Blast Wound Dehiscence During Descemet Membrane Endothelial Keratoplasty Rebubbling in a Previous Penetrating Keratoplasty: A Case Report
Conclusions:
DMEK graft rebubbling in patients with previous PK may lead to traumatic wound dehiscence. Avoidance of excessive increases in intraocular pressure during the rebubbling procedure should be encouraged to decrease the risk of this rare complication. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Surgical Management of Ocular Cicatricial Pemphigoid in a Pediatric Patient
Conclusions:
Tarsal fracture surgery may be considered part of the treatment in pediatric patients with stable ocular cicatricial pemphigoid presenting with severe entropion and trichiasis. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Case Report of Conjunctival Melanoacanthoma
Conclusions:
Only 1 prior case of conjunctival melanoacanthoma has been documented. As such, there is no standard of care regarding appropriate management. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Case Report Source Type: research
U-Net Convolutional Neural Network for Segmenting the Corneal Endothelium in a Mouse Model of Fuchs Endothelial Corneal Dystrophy
Conclusions:
We demonstrated proof of concept for application of U-Net for objective analysis of corneal endothelial cells and guttae in Fuchs endothelial corneal dystrophy, based on limited ground truth data. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Ultrasound-Enhanced Transcorneal Drug Delivery for Treatment of Fungal Keratitis
Purpose:
Transcorneal drug delivery is hindered by ocular physical and biochemical properties, such as tear production, the epithelial layer of the cornea, and blinking. The aim of this study was to determine whether ultrasound can be applied to increase the transcorneal drug delivery of natamycin used in the treatment of fungal keratitis without dangerously overheating the surrounding ocular tissues.
Methods:
To verify the safety of various sets of ultrasound parameters, modeling studies were conducted using OnScale, an ultrasonic wave modeling software. Ultrasound parameters determined optimal for ocular tissu...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Changes in Corneal Biomechanical Properties After Small-Incision Lenticule Extraction and Photorefractive Keratectomy, Using a Noncontact Tonometer
Purpose:
The aim of this study was to evaluate and compare early corneal biomechanical changes after small-incision lenticule extraction (SMILE) and photorefractive keratectomy (PRK).
Methods:
The study comprised 74 patients eligible for refractive surgery, equally allocated to PRK (37 patients) and SMILE (37 patients). Corneal biomechanical properties were recorded and compared between the 2 groups at preoperatively and 3 months after surgery using a dynamic ultra-high-speed Scheimpflug camera equipped with a noncontact tonometer.
Results:
Both procedures significantly affected corneal biomechanical prop...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Corneal Cellular and Neuroinflammatory Changes After SARS-CoV-2 Infection
Purpose:
The purpose of this study was to evaluate corneal cellular and ultrastructural changes and to quantify the neuroinflammatory process in patients after mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods:
Thirty patients after SARS-CoV-2 infection and 41 age-matched controls were examined. All subjects underwent in vivo confocal microscopy of the corneal cell layers and subbasal nerve fibers with the Heidelberg Retina Tomograph II. Semiautomated analysis of basal epithelial, anterior and posterior stromal keratocyte, and endothelial cell density was performed. Dendritic c...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Progression of Pediatric Keratoconus After Corneal Cross-Linking: A Systematic Review and Pooled Analysis
This study aimed to establish the most commonly used criteria for progression and to conduct a systematic review of the literature with pooled analysis to assess children's keratoconus progression after CXL.
Methods:
A systemic literature review combined with pooled analysis was performed on full-length studies of KC after CXL treatment in a pediatric population and the methods used to report progression were analyzed.
Results:
Thirty-seven studies (2078 eyes) were identified on the rates of KC progression after CXL. The most common method to report progression was increased Kmax, Kmean, or Ksteep by ≥1.0 d...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Cytokeratin 13 Is a New Biomarker for the Diagnosis of Limbal Stem Cell Deficiency
Purpose:
The purpose of this study was to evaluate the expression of cytokeratin (K) 13 on the corneal surface and to validate its application in the diagnosis of limbal stem cell deficiency (LSCD).
Methods:
This prospective comparative study included 26 corneal impression cytology (IC) specimens from patients diagnosed with LSCD. Twenty-three IC specimens from normal donors served as controls. K12 and K13 expression were detected on the IC specimens by immunohistochemistry study. The number of K12+ or K13+ cells in all areas of the IC was quantified using ImageJ software.
Results:
The epithelial cells ha...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Trends in Corneal Transplantation in a Tertiary Hospital in Brazil
Purpose:
The purpose of this study was to analyze the evolving trends of surgical techniques and indications of corneal transplantation (CT) at a tertiary hospital in Brazil.
Methods:
The medical records of all patients who underwent CT at the Hospital Oftalmológico de Sorocaba (Sorocaba Eye Hospital) from the Banco de Olhos de Sorocaba (Sorocaba Eye Bank) group in Sorocaba, Brazil, from January 1, 2012, to December 31, 2019, were analyzed. Data regarding age, sex, transplant indication, and surgical technique were collected.
Results:
A total of 16,250 CTs were performed. There was a statistically signif...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
High-Dose Oral Posaconazole for the Treatment of Recalcitrant Fungal Keratitis
Conclusions:
In cases of recalcitrant FK failing to respond to conventional therapies, high-dose posaconazole, in the delayed-release tablet formulation, can be an effective treatment option. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Correlation of Measures From the OCULUS Keratograph and Clinical Assessments of Dry Eye Disease in the Dry Eye Assessment and Management Study
Conclusions:
In the Dry Eye Assessment and Management study, NIKBUT, TMH, and BR were weakly correlated with their clinical counterparts. No measurements were correlated with the OSDI score. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Comparing ProKera With Amniotic Membrane Transplantation: Indications, Outcomes, and Costs
Conclusions:
ProKera allowed for a faster corneal healing than sutured AMT, although its total healed area was less than the latter. Moreover, ProKera is more cost-effective than AMT, thus reducing financial burden to our health care system. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Trends in Early Graft Failure Leading to Regrafting After Endothelial Keratoplasty in the United States
Conclusions:
The proportion of early graft failures in DMEK decreased over time and was comparable with failure rates in DSAEK at the end of the study period. The surgical learning curve might have played a role. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Corneal Remodeling After Myopic SMILE Versus FS-LASIK: A Spatial Analysis of Short- and Mid-Term Corneal Thickness, Volume, and Shape Changes
Conclusions:
CTSP and CVD between the 2-month and 3-year examination showed a similar increase after SMILE and FS-LASIK. During the postoperative course, the anterior and posterior corneal asphericity remained more stable after SMILE compared with FS-LASIK. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
