Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial
Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe issue among ICU patients. Resistance training and beta-hydroxy-beta-methylbutyrate (HMB) intervention have demonstrated the potential to... (Source: Critical Care)
Source: Critical Care - December 15, 2023 Category: Intensive Care Authors: Ting-Ting Wu, Qiao-Ling Chen, Xiu-Xia Lin, Mei-Lian Xu, Xue-Xian Chen, Chen-Juan Luo, Yao-Ning Zhuang, Yue-Qing Wei, Jing-Bing Wu, Jing Xiong, Li-Li Chen and Hong Li Tags: Research Source Type: research
Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest
Brain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac arrest; therefore, therapies tha... (Source: Critical Care)
Source: Critical Care - December 14, 2023 Category: Intensive Care Authors: Joseph M. Wider, Erin Gruley, Paul T. Morse, Junmei Wan, Icksoo Lee, Anthony R. Anzell, Garrett M. Fogo, Jennifer Mathieu, Gerald Hish, Brian O ’Neil, Robert W. Neumar, Karin Przyklenk, Maik Hüttemann and Thomas H. Sanderson Tags: Research Source Type: research
Reply to “Zimmermann, T., Lopez-Ayala, P. & Singer, M. Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest ”
(Source: Critical Care)
Source: Critical Care - December 14, 2023 Category: Intensive Care Authors: Johannes Grand, Christian Hassager, Jesper Kjaergaard and Jacob E. M øller Tags: Matters Arising Source Type: research
Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis
Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep... (Source: Critical Care)
Source: Critical Care - December 13, 2023 Category: Intensive Care Authors: Huachen Wang, Meixiang Wang, Junlan Chen, Hongda Hou, Zheng Guo, Hong Yang, Hua Tang and Bing Chen Tags: Research Source Type: research
Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study
There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for be... (Source: Critical Care)
Source: Critical Care - December 11, 2023 Category: Intensive Care Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizo Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra Tags: Research Source Type: research
Continuous monitoring of the lower limit of reactivity in traumatic brain injury patients: understanding what is feasible
(Source: Critical Care)
Source: Critical Care - December 11, 2023 Category: Intensive Care Authors: Erta Beqiri, Joseph Donnelly, Marcel Aries, Ari Ercole and Peter Smielewski Tags: Matters Arising Source Type: research
Publisher Correction: Early corticosteroids are associated with lower mortality in critically ill patients with COVID ‑19: a cohort study
(Source: Critical Care)
Source: Critical Care - December 11, 2023 Category: Intensive Care Authors: Pablo Monedero, Alfredo Gea, Pedro Castro, Angel M. Candela ‑Toha, Maria L. Hernandez‑Sanz, Egoitz Arruti, Jesus Villar and Carlos Ferrando Tags: Publisher Correction Source Type: research
Do critical illness survivors with multimorbidity need a different model of care?
There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has largely focussed on rehabilitation interventions which aimed to address p... (Source: Critical Care)
Source: Critical Care - December 8, 2023 Category: Intensive Care Authors: Jonathan Stewart, Judy Bradley, Susan Smith, Joanne McPeake, Timothy Walsh, Kimberley Haines, Nina Leggett, Nigel Hart and Danny McAuley Tags: Review Source Type: research
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically ... (Source: Critical Care)
Source: Critical Care - December 8, 2023 Category: Intensive Care Authors: Jamie O. Yang, Matt S. Zinter, Matteo Pellegrini, Man Yee Wong, Kinisha Gala, Daniela Markovic, Brian Nadel, Kerui Peng, Nguyen Do, Serghei Mangul, Vinay M. Nadkarni, Aaron Karlsberg, Dhrithi Deshpande, Manish J. Butte, Lisa Asaro, Michael Agus & hellip; Tags: Research Source Type: research
Reflections from the bedside: a nursing perspective on three decades of intensive care
(Source: Critical Care)
Source: Critical Care - December 7, 2023 Category: Intensive Care Authors: Kathryn A. Riman and Deena Kelly Costa Tags: Editorial Source Type: research
Early administration of high protein for critically ill patients with acute kidney injury?
(Source: Critical Care)
Source: Critical Care - December 7, 2023 Category: Intensive Care Authors: Hasan M. Al-Dorzi and Yaseen M. Arabi Tags: Editorial Source Type: research
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur... (Source: Critical Care)
Source: Critical Care - December 7, 2023 Category: Intensive Care Authors: Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu and Lui G. Forni Tags: Research Source Type: research
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
(Source: Critical Care)
Source: Critical Care - December 7, 2023 Category: Intensive Care Authors: Frederic Michard, Denis Chemla and Jean-Louis Teboul Tags: Matters Arising Source Type: research
Critical illness among patients experiencing homelessness: a retrospective cohort study
To understand the epidemiology and healthcare use of critically ill patients experiencing homelessness compared to critically ill patients with stable housing. (Source: Critical Care)
Source: Critical Care - December 6, 2023 Category: Intensive Care Authors: K. M. Sauro, C. M. O ’Rielly, J. Kersen, A. Soo, S. M. Bagshaw and H. T. Stelfox Tags: Research Source Type: research
Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the immune response play an important role in its pathophysiolo... (Source: Critical Care)
Source: Critical Care - December 6, 2023 Category: Intensive Care Authors: Christian Bode, Sebastian Weis, Andrea Sauer, Pedro Wendel-Garcia and Sascha David Tags: Review Source Type: research
