier and Hadrien Winiszewski Tags: Editorial Source Type: research

Is access to intensive care equitable?
(Source: Critical Care)
Source: Critical Care - November 3, 2018 Category: Intensive Care Authors: Claudio M Martin Tags: Editorial Source Type: research

Optimizing micafungin dosing in critically ill patients: what about extracorporeal therapies?
(Source: Critical Care)
Source: Critical Care - November 1, 2018 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Leonel Barreto Gutierrez, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

Angiotensin in ECMO patients with refractory shock
(Source: Critical Care)
Source: Critical Care - November 1, 2018 Category: Intensive Care Authors: Marlies Ostermann, David W. Boldt, Michael D. Harper, George W. Lim and Kyle Gunnerson Tags: Letter Source Type: research

Clinical benefit of high-volume hemofiltration in severe burn injury: is it removing bad humors or actually avoiding hypervolemia?
(Source: Critical Care)
Source: Critical Care - November 1, 2018 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Thierry Preseau, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia
Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully und... (Source: Critical Care)
Source: Critical Care - November 1, 2018 Category: Intensive Care Authors: Sarah Berger, Cengiz Goekeri, Shishir K. Gupta, Julio Vera, Kristina Dietert, Ulrike Behrendt, Jasmin Lienau, Sandra-Maria Wienhold, Achim D. Gruber, Norbert Suttorp, Martin Witzenrath and Geraldine Nouailles Tags: Research Source Type: research

Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model
Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations i... (Source: Critical Care)
Source: Critical Care - October 30, 2018 Category: Intensive Care Authors: Beth A. Payne, Helen Ryan, Jeffrey Bone, Laura A. Magee, Alice B. Aarvold, J. Mark Ansermino, Zulfiqar A. Bhutta, Mary Bowen, J. Guilherme Cecatti, Cynthia Chazotte, Tim Crozier, Anne-Corn élie J. M. de Pont, Oktay Demirkiran, Tao Duan, Marlot Kallen, We Tags: Research Source Type: research

Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers
This study was designed to demonstrat... (Source: Critical Care)
Source: Critical Care - October 30, 2018 Category: Intensive Care Authors: Hannah Knaup, Klaus Stahl, Bernhard M. W. Schmidt, Temitayo O. Idowu, Markus Busch, Olaf Wiesner, Tobias Welte, Hermann Haller, Jan T. Kielstein, Marius M. Hoeper and Sascha David Tags: Research Source Type: research

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit
Whether perioperative hyperchloremia can induce postoperative acute kidney injury (AKI) is controversial. We investigated the association between perioperative hyperchloremia and postoperative AKI in patients ... (Source: Critical Care)
Source: Critical Care - October 30, 2018 Category: Intensive Care Authors: Tak Kyu Oh, In-Ae Song, Se Joong Kim, Sung Yoon Lim, Sang-Hwan Do, Jung-Won Hwang, Jinhee Kim and Young-Tae Jeon Tags: Research Source Type: research

Multicenter derivation and validation of an early warning score for acute respiratory failure or death in the hospital
Acute respiratory failure occurs frequently in hospitalized patients and often starts before ICU admission. A risk stratification tool to predict mortality and risk for mechanical ventilation (MV) may allow fo... (Source: Critical Care)
Source: Critical Care - October 30, 2018 Category: Intensive Care Authors: Mikhail A Dziadzko, Paul J Novotny, Jeff Sloan, Ognjen Gajic, Vitaly Herasevich, Parsa Mirhaji, Yiyuan Wu and Michelle Ng Gong Tags: Research Source Type: research

The global need for essential emergency and critical care
Critical illness results in millions of deaths each year. Care for those with critical illness is often neglected due to a lack of prioritisation, co-ordination, and coverage of timely identification and basic... (Source: Critical Care)
Source: Critical Care - October 29, 2018 Category: Intensive Care Authors: Carl Otto Schell, Martin Gerdin W ärnberg, Anna Hvarfner, Andreas Höög, Ulrika Baker, Markus Castegren and Tim Baker Tags: Viewpoint Source Type: research

Microcirculation in cardiogenic shock supported with extracorporeal membrane oxygenation: the need for a homogeneous population and strict evolution assessment
(Source: Critical Care)
Source: Critical Care - October 29, 2018 Category: Intensive Care Authors: Santiago Montero, Juliette Chommeloux, Guillaume Franchineau, Alain Combes and Matthieu Schmidt Tags: Letter Source Type: research

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation,... (Source: Critical Care)
Source: Critical Care - October 29, 2018 Category: Intensive Care Authors: Sandra-Maria Wienhold, Mario Macr ì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath and Holger C Müller-Re Tags: Research Source Type: research

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials
Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus revers... (Source: Critical Care)
Source: Critical Care - October 29, 2018 Category: Intensive Care Authors: Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl and Houssam S Itani Tags: Research Source Type: research

Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and... (Source: Critical Care)
Source: Critical Care - October 29, 2018 Category: Intensive Care Authors: Ari Moskowitz, Lars W. Andersen, David T. Huang, Katherine M. Berg, Anne V. Grossestreuer, Paul E. Marik, Robert L. Sherwin, Peter C. Hou, Lance B. Becker, Michael N. Cocchi, Pratik Doshi, Jonathan Gong, Ayan Sen and Michael W. Donnino Tags: Review Source Type: research

Angiotensin converting enzyme defects in shock: implications for future therapy
(Source: Critical Care)
Source: Critical Care - October 28, 2018 Category: Intensive Care Authors: Lakhmir S. Chawla, Steve Chen, Rinaldo Bellomo and George F. Tidmarsh Tags: Commentary Source Type: research

Determinants of sepsis knowledge: a representative survey of the elderly population in Germany
Sepsis is a life-threatening medical emergency requiring early diagnosis and urgent treatment. Knowledge is crucial, especially in major risk groups such as the elderly. We therefore assessed sophisticated kno... (Source: Critical Care)
Source: Critical Care - October 28, 2018 Category: Intensive Care Authors: Sarah Eitze, Carolin Fleischmann-Struzek, Cornelia Betsch and Konrad Reinhart Tags: Research Source Type: research

Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient? A multicentre, prospective, randomised controlled open trial
Pathogenic enteric bacteria aspirated from the oropharynx are the main cause of ventilator-associated pneumonia (VAP). Using chlorhexidine (CHX) orally or selective decontamination has been shown to reduce VAP... (Source: Critical Care)
Source: Critical Care - October 28, 2018 Category: Intensive Care Authors: Bengt Klarin, Anne Adolfsson, Anders Torstensson and Anders Larsson Tags: Research Source Type: research

Angiotensin-(1 –7) attenuates organ injury and mortality in rats with polymicrobial sepsis
Sepsis and related multiple organ dysfunction result in high morbidity and mortality. Angiotensin (Ang)-(1 –7), a biologically active peptide, has various opposing effects of Ang II. Because the effect of Ang-(... (Source: Critical Care)
Source: Critical Care - October 27, 2018 Category: Intensive Care Authors: Hsin-Jung Tsai, Mei-Hui Liao, Chih-Chin Shih, Shuk-Man Ka, Cheng-Ming Tsao and Chin-Chen Wu Tags: Research Source Type: research

Bacterial contamination of platelets for transfusion: strategies for prevention
Platelet transfusions carry greater risks of infection, sepsis, and death than any other blood product, owing primarily to bacterial contamination. Many patients may be at particular risk, including critically... (Source: Critical Care)
Source: Critical Care - October 27, 2018 Category: Intensive Care Authors: Jerrold H. Levy, Matthew D. Neal and Jay H. Herman Tags: Review Source Type: research

Permissive fluid volume in adult patients undergoing extracorporeal membrane oxygenation treatment
Extracorporeal membrane oxygenation (ECMO) is a cardiorespiratory support technique for patients with circulatory or pulmonary failure. Frequently, large-volume fluid resuscitation is needed to ensure sufficie... (Source: Critical Care)
Source: Critical Care - October 27, 2018 Category: Intensive Care Authors: Hyoungnae Kim, Jin Hyuk Paek, Joo Han Song, Hajeong Lee, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Sejoong Kim and Jung Tak Park Tags: Research Source Type: research

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The... (Source: Critical Care)
Source: Critical Care - October 27, 2018 Category: Intensive Care Authors: Andrew J. Boyle, Fabiana Madotto, John G. Laffey, Giacomo Bellani, T ài Pham, Antonio Pesenti, B. Taylor Thompson, Cecilia M. O’Kane, Adam M. Deane and Daniel F. McAuley Tags: Research Source Type: research

Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison
The continuous administration of opioids in critical care patients is a common therapy for the tolerance of mechanical ventilation. Opioid choice has a crucial impact on the length of mechanical ventilation. O... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Daniel A Klaus, Albert M de Bettignies, Rudolf Seemann, Claus G Krenn and Georg A Roth Tags: Research Source Type: research

Factors associated with recurrence and mortality in central line-associated bloodstream infections: a retrospective cohort study
Central line-associated bloodstream infections (CLABSIs) are associated with increased mortality, hospital length of stay, and cost. Antimicrobial treatment guidelines for CLABSIs are primarily based on expert... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Luis E Huerta, George E Nelson, Thomas G Stewart and Todd W Rice Tags: Research Source Type: research

Differences in attitudes towards end-of-life care among intensivists, oncologists and prosecutors in Brazil: a nationwide survey
(Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Jo ão Gabriel Rosa Ramos, Roberto D’Oliveira Vieira, Fernanda Correia Tourinho, Andre Ismael, Diaulas Costa Ribeiro, Humberto Jacques de Medeiro and Daniel Neves Forte Tags: Letter Source Type: research

Endocan, sepsis, pneumonia, and acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the facto... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Nathalie De Freitas Caires, Alexandre Gaudet, Lucie Portier, Anne Tsicopoulos, Daniel Mathieu and Philippe Lassalle Tags: Review Source Type: research

The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients
Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the therapy could provide benefit for highly sele... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Nattachai Srisawat, Somkanya Tungsanga, Nuttha Lumlertgul, Chalermchai Komaenthammasophon, Sadudee Peerapornratana, Nicha Thamrongsat, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Kriang Tungsanga and John A. Kellum Tags: Research Source Type: research