Descemetorhexis Without Endothelial Keratoplasty in Fuchs Endothelial Corneal Dystrophy: A Systematic Review and Meta-Analysis
Purpose:
Descemetorhexis without endothelial keratoplasty (DWEK) is an innovative corneal intervention and potentially effective against Fuchs endothelial corneal dystrophy (FECD). We aimed to conduct a systematic review and meta-analysis on the outcomes of DWEK, associated or not with phacoemulsification (PKE) and rho-kinase inhibitor (RHOKI) in FECD.
Method:
PubMed, Cochrane Library, Embase, ClinicalTrials.gov, and Science Direct were searched for studies until November 29, 2020. We performed random-effects meta-analyses and meta-regressions, stratified by the type of intervention and descemetorhexis size (PRO...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Long-Term Outcomes of Big Bubble Deep Anterior Lamellar Keratoplasty in Mucopolysaccharidoses: A Retrospective Case Series and Review of the Literature
Conclusions:
BB-DALK seems to be an acceptable long-term surgical option in patients with MPS. Our findings suggest that this technique is reproducible and can achieve clear corneal grafts with good visual results on a long-term follow-up. (Source: Cornea)
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Cornea Classic: Spoerl et al, 2007, the “Holy Grail of CXL”
Abstract:
Corneal collagen cross-linking has established itself as the only known treatment with a proven ability to arrest the progression of keratoconus. The efficacy and safety of the procedure have been entirely due to meticulous preparation by the innovators of this technique, before clinical application was confidently advocated. The article by Spoerl et al, entitled “Safety of UVA riboflavin crosslinking of the cornea,” one of the most frequently cited articles in the journal “Cornea,” explains the logic behind the formulation of the “Dresdon protocol” that remains the gold standard in the treatment ...
Source: Cornea - July 1, 2022 Category: Opthalmology Tags: Invited Submission Source Type: research
Early Endothelialization of Ab Interno Stromal Tectonic Patch in the Management of Corneal Perforation Secondary to Bacterial Keratitis
Conclusions:
This is the first case to our knowledge demonstrating that stromal tectonic grafts without the endothelium can successfully attach to the host tissue and seal a perforation. The stroma may undergo reendothelialization and begin to restore vision, even before penetrating keratoplasty. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Techniques Source Type: research
Refractive Shifts and Changes in Corneal Curvature Associated With Antibody–Drug Conjugates
This study is a retrospective case series including 58 eyes of 29 patients with ADC-related keratopathy from a single tertiary care cancer referral center (MSKCC). One eye (29 total) was randomly assigned for statistical analysis. In addition, a subset analysis of MEC location–refractive error correlation was performed on 20 eyes. Clinical records including slitlamp examination, indirect ophthalmoscopy, calculated spherical equivalence (SE), keratometry, and visual acuity were recorded at baseline, during, and off treatment.
Results:
A subset analysis of MEC location–refractive error correlation of 20 eyes revea...
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Techniques Source Type: research
Safety-Net Suture for Aphakic Descemet Membrane Endothelial Keratoplasty
Conclusions:
The safety-net suture is a simple, low-cost method of reducing the risk of intraoperative posterior dislocation for DMEK in unicameral, aphakic eyes. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Techniques Source Type: research
Corneal Epithelial Remodeling as a Cause of Chalazion-Induced Hypermetropia
Conclusions:
Chalazia can cause reversible corneal epithelial remodeling and should be considered as a differential diagnosis in cases of unexplained vision loss and changes in refractive status. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Microsporidial Endotheliitis Mimicking Graft Rejection After Deep Anterior Lamellar Keratoplasty
Conclusions:
Microsporidial endotheliitis may present as graft rejection. There should be a suspicion of microsporidial infection in cases of features mimicking as endothelial rejection after DALK. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy
Conclusions:
We report the initial confirmation of PRDX3 as the genetic basis of PPPCD in a previously unreported pedigree and expand the phenotype of PPPCD to include polychromatic lenticular deposits. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Anterior Scleral and Limbal Inflammatory Necrosis After Adjuvant Miltefosine for Recalcitrant Acanthamoeba Keratitis
Conclusions:
Miltefosine has been observed to result in the resolution of AK when used as an adjunctive therapy. It may also lead to a consecutive inflammatory necrosis of the anterior sclera and limbus. This inflammatory response may be significant enough to cause rapid scleral-limbal thinning with subsequent perforation. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Corneal Allograft Rejection Associated With Herpes Zoster Recombinant Adjuvanted Vaccine
Conclusions:
RZV, which elicits a more robust immune reaction than the zoster live-attenuated vaccine, ZVL, may increase the risk of allograft rejection in immunocompetent patients with preexisting corneal endothelial or penetrating transplants. Based on the available data, it may be reasonable to increase the topical corticosteroid regimen before the first dose, until approximately 3 months after the second dose of ZVL. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Descemet Membrane Endothelial Keratoplasty for Corneal Edema and Visually Significant Descemet Membrane Scrolls Due to Syphilitic Keratitis
Abstract:
The presence of Descemet membrane scrolls is an uncommon finding reported in syphilitic interstitial keratitis. We herein describe a novel surgical strategy for this entity; this report demonstrates that Descemet membrane endothelial keratoplasty surgery can be performed with excellent visual outcomes in the event of corneal edema as a late sequela of syphilitic keratitis. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Posterior Chamber Intraocular Lens Dislocation Into the Vitreous in Association With Descemet Stripping Lamellar Keratoplasty
Conclusions:
PCIOL dislocation is a possible and notable complication that requires attention while performing DSAEK on pseudophakic eyes. Not only plate-haptic silicone but also acrylic, single-piece PCIOLs with modified C loops may dislocate into the vitreous in association with DSAEK in cases with compromised capsular or zonular integrity. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
The Effect of COVID-19 on Corneal Donor Volumes and Eye Bank Processes: An Analysis From the Eye Bank of Canada (Ontario Division)
Conclusions:
The decline in ocular tissue donor volumes and transplant surgery was a result of an interplay of causes related to the COVID-19 pandemic. Most importantly, ruling out of COVID-19 carriers, lockdown measures affecting tissue retrieval processes, and shutdown of elective surgery were the 3 major factors accounting for tissue shortages and surgical volume reductions. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Retroprosthetic Membrane Formation in Boston Keratoprosthesis Type 1: Incidence, Predisposing Factors, Complications, and Treatment
Conclusions:
More than one third of patients who undergo BKPro will develop RPM, requiring close monitoring for retinal detachment. Simultaneous intraocular lens extraction seems protective, whereas simultaneous lens extraction increases the rate of RPM formation significantly. Nd:YAG membranectomy can be used as an initial noninvasive approach. (Source: Cornea)
Source: Cornea - May 24, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
