Increased dosing regimens of piperacillin-tazobactam are needed to avoid subtherapeutic exposure in critically ill patients with augmented renal clearance
(Source: Critical Care)
Source: Critical Care - January 16, 2019 Category: Intensive Care Authors: Thibaud Besnard, C édric Carrié, Laurent Petit and Matthieu Biais Tags: Letter Source Type: research

Outcomes used in randomised controlled trials of nutrition in the critically ill: a systematic review
No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the out... (Source: Critical Care)
Source: Critical Care - January 14, 2019 Category: Intensive Care Authors: Garry Taverny, Thomas Lescot, Emmanuel Pardo, Frederique Thonon, Manar Maarouf and Corinne Alberti Tags: Research Article Source Type: research

Predicting mortality in patients undergoing VA-ECMO after coronary artery bypass grafting: the REMEMBER score
This study was designed to develop a pre... (Source: Critical Care)
Source: Critical Care - January 11, 2019 Category: Intensive Care Authors: Liangshan Wang, Feng Yang, Xiaomeng Wang, Haixiu Xie, Eddy Fan, Mark Ogino, Daniel Brodie, Hong Wang and Xiaotong Hou Tags: Research Source Type: research

Hyperchloremia-associated acute chronic kidney injury: beware of confounders!
(Source: Critical Care)
Source: Critical Care - January 10, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

Early diuretic use and mortality in critically ill patients with vasopressor support: a propensity score-matching analysis
This study aimed to explore the relationship between loop diuretic use and hospital mortality in critic... (Source: Critical Care)
Source: Critical Care - January 10, 2019 Category: Intensive Care Authors: Yanfei Shen, Weimin Zhang and Yong Shen Tags: Research Source Type: research

Artificial intelligence in the intensive care unit
(Source: Critical Care)
Source: Critical Care - January 10, 2019 Category: Intensive Care Authors: Christopher A. Lovejoy, Varun Buch and Mahiben Maruthappu Tags: Editorial Source Type: research

A conceivable mechanism of harm in a stretched “teen lung”
(Source: Critical Care)
Source: Critical Care - January 10, 2019 Category: Intensive Care Authors: Jo ão Batista Borges Tags: Letter Source Type: research

Dosing adjuvant vitamin C in critically ill patients undergoing continuous renal replacement therapy: We are not there yet!
(Source: Critical Care)
Source: Critical Care - January 9, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

Intact cerebrovascular autoregulation in patients with refractory status epilepticus due to sufficient anesthetic treatment on a neurointensive care unit: a prospective cohort study
(Source: Critical Care)
Source: Critical Care - January 9, 2019 Category: Intensive Care Authors: Marco Meyer, Martin Juenemann, Tobias Braun, Ingo Schirotzek and Patrick Schramm Tags: Letter Source Type: research

Optimal pressing strength and time for capillary refilling time
(Source: Critical Care)
Source: Critical Care - January 8, 2019 Category: Intensive Care Authors: Rui Kawaguchi, Taka-aki Nakada, Taku Oshima, Masayoshi Shinozaki, Toshiya Nakaguchi, Hideaki Haneishi and Shigeto Oda Tags: Letter Source Type: research

Neurally adjusted ventilatory assist (NAVA) versus pressure support ventilation: patient-ventilator interaction during invasive ventilation delivered by tracheostomy
Prolonged weaning is a major issue in intensive care patients and tracheostomy is one of the last resort options. Optimized patient-ventilator interaction is essential to weaning. The purpose of this study was... (Source: Critical Care)
Source: Critical Care - January 7, 2019 Category: Intensive Care Authors: Olivier Lamouret, Laure Crognier, Fanny Vardon Bounes, Jean-Marie Conil, Caroline Dilasser, Thibaut Raimondi, Stephanie Ruiz, Antoine Rouget, Cl ément Delmas, Thierry Seguin, Vincent Minville and Bernard Georges Tags: Research Source Type: research

Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial
ICU patients must be kept conscious, calm, and cooperative even during the critical phases of illness. Enteral administration of sedative drugs might avoid over sedation, and would be as adequate as intravenou... (Source: Critical Care)
Source: Critical Care - January 7, 2019 Category: Intensive Care Authors: Giovanni Mistraletti, Michele Umbrello, Silvia Salini, Paolo Cadringher, Paolo Formenti, Davide Chiumello, Cristina Villa, Riccarda Russo, Silvia Francesconi, Federico Valdambrini, Giacomo Bellani, Alessandra Palo, Francesca Riccardi, Enrica Ferretti, Mau Tags: Research Source Type: research

Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients
Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology is evolving, only a few epidemiologic reports have described the uses and outcomes of ECMO. The aim of th... (Source: Critical Care)
Source: Critical Care - January 3, 2019 Category: Intensive Care Authors: Moon Seong Baek, Sang-Min Lee, Chi Ryang Chung, Woo Hyun Cho, Young-Jae Cho, Sunghoon Park, So-My Koo, Jae-Seung Jung, Seung Yong Park, Youjin Chang, Byung Ju Kang, Jung-Hyun Kim, Jin Young Oh, So Hee Park, Jung-Wan Yoo, Yun Su Sim & hellip; Tags: Research Source Type: research

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness
Cell-free plasma mitochondrial DNA (mtDNA) levels are associated with endothelial dysfunction and differential outcomes in critical illness. A substantial alteration in metabolic homeostasis is commonly observ... (Source: Critical Care)
Source: Critical Care - December 29, 2018 Category: Intensive Care Authors: P är I. Johansson, Kiichi Nakahira, Angela J. Rogers, Michael J. McGeachie, Rebecca M. Baron, Laura E. Fredenburgh, John Harrington, Augustine M. K. Choi and Kenneth B. Christopher Tags: Research Source Type: research

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia
Neutrophils release neutrophil extracellular traps (NETs) in response to invading pathogens. Although NETs play an important role in host defense against microbial pathogens, they have also been shown to play ... (Source: Critical Care)
Source: Critical Care - December 27, 2018 Category: Intensive Care Authors: Carmen Mikacenic, Richard Moore, Victoria Dmyterko, T. Eoin West, William A. Altemeier, W. Conrad Liles and Christian Lood Tags: Research Source Type: research

Kidney histopathology in lethal human sepsis
The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill patients remains an understudied area. Previous studies have identified that acute tubular necrosis (ATN) is not the only dri... (Source: Critical Care)
Source: Critical Care - December 27, 2018 Category: Intensive Care Authors: Adnan Aslan, Marius C. van den Heuvel, Coen A. Stegeman, Eliane R. Popa, Annemarie M. Leliveld, Grietje Molema, Jan G. Zijlstra, Jill Moser and Matijs van Meurs Tags: Research Source Type: research

Trigonometry in daily ultrasound practice
(Source: Critical Care)
Source: Critical Care - December 22, 2018 Category: Intensive Care Authors: Alessandro De Cassai, Ludovica Sandei and Michele Carron Tags: Letter Source Type: research

The pharmacokinetic challenge of treating invasive aspergillosis complicating severe influenzae assisted by extracorporeal membrane oxygenation
(Source: Critical Care)
Source: Critical Care - December 22, 2018 Category: Intensive Care Authors: Hadrien Winiszewski, Anne-Claire Rougny, Jennifer Lagoutte-Renosi, Laurence Millon, Gilles Capellier, Jean-Christophe Navellou, Gael Piton and Anne-Laure Clairet Tags: Letter Source Type: research

Blood purification in sepsis
(Source: Critical Care)
Source: Critical Care - December 22, 2018 Category: Intensive Care Authors: Achim J örres Tags: Editorial Source Type: research

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct re... (Source: Critical Care)
Source: Critical Care - December 21, 2018 Category: Intensive Care Authors: Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin Tags: Research Source Type: research

Intrapulmonary autologous transplant of bone marrow-derived mesenchymal stromal cells improves lipopolysaccharide-induced acute respiratory distress syndrome in rabbit
Lung diseases such as acute respiratory distress syndrome (ARDS) have a high incidence worldwide. The current drug therapies for ARDS have supportive effects, making them inefficient. New methods such as strom... (Source: Critical Care)
Source: Critical Care - December 20, 2018 Category: Intensive Care Authors: Mohammad Reza Mokhber Dezfouli, Massoumeh Jabbari Fakhr, Sirous Sadeghian Chaleshtori, Mohammad Mehdi Dehghan, Alireza Vajhi and Roshanak Mokhtari Tags: Research Source Type: research

Response to “Adjuvant vitamin C in cardiac arrest patients undergoing renal replacement therapy: an appeal for a higher high-dose”
(Source: Critical Care)
Source: Critical Care - December 19, 2018 Category: Intensive Care Authors: Angelique M. E. Spoelstra – de Man, Harm-Jan de Grooth, Paul W. G. Elbers and Heleen M. Oudemans – van Straaten Tags: Letter Source Type: research

Mild decrease in heart rate during early phase of targeted temperature management following tachycardia on admission is associated with unfavorable neurological outcomes after severe traumatic brain injury: a post hoc analysis of a multicenter randomized controlled trial
The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). ... (Source: Critical Care)
Source: Critical Care - December 19, 2018 Category: Intensive Care Authors: Akihiko Inoue, Toru Hifumi, Yasuhiro Kuroda, Naoki Nishimoto, Kenya Kawakita, Susumu Yamashita, Yasutaka Oda, Kenji Dohi, Hitoshi Kobata, Eiichi Suehiro and Tsuyoshi Maekawa Tags: Research Source Type: research

Estimating severity of influenza epidemics from severe acute respiratory infections (SARI) in intensive care units
While influenza-like-illness (ILI) surveillance is well-organized at primary care level in Europe, few data are available on more severe cases. With retrospective data from intensive care units (ICU) we aim to... (Source: Critical Care)
Source: Critical Care - December 19, 2018 Category: Intensive Care Authors: Liselotte van Asten, Angie Luna Pinzon, Dylan W. de Lange, Evert de Jonge, Frederika Dijkstra, Sierk Marbus, G é A. Donker, Wim van der Hoek and Nicolette F. de Keizer Tags: Research Source Type: research

Intra-aortic balloon pump: is the tide turning?
(Source: Critical Care)
Source: Critical Care - December 18, 2018 Category: Intensive Care Authors: Sandro Gelsomino, Daniel M. Johnson and Roberto Lorusso Tags: Editorial Source Type: research

Response to: A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock
(Source: Critical Care)
Source: Critical Care - December 18, 2018 Category: Intensive Care Authors: Naoshi Takeyama Tags: Letter Source Type: research

Response to “Categorization of post-cardiac arrest patients according to the pattern of amplitude-integrated electroencephalography after return of spontaneous circulation”
(Source: Critical Care)
Source: Critical Care - December 18, 2018 Category: Intensive Care Authors: Jia Li, Ning-Tao Li and Yong-Gang Peng Tags: Letter Source Type: research

Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis
This study aimed to identify subclasses of sepsis and its responses to different amounts ... (Source: Critical Care)
Source: Critical Care - December 18, 2018 Category: Intensive Care Authors: Zhongheng Zhang, Gensheng Zhang, Hemant Goyal, Lei Mo and Yucai Hong Tags: Research Source Type: research

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study
Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. There... (Source: Critical Care)
Source: Critical Care - December 18, 2018 Category: Intensive Care Authors: Kirsten van de Groep, Stefan Nierkens, Olaf L. Cremer, Linda M. Peelen, Peter M. C. Klein Klouwenberg, Marcus J. Schultz, C. Erik Hack, Tom van der Poll, Marc J. M. Bonten and David S. Y. Ong Tags: Research Source Type: research

Inhaled amikacin for severe Gram-negative pulmonary infections in the intensive care unit: current status and future prospects
Recently, the use of nebulized antibiotics in the intensive care unit, in particular amikacin, has been the subject of much discussion, owing to unconvincing results from the latest randomized clinical trials.... (Source: Critical Care)
Source: Critical Care - December 17, 2018 Category: Intensive Care Authors: Antoni Torres, Anna Motos, Denise Battaglini and Gianluigi Li Bassi Tags: Review Source Type: research

Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study
Tigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury (AKI) is a common complication in the ICU requiring con... (Source: Critical Care)
Source: Critical Care - December 17, 2018 Category: Intensive Care Authors: A. Broeker, S. G. Wicha, C. Dorn, A. Kratzer, M. Schleibinger, F. Kees, A. Heininger, M. G. Kees and H. H äberle Tags: Research Source Type: research

Comparison of diagnostic accuracy among procalcitonin, C-reactive protein, and interleukin 6 for blood culture positivity in general ICU patients
(Source: Critical Care)
Source: Critical Care - December 17, 2018 Category: Intensive Care Authors: Qin Wu, Hao Yang and Yan Kang Tags: Letter Source Type: research

Patients ’ primary activities prior to critical illness: how well do clinicians know them and how likely are patients to return to them?
(Source: Critical Care)
Source: Critical Care - December 17, 2018 Category: Intensive Care Authors: Alexi T. Gosset, Michael C. Sklar, Aaron M. Delman and Michael E. Detsky Tags: Letter Source Type: research

What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study
Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic tests are limited. We evaluated the generalizability and validity of single... (Source: Critical Care)
Source: Critical Care - December 17, 2018 Category: Intensive Care Authors: Daniel A. Kelmenson, Dianna Quan and Marc Moss Tags: Research Source Type: research

Gram stain-guided antibiotic choice: a GRACEful method to safely restrict overuse of broad-spectrum antibiotic agents
(Source: Critical Care)
Source: Critical Care - December 14, 2018 Category: Intensive Care Authors: Jumpei Yoshimura, Kazuma Yamakawa, Takahiro Kinoshita and Satoshi Fujimi Tags: Letter Source Type: research

Antimicrobial exposure and the risk of delirium in critically ill patients
Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimi... (Source: Critical Care)
Source: Critical Care - December 12, 2018 Category: Intensive Care Authors: Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely and Mayur B. Patel Tags: Research Source Type: research

Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity
Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). P... (Source: Critical Care)
Source: Critical Care - December 11, 2018 Category: Intensive Care Authors: Simon Lambden, James Tomlinson, Sophie Piper, Anthony C. Gordon and James Leiper Tags: Research Source Type: research

Comparison of complaints to the intensive care units and those to the general wards: an analysis using the Healthcare Complaint Analysis Tool in an academic medical center in Taiwan
The management of complaints in the setting of intensive care may provide opportunities to understand patient and family experiences and needs. However, there are limited reports on the structured application ... (Source: Critical Care)
Source: Critical Care - December 6, 2018 Category: Intensive Care Authors: Jih-Shuin Jerng, Szu-Fen Huang, Hsin-Yu Yu, Yi-Chun Chan, Huang-Ju Liang, Huey-Wen Liang and Jui-Sheng Sun Tags: Research Source Type: research

Is KingVision videolaryngoscope with a bougie really an effective solution for emergency intubation?
(Source: Critical Care)
Source: Critical Care - December 5, 2018 Category: Intensive Care Authors: Fu-Shan Xue, Rui-Juan Guoa and Liu-Jia-Zi Shao Tags: Letter Source Type: research

Didn ’t inhale? Time to reconsider aerosolized antibiotics in the treatment of ventilator-associated pneumonia
(Source: Critical Care)
Source: Critical Care - December 5, 2018 Category: Intensive Care Authors: Daniel A. Sweeney and Andre C. Kalil Tags: Editorial Source Type: research

Impact of Rothman index on delay of ICU transfer for hematology and oncology patients deteriorating in wards
(Source: Critical Care)
Source: Critical Care - December 4, 2018 Category: Intensive Care Authors: Neal Fitzpatrick, Daniel Guck and Andry Van de Louw Tags: Letter Source Type: research

Response to Gunst and Casaer on the letter to the editor “Is the protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?”
(Source: Critical Care)
Source: Critical Care - December 4, 2018 Category: Intensive Care Authors: Arthur Raymond Hubert van Zanten Tags: Letter Source Type: research

Intravenous zanamivir for influenza myocarditis and enteral malabsorption
(Source: Critical Care)
Source: Critical Care - December 4, 2018 Category: Intensive Care Authors: Fritz-Patrick Jahns, Nawfel Ben-Hamouda, Matthias Kirsch, Aur élien Roumy and Lucas Liaudet Tags: Letter Source Type: research

Effect of plasma exchange in acute respiratory failure due to Anti-neutrophil cytoplasmic antibody-associated vasculitis
Acute respiratory failure related to diffuse alveolar hemorrhage (DAH) is a typical presentation of small-vessel vasculitis that requires prompt multidisciplinary management. The primary treatment is based on ... (Source: Critical Care)
Source: Critical Care - December 4, 2018 Category: Intensive Care Authors: Guillaume Geri, Benjamin Terrier, Farhad Heshmati, Hanafi Moussaoui, Julien Massot, Jean-Paul Mira, Luc Mouthon and Fr édéric Pène Tags: Letter Source Type: research

Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular systolic function during different experimental loading and contractile conditions
Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compar... (Source: Critical Care)
Source: Critical Care - November 29, 2018 Category: Intensive Care Authors: Manuel Ignacio Monge Garcia, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib and Michael R. Pinsky Tags: Research Source Type: research

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study
We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stre... (Source: Critical Care)
Source: Critical Care - November 23, 2018 Category: Intensive Care Authors: Robert Hatch, Duncan Young, Vicki Barber, John Griffiths, David A. Harrison and Peter Watkinson Tags: Research Source Type: research

The paramount parameter: arterial oxygen tension versus arterial oxygen saturation as target in trials on oxygenation in intensive care
(Source: Critical Care)
Source: Critical Care - November 22, 2018 Category: Intensive Care Authors: Olav Lilleholt Schj ørring and Bodil Steen Rasmussen Tags: Editorial Source Type: research

Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study
Infected pancreatic necrosis, which occurs in about 40% of patients admitted for acute necrotizing pancreatitis, requires combined antibiotic therapy and local drainage. Since 2010, drainage by open surgical n... (Source: Critical Care)
Source: Critical Care - November 22, 2018 Category: Intensive Care Authors: Lucie Darrivere, Nathanael Lapidus, Nikias Colignon, Najim Chafai, Ulriikka Chaput, Franck Verdonk, Fran çois Paye and Thomas Lescot Tags: Research Source Type: research

Adjuvant Vitamin C in critically ill patients undergoing renal replacement therapy: What ’s the right dose?
(Source: Critical Care)
Source: Critical Care - November 22, 2018 Category: Intensive Care Authors: Paul E Marik and Michael H Hooper Tags: Letter Source Type: research

Prognostic value of computed tomography score in patients after extracorporeal cardiopulmonary resuscitation
We evaluated whether Alberta Stroke Program Early Computed Tomography Score (ASPECTS) with some modifications could be used to predict neurological outcomes in patients after extracorporeal cardiopulmonary res... (Source: Critical Care)
Source: Critical Care - November 22, 2018 Category: Intensive Care Authors: Jeong-Am Ryu, Young Hwan Lee, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Kyeongman Jeon, Gee Young Suh, Taek Kyu Park, Joo Myung Lee, Minjung Kathy Chae, Jeong-Ho Hong, Sei Hee Lee, Hyoung Soo Kim and Jeong Hoon Yang Tags: Research Source Type: research