Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty
Conclusions: Repeat PK provided relatively safe and effective moderately long-term surgical outcomes. (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Early Results of Penetrating Keratoplasty in Patients With Unilateral Chemical Injury After Simple Limbal Epithelial Transplantation
Conclusions: PKP was found to have a good outcome when the surface has been stabilized by SLET as an initial procedure in unilateral ocular chemical injury. The visual outcome was restricted mainly by other causes such as glaucoma and amblyopia. (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Indications and Outcomes of Penetrating Keratoplasty in Infants and Children of Beijing, China
Purpose: To retrospectively investigate the indications and outcomes of pediatric penetrating keratoplasty (PKP) and to explore factors that affect graft survival. Methods: Patients who had undergone PKP from May 2010 to December 2016, aged ≤12 years were categorized as infants (≥3 months and (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Visual Outcomes and Prognostic Factors of Successful Penetrating Keratoplasty in 0- to 7-Year-Old Children With Congenital Corneal Opacities
Conclusions: Most of the clear grafts after PK in children with congenital corneal opacities achieved ambulatory vision. The visual outcome was better in binocular opacity cases than in monocular ones. (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcome of Human Donor Corneas Stored for More Than 4 Weeks
Conclusions: Corneas stored in organ culture for more than 4 weeks are equally suitable for DSAEK and PKP transplantation as corneas stored in organ culture for up to 4 weeks. (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Visual Acuity Outcomes Between Nanothin Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty
Conclusions: Compared with DMEK, NT-DSAEK provides comparable visual outcomes and complications rates. (Source: Cornea)
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Cross-Linking: Current USA StatusReport From the Cornea Society
Abstract: The initial published clinical report on riboflavin/ultraviolet A corneal cross-linking (CXL) for treatment of progressive keratoconus dates back to 2003. CXL has since then been widely used outside the United States for treatment of progressive keratoconus and post-laser in situ keratomileusis ectasia. The Food and Drug Administration (FDA) approved Avedro Inc.'s corneal cross-linking system (KXL) for treatment of patients with progressive keratoconus and post-laser in situ keratomileusis ectasia in April 2016. The procedure is not currently approved for stable keratoconus. There are 2 FDA-approved topical oph...
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Special Article Source Type: research

The Barcelona Principles: An Agreement on the Use of Human Donated Tissue for Ocular Transplantation, Research, and Future Technologies©
Preamble The Barcelona Principles: An Agreement on the use of human donated tissue for ocular transplantation, research, and future technologies (Agreement) is a global bioethical framework (GBF), developed by the eye bank and ophthalmic communities, to inform on the management of altruistic and voluntary donations; their subsequent utility within ophthalmology and research; their retention as a public resource for the shared benefit of all; and their accessibility by waiting recipients. The Agreement is the result of global sector engagement over a 12-month period—led by the Global Alliance of Eye Bank Associatio...
Source: Cornea - September 8, 2018 Category: Opthalmology Tags: Special Article Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Changes in Central Corneal Thickness With Corneal Collagen Cross-Linking
No abstract available (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Interface Fungal Keratitis After Descemet Stripping Automated Endothelial Keratoplasty: A Review of the Literature With a Focus on Outcomes
Conclusions: Penetrating keratoplasty is frequently required to eliminate interface fungal infection after Descemet stripping automated EK. A satisfactory visual outcome is usually achieved. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Review Source Type: research

Etiology of Global Corneal Blindness and Current Practices of Corneal Transplantation: A Focused Review
Conclusions: Most corneal blindness worldwide is secondary to anterior corneal pathology because of infections and trauma. However, this does not align with the current trends and practices in the field of corneal transplantation. We discuss potential solutions to address the current leading causes of global corneal blindness, including increasing the number of anterior lamellar keratoplasties performed, using long-term preserved corneas by trained surgeons, and improving eye bank handling and distribution of procured tissues. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Review Source Type: research

Cincinnati Protocol for Preoperative Screening and Donor Selection for Ocular Surface Stem Cell Transplantation
Conclusions: Our protocol for OSST preoperative screening and donor selection minimizes the antigenic burden for transplanted tissue by selecting the best available donor match. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Simulation Model for DMEK Donor Preparation
Conclusions: The described simulation model can assist surgeons and eye bank technicians to learn steps in donor preparation in DMEK. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Double-Bubble Technique in Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes: A Case Series
Conclusions: This technique (double bubble technique) enables safe and easy DMEK surgery, even in eyes that have been previously vitrectomized and IOL-sutured. Further clinical studies with a large number of patients exhibiting complex eyes are required to definitively establish the clinical value of this technique. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Isolated Conjunctival Inflammation as a Manifestation of IgG4-Related Disease
Conclusions: Isolated conjunctival inflammation without orbital involvement can be a presentation of IgG4-RD. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Sclerocornea–Microphthalmia–Aphakia Complex: Description of Two Additional Cases Associated With Novel FOXE3 Mutations and Review of the Literature
Conclusions: The sclerocornea–microphthalmia–aphakia complex is a severe malformative ocular phenotype resulting from mutations in the FOXE3 transcription factor. To date, patients from at least 14 families with this uncommon ocular disorder have been described. The identification of 2 novel pathogenic variants in our patients expands the mutational spectrum in FOXE3-related congenital eye disorders. In addition, we performed a review of the clinical and genotypic characteristics of all published patients carrying biallelic FOXE3 mutations. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report
Conclusions: LSCD can be a rare complication of DNNAS. After control of ocular surface inflammation, autologous limbal stem cell grafting and amniotic membrane transplantation can be effective in normalizing the ocular surface. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Validity and Reliability of a Novel Handheld Osmolarity System for Measurement of a National Institute of Standards Traceable Solution
Conclusions: The osmolarity system reliably and accurately measured the osmolarity of an NIST solution in a laboratory setting, using an adaptor to correct for differences in resistance between a laboratory NIST solution measurement and direct measurements on the palpebral conjunctiva of the eyelid. The handheld osmolarity system represents a rapid and accurate instrument for measurement of tear osmolarity in a simulated testing setting. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Designing Minimally Invasive Preocular Contact Tips for Potential Application in Tear Collection
Conclusions: The PCT proposed in this study can be a promising tool for minimally invasive collection of basal tears from the inferior palpebral conjunctiva. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Predictive Value of Corneal Donor Demographics on Endothelial Cell Density
Purpose: Corneal endothelial cell density (ECD) is an important measure for determining suitability for transplantation. Although age has been correlated with ECD, the impact of sex and ethnicity is unclear. Methods: Corneal donor information from SightLife Eye Bank was collected between 2012 and 2016. Tests of association were adjusted for covariates using linear regression including age, race, and sex. “Unsuitable for transplantation” was a label assigned to specimens with extensive cell dropout, ECD (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Outcomes of Thermal Pulsation Treatment for Dry Eye Syndrome in Patients With Sjogren Disease
Purpose: To evaluate the clinical outcomes of thermal pulsation treatment in patients with meibomian gland dysfunction (MGD) and dry eye secondary to Sjogren disease. Methods: Twenty-four eyes from 13 patients with previously diagnosed Sjogren disease who presented to our institution with dry eye symptoms and had thermal pulsation treatment were prospectively followed up. Patients underwent comprehensive slit-lamp examination, including MGD grading, gland oil flow, corneal and conjunctival staining scores, and tear break-up time (TBUT). Tear osmolarity was tested before and after treatment. Results: The average pat...
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Ocular Surface Findings in Patients With Lichen Planopilaris
Conclusions: Patients with LPP, scored worse in ocular surface tests. This finding warrants special scrutiny for dry eye and MG dysfunction in these patients. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of the Effectiveness of Cross-Linking Combined With Photorefractive Keratectomy for Treatment of Keratoconus
Conclusions: CXL Plus improved the refractive status of keratoconus during 18 months of follow-up, despite its potential early postoperative complications of delayed epithelial healing and corneal haze. CXL Plus reduced the myopic component more than the astigmatic component of keratoconus. However, the safety and stability of the procedure were offset by longer-term postoperative complications and a high rate of postoperative progression of keratoconus. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Central Corneal Thickness Increase Due to Stromal Thickening With Diabetic Peripheral Neuropathy Severity
Conclusions: This study demonstrates that CCT increases with DPN severity because of an increase in stromal thickness. CCT increase associated with DPN has important clinical implications including glaucoma progression, keratoconus susceptibility, and intraocular pressure assessment and should be accounted for when evaluating patients with diabetes. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Subbasal Nerve Density and Sensitivity After Pars Plana Vitrectomy Using Contact or Noncontact Wide-Angle Viewing Systems
Purpose: To assess corneal subbasal nerve density (SBND) and corneal sensitivity (CS) after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) without intraoperative 360-degree laser treatment using contact or noncontact panoramic viewing systems. Methods: This is a prospective study of 34 eyes affected by RRD, which underwent PPV using contact (18 eyes) and noncontact (16 eyes) panoramic viewing systems; 12 eyes which underwent scleral buckling, and 17 eyes which underwent cataract surgery. SBND and CS were assessed before surgery and 3 and 6 months postoperatively by in vivo confocal microscopy ...
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Risk Factors for Sporadic Diffuse Lamellar Keratitis After Microkeratome Laser-Assisted In Situ Keratomileusis: A Retrospective Large Database Analysis
Purpose: To determine the factors associated with sporadic diffuse lamellar keratitis (DLK) after microkeratome laser-assisted in situ keratomileusis (LASIK). Methods: This large database retrospective study included consecutive cases of LASIK performed between 2007 and 2016 at Care-Vision Laser Centers, Tel-Aviv, Israel. Patients were divided into 2 groups according to whether or not they subsequently developed DLK. Results: A total of 24,026 eyes of 12,013 patients with a mean age of 32.9 ± 10.3 years were included. Post-LASIK DLK developed in 464 eyes (1.9%), and the annual rate decreased from 7.1% (2007)...
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Incidence, Indications, and Outcomes of Eyes Needing Early Flap Lifting After LASIK
Purpose: To analyze the incidence, indications, and outcomes associated with early flap relifting after uncomplicated laser in situ keratomileusis (LASIK). Methods: All LASIK cases from a single surgical center between 2007 and 2015 were reviewed. Early postoperative flap lift cases ( (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Functional Optical Zone After Small-Incision Lenticule Extraction as Stratified by Attempted Correction and Optical Zone
Purpose: To compare the functional optical zone (OZ) with different levels of myopia and different OZ groups after small-incision lenticule extraction. Methods: This retrospective study included 249 patients (120 men) after small-incision lenticule extraction correction. We grouped participants according to attempted correction [low: spherical equivalent (SE)> −3.0 D; moderate: −6.0 D ≥ SE ≥ −3.0 D; high: SE ≥ −6.0 D] and planned functional optical zone (PFOZ) (OZ-1: PFOZ ≤ 6.3 mm; OZ-2: 6.3 mm 6.5 mm), and we compared the achieved functional optical zone (AFOZ) and total corneal...
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study
Conclusions: A longer preservation time was not associated with a higher rate of positive donor rim cultures. The overall rate of infection across the entire cohort was low. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Endothelium-in Versus Endothelium-out Insertion With Descemet Membrane Endothelial Keratoplasty
Conclusions: The outcomes were similar for endothelium-out and endothelium-in (trifold) insertion methods with DMEK, suggesting that the choice is a matter of surgeon preference. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty After Penetrating Keratoplasty: Features for Success
Conclusions: DMEK is a viable option for cases of failed PKP. DMEK failure after PKP might be associated with lower visual acuity before DMEK surgery, higher number of rebubble interventions, and manual descemetorhexis rather than femtosecond laser-enabled DMEK. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Anterior Segment Optical Coherence Tomography of Post-Descemet Stripping Automated Endothelial Keratoplasty Eyes to Evaluate Graft Morphology and Its Association With Visual Outcome
Purpose: To evaluate the relationship between graft thickness/regularity and visual outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: Records of post-DSAEK patients who were examined by anterior segment optical coherence tomography at “Villa Igea” Private Hospital (Forlì, Italy) since April 2015 were reviewed. Pachymetric and elevation maps of both host cornea and graft were analyzed. Graft regularity was determined based on the root mean square error (RMSE) of the graft pachymetric measurements taken 3 and 6 mm from the center and the RMSE of the corneal elevation ...
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation
Conclusions: Immune cells were observed on the corneal endothelial grafts in all 54 patients who underwent PK or DSAEK. Although the number of immune cells varied between patients and showed no correlation with clinical parameters, it would be beneficial to conduct a future prospective study to analyze the effect of immune cells on postoperative corneal endothelial cell loss. (Source: Cornea)
Source: Cornea - August 8, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Peripheral Corneal Hydrops Secondary to Pellucid Marginal Degeneration Managed With a Manually Dissected Semicircular Endothelial Keratoplasty Lenticule
No abstract available (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Does Mucous Membrane Grafting Have a Clear Advantage Over Amniotic Membrane Grafting in Refractory Giant Papillae?
No abstract available (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Measuring Endothelial Cell Loss on DMEK Grafts After Transplantation in Human Cadaveric Whole Eyes: Description of the Technique and Pilot Study
Conclusions: Our proof-of-principle experiment shows that this imaging approach enables quantification of ECL caused by different instruments and surgical techniques after graft implantation. We have used this method to visualize the learning curve of 1 surgeon when learning a new surgical technique. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Overview of Systemic Candida Infections in Hospital Settings and Report of Candida After DMEK Successfully Treated With Antifungals and Partial Graft Excision
Conclusions: The incidence of nosocomial fungal infections, particularly non-albicans Candida, is increasing, as are the rates of positive fungal cultures from corneal donor tissue and postkeratoplasty fungal infections. Prospective studies are needed to assess the value of routine donor cultures, compare the safety and efficacy of various prophylactic treatments, and evaluate addition of antifungals to cold storage media. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

A Case of Corneal Neovascularization Misdiagnosed as Total Limbal Stem Cell Deficiency
Conclusions: Clinical presentation alone is insufficient to correctly diagnose LSCD in complex cases. Additional diagnostic tests, such as IVCM, are necessary to confirm the diagnosis before any surgical intervention. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Atypical Presentation of Iridocorneal Endothelial Syndrome With Band Keratopathy but No Corneal Edema Managed With Descemet Membrane Endothelial Keratoplasty
Conclusions: To the best of our knowledge, this is the first case in the literature that reports the association of ICE syndrome with band keratopathy. As band keratopathy recurred shortly after EDTA chelation, endothelial keratoplasty (DMEK) may be indicated to successfully treat such cases. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Experimental Evidence of the Healing Properties of Lactobionic Acid for Ocular Surface Disease
Conclusions: Our findings support the hypothesis that LA could be a useful supplement to artificial tears to treat ocular surface dysfunction such as dry eye. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Relationship Between Central Epithelial Thickness and Central Corneal Thickness in Healthy Eyes and Eyes After Laser In Situ Keratomileusis
In this study, we included 150 patients (150 eyes) who underwent LASIK and 83 healthy individuals (83 eyes). In all patients, CET and CCT were measured using anterior segment optical coherence tomography with Copernicus REVO on B-scans. Statistical analysis was performed using the Spearman rank test, t test, and receiver operating characteristic curve analysis. Results: In healthy individuals, CET positively correlated with CCT (r = 0.5, P (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Scleral Shape and Its Correlations With Corneal Astigmatism
Purpose: To assess the correlation between the scleral shape and corneal astigmatism. Methods: Twenty-two participants (11 nonastigmatic and 11 astigmatic) aged from 19 to 36 years and with no previous ocular surgeries were included in this study. Three-dimensional (3D) corneoscleral maps from both eyes (44 eyes) were acquired using a corneoscleral topographer (Eye Surface Profiler). Each 3D map was split into 13 concentric annuli, each 0.5-mm wide, starting at 1.0-mm radius from the corneal apex to the scleral periphery at 7.5 mm from the apex. Each ring was fitted to a quadratic function of the radial distance to th...
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Multiplex Polymerase Chain Reaction Assay for Screening of Mycotoxin Genes From Ocular Isolates of Fusarium species
Conclusions: Fumonisin B biosynthetic gene 1 may be common among clinical Fusarium isolates and contribute to worse initial visual acuity and high-risk progression to penetrating keratoplasty. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Possible Risk Factors and Clinical Outcomes of Black Areas in Small-Incision Lenticule Extraction
Purpose: To investigate the possible risk factors and clinical effects of black areas in small-incision lenticule extraction. Methods: Thirty-one cases and 126 controls were enrolled in a case–control study from the database of a single center from September 2012 to July 2017. A retrospective analysis of surgical procedures with video and medical records was performed. Logistic regression analysis was used to assess the possible risk factors for black areas between cases with black areas and controls without black areas. Results: In the study, 19 eyes (61.3%) with black areas were associated with the presence...
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Diagnostic Ability of Corneal Shape and Biomechanical Parameters for Detecting Frank Keratoconus
Purpose: To assess the diagnostic capability of corneal shape and biomechanical parameters for distinguishing normal eyes from frank keratoconus (KCN). Methods: This is a retrospective analysis of eyes of 137 control subjects and 145 patients with KCN, with one of their eyes randomly selected as the study eye. Corneal biomechanical parameters were assessed using the Corvis ST (Oculus Optikgeräte GmbH) and Oculus Response Analyzer (Reichert Ophthalmic Instruments). Corneal tomography was performed using the Oculus Pentacam. The clinical diagnosis of KCN was based on slit-lamp findings (eg, Fleischer ring, Vogt str...
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Epithelium-Off Versus Transepithelial Corneal Collagen Cross-Linking for Keratoconus: A Systematic Review and Meta-Analysis
Conclusions: With the exception of less reduction in mean K with current iontophoretic protocols, analysis of the limited number of comparative studies available seems to demonstrate that SCXL and TECXL have a comparable effect on visual, refractive, pachymetric, and endothelial parameters at 1 year after surgery. Further follow-up is required to determine whether these techniques are comparable in the long-term. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Cross-Linking in Pediatric Patients: Evaluating Treated and Untreated Eyes—5-Year Follow-Up Results
Conclusions: Our long-term follow-up study suggests that CXL is a safe procedure in the pediatric age, and there is no urgency in treating pediatric patients with keratoconus without proof of progression. (Source: Cornea)
Source: Cornea - July 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research