Asymptomatic Infection in Decompensated Full-Thickness Corneal Grafts Referred for Repeat Penetrating Keratoplasty
Conclusions: Apparently quiet eyes with failed PK can harbor slow-growing asymptomatic infection. An epithelial defect in a failed PK graft should raise suspicion of infection. Routine cultures and histological examination of the excised corneal buttons are instrumental in the diagnosis of these infections and can guide further treatment. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination
Conclusions: Trained corneal specialists have a high degree of agreement in location and degree of corneal thinning when measured in a standardized fashion on the same day. Other testing modalities had acceptable reproducibility and agreement with clinical examination and each other, although Scheimpflug imaging fared worse for corneal thinning, particularly in the periphery, than the other modalities. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Precision of Epithelial Defect Measurements
Conclusions: Cornea specialists showed good reliability in the measured EDs; however, depending on the threshold for clinical significance, a nontrivial percentage of cases have high interexaminer clinical variability. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Neonatal Bacterial Conjunctivitis in Korea in the 21st Century
Conclusions: The prevalence of neonatal gonococcal or chlamydial conjunctivitis has decreased in the 21st century. However, methicillin-resistant S. aureus has been increasing, but these cases are responsive to tosufloxacin. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Findings of Anterior Segment Spectral Domain Optical Coherence Tomography Images in Cytomegalovirus Corneal Endotheliitis
Conclusions: The anterior segment SD-OCT examination represents a useful noninvasive alternative to diagnose and monitor CMV corneal endotheliitis. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Densitometry as a Tool to Measure Epithelial Ingrowth After Laser In Situ Keratomileusis
Conclusions: Corneal densitometry seems to be an objective measure of the severity and progression of EI after LASIK. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Visual Outcomes After SMILE, LASEK, and LASEK Combined With Corneal Collagen Cross-Linking for High Myopic Correction
Conclusions: SMILE, LASEK, and LASEK-CXL surgery appear to be safe and effective for high-degree myopic correction. However, the SMILE group had no haze and fewer induction of some higher-order aberrations compared with the LASEK and LASEK-CXL groups. (Source: Cornea)
Source: Cornea - March 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Retrospective Comparative Study of Topical Interferon a2b Versus Mitomycin C for Primary Ocular Surface Squamous Neoplasia
Purpose: To compare the efficacy and safety of topical interferon alpha 2b (IFNα2b) and mitomycin C (MMC) for ocular surface squamous neoplasia. Methods: In this retrospective study, medical records of 51 eyes of 50 patients with a diagnosis of primary ocular surface squamous neoplasia were included. All cases were treated with either topical IFNα2b (1 million IU/mL) or MMC (0.4 mg/mL) 4 times a day. The primary outcome measure was frequency of clinical resolution of tumors along with failure and recurrence rates after treatment. Other outcome measures included the duration of treatment and adverse effects ass...
Source: Cornea - February 8, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Eventual Endothelial Failure After Initial Corneal Clearing After a Detached Endothelial Graft in Fuchs Dystrophy
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Keratoconus and Bowman Layer Transplantation
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Conjunctival Autograft Versus Amniotic Membrane Transplantation Following Double Pterygium Excision: A Randomized Trial
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Re: Godefrooij DA, Soeters N, Imhof SM, Wisse RP. Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results. Cornea. 2016 Jul;35(7):954-8
No abstract available (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Human Ex Vivo Artificial Anterior Chamber Model for Practice DMEK Surgery
Conclusions: This wet lab model allows practicing steps of DMEK and learning significant surgical skills. Reusable instruments can be used in regular operating facilities resulting in reasonable costs. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Techniques for Learning Descemet Membrane Endothelial Keratoplasty for Eyes of Asian Patients With Shallow Anterior Chamber
Conclusions: Although DMEK is technically difficult, especially for inexperienced surgeons who operate on eyes of Asian patients, controlling anterior chamber pressure using various manipulations may help to prevent iatrogenic primary graft failure and lead to successful DMEK. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Wet-Peeling Technique of Deep Anterior Lamellar Keratoplasty With Hypotonic Water and Blunt Dissection for Healed Hydrops
Purpose: To describe the surgical technique and outcomes of “wet-peeling” deep anterior lamellar keratoplasty (DALK) using sterile water and blunt dissection in cases with corneal scarring after healed corneal hydrops. Methods: Manual DALK using a “wet-peeling” technique was performed in 20 eyes of 20 consecutive patients with healed corneal hydrops between June 2011 and October 2013. Results: Intraoperative microperforations were encountered in 2 (10%) cases. None of the cases required conversion to penetrating keratoplasty. There was significant improvement in mean best-corrected visual acuity a...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Persistent Epithelial Defects and Corneal Opacity After Collagen Cross-Linking With Substitution of Dextran (T-500) With Dextran Sulfate in Compounded Topical Riboflavin
Purpose: Collagen cross-linking (CXL) is a commonly performed procedure to prevent the progression of keratoconus. Riboflavin is an essential part of the procedure, which facilitates both the cross-linking process and protection of intraocular structures. Dextran can be added to riboflavin to create an isotonic solution. This case report highlights the importance of compounding riboflavin with the correct dextran solution. Methods: A retrospective case series. Results: Six eyes of 4 male patients with keratoconus aged from 20 to 38 years underwent CXL with substitution of 20% dextran (T-500) with 20% dextran sulfate in a...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Ten-Year Clinical Outcome of the First Patient Undergoing Descemet Membrane Endothelial Keratoplasty
Conclusions: The first DMEK patient worldwide may show all short and long-term characteristics of this endothelial keratoplasty technique: outstanding patient satisfaction, quick visual recovery, low incidence of complications, and graft longevity. Published studies in the past decade would suggest that this case was the start of a new era in corneal transplantation. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal
Conclusions: Contrary to current literature, it seems that tamoxifen-induced corneal abnormalities may persist for years after drug withdrawal. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Management of Descemet Membrane Detachment After Forceps Birth Injury
Conclusions: Prolonged corneal edema should alert the physician to probable DM detachment after forceps-related birth injury. Injecting air alone may not be sufficient to reattach the detached DM. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Conclusions: We present an unusual case of paraproteinemic keratopathy with a uniquely asymmetric presentation that resulted in a diagnosis of multiple myeloma. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Age-Stratified Analysis of Diabetes and Pseudophakia Effects on Corneal Endothelial Cell Density: A Retrospective Eye Bank Study
Purpose: To perform an age-stratified analysis of the effect of diabetes and pseudophakia on corneal endothelial cell density (ECD). Methods: This is a comparative analysis of donor characteristics from data supplied by the Lions Eye Institute for Transplant and Research on tissue harvested from July 1, 2007, through May 23, 2014. The mixed-effects model was used to compare age-adjusted mean corneal ECD between donors with and without diabetes. Results: A total of 20,026 nondiabetic donor eyes and 13,617 diabetic donor eyes were included in this study. ECD was 2604 cells per square millimeter in nondiabetic corneas and 2...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Exponential Decay Metrics of Topical Tetracaine Hydrochloride Administration Describe Corneal Anesthesia Properties Mechanistically
Conclusions: Use of a small drop volume of a topical anesthetic (as low as 11 μL) is bioequivalent to conventional drop size and seems to optimize dosing regiments with a little effect on ke. Prolongation of corneal anesthesia may therefore be best achieved with administration of small drop volumes at time intervals corresponding to the half-life of drug decay from the corneal compartment. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis
Conclusions: This is the first study to show that P. aeruginosa strains with ocular pathogenicity carry the cif gene and that the presence of this gene may be enriched over its prevalence in the environment. Taken together, these results suggest a potential role for Cif in acute bacterial keratitis. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis
Purpose: We hypothesized that bacteria may be a factor contributing to the development of Acanthamoeba keratitis (AK). We investigated interactions between Acanthamoeba and Pseudomonas aeruginosa for the development of keratitis in rabbit corneas. Methods: Acanthamoeba castellanii (ATCC50492) and P. aeruginosa (PAO-1) were used. Two densities of P. aeruginosa (high, 1 × 108/mL; low, 3 × 105/mL) and 2 durations of coincubation (long, 6 h; short, 2 h) of Acanthamoeba with 1 × 108/mL of P. aeruginosa were tested. Acanthamoeba alone or Acanthamoeba coincubated with P. aeruginosa was inoculated into rabbit co...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Characterization of the Corneal Subbasal Nerve Plexus in Limbal Stem Cell Deficiency
Purpose: To quantify the changes in the subbasal nerve plexus in patients with limbal stem cell deficiency (LSCD) using in vivo laser scanning confocal microscopy. Methods: In this retrospective cross-sectional comparative study, confocal images of 51 eyes of 37 patients with LSCD collected between 2010 and 2015 by the Heidelberg Retina Tomograph III Rostock Corneal Module Confocal Microscope were analyzed. Two independent observers evaluated the scans of the central cornea. Seventeen normal eyes of 13 subjects served as controls. Total subbasal nerve density (SND), density of long nerves (ie, nerves 200 μm or longer),...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser–Fleischer Ring in Wilson Disease
Conclusions: AS-OCT is an alternative method of evaluating the KF ring in WD, which can be used in combination with slit-lamp examination. The KF ring can be easily measured using the gray scale of AS-OCT. Further studies are required to study the potential advantages of AS-OCT including assessing the density of the KF ring, as a tool to assess response to treatment in WD, in differentiating the KF ring of WD disease from copper deposits in other situations and pigmented corneal rings in non-Wilsonian liver disease. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Prevalence of Ocular Manifestations and Visual Outcomes in Patients With Herpes Zoster Ophthalmicus
Purpose: To investigate the prevalence of ocular manifestations and visual outcomes in patients with herpes zoster ophthalmicus (HZO). Methods: Consecutive cases diagnosed with HZO who attended 2 hospitals between July 1, 2011, and June 30, 2015, were retrospectively reviewed. Patient demographics, clinical presentations, and management were reviewed. The logistic regression model was used to estimate the odds ratio of visual loss with ocular manifestations. Results: A total of 259 patients were included. Of these, 110 (42.5%) patients were (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Reversibility of Gland Dropout and Significance of Eyelid Hygiene Treatment in Meibomian Gland Dysfunction
Purpose: To observe reversibility of meibomian gland (MG) dropout and analyze correlated factors and to compare the treatment efficiency with and without eyelid hygiene in patients with meibomian gland dysfunction (MGD). Methods: Consecutive 78 eyes of 78 MGD (stage 2–3) patients who finished follow-up examination after 1-month of treatment were recruited in this retrospective study. All patients were treated with artificial lubricant and eyelid hygiene. Related ocular surface evaluation and meibomian gland assessment were examined. Results: There were 26 (33%) patients (included in group 1) who ignored doctors' or...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Retrospective Comparative Study of Topical Interferon α2b Versus Mitomycin C for Primary Ocular Surface Squamous Neoplasia
Purpose: To compare the efficacy and safety of topical interferon alpha 2b (IFNα2b) and mitomycin C (MMC) for ocular surface squamous neoplasia. Methods: In this retrospective study, medical records of 51 eyes of 50 patients with a diagnosis of primary ocular surface squamous neoplasia were included. All cases were treated with either topical IFNα2b (1 million IU/mL) or MMC (0.4 mg/mL) 4 times a day. The primary outcome measure was frequency of clinical resolution of tumors along with failure and recurrence rates after treatment. Other outcome measures included the duration of treatment and adverse effects ass...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Nodulo-Ulcerative Ocular Surface Squamous Neoplasia in 6 Patients: A Rare Presentation
Conclusions: The nodulo-ulcerative variant of OSSN is rare and is most often misdiagnosed as necrotizing scleritis/sclerokeratitis causing a delay in the diagnosis. It is an aggressive lesion with increased occurrence of intraocular or orbital tumor extension. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Trabeculotomy on Corneal Endothelial Cell Loss in Cases of After Penetrating-Keratoplasty Glaucoma
Purpose: The aim of this study was to evaluate the effect of trabeculotomy (TLO) on glaucoma and endothelial cell loss after penetrating keratoplasty (PK). Methods: A retrospective study was conducted on consecutive patients who underwent PK and in whom more than 24 months of follow-up was available. Patients were categorized into the PK+TLO group [ie, TLO for post-PK glaucoma (n = 10)] and the PK group [PK alone (n = 73)]. Intraocular pressure (IOP) was evaluated during each follow-up examination. Central corneal endothelium images were obtained and analyzed to determine corneal endothelial cell (CEC) density. Results: ...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Biomechanical Properties After Penetrating Keratoplasty or Deep Anterior Lamellar Keratoplasty Using the Ocular Response Analyzer: A Meta-Analysis
We present the results as weighted mean difference (WMD) with a corresponding 95% confidence interval (CI). Results: Eight studies with a total of 750 eyes were included in the post-PK versus control group, and 4 studies with a total of 218 eyes were included in the post-DALK versus control group. The pooled results showed that CH and CRF were significantly reduced (P (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Russian Keratoprosthesis in Stevens–Johnson Syndrome
Conclusions: The MICOF KPro improved vision of patients with SJS, but lifelong surveillance is necessitated because of a high rate of postoperative complications. Corneal melting was the main reason for KPro failure. Infectious endophthalmitis and glaucoma were the main risk factors for visual loss. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty for Recurrence of Granular Corneal Dystrophy in Postkeratoplasty Eyes
Conclusions: FALK is a safe and effective technique for the management of recurrence of GCD in post-penetrating keratoplasty and post-PTK eyes. BCVA improved by>2 lines after the FALK procedure. None of the patients in this series had any intraoperative or postoperative complications, which was indicative of the safety of the procedure. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Trends and Determinants of Familial Consent for Corneal Donation in Chinese
Purpose: Corneal transplantation is the treatment of choice for many corneal diseases. At present, there is a global shortage of corneal transplant tissues, and failure to obtain consent from families of potential donors is a major limiting factor in tissue procurement. Methods: All family members of potential donors after cardiac death approached by the local eye bank staff members from January 2008 to December 2014 in Hong Kong were included. Reasons for consent or refusal and sociodemographic details of the deceased and the family members approached were reviewed. Trends in consent rates from 2008 to 2014 were examined...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Pupillary Abnormalities in Descemet Membrane Endothelial Keratoplasty After Nearly Full Tamponade
Conclusions: Nonischemic pupillary abnormalities can be seen in patients with DMEK using a nearly full air/gas tamponade in the AC after surgery despite patent iridectomy especially when combined with cataract surgery. Ensuring complete mydriasis in the immediate postoperative period and a free-floating bubble in the AC above the inferior pupillary margin may reduce its incidence. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcomes of Descemet Membrane Endothelial Keratoplasty in Patients With Previous Glaucoma Surgery
Purpose: To evaluate outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with previous trabeculectomy or a drainage device. Methods: This is a retrospective study of 108 consecutive DMEK performed between October 2013 and December 2015. All eyes were divided into 3 groups: surgical treatment (ST) group, medical treatment (MT) group, and control group. Visual improvement, endothelial cell loss, and postoperative complications, including rejection, graft failure, and intraocular pressure elevation (≥25 mm Hg) were evaluated. Results: The length of follow-up was 9.7 ± 7.3 months. Best-corrected v...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Enhancing Descemet Membrane Endothelial Keratoplasty in Postvitrectomy Eyes With the Use of Pars Plana Infusion
Conclusions: The use of posterior pars plana infusion in previously vitrectomized eyes stabilizes the anterior segment during DMEK, allowing for performance of DMEK surgery, and can potentially reduce intraoperative and postoperative complications. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Experienced DSAEK Surgeon's Transition to DMEK: Outcomes Comparing the Last 100 DSAEK Surgeries With the First 100 DMEK Surgeries Exclusively Using Previously Published Techniques
Purpose: To compare outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) when an experienced DSAEK surgeon transitions to DMEK while following 2 published endothelial keratoplasty surgical techniques. Methods: This is a retrospective review of 200 eyes of 132 patients with Fuchs corneal dystrophy that underwent endothelial keratoplasty performed by one surgeon. Published, standardized techniques were followed for both DSAEK and DMEK. Postoperative complications were recorded. Best spectacle-corrected visual acuity (BSCVA), intraocular pressure, and...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Astigmatism Correction With Toric Intraocular Lenses in Descemet Membrane Endothelial Keratoplasty Triple Procedures
Purpose: To report the clinical efficacy of astigmatism correction with toric intraocular lenses (IOLs) in patients undergoing the Descemet membrane endothelial keratoplasty (DMEK) triple procedure and to evaluate the accuracy of the correction. Methods: Fifteen eyes of 10 patients who received cataract extraction, toric IOL placement, and DMEK surgery for Fuchs corneal dystrophy and cataracts were evaluated. The cylinder power of toric IOLs was determined by an online toric calculator with keratoscopy measurements obtained using Scheimpflug corneal imaging. Prediction errors were assessed as a difference vector between t...
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Factors Associated With Graft Detachment After Primary Descemet Stripping Automated Endothelial Keratoplasty
Conclusions: Previous PK and trabeculectomy are independent risk factors for postoperative graft detachment in primary DSAEK. (Source: Cornea)
Source: Cornea - February 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Herpes Simplex Virus Keratitis and Resistance to Acyclovir
No abstract available (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Descemet Blues
No abstract available (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD-Specific Metric
Conclusions: The newly proposed ICCGVHD diagnostic criteria can be used reproducibly for the diagnosis and determination of severity of chronic ocular GVHD. However, larger prospective studies are needed to further validate it. (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Review Source Type: research

Ethical Issues in Transnational Eye Banking
Conclusions: Further analysis of specific ethical issues in eye banking is necessary to inform development of guidelines and other governance tools that will assist policy makers and professionals to support ethical practice. (Source: Cornea)
Source: Cornea - January 10, 2017 Category: Opthalmology Tags: Review Source Type: research