Long-Term Stability of Keratometry, Scheimpflug-Derived True Net Power, and Total Corneal Refractive Power After Primary Pterygium Excision
Conclusions: Keratometric values including TNP and TCRP were stable as soon as 1 week after pterygium excision. This information might help clinicians in planning subsequent intraocular surgery that requires biometric assessment for intraocular lens implantation. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Tear Osmolarity and Correlation With Ocular Surface Parameters in Patients With Dry Eye
Conclusions: Individuals with symptomatic dry eye that is not yet clinically significant seem to have higher and more variable osmolarity measurements than controls, potentially indicating that changes in osmolarity precede clinical findings. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Preparation and Biomechanical Properties of an Acellular Porcine Corneal Stroma
Conclusions: The aPCS prepared in this study had good biocompatibility, safety, and low antigenicity, which has great potential for corneal disease treatment. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Densitometry in Healthy Corneas and Its Correlation With Endothelial Morphometry
Purpose: To evaluate the correlations between corneal endothelial cell properties and corneal densitometry values and to investigate whether corneal densitometry may be used as an indicator of the health of corneal endothelium. Methods: Two hundred fifty-three eyes were analyzed in this prospective cross-sectional study. Corneal densitometry was measured with densitometry software of Pentacam HR-Scheimpflug corneal topography over a 12-mm diameter of the cornea. Furthermore, corneal endothelial cell properties including cell density (CD), average cell area, SD of the cell area, coefficient of variation (CV) of the cell ar...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Changes in Corneal Density After Accelerated Corneal Collagen Cross-linking With Different Irradiation Intensities and Energy Exposures: 1-Year Follow-up
Purpose: To determine and compare the changes in corneal density after 2 different protocols of accelerated corneal collagen cross-linking (A-CXL) in patients with progressive keratoconus. Methods: Two groups of eyes received A-CXL treatment; 20 eyes received A-CXL using continuous UVA light exposure at 9 mW/cm2 for 10 minutes with a total energy dose of 5.4 J/cm2, and 24 eyes received A-CXL using continuous UVA light exposure at 30 mW/cm2 for 4 minutes with a total energy dose of 7.2 J/cm2. Corneal density was measured with Scheimpflug tomography at 1, 3, 6, and 12 months of follow-up. Results: Densitometry peaked at 1 ...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-Term Follow-up of Intrastromal Corneal Ring Segments (210-Degree Arc Length) in Central Keratoconus With High Corneal Asphericity
Purpose: To assess the long-term outcomes of implanting intrastromal corneal ring segments (ICRSs) to correct central keratoconus with a high corneal asphericity value. Methods: Forty-three eyes with central keratoconus with a corneal asphericity value ≥−1.00 were evaluated before and after implanting an inferior 210-degree arc-length Ferrara-type AFR5 ICRS (AJL Ophthalmic, Spain). Logarithm of the minimum angle of resolution uncorrected (UDVA) and best-corrected (CDVA) distance visual acuity, corneal asphericity, root mean square for coma-like aberrations [computed for the Zernike terms Z (3, 1) and Z (3, &minus...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-Term Tomographic Evaluation of Unilateral Keratoconus
Conclusions: Keratoconus is believed to be a bilateral disease that can present asymmetrically. We present 5 cases that appear to be true unilateral keratoconus with no associated mechanical environmental factors. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty
Conclusions: The stepwise topography-guided photorefractive keratectomy approach in cases of irregular astigmatism after PKP or DALK can help improve visual acuity outcomes. Patients should be appropriately counseled that more than 1 treatment will likely be needed. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty in Eyes With Previous Laser Refractive Surgery: Outcomes and Complications
Purpose: To evaluate the refractive predictability and efficacy of Descemet membrane endothelial keratoplasty (DMEK) for patients with previous laser refractive surgery. Methods: We retrospectively reviewed our cohort of endothelial keratoplasty surgical cases. We identified 21 eyes that underwent laser-assisted in situ keratomileusis (n = 17) or photorefractive keratectomy (n = 4) and were treated with DMEK for endothelial failure. Patients were analyzed preoperatively and at 6 months postoperatively for changes in visual acuity, refraction, and corneal topography. Results: Six months after surgery, eyes significantly i...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Quantitative Analysis of Endothelial Cell Loss in Preloaded Descemet Membrane Endothelial Keratoplasty Grafts
Conclusions: Preloading DMEK tissue is safe and may provide an alternative technique for tissue distribution and surgery for DMEK. The use of MetaMorph software for quantifying ECL is a novel and accurate imaging method with increased efficiency and reproducibility compared with the previously validated Fiji. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Preoperative Higher-Order Aberrations Must Be Considered in Determination of Visual Performance
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Trends and Determinants of Familial Consent for Corneal Donation in Chinese
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Potential Clue to the Pathogenesis of Varicella-Zoster Virus Stromal Keratitis
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Corneal Endothelial Dystrophy Associated With Myotonic Dystrophy: A Report of 2 Cases
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Anterior Chamber Gas Fill After DMEK
No abstract available (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Recurrence Rate and Graft Stability With Fibrin Glue Compared With Suture and Autologous Blood Coagulum for Conjunctival Autograft Adherence in Pterygium Surgery: A Meta-Analysis
Conclusions: This meta-analysis reveals the superiority of FG over sutures as the use of FG can significantly reduce the recurrence rate, but no significant difference in graft stability was found between FG and sutures. No significant difference was found in the recurrence rate between FG and ABC, but graft stability was found to be better with FG compared with ABC. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Review Source Type: research

Simple Preoperative Ink Test as a Novel Adjunct to Intrastromal Keratopigmentation for Post-laser Peripheral Iridotomy Dysphotopsias
Conclusions: The preoperative ink test before intrastromal keratopigmentation is a novel adjunct to the treatment of post-LPI dysphotopsias. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Rabbit Model of Corneal Endothelial Injury Established Using the Nd: YAG Laser
Conclusions: Nd:YAG laser treatment in a 9-mm diameter zone of the endothelium can effectively induce bullous keratopathy in a rabbit, whereas treatment for the entire corneal endothelium maintains bullous keratopathy for a longer period. The procedure is simple and reproducible, and it retains normal intraocular structures. This study provided a promising model for future research into endothelial cell damage and for the development of new therapies. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Peripheral Blunt Dissection: Using a Microhoe-Facilitated Method for Descemet Membrane Endothelial Keratoplasty Donor Tissue Preparation
Conclusions: The peripheral blunt dissection technique offers an improvement over the technique originally described by Melles et al, as the incidence of tissue wastage and tears is lower, it is easy to learn, has low stress, and is reproducible. Combining this with a stromal surface letter mark ensures correct orientation of the tissue against the corneal stroma of the recipient. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Role of Scleral Contact Lenses in Management of Coexisting Keratoconus and Stevens–Johnson Syndrome
Conclusions: Keratoconus, a noninflammatory condition of the cornea coexisted with inflammatory SJS. Managing such patients with ScCLs may improve vision and comfort. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Case Reports Source Type: research

Mechanical Modeling of a Keratoconic Cornea
Conclusions: Our findings suggest that the disease progresses under environmental stresses, but only when there is an initial defect, and especially when there is a thinning down defect. This thinning down defect may be induced by continual eye rubbing. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Case Reports Source Type: research

Elimination of Anterior Corneal Steepening With Descemet Membrane Endothelial Keratoplasty in a Patient With Fuchs Dystrophy and Keratoconus: Implications for IOL Calculation
Conclusions: This is the first case report of the role of DMEK in normalizing corneal topography in coexistent FECD and KCN. The potential impact of DMEK on anterior curvature and TCRP must be considered in intraocular lens power calculation for cataract surgery in patients with FECD and KCN. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Case Reports Source Type: research

CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel
Conclusions: We present an uncommon mutation and clinical description of CYP1B1. This report and further studies could provide us better understanding of the mutational spectrum of CYP1B1. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes
Conclusions: Our study indicates that all studied pGDs decrease the viability of the corneal epithelial cells, but none of the tested compounds were able to destabilize cellular membranes. The pGDs seem to be internalized and can induce apoptosis through C/EBP homologous protein recruitment. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Refractive Surgery: Malpractice Litigation Outcomes
Conclusions: Malpractice litigation in refractive surgery tends to favor the defendant. However, large awards and settlements were given in cases that were favorable to the plaintiff. The need for future surgery and surgery leading to keratoconus increased the chance of an unfavorable outcome. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Observation of Retrocorneal Plaques in Patients With Infectious Keratitis Using Anterior Segment Optical Coherence Tomography
Conclusions: Endothelial plaques in patients with fungal keratitis could continue from the corneal lesion. Observation of retrocorneal plaques using AS-OCT could be used in the diagnosis of infectious keratitis. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Changes in Higher-Order Aberrations After Phototherapeutic Keratectomy for Subepithelial Corneal Infiltrates After Epidemic Keratoconjunctivitis
Conclusions: PTK is an effective method for treating corneal opacity after epidemic keratoconjunctivitis, which yields significant improvements in both VA and visual quality. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Recurrence of Granular Corneal Dystrophy Type 1 After Phototherapeutic Keratectomy, Lamellar Keratoplasty, and Penetrating Keratoplasty in a Single Population
Conclusions: This series indicates that GCD1 recurrence-free survival is longest after PKP with an associated delay in attaining BCVA. Conversely, PTK provided the fastest visual recovery with shorter recurrence-free survival. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Correlation of Corneal Biomechanical Stiffness With Refractive Error and Ocular Biometry in a Pediatric Population
Purpose: To assess the correlation between corneal biomechanical stiffness and refractive error (RE) in the pediatric population. Methods: A total of 733 pediatric eyes were included in the study retrospectively. All eyes underwent corneal tomography (Pentacam), RE assessment, and air-puff deformation (Corvis-ST). Waveform analyses of deformation provided corneal stiffness (CS) and extraocular tissue stiffness (EOS). Eyes were subgrouped into emmetropia [manifest refraction spherical equivalent (MRSE) ∼ 0 D], hyperopia (MRSE> 0 D), myopia I (MRSE between 0 D and −3 D), myopia II (MRSE between −3 D and &...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Outcomes Between Combined Transepithelial Photorefractive Keratectomy With and Without Accelerated Corneal Collagen Cross-Linking: A 1-Year Study
Purpose: To investigate the effects of combined transepithelial photorefractive keratectomy (tPRK) and accelerated corneal collagen cross-linking (CXL) on visual acuity and refractive outcomes. Methods: The medical records of 89 eyes (89 patients) undergoing combined tPRK and CXL (tPRK-CXL group) or tPRK alone (tPRK group) were retrospectively analyzed. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity, and manifest refraction spherical equivalent (MRSE) were evaluated preoperatively and 2 weeks, 1, 3, 6, and 12 months after surgery. Results: At 2 weeks after surgery, the tPRK-CXL group had bett...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Codeine Plus Acetaminophen for Pain After Photorefractive Keratectomy: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial
Background: Pain after photorefractive keratectomy (PRK) is significant, and the analgesic efficacy and safety of oral opioids in combination with acetaminophen has not been fully investigated in PRK trials. Purpose: To assess the efficacy and safety of the combination of codeine plus acetaminophen (paracetamol) versus placebo as an add-on therapy for pain control after PRK. Study design: Randomized, double-blind, placebo-controlled trial. Setting: Single tertiary center. Methods: One eye was randomly allocated to the intervention, whereas the fellow eye was treated with a placebo. Eyes were operated 2 weeks apart. The...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Scleral Pneumatonometry in Penetrating Keratoplasty: A Clinical Study
Purpose: To evaluate the reliability between pneumatonometry intraocular pressure (IOP) measurement in different scleral locations and corneal IOP in a penetrating keratoplasty (PK) setting. Our aim is to validate a method that can potentially be used for patients with keratoprostheses. Methods: This is a prospective observational study of 40 patients who underwent monocular PK by a single surgeon and had no significant anterior segment condition in the contralateral eye. Participants were recruited during routine visits to the Cornea Clinic at the Stein Eye Institute, between November 2016 and February 2017. Goldmann app...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Tacrolimus Eye Drops as Adjunct Therapy in Severe Corneal Endothelial Rejection Refractory to Corticosteroids
Conclusions: Tacrolimus eye drops may be able to play an adjunctive therapeutic role in patients with severe corneal endothelial rejection refractory to conventional steroid treatment. Controlled studies are needed to further investigate the role of tacrolimus in this setting. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of 5% Sulfur Hexafluoride Versus 100% Air Tamponade in Descemet Membrane Endothelial Keratoplasty
Purpose: To compare the rebubbling rate and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) with 5% sulfur hexafluoride (SF6) gas versus 100% air as a tamponade for graft attachment. Methods: Retrospective, comparative, interventional case series including 368 consecutive pseudophakic eyes with Fuchs endothelial dystrophy or pseudophakic bullous keratopathy that underwent DMEK in a tertiary referral center between October 2010 and August 2015 using either air (group 1, 191 eyes) or 5% SF6 (group 2, 177 eyes) as a tamponade. The rebubbling rate, complications, best-corrected distance visual acuity (B...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Donor and Recipient Diabetes Status on Descemet Membrane Endothelial Keratoplasty Adherence and Survival
Purpose: To evaluate whether donor and/or recipient diabetes status affects the outcomes of Descemet membrane endothelial keratoplasty (DMEK). Methods: A consecutive, single-center DMEK case series was reviewed. The outcome measures were success of surgeon tissue preparation, air reinjection rate, Kaplan–Meier 4-year graft replacement/failure rate for any reason, and endothelial cell loss. Results: The donor had a history of diabetes in 504 of 1791 cases (28%) and the recipient in 14%. For donors without and with diabetes, the preparation success rate was 99% versus 95% (P (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Simple Single-Pass Technique for Ultrathin Descemet Stripping Automated Endothelial Keratoplasty: A Pilot Study
Conclusions: This pilot study demonstrates a simple graft deturgescence technique that reproducibly creates ultrathin grafts without donor wastage. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Technician Consistency in Specular Microscopy Measurements: A “Real-World” Retrospective Analysis of a United States Eye Bank
Conclusions: There was significant ECD variability associated with specular microscopy technicians and with the date of measurement. We recommend that eye banks collect data related to laboratory factors that have been shown to influence ECD variability. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy
Purpose: In advanced Fuchs endothelial corneal dystrophy (FECD), central endothelial changes do not correlate with disease severity. The peripheral endothelial cell count (ECC) has not been studied as a marker of FECD severity. The goal of this study was to determine the relationship between the peripheral ECC and known clinical markers of FECD in advanced cases. Methods: Patients with FECD examined between January 1, 2013, and September 1, 2016, by 1 cornea specialist were identified. Medical records from all previous visits were reviewed to include eyes with high-quality central and peripheral in vivo confocal microscop...
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Teleophthalmic Approach for Detection of Corneal Diseases: Accuracy and Reliability
Conclusions: External photographs taken by standard, nonenhanced portable cameras and interpreted remotely by ophthalmologist graders yielded sensitivity values that are not yet suitable for telemedicine applications. Additional work is needed to improve the ability to detect AS pathology remotely. (Source: Cornea)
Source: Cornea - September 12, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis
No abstract available (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Chandelier Illumination for Descemet Membrane Endothelial Keratoplasty
Conclusions: The chandelier illuminator provided good visibility of the anterior chamber and enhanced the safety of surgery by preventing formation of an inverted graft. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Vent Incisions to Facilitate Peripheral Unfolding of the DMEK Graft
Conclusions: This technique provides a different DMEK no-touch approach that could be used in challenging cases of graft unfolding such as young donors and/or large-sized grafts. It may also avoid excessive unfolding times and direct manipulation that are related to higher endothelial cell loss. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Femtosecond Laser-Assisted Tuck-In Penetrating Keratoplasty for Advanced Keratoglobus With Endothelial Damage
Conclusions: Femtosecond laser-assisted tuck-in penetrating keratoplasty can provide excellent anatomical and functional rehabilitation of patients with severe KTG and endothelial damage, through a single-step surgical procedure and a single donor cornea per eye. The femtosecond laser permits accurate dissection of these already thin corneas without inadvertent perforation risk. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Rose Bengal Photodynamic Antimicrobial Therapy: A Novel Treatment for Resistant Fusarium Keratitis
Conclusions: Rose bengal PDAT is a novel treatment that may be considered in cases of aggressive infectious keratitis. Further studies are needed to understand the mechanisms of PDAT in vivo. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Case of Presumed Transient Light-Sensitivity Syndrome After Small-Incision Lenticule Extraction
Conclusions: TLSS is a rare and minor complication of SMILE. Photophobic symptoms associated with post-SMILE TLSS are fully responsive to topical corticosteroids. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Efficacy of Sodium Hyaluronate in Murine Diabetic Ocular Surface Diseases
Purpose: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. Methods: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls. Corneal epithelial wound healing rate, corneal sensation, nerve fiber density, conjunctival goblet cell number, and MUC-5AC...
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Pythium Insidiosum Keratitis: Histopathology and Rapid Novel Diagnostic Staining Technique
Conclusions: Pythium insidiosum keratitis is perhaps not more devastating than fungal keratitis but late diagnosis, misdiagnosis, and treatment as fungal infection are major heralds. Early diagnosis may markedly improve the patient outcome. IKI-H2SO4 is a cost-effective, simple, sensitive, and specific stain for the diagnosis of oomycete Pythium. (Source: Cornea)
Source: Cornea - August 9, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research