Morphology and Function of Meibomian Glands and Other Tear Film Parameters in Junior High School Students
Purpose: We measured tear film parameters, including the morphology and function of meibomian glands, in junior high school students at 15 years of age. Methods: A total of 111 eyes of 111 students (56 males and 55 females) were enrolled in the study. The ocular symptom score (0–14), after-school study time, lipid layer thickness (LLT) of the tear film, partial blink rate, lid margin abnormalities (0–4), tear film breakup time, corneal and conjunctival epithelial damage (fluorescein staining score, 0–9), meiboscore as determined by noncontact meibography (0–6), Schirmer test value, and meibum grade...
Source: Cornea - July 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Efficacy of 2-Month Treatment With Cord Blood Serum Eye Drops in Ocular Surface Disease: An In Vivo Confocal Microscopy Study
Purpose: To investigate the morphological changes of corneal epithelium and subbasal nerves by in vivo confocal microscopy in patients with ocular surface disease (OSD) treated with cord blood serum (CBS) eye drops. Methods: Twenty patients with OSD (mean age 61.1 ± 12.6 years) were included in this prospective 1-arm study and treated with CBS eye drops for 2 months. Corneal sensitivity, Schirmer test score, breakup time, subjective symptoms [Ocular Surface Disease Index (OSDI) and Visual Analogue Scale (VAS)], and corneal staining were evaluated before (T0) and after (T1) treatment. In vivo confocal microscopy ana...
Source: Cornea - July 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Effects of Diquafosol Ophthalmic Solution on Quality of Life in Dry Eye Assessed Using the Dry Eye–Related Quality-of-Life Score Questionnaire: Effectiveness in Patients While Reading and Using Visual Display Terminals
Conclusions: Diquafosol ophthalmic solution was effective in patients with dry eye, especially those with foreign body sensation and problems when reading and using visual display terminals. (Source: Cornea)
Source: Cornea - July 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Central Connections of the Lacrimal Functional Unit
Conclusions: The wetting length was reduced by topical anesthesia, when instilled bilaterally and ipsilaterally. The latter response implies an ipsilateral, reflex sensory drive to lacrimal secretion. In the unanesthetized fellow eye, the reduction compared with its saline control was not quite significant. This implies a relative lack of central, sensory, reflex cross-innervation, although the possibility cannot entirely be ruled out. These results are relevant to the possibility of reflex lacrimal compensation from a normal fellow eye, in cases of unilateral corneal anesthesia. (Source: Cornea)
Source: Cornea - July 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Patients' Perceived Treatment Effectiveness in Dry Eye Disease
This study aimed to evaluate patients' PTE in dry eye disease (DED) and investigate factors contributing to these patients' perceptions. Methods: This cross-sectional study included 66 patients with DED. At enrollment, all patients had comprehensive ophthalmic assessment. In addition, to evaluate the patient's PTE, they were asked to use a 10-point scale ranging from “strongly disagree (score 1)” to “strongly agree (score 10)” to score their views on whether their DED treatments had been effective. Changes in clinical parameters of DED over time during their care were also evaluated retrospectively...
Source: Cornea - July 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Femtosecond Laser Assisted Pterygium Surgery
Conclusions: FLAPS is a new technique, in which the preparation of an ultrathin CAG is done by the FSL. After optimization in porcine eyes, the clinical trial in the first 6 eyes was performed without any complications and the FSL might assist in further standardizing the surgical procedure. Longer follow-up and larger cohorts are needed to assess recurrence rates. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Techniques Source Type: research

New Technique of Femtosecond Laser-Assisted Intracorneal Ring Segment Implantation
Conclusions: The results of this pilot study are promising. A comparative prospective study with more eyes and longer follow-up may confirm whether this technique is better than the conventional femtosecond laser-assisted one. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Microkeratome-Assisted Anterior Lamellar Keratoplasty for the Correction of High-Degree Postkeratoplasty Astigmatism
Conclusions: MALK is an effective and safe technique for the correction of high-degree postkeratoplasty astigmatism. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Bilateral Herpetic Keratitis After Bilateral Intravitreal Bevacizumab for Exudative Macular Degeneration
Conclusions: To our knowledge, this is the first documented account of bilateral herpetic epithelial keratitis after bilateral intravitreal bevacizumab injections. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Solitary Iris Plasmacytoma With Anterior Chamber Crystalline Deposits
Conclusions: Iris plasmacytoma is rare and should prompt systemic evaluation to rule out multiple myeloma. Solitary iris plasmacytoma can be successfully treated with plaque radiotherapy. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Immunohistochemical Profiling of Corneas With Fuchs Endothelial Corneal Dystrophy
Purpose: Fuchs endothelial corneal dystrophy (FECD) is the leading indication for endothelial keratoplasty. Further insight into its pathophysiology is needed to develop alternative therapies. Methods: Sixteen genes from a previous microarray expression experiment (FECD vs. normal) were validated using immunohistochemistry on paraffin-embedded corneas (n = 6 FECD, n = 6 normal). The results were quantified manually and semiautomatically. Results: A higher percentage of corneal endothelial cells stained for alpha–smooth muscle actin (αSMA), cytokeratin 7, and superoxide dismutase 3 in FECD versus normal [odds ...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Comparison of 2 Different Methods of Transepithelial Corneal Collagen Cross-Linking: Analysis of Corneal Histology and Hysteresis
Conclusions: Accelerated transepithelial CXL using pulsed UVA showed considerably deeper effect in the stroma with keratocyte loss than transepithelial CXL using continuous UVA. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Biomechanical and Histopathologic Effects of Pulsed-Light Accelerated Epithelium-On/-Off Corneal Collagen Cross-Linking
Conclusions: Both transepithelial and accelerated epithelium-off CXL produced biomechanical and histopathologic improvements, which were not significantly different between the 2 pulsed-light accelerated CXL treatments. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Short-Term Effects of Y-27632, a Rho-Associated Protein Kinase Inhibitor, on Chromatin Supraorganization and DNA Amount in Epithelial Cells of the Rat Cornea and Limbus
Conclusions: Changes in chromatin supraorganization and DNA amount, such as seen in this study, are indicative of cell proliferation and do not seem to be associated with disturbances in gene activity and transcription of DNA. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium
Purpose: The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. Methods: Ten normal bulbar conjunctivae, 35 primary pterygia, and 35 recurrent pterygia were obtained. Formalin-fixed, paraffin-wax–embedded tissues were analyzed by immunohistochemistry with peroxiredoxin 2 and VEGFR2 antibodies. Results: There was no statistical difference between primary pterygia and recurrent pterygia i...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Proposal for a Novel Severity Grading System for Pterygia Based on Corneal Topographic Data
Purpose: To propose a grading system of pterygium severity based on corneal higher-order irregularity (HOI) and to evaluate postoperative changes in corneal irregularity of the graded pterygia. Methods: In 268 eyes of 226 patients undergoing excision surgery of primary nasal pterygium, Placido corneal topography images were taken before and until 6 months after surgery. The best-corrected visual acuity (BCVA) and pterygium size with respect to the corneal diameter were also measured. HOI components within 1.0-, 3.0-, and 5.0-mm diameters were obtained using Fourier harmonic analysis of corneal topography data. With thresh...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Estimating Total Corneal Astigmatism From Anterior Corneal Data
Conclusions: It was possible to estimate TCA accurately from anterior corneal data with a new formula. However, application of both this model on keratometric data and of direct Pentacam measurements in a group of 40 eyes with TIOLs did not completely eradicate the refractive error in TIOL calculation. More studies comparing Pentacam TCA and refractive astigmatism are required. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Axial Length and Anterior Segment Alterations in Former Preterm Infants and Full-Term Neonates Analyzed With Scheimpflug Imaging
Conclusions: This study demonstrated altered axial length and anterior segment morphology in former preterm infants, especially in the first years of life. In addition, we observed that preterm infants seemed to catch up, so that the differences in ocular growth in terms of spherical equivalent, astigmatism, and axial length decreased within the first 8 years of life. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

One-Year Clinical Outcomes of a Corneal Inlay for Presbyopia
Conclusions: The Flexivue Microlens provided patients with improved near vision, as a result of a negative spherical aberration. A significant loss of corrected distance visual acuity in the operated eyes was observed. Overall, this intracorneal inlay was an effective alternative to other procedures for the correction of presbyopia. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Effects of Tear Film Lipid Layer Thickness and Blinking Pattern on Tear Film Instability After Corneal Refractive Surgery
Purpose: To investigate associations between changes in tear film instability and the lipid layer thickness (LLT) and blink pattern after corneal refractive surgery (CRS). Methods: Forty patients were enrolled in this study. The LLT and blink pattern were evaluated 1 week before and 30 days after CRS using a novel interferometer and an ocular surface disease index (OSDI) questionnaire, and other tear film stability markers were also evaluated. Results: Mean OSDI scores increased from 5.52 to 8.54 (P = 0.016), corneal fluorescence staining scores increased from 0.05 to 0.25 (P = 0.034), first noninvasive tear breakup time...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome
Purpose: To compare tear osmolarity (TO) and other dry eye parameters in rheumatoid arthritis (RA) patients with or without secondary Sjogren syndrome (sSS). Methods: Consecutive patients with RA were divided into a sSS group and no-sSS group using conventional diagnostic criteria by rheumatologists using symptomatology, Schirmer test score, and anti-Ro or anti-La autoantibody status. The TO, Ocular Surface Disease Index, dry eye disease (DED) parameters [such as tear breakup time (TBUT) and corneal staining score] and the systemic inflammatory markers [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] we...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

A Pilot Randomized Trial on Safety and Efficacy of a Novel Topical Combined Inhibitor of Janus Kinase 1/3 and Spleen Tyrosine Kinase for GVHD-Associated Ocular Surface Disease
Conclusions: This pilot study indicates that 0.5% R348 JAK/SYK inhibitor ophthalmic solution is well tolerated and may have some therapeutic efficacy in treating ocular GVHD. Larger trials are required to derive more definitive data. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis
Purpose: To determine differences in key tear film cytokines between mild and severe cases of acanthamoeba keratitis (AK) and control contact lens (CL) wearers. Methods: This was a prospective study of CL wearers with AK attending Moorfields Eye Hospital and control CL wearers from the Institute of Optometry, London. Basal tear specimens were collected by 10-μL capillary tubes (BLAUBRAND intraMark, Wertheim, Germany), and tear protein levels were measured with a multiplex magnetic bead array (Luminex 100; Luminex Corporation, Austin, TX) for cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, IL-17E, IL-17F,...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Free-Living Amoebae Keratitis
Conclusions: Acanthamoeba is not the only cause of amoebic keratitis, because this condition may also be caused by other FLA, such as Hartmannella and vahlkampfiid amoebae. This finding is epidemiologically interesting, suggesting a possible different geographical prevalence of the different FLA responsible for keratitis. Early diagnosis and proper antiamoebic treatment are crucial to yielding a cure. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcome and Histopathology of Secondary Penetrating Keratoplasty Graft Failure Managed by Descemet Membrane Endothelial Keratoplasty
Purpose: To describe the clinical outcome and histopathology of Descemet membrane endothelial keratoplasty (DMEK) performed for secondary graft failure after penetrating keratoplasty (PK). Methods: A total of 11 eyes from 10 patients who underwent DMEK for secondary PK graft failure at a tertiary referral center were included in this retrospective study. Best-corrected visual acuity, endothelial cell density, and central pachymetry were evaluated before and at regular time intervals up to 36 months after DMEK and complications were recorded; 1 post mortem cornea was available for light microscopy. Results: At their last ...
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Outcome of Rebubbling for Graft Detachment After Descemet Membrane Endothelial Keratoplasty
Conclusions: Rebubbling for DMEK graft detachment may result in similar visual outcomes as in uncomplicated DMEK, when performed within the first 6 to 8 postoperative weeks. However, rebubbled eyes may have lower ECD, which may be attributed to additional air bubble trauma and/or selection bias through more extensive manipulation during initial DMEK or higher risk of graft detachment in more complicated eyes. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Femtosecond Laser-Enabled Descemetorhexis and Manual Descemetorhexis in Descemet Membrane Endothelial Keratoplasty
Conclusions: FE-DMEK shows efficacy similar to that of M-DMEK with apparently less graft detachment and reduced need for rebubbling. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty After Failed Descemet Stripping Without Endothelial Keratoplasty
Conclusions: DMEK is a reliable procedure to facilitate corneal rehabilitation and visual recovery in the event of poor corneal clearance after Descemet stripping without endothelial keratoplasty. (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Richard C. Troutman, MD: A Pioneer
No abstract available (Source: Cornea)
Source: Cornea - June 13, 2017 Category: Opthalmology Tags: Obituary Source Type: research

Pulsed Light Accelerated Corneal Collagen Cross-Linking: 1-Year Results
No abstract available (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Copper in Keratoconic Corneas: Erratum
No abstract available (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Erratum Source Type: research

Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth
Conclusions: We conclude that intraoperative OCT is a useful tool during DSAEK surgery, particularly in complicated cases such as anterior segment fibrous ingrowth and significant corneal edema. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Application of Scanning Electron Microscopy With Energy-Dispersive X-Ray Spectroscopy for Analyzing Ocular Surface Particles on Schirmer Strips
Purpose: To demonstrate the application of scanning electron microscopy with energy-dispersive x-ray spectroscopy (SEM/EDS) for analyzing Schirmer strips for particle concentration, size, morphology, and type distribution. Methods: A cross-sectional design was used. Patients were prospectively recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic, and they underwent a complete ocular surface examination. The size, type, and chemical composition of particulate matter on Schirmer strips (from the left eye) were analyzed using SEM/EDS. Results: Schirmer strips from all 6 patients showed particle loadin...
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Simultaneous Keratolimbal Autograft and Penetrating Autokeratoplasty: A Single-Stage Procedure to Restore Monocular Vision of a Blind Patient With Limbal Stem Cell Deficiency
Conclusions: Keratolimbal autograft and penetrating autokeratoplasty, as a one-stage procedure, proved to be effective in restoring monocular vision in a patient with LSCD. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Ocular Argyrosis Mimicking Conjunctival Melanoma
Conclusions: Despite its limited negative health effects, ocular argyrosis should be considered in the differential diagnosis of conjunctival pigmented lesions because of the potential for misidentification of neoplastic growth. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Ocular Surface Squamous Neoplasia in Papillon–Lefèvre Syndrome: Outcome at Long-Term Follow-Up of 12 Years
Conclusions: OSSN in PLS is associated with poor prognosis. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Reactivation of Herpes Zoster Keratitis With Corneal Perforation After Zoster Vaccination
Conclusions: We present a case of reactivation of herpes keratouveitis shortly after vaccination with Zostavax in a patient with previous herpes zoster ophthalmicus. We demonstrate, for the first time, ultrastructural evidence consistent with inactive virus capsids in diffusely degenerated keratocytes in the extracted corneal tissue. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Transmission of Donor-Derived Breast Carcinoma as a Recurrent Mass in a Keratolimbal Allograft
Conclusions: We report a case of donor-derived breast carcinoma in a keratolimbal allograft recipient. The grafted tissue harbored donor-derived tumor cells for more than 4 years after surgery even after systemic immunosuppression was discontinued. Although no similar reports of tumor transfer could be found in the literature, this case suggests the need for increased stringency in donor selection and heightened surveillance for such tumor transmission. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Measuring Forward Light Scatter by the Boston Keratoprosthesis in Various Configurations
Conclusions: Most of the scattered light in eyes implanted with a KPro originates from the surrounding hazy corneal graft. The standard addition of a backplate reduces light scatter. There was no difference in forward light scatter between the aphakic and the pseudophakic KPro. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril
This study investigated the efficacy of monotherapy versus combination of menhaden oil, α-lipoic acid, and enalapril on corneal sensation and morphometry and other neuropathy-related endpoints in a rat model of type 2 diabetes. Methods: Male Sprague-Dawley rats (aged 12 weeks) were fed a high-fat diet for 8 weeks followed by 30 mg/kg streptozotocin. After 16 weeks of hyperglycemia, 12-week treatments consisting of menhaden oil, α-lipoic acid, enalapril, or their combination were initiated. Before and after treatments, we performed analyses of multiple neural and vascular endpoints including corneal sensitivity...
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Influence of Pilocarpine and Timolol on Human Meibomian Gland Epithelial Cells
Conclusions: Our results support our hypothesis and demonstrate that these antiglaucoma drugs, pilocarpine and timolol, have direct effects on HMGECs that may influence their morphology, survival, and proliferative capacity. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Implications for Ophthalmic Formulations: Ocular Buffers Show Varied Cytotoxic Impact on Human Corneal–Limbal and Human Conjunctival Epithelial Cells
Purpose: To investigate toxicity associated with buffers commonly used in topical ocular drug formulations using a human corneal–limbal epithelial (HCLE) and a human conjunctival epithelial (HCjE) cell model. Methods: HCLE and HCjE cells were incubated for 10, 30, or 60 minutes with 4 different buffers based on borate, citrate, phosphate, and Tris-HCl at 10, 50, and 100 mM concentrations. To detect possible delayed effects on cell viability, after 60 minutes of buffer incubation, cells were further incubated for 24 hours with a cell medium. Cell viability was determined using a colorimetric XTT–based assay. Th...
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Revisiting the Cornea and Trabecular Meshwork Junction With 2-Photon Excitation Fluorescence Microscopy
Conclusions: Two-photon excited fluorescence microscopy has improved our understanding of the peripheral corneal architecture. CB tendon insertions in this region may contribute to the radial tears encountered when preparing DM endothelial keratoplasty grafts. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Corneal K-Values as a Diagnostic Screening Tool for Marfan Syndrome
We present statistical evaluation of using corneal K-values for identifying MFS. Methods: A retrospective study of K-values of 74 right eyes of 74 patients with MFS, who were compared with an age- and AXL-matched group of 74 right eyes of 74 patients without MFS. After multivariate analysis, receiver operating characteristic curves were calculated. Results: Mean age was 44.1 years versus 44.9 years (P = 0.834). Mean AXL was 25.22 mm versus 25.47 mm (P = 0.661). K-values showed significant differences: mean Kmax was 8.25 mm (40.91 D) versus 7.9 mm (42.72 D) (P (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Endocan Overexpression in Pterygium
Conclusions: The results suggest that endocan may have a role in the pathogenesis of pterygium. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Validation of an Objective Keratoconus Detection System Implemented in a Scheimpflug Tomographer and Comparison With Other Methods
Conclusions: KA is effective at detecting early keratoconus and agrees with trained clinical judgment. As keratoconus detection depends on the method used, we recommend using multiple methods side by side. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Estimation of Prevalence of Meibomian Gland Dysfunction in Japan
Purpose: To estimate the prevalence of meibomian gland dysfunction (MGD) in the Japanese population using new diagnostic criteria, including lid margin abnormalities and signs of occlusion of the meibomian gland orifices as essential signs. Methods: The participants were consecutive patients scheduled for cataract surgery at Inouye Eye Hospital. All participants were aged 50 years or older. The participants completed a symptoms questionnaire and underwent a comprehensive slit-lamp examination. MGD was diagnosed when both of the following 2 factors were positive: lid margin abnormalities and signs of occlusion of the meibo...
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Ocular Surface Parameters Predicting Patient Satisfaction After a Single Vectored Thermal Pulsation Procedure for Management of Symptomatic Meibomian Gland Dysfunction
Conclusions: VTP can be effective in treating dry eye symptoms of patients with MGD. Our data show that objective findings of dry eye, as evidenced by lower tear production, higher corneal and conjunctival staining scores, and higher osmolarity, tend to be markers present in the group of patients responding positively to VTP. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study
Conclusions: This study indicated that both 0.005% tacrolimus and IFN alpha-2b are effective and appear to be safe in treatment of recalcitrant VKC. (Source: Cornea)
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Rates of Intraocular Pressure Elevation and Use of Topical Antihypertensive Medication After Descemet Stripping Automated Endothelial Keratoplasty
Purpose: To investigate intraocular pressure (IOP) elevation and medication augmentation after Descemet stripping automated endothelial keratoplasty (DSAEK) in those with and without glaucoma. Methods: The records of 379 patients who underwent DSAEK at the Cleveland Clinic Foundation between January 2009 and 2014 were retrospectively reviewed. Postoperative IOP elevations were considered significant if IOP was ≥22 mm Hg on at least 1 follow-up visit or if it increased by ≥10 mm Hg from baseline. Results: The incidence rate of IOP elevation was 4% per person-month (confidence interval [CI], 3%–6%) in patients ...
Source: Cornea - May 9, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research