Descemet Membrane Suturing for Large Descemet Membrane Detachment After Cataract Surgery
Conclusions: DM suturing can reattach DM, especially in moderate to severe, recurrent DMD with fewer postoperative complications and thereby reduce the need for corneal transplantation. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-term Outcomes on de novo Ocular Hypertensive Response to Topical Corticosteroids After Corneal Transplantation
Conclusions: The use of alternate topical corticosteroids may be considered in cases of steroid-induced ocular hypertension after PKP because they offer good antiinflammatory prophylaxis with reduced hypertensive response. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Recurrence of Infection in Corneal Grafts After Therapeutic Penetrating Keratoplasty for Microbial Keratitis
Purpose: To determine the factors responsible for the recurrence of infection after therapeutic penetrating keratoplasty (TPK) in severe microbial keratitis. Methods: This is a retrospective interventional case series that reviewed the medical records of 229 consecutive patients (2005–2017) who underwent TPK for microbial keratitis at a tertiary eye care center in Central India. The primary outcome was recurrence of the primary infection. The factors responsible for recurrence were identified by univariate and multivariate regression analysis. Results: The overall outcomes were clear graft in 50 (21.8%) eyes,...
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Densitometry Analysis of Corneal Backscatter After Pre-Descemet Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy
Purpose: To quantify corneal backscattering by densitometry analysis after pre-Descemet endothelial keratoplasty (PDEK). Design: This is a prospective observational case series. Methods: Setting: Tertiary care hospital. Participants: Postoperative PDEK eyes with best-corrected visual acuity (BCVA) ≥20/40 without comorbidity. Observation procedure: Slit-lamp examination, Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany), endothelial cell density (cells/mm2), and central corneal thickness (Visante; Carl Zeiss AG, Oberkochen, Germany) were performed. Corneal densitometry values for the entire depth of the co...
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Lamellar Dissection Technique for Descemet Membrane Endothelial Keratoplasty Graft Preparation
Conclusions: The lamellar dissection technique has a similar rate of ECL compared with the peeling technique for DMEK graft preparation. This technique also has a low rate of graft preparation failure and may be a useful technique for diabetic donor tissue. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Graft Survival After Penetrating and Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome
Conclusions: The results indicate no difference in graft survival between PK and EK for ICE syndrome. Graft survival in ICE syndrome is intermediate between that of FED and PBK. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty Under Failed Penetrating Keratoplasty Without Host Descemetorhexis for the Management of Secondary Graft Failure
Conclusions: DMEK under PK without host descemetorhexis is a feasible surgical alternative for the treatment of graft failure after PK. It is associated with equivalent levels of efficacy and safety compared with Descemet membrane stripping DMEK techniques but simplifies the surgical procedure and avoids potential intraoperative complications associated with Descemet stripping. Further studies with a larger sample and a longer follow-up are necessary to confirm our preliminary outcomes. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty in Irreversible Corneal Edema Due to Herpes Simplex Virus Endotheliitis
Purpose: To report the clinical outcome and postoperative course of Descemet membrane endothelial keratoplasty (DMEK) in irreversible corneal edema due to herpes simplex virus (HSV) endotheliitis. Methods: This is a retrospective, noncomparative, interventional case series. Nineteen eyes of 19 patients underwent standard DMEK combined with cataract surgery (triple DMEK) between May 2016 and April 2018. All patients received perioperative oral acyclovir (ACV) and prednisolone. Patients were followed up on day 1, on day 7, at 1 month, and then at 3 monthly intervals. Preoperative and postoperative best spectacle-correct...
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Surgeon Preference for Endothelial Keratoplasty Techniques
Conclusions: There is substantial interest in learning to perform DMEK among the surgical community. Barriers identified in this survey may be addressed to help surgeons increase DMEK adoption. (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Letter From the New Editor-in-Chief
No abstract available (Source: Cornea)
Source: Cornea - December 6, 2019 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on: “Effect of Riboflavin Solution With Hydroxypropyl Methylcellulose and Eyelid Speculum on Pachymetry Changes During Accelerated Collagen Crosslinking”
No abstract available (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Other Causes of Limbal Stem Cell Deficiency
No abstract available (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

A Review of the Literature on the Global Epidemiology of Corneal Blindness
Conclusions: The results demonstrate the somewhat inconsistent and fragmented information regarding corneal causes of vision loss. A significant outcome of this research is the demonstration of a need for further research into global corneal blindness and the necessary steps to address the problem. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Review Source Type: research

Management of Nocardia Interface Keratitis After Descemet Membrane Endothelial Keratoplasty
Conclusions: Nocardia interface keratitis is a rare entity, which can occur after DMEK. Proper clinical evaluation and microbiological workup helped us in accurate diagnosis and management. Repeat DMEK after complete resolution of the infection resulted in good outcomes regarding corneal clarity and vision improvement. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Treatment of Severe Keratoconus Hydrops With Intracameral Platelet-Rich Plasma Injection
Conclusions: In this case, intraocular E-PRP was a promising, apparently safe, and effective treatment option in management of corneal hydrops, in which conventional approaches failed. This is the first case in the literature to describe OCT appearance of corneal hydrops and intracameral use of E-PRP for the resolution of DM rupture in acute corneal hydrops. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Glaucoma After Corneal Trauma or Surgery—A Rapid, Inflammatory, IOP-Independent Pathway
Conclusions: A rapidly initiated, inflammatory (TNF-α mediated), IOP-independent pathway to glaucoma, resulting from acute anterior segment trauma or surgery, has been identified in laboratory studies. Prompt prophylactic treatment with antiinflammatory agents has been shown to be markedly neuroprotective of retinal ganglion cells, presumably capable of reducing the risk of late glaucoma. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Special Article Source Type: research

Early Corneal Wound Healing Response After Small Incision Lenticule Extraction
Conclusions: The scar tissue response in the peripheral cornea is related to the epithelium debridement. Inflammatory cells begin to be recruited by 1 hour after surgery. Therefore, it is necessary to implement antiinflammation interventions at a very early stage. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Effect of Obstructive Sleep Apnea on Corneal Morphological Characteristics
Purpose: To determine central corneal thickness (CCT) and the corneal parameters in patients with obstructive sleep apnea (OSA), evaluate the relationship between the severity of OSA, minimum peripheral capillary oxygen saturation (min. SpO2), and corneal morphological characteristics. Methods: Patients with OSA diagnosed by full-night polysomnography before treatment were included. Patients with OSA were divided into 3 groups according to the Apnea–Hypopnea Index (AHI). The control group (CG) was examined to exclude the possibility of OSA and ocular diseases. The following data were recorded: age, sex, body mas...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs
Conclusions: This comprehensive assessment of ADDE-affected WHWTs depicts the ocular surface changes associated with quantitative lacrimal gland dysfunction. Importantly, ADDE-affected WHWTs may prove a valuable naturally occurring ADDE model for investigating underlying pathophysiological mechanisms and the development of novel therapeutics. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

In Vitro Antifungal Effect of Acrylic Corneal Glue (N-Butyl-2-Cyanoacrylate)
Conclusions: nB2CA has shown antifungal activity against 18 different mold and yeast species, but not against A. flavus, A. oryzae, and Chrysosporium spp. molds. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Are BALB/c Mice Relevant Models for Understanding Sex-Related Differences in Gene Expression in the Human Meibomian Gland?
Conclusions: Our results indicate that BALB/c mice are not optimal models for understanding sex-related differences in gene expression of the human MG. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Fire Ant Punctate Keratopathy: A Novel Diagnosis Based on Clinical and Anterior Segment Optical Coherence Tomography Findings
Conclusions: LFA bites can cause long-lasting corneal injury in humans with characteristic clinical biomicroscopic findings. The corneal lesions do not respond to conventional topical treatment. AS-OCT imaging can be a useful modality for diagnosis and follow-up. Awareness by both patients and ophthalmologists of this clinical entity may be helpful in diagnosis and management. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Short- and Long-Term Results of Xenogeneic-Free Cultivated Autologous and Allogeneic Limbal Epithelial Stem Cell Transplantations
Conclusions: This study shows that anatomical and functional success rates of CLET decrease over time. We believe that the decline of success is related to the extent of disease, cell origin, and lack of niche protection because subtotal LSCD and autologous donor cells confer a higher chance of success in the long-term. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Fourier Analysis of Corneal Irregular Astigmatism After Small Incision Lenticule Extraction and Comparison to Femtosecond Laser-Assisted Laser In Situ Keratomileusis
Purpose: Evaluation of spherical component (SC), regular astigmatism (RA), and irregular astigmatism (IA, ie, Asymmetry and Irregularities) 3 years after small incision lenticule extraction (SMILE) and comparison to femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). Methods: Thirty-two eyes of 21 patients who underwent SMILE for myopia and astigmatism were compared with 32 eyes of 21 patients treated with FS-LASIK. Scheimpflug images were obtained preoperatively and 3 years postoperatively. Fourier analysis of keratometric-derived parameters (SC, RA, Asymmetry, and Irregularities) of the anterior, pos...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcomes of Flap Lift Laser In Situ Keratomileusis Enhancements in a Large Patient Population: Does Application of a Bandage Contact Lens Affect Incidence of Epithelial Ingrowth?
Conclusions: We found no relevant differences in LASIK enhancement between patients who received a bandage CL and those who did not regarding the incidence of EIG and visual outcomes. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Keratoconus Could Be Associated With Psoriasis: Novel Findings From a Comparative Study
Conclusions: Serious changes in topography maps may occur in psoriatic patients. The changes were found to be more evident in the presence of a higher PASI score and the early beginning and longer duration of the disease. The results hinted a potential relationship between psoriasis and KC. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Pediatric Microbial Keratitis in Queensland, Australia (2005 to 2015)
Purpose: To estimate the incidence and define the demographic and microbiological profile of pediatric microbial keratitis (MK) in Queensland, Australia. Methods: This is a retrospective study based on the multicenter database of all patients with positive corneal scrapes in Queensland, Australia, between 2005 and 2015. Pathology organizations in Queensland were identified by online and local directory search and were requested to provide digital records of the corneal scrapes, including patient demographics and culture and antibiotic sensitivity results. Patient demographics, yearly incidence (based on state populati...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Permethrin Cream for the Treatment of Demodex Blepharitis
Conclusions: Treatment of Demodex blepharitis with permethrin 5% cream resulted in a decrease in parasite burden and improvement in blepharitis signs and symptoms, with no reported adverse events. Permethrin might be a safe and effective alternative for the treatment of blepharitis associated with Demodex infection. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Meibomian Gland Morphology: The Influence of Structural Variations on Gland Function and Ocular Surface Parameters
Purpose: To objectively and quantitatively characterize meibomian gland morphology and to investigate the influence of morphological variations on gland function and ocular surface and tear film parameters. Methods: One hundred fifty subjects were enrolled. The examinations included tear osmolarity, tear meniscus height, bulbar conjunctival hyperemia, noninvasive tear film breakup time, lid margin thickness, foam secretion, meibomian gland expressibility, count of functioning glands, corneal and conjunctival staining, fluorescein breakup time, lid wiper epitheliopathy, and Schirmer test. Patient symptoms were assessed...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Prevalence of Novel Candidate Sjögren Syndrome Autoantibodies in the Penn Sjögren's International Collaborative Clinical Alliance Cohort
Conclusions: In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS. Further longitudinal studies are needed to determine the clinical significance of these findings. (Source: Cornea)
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Risk Factors for Dry Eye After Refractive Surgery
Purpose: To determine the factors associated with clinically significant dry eye after keratorefractive surgery. Methods: This is a large database retrospective study that included consecutive cases of myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy performed between 2008 and 2016 at Care-Vision Laser Center, Israel. Patients were divided into 2 groups according to whether they developed clinically significant dry eye. Results: A total of 25,317 right eyes of 25,317 patients, with a mean age of 27.0 ± 8.3 years, were included. Postoperative dry eye developed in 1518 eyes (6.0%). Th...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluating Dry Eye and Meibomian Gland Dysfunction With Meibography in Patients With Stevens–Johnson Syndrome
Purpose: To investigate ocular surface and meibomian gland characteristics using infrared meibography in patients with Stevens–Johnson syndrome (SJS). Methods: This is a single-center, prospective, noncontrolled, observational study. Thirty-two Thai patients (64 eyes) with SJS for 1 year or longer (1–44 years) were enrolled in the study. All participants underwent a comprehensive ophthalmic examination including slit-lamp biomicroscopy, tear meniscus height, fluorescein tear breakup time, ocular surface fluorescein staining, eyelid morphology, Schirmer 1 test, meibomian gland expressibility, and upper and ...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Short-Term Effects of Ground-Level Ozone in Patients With Dry Eye Disease: A Prospective Clinical Study
Purpose: To investigate changes in the clinical features of patients with dry eye disease (DED) according to short-term outdoor ground-level ozone exposure. Methods: This prospective observational study included patients with DED who were treated with the same topical drugs (0.05% cyclosporine or 3% diquafosol) and visited the hospital twice at 2-month intervals. Patients who showed a short tear film breakup time and positive ocular surface staining were assigned to the diquafosol and cyclosporine groups, respectively. The ocular surface disease index (OSDI) score, tear secretion, tear film breakup time, and corneal f...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Tear Film and Meibomian Gland Characteristics in Adolescents
Purpose: To establish normative values of ocular surface parameters in adolescents and explore factors associated with meibomian gland (MG) dropout. Methods: Subjects between 8 and 17 years of age were enrolled in this cross-sectional study. All subjects were given dry eye and lifestyle questionnaires. Tear film assessments and meibography were performed. Statistical tests included a one-way analysis of variance to test differences in ocular surface parameters between age groups and linear correlations between clinical findings and lifestyle factors. Results: Two hundred twenty-five subjects completed the study. Th...
Source: Cornea - November 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

What Causes Heterogeneity in the Pooled Effect of Omega-3 on Dry Eye Symptom Score? Countries or Measurements?
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Re: “Deep Anterior Lamellar Keratoplasty in Eyes With Intrastromal Corneal Ring Segments”
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

RE: “Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty”
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

A Modified Technique Using Disposable Soft Contact Lens for Penetrating Keratoplasty Combined With Cataract Extraction and Intraocular Lens Implantation
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Increasing Povidone-Iodine Exposure in Endothelial Keratoplasty Tissue Processing and Fungal Infection Impact
No abstract available (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Systematic Review and Meta-Analysis of the Medium- and Long-Term Outcomes of the Boston Type 1 Keratoprosthesis
Conclusions: The 2-year results indicate that there is a place for the Boston type 1 KPro in the management of corneal blindness. However, there is scarce evidence regarding its medium- and long-term efficacy and safety. The high rate of reported complications necessitates strict patient selection and stringent follow-up. (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Review Source Type: research

Novel Application Software for the Semi-Automated Analysis of Infrared Meibography Images
Purpose: To develop semi-automated application software that quickly analyzes infrared meibography images taken with the CSO Sirius Topographer (CSO, Italy) and to compare them to the manual analysis system on the device (Phoenix software platform). Methods: A total of 52 meibography images verified as high quality were used and analyzed through manual and semi-automated meibomian gland (MG) detector software in this study. For the manual method, an experienced researcher circumscribed the MGs by putting dots around grape-like clusters in a predetermined rectangular area, and Phoenix software measured the MG loss area...
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Techniques Source Type: research

In Vivo Confocal Microscopy of Prominent Conjunctival and Corneal Nerves in Multiple Endocrine Neoplasia Type 2B
Conclusions: To date, this is the first report which documents conjunctival neuromas by confocal microscopy in MEN2B. (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Cenegermin in Pediatric Neurotrophic Keratopathy
Conclusions: Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK. (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization
Conclusions: This study suggests that circRNAs are involved in the pathogenesis of corneal neovascularization. cZFP609 and cKifap3 may serve as promising targets for the treatment of corneal neovascularization. (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Human Corneal Endothelial Cell Assessment From Tissues Preserved in Serum-Based and Synthetic Storage Media
Purpose: To assess the difference between endothelial cells from tissues preserved in media supplemented with fetal bovine serum (FBS) and recombinant human serum albumin (rHSA). Methods: In a donor-matched study, 48 tissues were preserved for 28 days at 31°C in Cornea Max and Cornea Syn supplemented with FBS and rHSA, respectively. Endothelial cells were visualized by 2 masked observers before and after preservation. Endothelial cell density (ECD) and the number of iatrogenic folds were counted manually. Alizarin red staining and tight junction protein (Zonula Occludens-1) were used to assess cell morphology (hex...
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research