Repeated High-Fluence Accelerated Slitlamp-Based Photoactivated Chromophore for Keratitis Corneal Cross-Linking for Treatment-Resistant Fungal Keratitis
Conclusions:
PACK-CXL protocols delivering a total UV fluence of 5.4 J/cm2 (as per the original Dresden protocol for corneal ectasia cross-linking) can be an effective primary therapy for initial or superficial corneal infections because approximately half of the energy is absorbed in the first 100 μm of a riboflavin-soaked cornea. However, fungal keratitis may require higher fluences than 5.4 J/cm2 because, unlike ectatic corneas, corneal ulcers are not transparent, and the infection may involve deep stroma. This case illustrates how repeated high-fluence accelerated PACK-CXL can be used to successfully treat fungal ...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Harboyan Syndrome: A Novel SLC4A11 Variant With Unique Genotype–Phenotype Correlation
Conclusions:
We report a novel homozygous SLC4A11 variant with a previously undocumented phenotype of CHED in association with prelingual sensorineural hearing loss and hydronephrosis, thus broadening our understanding of the spectrum of genotypic and phenotypic findings of Harboyan syndrome. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Conjunctival Myxoma: High-Resolution Optical Coherence Tomography Findings of a Rare Tumor
Conclusions:
The HR-OCT optical signs found in our 2 cases strongly correlated with the microscopic findings. Disclosing the optical signs observed on HR-OCT can help clinicians diagnose and differentiate this lesion, guiding its management. However, more studies with a larger number of patients comparing conjunctival myxoma and other ocular surface tumors are needed to enlighten readers about the unique pattern observed by HR-OCT. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Late-Onset Nontuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction
Conclusions:
Cap amputation and intrastromal antibiotic injection for intractable post-SMILE keratitis can prevent the need for therapeutic keratoplasty. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Lacrimal Gland Hypoplasia and Corneal Anesthesia in MIRAGE Syndrome: A Case Report and Literature Review
Conclusions:
This case presents deficient lacrimation as a manifestation of MIRAGE syndrome and is the first to identify lacrimal gland hypoplasia and corneal anesthesia. Autonomic and neurologic dysfunction have been proposed to play a role in the pathophysiology of hypolacrimation in similar syndromes and likely contributed to the poor ocular surface in this case. Patients with MIRAGE should undergo ophthalmic assessment as soon as possible after birth because early intervention is essential to preventing irreversible corneal damage. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Importance of Corneal Angiography in Subclinical Limbitis in a Case of Atopic Keratoconjunctivitis
Conclusions:
Active allergic corneal limbitis may present as subclinical inflammation, with no signs of activity at the slit lamp examination. Therefore, its diagnosis can be challenging without the use of corneal angiography. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Corneal Toxicity After Stinging by a Sea Anemone, Anthopleura uchidai: A Case Report With Confirmation by In Vitro Study
Conclusions:
It is necessary to be cautious of effluents from sea anemones along the coast, and ophthalmologists should be aware that sea anemones can cause corneal endothelial dysfunction. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Effect of Collagenase A on Descemet Membrane Endothelial Keratoplasty Scroll Tightness
Purpose:
The scrolling properties of the Descemet membrane endothelial keratoplasty (DMEK) graft are essential for surgical success. Currently, there is limited knowledge on what dictates the tightness of the DMEK scroll. The purpose of this study was to determine the impact of temperature and protein digestion on DMEK graft scroll tightness.
Methods:
For the temperature experiment, a total of 28 eyes were used for this study. Scrolls in the cold group were kept at 4°C while scrolls in the hot group were kept at 37°C. Scroll width was recorded at the 5-, 15-, and 30-minute mark. For the protein digestion exper...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Assessing the Quality, Reliability, and Readability of Online Information on Dry Eye Disease
Purpose:
The purpose of this study was to assess the quality, reliability, readability, and technical quality of web sites relating to dry eye disease.
Methods:
A cross-sectional study was conducted that evaluated the first 75 web sites on a Google Search by using the keyword “dry eyes.” Each web site was evaluated by 2 independent reviewers using the DISCERN, HONcode, and JAMA criteria to assess quality and reliability. Interrater reliability was also analyzed. Readability was assessed using the Flesch–Kincaid readability tests and the Gunning fog, Simple Measure of Gobbledygook, Coleman–Liau, and autom...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
What Hundreds of Millions of Patients With Dry Eye Will Find on YouTube: A Quality and Reliability Research of the YouTube Videos
Purpose:
The aim of this study was to evaluate the demographic features, quality, and reliability of YouTube videos addressing dry eye disease (DED).
Methods:
The term “dry eye disease” has been searched on YouTube. The first 500 videos that emerged using the defined search term were evaluated. Duplicated-split videos, videos shorter than 60 seconds, videos with a language other than English or videos with an unintelligible English accent, and videos unrelated to DED were excluded. Video uploaders, types, origins, durations, and viewer interactions of the videos were noted. DISCERN, the Global Quality Score,...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants
This study aims to compare the difference in anterior segment phenotypes such as those involving the cornea, iris, lens, and anterior chamber angle between cases with disease-causing sequence variations in FOXC1 and PITX2.
Methods:
This cross-sectional study involved 61 individuals, from 32 families with pathogenic FOXC1 or PITX2 variants, who were registered with the Australian and New Zealand Registry of Advanced Glaucoma.
Results:
The median age of the cohort was 39 years at the time of last assessment (range 3–85 years; females, 54%). Thirty-two patients had pathogenic variants in the FOXC1 gene, and 29...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Corneal Densitometry After Uneventful Descemet Membrane Endothelial Keratoplasty—5-Year Outcomes
Purpose:
The purpose of this study is to analyze the course of corneal densitometry (CD), endothelial cell density (ECD), best-corrected visual acuity (BCVA), and central corneal thickness (CCT) 5 years after uneventful Descemet membrane endothelial keratoplasty (DMEK).
Methods:
Sixty uneventful cases (51 patients) with a minimum follow-up of 5 years were included. CD of various corneal layers (anterior, central, posterior, and total layer) and zones (0–2 mm, 2–6 mm, and 6–10 mm) were measured with Scheimpflug tomography. ECD, BCVA, and CCT were also evaluated.
Results:
Total CD at 0 to 2 mm and 2 t...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Cell Morphology as an In Vivo Parameter for the Diagnosis of Limbal Stem Cell Deficiency
Purpose:
The aim of this study was to investigate basal epithelial cell morphology (CM) in the central cornea and limbal areas of eyes with limbal stem cell deficiency (LSCD).
Methods:
This was a prospective, cross-sectional comparative study. We developed a CM scoring system based on basal epithelial cell phenotypes graded from 0 (normal) to 3 (severe morphologic alterations); this system was evaluated by 2 independent masked observers. The CM score was compared with the LSCD clinical score, mean best-corrected visual acuity, and in vivo laser scanning confocal microscopy parameters used to stage LSCD (ie, basa...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Topical Insulin—Utility and Results in Refractory Neurotrophic Keratopathy in Stages 2 and 3
Purpose:
The purpose of this study was to evaluate the clinical outcome of patients with refractory neurotrophic keratopathy (NK) in stages 2 and 3 treated with topical insulin.
Methods:
Retrospective analysis of eyes with NK in stages 2 and 3 refractory to standard medical and/or surgical treatment which were treated with topical insulin (1 unit per mL). This treatment was applied 4 times per day and was continued until the persistent epithelial defect (PED) or ulcer resolved. The primary outcome of the study was the complete reepithelialization of the PED or persistent ulcer. “Best-corrected visual acuity”...
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Thermokeratoplasty for Keratoconus: A More Than 30-Year Follow-Up Study
Conclusions:
TKP for KC resulted in relatively favorable surgical outcomes over the long-term postoperative period. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
