Double carbapenem as a rescue strategy for the treatment of severe carbapenemase-producing Klebsiella pneumoniae infections: a two-center, matched case –control study
Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate th... (Source: Critical Care)
Source: Critical Care - July 5, 2017 Category: Intensive Care Authors: Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane and Massim Source Type: research

Does anti-VEGF bevacizumab improve survival in experimental sepsis?
(Source: Critical Care)
Source: Critical Care - July 5, 2017 Category: Intensive Care Authors: Emmanuel Besnier, Ebba Brakenhielm, Vincent Richard and Fabienne Tamion Source Type: research

Decisions regarding admission to the ICU and international initiatives to improve the decision-making process
(Source: Critical Care)
Source: Critical Care - July 4, 2017 Category: Intensive Care Authors: Christopher Bassford Source Type: research

Is it time to consider visual feedback systems the gold standard for chest compression skill acquisition?
(Source: Critical Care)
Source: Critical Care - July 4, 2017 Category: Intensive Care Authors: Andrea Cortegiani, Vincenzo Russotto, Enrico Baldi, Enrico Contri, Santi Maurizio Raineri and Antonino Giarratano Source Type: research

Open-chest versus closed-chest cardiopulmonary resuscitation in blunt trauma: analysis of a nationwide trauma registry
Although open-chest cardiopulmonary resuscitation (OCCPR) is often considered as the last salvage maneuver in critically injured patients, evidence on the effectiveness of OCCPR has been based only on the desc... (Source: Critical Care)
Source: Critical Care - July 3, 2017 Category: Intensive Care Authors: Akira Endo, Atsushi Shiraishi, Yasuhiro Otomo, Makoto Tomita, Hiroki Matsui and Kiyoshi Murata Source Type: research

Limited evidence to recommend lactate kinetics-guided therapy
(Source: Critical Care)
Source: Critical Care - July 3, 2017 Category: Intensive Care Authors: Daniel O. Thomas-R üddel and Michael Bauer Source Type: research

Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids
Restoration of endothelial glycocalyx (EG) barrier may be an essential therapeutic target for successful resuscitation. The aim of this study was to compare in vivo the effects of resuscitation with normal sal... (Source: Critical Care)
Source: Critical Care - June 29, 2017 Category: Intensive Care Authors: Luciana N. Torres, Kevin K. Chung, Christi L. Salgado, Michael A. Dubick and Ivo P. Torres Filho Source Type: research

Evaluation of early antimicrobial therapy adaptation guided by the BetaLACTA ® test: a case-control study
Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in intensive care unit patients, besides reducing the us... (Source: Critical Care)
Source: Critical Care - June 28, 2017 Category: Intensive Care Authors: Marc Garnier, Sacha Rozencwajg, T ài Pham, Sophie Vimont, Clarisse Blayau, Mehdi Hafiani, Jean-Pierre Fulgencio, Francis Bonnet, Jean-Luc Mainardi, Guillaume Arlet, Muriel Fartoukh, Salah Gallah and Christophe Quesnel Source Type: research

Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials
Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly... (Source: Critical Care)
Source: Critical Care - June 27, 2017 Category: Intensive Care Authors: Emmanuel Weiss, Wafa Essaied, Christophe Adrie, Jean-Ralph Zahar and Jean-Fran çois Timsit Source Type: research

Untangling glycaemia and mortality in critical care
Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate th... (Source: Critical Care)
Source: Critical Care - June 24, 2017 Category: Intensive Care Authors: Vincent Uyttendaele, Jennifer L. Dickson, Geoffrey M. Shaw, Thomas Desaive and J. Geoffrey Chase Source Type: research

Marked regional endothelial dysfunction in mottled skin area in patients with severe infections
Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized tha... (Source: Critical Care)
Source: Critical Care - June 23, 2017 Category: Intensive Care Authors: Simon Bourcier, J érémie Joffre, Vincent Dubée, Gabriel Preda, Jean-Luc Baudel, Naïke Bigé, Guillaume Leblanc, Bernard I. Levy, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella Source Type: research

Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support under extracorporeal cardiopulmonary resuscitation (eCPR) is the last option and may be offered to selected patients. Several factors predict ... (Source: Critical Care)
Source: Critical Care - June 22, 2017 Category: Intensive Care Authors: Tobias Wengenmayer, Stephan Rombach, Florian Ramshorn, Paul Biever, Christoph Bode, Daniel Duerschmied and Dawid L. Staudacher Source Type: research

Nucleated red blood cells, critical illness survivors and postdischarge outcomes: a cohort study
Little is known about risk factors associated with out-of-hospital outcomes in survivors of critical illness. We hypothesized that the presence of nucleated red blood cells in patients who survived critical ca... (Source: Critical Care)
Source: Critical Care - June 21, 2017 Category: Intensive Care Authors: Steven W. Purtle, Clare M. Horkan, Takuhiro Moromizato, Fiona K. Gibbons and Kenneth B. Christopher Source Type: research

Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33  °C and 36 °C
We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33  °C and 36 °C) on serum ... (Source: Critical Care)
Source: Critical Care - June 20, 2017 Category: Intensive Care Authors: Pascal Stammet, Josef Dankiewicz, Niklas Nielsen, Fran çois Fays, Olivier Collignon, Christian Hassager, Michael Wanscher, Johan Undèn, Jorn Wetterslev, Tommaso Pellis, Anders Aneman, Jan Hovdenes, Matt P. Wise, Georges Gilson, David Erlinge, Janneke Ho Source Type: research

Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?
Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospect... (Source: Critical Care)
Source: Critical Care - June 20, 2017 Category: Intensive Care Authors: Chih-Chung Shiao, Tao-Min Huang, Herbert D. Spapen, Patrick M. Honore and Vin-Cent Wu Source Type: research

Transpulmonary thermodilution: advantages and limits
For complex patients in the intensive care unit or in the operating room, many questions regarding their haemodynamic management cannot be answered with simple clinical examination. In particular, arterial pre... (Source: Critical Care)
Source: Critical Care - June 19, 2017 Category: Intensive Care Authors: Xavier Monnet and Jean-Louis Teboul Source Type: research

Human leukocyte antigen-DR expression might predict outcomes in severe sepsis, but diabetes mellitus cannot be ignored
(Source: Critical Care)
Source: Critical Care - June 19, 2017 Category: Intensive Care Authors: Jun Li, Xianshi Zhou, Ye Ye and Guanghua Guanghua Source Type: research

Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms
Ventilator-associated pneumonia (VAP) is a common and serious problem in intensive care units (ICUs). Several studies have suggested that the Gram stain of endotracheal aspirates is a useful method for accurat... (Source: Critical Care)
Source: Critical Care - June 19, 2017 Category: Intensive Care Authors: Jumpei Yoshimura, Takahiro Kinoshita, Kazuma Yamakawa, Asako Matsushima, Naoki Nakamoto, Toshimitsu Hamasaki and Satoshi Fujimi Source Type: research

Assessment of pulmonary mechanics in mechanical ventilation
(Source: Critical Care)
Source: Critical Care - June 19, 2017 Category: Intensive Care Authors: Federico Gordo and Beatriz Lobo-Valbuena Source Type: research

Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey
The optimal hemoglobin (Hb) threshold at which to initiate red blood cell (RBC) transfusion in patients with acute brain injury is unknown. The aim of this survey was to investigate RBC transfusion practices u... (Source: Critical Care)
Source: Critical Care - June 17, 2017 Category: Intensive Care Authors: Rafael Badenes, Mauro Oddo, Jos é I. Suarez, Massimo Antonelli, Jeffrey Lipman, Giuseppe Citerio and Fabio Silvio Taccone Source Type: research

Retinal involvement in sepsis: from the eye of the patient to the eye of the beholder
(Source: Critical Care)
Source: Critical Care - June 17, 2017 Category: Intensive Care Authors: E. Christiaan Boerma Source Type: research

Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis
Acute kidney injury (AKI) is a common clinical complication of cardiac surgery and increases mortality and hospitalization. We aimed to explore and perform an updated meta-analysis of qualitative and quantitat... (Source: Critical Care)
Source: Critical Care - June 17, 2017 Category: Intensive Care Authors: Honghong Zou, Qianwen Hong and Gaosi XU Source Type: research

Antiarrhythmic drugs in out-of-hospital cardiac arrest: is there a place for potassium chloride?
(Source: Critical Care)
Source: Critical Care - June 17, 2017 Category: Intensive Care Authors: Romain Jouffroy and Beno ît Vivien Source Type: research

On-line plasma lactate concentration monitoring in critically ill patients
(Source: Critical Care)
Source: Critical Care - June 16, 2017 Category: Intensive Care Authors: Christian De Tymowski, Sabri Soussi, Fran çois Depret and Matthieu Legrand Source Type: research

9th International Symposium on Intensive Care and Emergency Medicine for Latin America
(Source: Critical Care)
Source: Critical Care - June 13, 2017 Category: Intensive Care Source Type: research

Effect of perioperative goal-directed hemodynamic therapy on postoperative recovery following major abdominal surgery —a systematic review and meta-analysis of randomized controlled trials
Goal-directed hemodynamic therapy (GDHT) has been used in the clinical setting for years. However, the evidence for the beneficial effect of GDHT on postoperative recovery remains inconsistent. The aim of this... (Source: Critical Care)
Source: Critical Care - June 12, 2017 Category: Intensive Care Authors: Yanxia Sun, Fang Chai, Chuxiong Pan, Jamie Lee Romeiser and Tong J. Gan Source Type: research

A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient —the SPIRIT trial
Diarrhea is frequent in patients in intensive care units (ICU) and is associated with discomfort and complications and may increase the length of stay and nursing workload. (Source: Critical Care)
Source: Critical Care - June 10, 2017 Category: Intensive Care Authors: Stephan M. Jakob, Lukas B ütikofer, David Berger, Michael Coslovsky and Jukka Takala Source Type: research

A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial
Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existing clinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein receive... (Source: Critical Care)
Source: Critical Care - June 9, 2017 Category: Intensive Care Authors: Paul E. Wischmeyer, Michel Hasselmann, Christine Kummerlen, Rosemary Kozar, Demetrios James Kutsogiannis, Constantine J. Karvellas, Beth Besecker, David K. Evans, Jean-Charles Preiser, Leah Gramlich, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Xuran Jiang, A Source Type: research

Transthoracic echocardiography: an accurate and precise method for estimating cardiac output in the critically ill patient
Cardiac output (CO) monitoring is a valuable tool for the diagnosis and management of critically ill patients. In the critical care setting, few studies have evaluated the level of agreement between CO estimat... (Source: Critical Care)
Source: Critical Care - June 9, 2017 Category: Intensive Care Authors: Pablo Mercado, Julien Maizel, Christophe Beyls, Dimitri Titeca-Beauport, Magalie Joris, Loay Kontar, Antoine Riviere, Olivier Bonef, Thierry Soupison, Christophe Tribouilloy, Bertrand de Cagny and Michel Slama Source Type: research

The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: a retrospective propensity matched cohort study
The efficacy of corticosteroid use in acute respiratory distress syndrome (ARDS) remains controversial. Generally, short-term high-dose corticosteroid therapy is considered to be ineffective in ARDS. On the ot... (Source: Critical Care)
Source: Critical Care - June 8, 2017 Category: Intensive Care Authors: Makoto Takaki, Kazuya Ichikado, Kodai Kawamura, Yasuhiro Gushima and Moritaka Suga Source Type: research

Severe varicella-zoster virus pneumonia: a multicenter cohort study
Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of criti... (Source: Critical Care)
Source: Critical Care - June 7, 2017 Category: Intensive Care Authors: Adrien Mirouse, Philippe Vignon, Prescillia Piron, Ren é Robert, Laurent Papazian, Guillaume Géri, Pascal Blanc, Christophe Guitton, Claude Guérin, Naïke Bigé, Antoine Rabbat, Aurélie Lefebvre, Keyvan Razazi, Muriel Fartoukh, Eric Mariotte, Lila Bou Source Type: research

Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study
The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock. (Source: Critical Care)
Source: Critical Care - June 7, 2017 Category: Intensive Care Authors: Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma and Hiroyasu Ishikura Source Type: research

Between chromatin and SNPs: genetic variability and the susceptibility to acute kidney injury
(Source: Critical Care)
Source: Critical Care - June 6, 2017 Category: Intensive Care Authors: Hernando G ómez Source Type: research

Role of nutrition support in adult cardiac surgery: a consensus statement from an International Multidisciplinary Expert Group on Nutrition in Cardiac Surgery
Nutrition support is a necessary therapy for critically ill cardiac surgery patients. However, conclusive evidence for this population, consisting of well-conducted clinical trials is lacking. To clarify optim... (Source: Critical Care)
Source: Critical Care - June 5, 2017 Category: Intensive Care Authors: Christian Stoppe, Andreas Goetzenich, Glenn Whitman, Rika Ohkuma, Trish Brown, Roupen Hatzakorzian, Arnold Kristof, Patrick Meybohm, Jefferey Mechanick, Adam Evans, Daniel Yeh, Bernard McDonald, Michael Chourdakis, Philip Jones, Richard Barton, Ravi Tripa Source Type: research

Effect sizes in ongoing randomized controlled critical care trials
An important limitation of many critical care trial designs is that they hypothesize large, and potentially implausible, reductions in mortality. Interpretation of trial results could be improved by systematic... (Source: Critical Care)
Source: Critical Care - June 5, 2017 Category: Intensive Care Authors: Elliott E. Ridgeon, Rinaldo Bellomo, Scott K. Aberegg, Rob Mac Sweeney, Rachel S. Varughese, Giovanni Landoni and Paul J. Young Source Type: research

Daily cost of delay to adequate antibiotic treatment among patients surviving a hospitalization with community-onset Acinetobacter baumannii pneumonia or sepsis
(Source: Critical Care)
Source: Critical Care - June 5, 2017 Category: Intensive Care Authors: Marya D. Zilberberg, Brian H. Nathanson, Kate Sulham, Weihong Fan and Andrew F. Shorr Source Type: research

Resting energy expenditure and optimal nutrition in critical care: how to guide our calorie prescriptions
(Source: Critical Care)
Source: Critical Care - June 5, 2017 Category: Intensive Care Authors: Oren Zusman and Pierre Singer Source Type: research

Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury —a case report
(Source: Critical Care)
Source: Critical Care - June 4, 2017 Category: Intensive Care Authors: Serge Jennes, Maia Merabishvili, Patrick Soentjens, Kim Win Pang, Thomas Rose, Elkana Keersebilck, Olivier Soete, Pierre-Michel Fran çois, Simona Teodorescu, Gunther Verween, Gilbert Verbeken, Daniel De Vos and Jean-Paul Pirnay Source Type: research

Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease
Neurally adjusted ventilatory assist (NAVA) could improve patient-ventilator interaction; its effects on ventilation distribution and dead space are still unknown. The aim of this study was to evaluate the eff... (Source: Critical Care)
Source: Critical Care - June 2, 2017 Category: Intensive Care Authors: Qin Sun, Ling Liu, Chun Pan, Zhanqi Zhao, Jingyuan Xu, Airan Liu and Haibo Qiu Source Type: research

Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis
The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain. (Source: Critical Care)
Source: Critical Care - June 1, 2017 Category: Intensive Care Authors: Karen E. A. Burns, Ibrahim Soliman, Neill K. J. Adhikari, Amer Zwein, Jessica T. Y. Wong, Carolina Gomez-Builes, Jose Augusto Pellegrini, Lu Chen, Nuttapol Rittayamai, Michael Sklar, Laurent J. Brochard and Jan O. Friedrich Source Type: research

Critical care at the end of life: a population-level cohort study of cost and outcomes
In this study, our goal was to ... (Source: Critical Care)
Source: Critical Care - May 31, 2017 Category: Intensive Care Authors: Dipayan Chaudhuri, Peter Tanuseputro, Brent Herritt, Gianni D ’Egidio, Mathieu Chalifoux and Kwadwo Kyeremanteng Source Type: research

A critical age: can we reliably measure frailty in critical care?
(Source: Critical Care)
Source: Critical Care - May 31, 2017 Category: Intensive Care Authors: Richard J. Pugh, Chris M. Thorpe and Christian P. Subbe Source Type: research

Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany
This study investigates differences in treatment and outcome of ventilated patients with acute respiratory distress syndrome (ARDS) between university and non-university hospitals in Germany. (Source: Critical Care)
Source: Critical Care - May 30, 2017 Category: Intensive Care Authors: Konstantinos Raymondos, Tamme Dirks, Michael Quintel, Ulrich Molitoris, J örg Ahrens, Thorben Dieck, Kai Johanning, Dietrich Henzler, Rolf Rossaint, Christian Putensen, Hermann Wrigge, Ralph Wittich, Maximilian Ragaller, Thomas Bein, Martin Beiderlinden, Source Type: research

Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and meta-regression of randomized controlled trials
The aims of this systematic review and meta-analysis of randomized controlled trials are to evaluate the effects of active heated humidifiers (HHs) and moisture exchangers (HMEs) in preventing artificial airwa... (Source: Critical Care)
Source: Critical Care - May 29, 2017 Category: Intensive Care Authors: Maria Vargas, Davide Chiumello, Yuda Sutherasan, Lorenzo Ball, Antonio M. Esquinas, Paolo Pelosi and Giuseppe Servillo Source Type: research

How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?
Sepsis results in complex alterations to the immune system. Our understanding of how these alterations in immune responses could help characterize extreme immune phenotypes, identify biomarkers with the abilit... (Source: Critical Care)
Source: Critical Care - May 26, 2017 Category: Intensive Care Authors: M. Shankar-Hari Source Type: research

Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia
Early administration of appropriate antimicrobials has been correlated with a better prognosis in patients with bacteremia, but the optimum timing of early antibiotic administration as one of the resuscitation... (Source: Critical Care)
Source: Critical Care - May 26, 2017 Category: Intensive Care Authors: Ching-Chi Lee, Chung-Hsun Lee, Ming-Yuan Hong, Hung-Jen Tang and Wen-Chien Ko Source Type: research

Diaphragm electrical activity monitoring as a breakpoint in the management of a tetraplegic child
(Source: Critical Care)
Source: Critical Care - May 26, 2017 Category: Intensive Care Authors: Guillaume Mortamet, Fran çois Proulx, Benjamin Crulli, Nadia Savy, Philippe Jouvet and Guillaume Emeriaud Source Type: research

Circulating microparticle levels are reduced in patients with ARDS
It is unclear how to identify which patients at risk for acute respiratory distress syndrome (ARDS) will develop this condition during critical illness. Elevated microparticle (MP) concentrations in the airspa... (Source: Critical Care)
Source: Critical Care - May 25, 2017 Category: Intensive Care Authors: Ciara M. Shaver, Justin Woods, Jennifer K. Clune, Brandon S. Grove, Nancy E. Wickersham, J. Brennan McNeil, Gregory Shemancik, Lorraine B. Ware and Julie A. Bastarache Source Type: research

Echocardiography accurately predicts pulmonary hypertension in patients with advanced lung disease
(Source: Critical Care)
Source: Critical Care - May 25, 2017 Category: Intensive Care Authors: Silvia Cottini, Christian Benden, Lars C. Huber and Mattia Arrigo Source Type: research

Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study
The objective of this study was to confirm a beneficial effect on fluid balance with sodium lactate infusion and to specify wheth... (Source: Critical Care)
Source: Critical Care - May 19, 2017 Category: Intensive Care Authors: Thibault Duburcq, Arthur Durand, Anne-Fr édérique Dessein, Joseph Vamecq, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Claire Douillard, Patrice Maboudou, Valery Gmyr, François Pattou, Mercé Jourdain, Fabienne Tamion, Julien Poissy, Daniel Ma Source Type: research