Use of Topical Rho Kinase Inhibitors in the Treatment of Fuchs Dystrophy After Descemet Stripping Only
This study prospectively evaluated the use of ripasudil in patients undergoing DSO for FD. Methods: Enrolled patients underwent DSO with or without cataract surgery, performed by 1 surgeon. On the first postoperative day, patients were assigned to topical ripasudil 0.4% (Glanatec) 4 times a day for 2 months or no ripasudil and followed up monthly for the first 6 months and then at 9 and 12 months after surgery. Endothelial cell density (ECD) and pachymetry were evaluated at each postoperative visit. Results: Eighteen patients were enrolled, including 8 women and 1 man in each group. Overall, patients who underwent DS...
Source: Cornea - April 2, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Novel Unassisted Pterygium Excision Technique
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on: “Influence of Postoperative Intraocular Pressure on Graft Detachment After Descemet Membrane Endothelial Keratoplasty”
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on “Visual Outcomes and Prognostic Factors of Successful Penetrating Keratoplasty in 0- to 7-Year-Old Children With Congenital Corneal Opacities”
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on “Visual Outcomes and Prognostic Factors of Successful Penetrating Keratoplasty in 0- to 7-Year-Old Children With Congenital Corneal Opacities”
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reflections on the Barcelona Principles—Planning for the Future
No abstract available (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Feasibility of Intraocular Projection for Treatment of Intractable Corneal Opacity
In this study, we review previous work and recent technologic developments relevant to the development of such an intraocular projection system. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Review Source Type: research

Surgical Corneal Anatomy in Deep Anterior Lamellar Keratoplasty: Suggestion of New Acronyms
Abstract: Deep anterior lamellar keratoplasty (DALK) is the ideal surgery for corneal stromal diseases with a healthy endothelium. This technique offers substantial advantages compared with penetrating keratoplasty, primarily the avoidance of endothelial rejection and longer graft survival. Several DALK techniques have been described and classified into 2 categories, descemetic DALK (dDALK) and predescemetic DALK (pdDALK) depending on whether Descemet membrane-endothelium was thought to be exposed or minimal residual stroma was left behind. This classification was crucial to identify the conditions to achieve good visual...
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Review Source Type: research

Novel Use of Telemedicine for Corneal Tissue Evaluation in Eye Banking: Establishing a Standardized Approach for the Remote Evaluation of Donor Corneas for Transplantation
Conclusions: Results from this pilot study suggest that telemedical review of corneal tissue using high-quality digital images may be adequate for accurate identification of specific corneal findings commonly encountered by eye banks. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Peripheral Pneumatic Dissection and Scar Peeling to Complete Deep Anterior Lamellar Keratoplasty in Eyes With Healed Hydrops
Conclusions: Peripheral pneumatic dissection and central scar peeling technique is a useful technique to complete DALK in eyes with scars due to previous hydrops. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Polyquaternium-1–Associated Dendritiform Keratopathy
Conclusions: Polyquaternium-1–associated dendritiform keratopathy can occur in patients who have previously tolerated the preservative. Because keratopathy seems to have developed and improved because of dose-dependent factors, the mechanism is more likely toxicity than hypersensitivity. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Partial Scleral Rupture Presenting 4 Years After Laser in Situ Keratomileusis
Conclusions: The pattern and location of thinning without findings consistent with inflammatory disease suggest that the partial bilateral scleral rupture was because of mechanical damage at the time of LASIK, possibly compounded by the hormonal changes of pregnancy. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Lucia and Beyond: Development of an Affordable Keratoprosthesis
Conclusions: We have developed a modified Boston keratoprosthesis type I, which we call the “Lucia.” The Lucia retains the 2 piece design and ease of assembly of the predicate device, but would allow for manufacturing at a reduced cost. Its appearance should prove more acceptable to implanted patients. Successful keratoprosthesis outcomes require daily medications for the life of the patient and rigorous, frequent, postoperative care. Effective implementation of the device in resource-poor settings will require further innovations in eye care delivery. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Special Article Source Type: research

Impact of Nanostructured Lipid Carriers as an Artificial Tear Film in a Rabbit Evaporative Dry Eye Model
Conclusions: NLCs eye drops are biocompatible in rabbit eyes and show potential as a tear replacement vehicle for the treatment of dry eye disease. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Biobanking of Dehydrated Human Donor Corneal Stroma to Increase the Supply of Anterior Lamellar Grafts
Conclusions: Human donor corneal stroma can be biobanked for up to 2 weeks in a dehydrated condition without losing their molecular or biomechanical properties after rehydration. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Optimized Protocol for Regeneration of the Conjunctival Epithelium Using the Cell Suspension Technique
Conclusions: Our findings pave the way for ex vivo cultivation of conjunctival epithelial cells onto a scaffold using the cell suspension technique by means of animal-free media. This would allow us to obtain conjunctival grafts for clinical purposes, thus giving a therapeutic option to patients with conjunctival diseases refractory to current therapies. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis
Conclusions: Reduction in Acanthamoeba cyst density with treatment can be monitored by IVCM, which in turn can be used clinically in prognostication and disease monitoring of AK. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Effectiveness of Cryopreserved Amniotic Membrane Transplantation in Corneal Ulceration: A Meta-Analysis
Purpose: To evaluate the effectiveness of cryopreserved amniotic membrane transplantation (AMT) in corneal ulceration. Methods: The following electronic databases were searched: PubMed, EMBASE, and Cochrane Library. We evaluated the corneal epithelium healing rate (CEHR) and vision improvement rate (VIR) after AMT in the treatment of corneal ulceration. We analyzed the differences in the CEHR and VIR between the 2 groups of infective and noninfective corneal ulcerations. Subgroup analysis for the CEHR and VIR was performed based on the surgical methods. There were 3 subgroups: single-layered inlay, multilayered inlay,...
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Small-Incision Femtosecond Laser–Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus
Conclusions: Both SFII and PKP surgical procedures resulted in a stable corneal volume and improved visual acuity in this long-term study. SFII was less invasive and more efficient compared with PKP. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Retinoscopy as a Screening Tool for Keratoconus
Conclusions: Retinoscopy appears to be a very sensitive and reliable test for detecting keratoconus including early disease. Such a test may be implemented in population-based screening programs for keratoconus. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparative Functional Outcomes After Corneal Crosslinking Using Standard, Accelerated, and Accelerated With Higher Total Fluence Protocols
Conclusions: All 3 protocols showed improvements in K Max, CDVA, and other variables, with similar functional outcomes for each despite greater change in keratoconus indices after S3/30-CXL. Correlations between change in measured variables and CDVA were poor overall; however, K Mean, central keratoconus index, and anterior asphericity were better correlated with CDVA than K Max. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Donor Cornea Endothelial Cell Density Determined by Eye Banks and by a Central Reading Center in the Cornea Preservation Time Study
Purpose: To evaluate agreement between eye banks (EBs) and a reading center on endothelial cell density (ECD) determinations in the Cornea Preservation Time Study. Methods: The Cornea Image Analysis Reading Center (CIARC) performed variable frame image analysis on EB-obtained–preoperative central endothelial images (after lamellar dissection for Descemet stripping automated endothelial keratoplasty by the EBs or before shipping, if surgeon prepared) to determine ECD. The EBs performed their usual method of ECD determination. The CIARC and EBs also provided ECD determinations from screening central endothelial im...
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Do Donated Corneas Become Transplanted Corneas? The Causes of Discard in Southern Brazil
Conclusions: The corneal discard rate was high in all macroregions studied, with positive serology, viability, and quality of the donated corneas being the main causes of discard. Discards were more prevalent in older age groups (50–64 years and 65 or above age groups). Considering the presented results, the assessment process of potential cornea donors should be changed to reduce losses and costs. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Cytomegalovirus Corneal Endotheliitis After Descemet Membrane Endothelial Keratoplasty
Conclusion: CMV corneal endotheliitis may occur after DMEK and can closely mimic graft rejection. Polymerase chain reaction testing of aqueous humor is advised for suspect cases. A high index of suspicion is important for prompt diagnosis and initiation of appropriate antiviral treatment. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Influence of Lens Status on Outcomes of Descemet Membrane Endothelial Keratoplasty
Conclusions: Our study demonstrates no difference in DMEK outcome with regard to rebubble rate whether the procedure is performed in combination with cataract surgery, in pseudophakia, or in phakia. Furthermore, donor age, initial graft cell count, and graft preparation technique did not impact rebubble rate. BCVA was also not affected by the need for rebubbling. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Graft Thickness Measured by an Eye Bank With Graft Thickness Measured After Descemet Stripping Automated Endothelial Keratoplasty
Purpose: To compare donor lenticule thickness reported by the eye bank with lenticule thickness measured at 6 months after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This prospective, interventional case series enrolled 30 eyes from 30 patients who underwent DSAEK using precut eye bank tissue. Preoperative thickness measurements of the donor lenticules were taken centrally and at pericentral and peripheral graft areas using an anterior segment optical coherence tomography system. The same measurements were repeated 6 months postoperatively. The preoperative and postoperative values were co...
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Secondary Intraocular Lens Implantation After Simultaneous Penetrating Keratoplasty and Cataract Extraction for Coexisting Corneal and Lens Opacities
Conclusions: Postponing IOL implantation some months after simultaneous penetrating keratoplasty and cataract extraction has a negligible effect on the corneal graft endothelium and achieves near postoperative target refraction with significant improvement in UDVA. (Source: Cornea)
Source: Cornea - March 6, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Response to “Descemet Membrane Endothelial Keratoplasty for Failed Penetrating Keratoplasty: Visual Outcomes and Graft Survival”
No abstract available (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comparison of Tri-folded and Scroll-based Graft Viability in Preloaded Descemet Membrane Endothelial Keratoplasty
Conclusions: All techniques used resulted in clinically acceptable levels of ECL. Tri-folded tissue in a plastic cartridge did not result in ECL inferior to a scroll when prepared either immediately or preloaded for 48 hours. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Femtosecond Laser-Assisted Deep Lamellar Descemet Membrane Endothelial Keratoplasty for the Treatment of Endothelial Dysfunction Associated With Posterior Stromal Scarring
Conclusions: As long as the anterior and mid-stroma are unaffected, those with endothelial diseases associated with opacification of the posterior stroma can benefit from endothelial keratoplasty through a Femto-DL-DMEK procedure, avoiding all well-known drawbacks of penetrating keratoplasty. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Conjunctival Colloid Milium
Conclusions: Adult periocular colloid milium is an unusual presentation of a rare cutaneous deposition disease. The occurrence of conjunctival colloid milium is rare, and we report this case to increase knowledge and management regarding this rare disease and to differentiate it from other diseases such as amyloidosis, lipoid proteinosis, plasmacytoma, and conjunctival lymphoma, which carry a graver prognosis, and have a similar clinical appearance and can be distinguished only on the basis of histopathological characteristics. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non–Small-cell Lung Carcinoma
Conclusions: To the best of our knowledge, this is the first case in the literature that reports afatinib-related ulcerative keratitis. Careful monitoring for signs of ocular adverse events is recommended during treatment with afatinib for non–small-cell lung carcinoma. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Ocular and Genetic Characteristics Observed in Two Cases of Fish-Eye Disease
Conclusions: Although it is a rare genetic disorder, FED should be considered in the differential diagnosis of corneal clouding. Corneal lipid deposits, visible on AS-OCT are suggestive of FED, and genetic analysis can be used to confirm the clinical diagnosis. Finally, there may be a relationship between dry eye disease and LCAT enzyme deficiency disorders, which should be investigated in further studies. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Deep Anterior Lamellar Keratoplasty in a Case of Hurler–Scheie Syndrome Undergoing Enzyme Replacement Therapy
Conclusions: The present case highlights the possible effectiveness of DALK in patients with mucopolysaccharidosis (MPS)-related corneal stromal opacification, treated with ERT. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency
Conclusions: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Special Article Source Type: research

Evaluation of Patent Blue as the Vital Dye in an Animal Model of Descemet Membrane Endothelial Keratoplasty
Conclusions: PB at 0.5% to 1.0% is biocompatible and can stain the graft sufficiently, making it an alternative for DMEK surgery. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model
Conclusions: Canine corneal endothelial function recovers at a similar rate as NHPs but more slowly than rabbits after cryoinjury. Faster corneal endothelial wound healing was observed by in vivo confocal microscopy and FD-OCT in dogs treated with Y27632 versus vehicle controls. Thus, a canine cryoinjury model may be a useful alternative to NHPs in detecting a response to therapies directed at endothelial regeneration. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis
Purpose: To investigate the expression of thymic stromal lymphopoietin (TSLP) and the relevant signaling pathways in the giant papillae obtained from patients with vernal keratoconjunctivitis (VKC) and to study the potential functional role and molecular mechanism of TSLP. Methods: Giant papillae from VKC patients and control samples were used to perform immunohistochemical staining and analyze the mRNA expression of TSLP and related pathway by real-time polymerase chain reaction. Results: TSLP was markedly expressed in the epithelial cells and some inflammatory cells of giant papillae, but not in the control conju...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Late-Onset Sterile Peripheral Ulcerative Keratitis Post-Corneal Collagen Crosslinking
Conclusions: PUK is a rare but serious complication after CXL. Long-term follow-up is necessary to detect late-onset PUK. It is a treatable condition associated with older age and autoimmune conditions but has a good visual outcome. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Imaging Kayser-Fleischer Ring in Wilson Disease Using In Vivo Confocal Microscopy
Conclusions: IVCM images can be used as an objective clinical diagnostic tool to facilitate the identification of K-F rings and the diagnosis of WD. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Endothelial Cell Density and Morphology After Phacoemulsification in Patients With Primary Open-Angle Glaucoma and Cataracts: 2-Year Results of a Randomized Multicenter Trial
Purpose: To evaluate corneal endothelial cell density (ECD) and morphology 2 years after phacoemulsification in subjects from the COMPASS trial (ClinicalTrials.gov, NCT01085357) who had mild-to-moderate primary open-angle glaucoma and visually significant cataracts. Methods: The central corneal endothelium was evaluated by serial specular microscopy at 0 to 24 months. ECD, coefficient of variation, and percentage of hexagonal cells were evaluated by a central image analysis reading center and central corneal thickness (CCT) was evaluated by ultrasound pachymetry. Results: Of 131 subjects who underwent routine phaco...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Relationship Between Ocular Surface Epithelial Damage, Tear Abnormalities, and Blink in Patients With Dry Eye
This study involved 45 eyes of 45 female patients with dry eye (mean age: 57.6 years). In all eyes, tear meniscus radius (mm), spread grade of the tear film lipid layer (SG: 1-5: 1 being the best), fluorescein breakup time (FBUT, seconds), corneal and bulbar conjunctival epithelial damage (CED: 15 points maximum and CONJUNCTIVAL EPITHELIAL DAMAGE (CjED): 6 points maximum, respectively), and Schirmer I test (ST1, mm) were evaluated. Blink rate (BR, blinks per minute), palpebral aperture height (mm), upper-eyelid opening-phase amplitude/upper-eyelid closing-phase amplitude (mm), upper-eyelid opening-phase duration/upper-eyel...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Association Between Sleep Quality, Mood Status, and Ocular Surface Characteristics in Patients With Dry Eye Disease
Purpose: To evaluate sleep and mood status in patients with dry eye disease (DED) and analyze the association between sleep quality, mood status, and ocular surface characteristics. Methods: Consecutive patients with DED (N = 106) and age- and sex-matched healthy controls (N = 50) were enrolled. Tear fluid break up time (TBUT), corneal fluorescein staining, and Schirmer I tests were performed in the order listed here to evaluate dry eye. A visual analog scale was used to assess dry eye symptom severity. All subjects also completed the Pittsburgh Sleep Quality Index (PSQI, scores ≥5.5 indicated poor sleep), Patient ...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease
Purpose: To investigate the efficacy of topical carbomer-based lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D) supplementation. Methods: A total of 116 patients with DED from June 2015 to June 2016 were included. The participants were divided into the vitamin D deficiency (VDD) group and the non-VDD group according to their serum 25HD levels. The patients determined the ways of cholecalciferol supplementation. Ocular Surface Disease Index (OSDI) score, visual analog pain scale score, li...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Direct and Indirect Flap Measurements in Femtosecond Laser–Assisted In Situ Keratomileusis
Purpose: To compare direct and indirect LASIK flap thickness measurements using ultrasound and Scheimpflug technology. Methods: Eighty-two eyes treated with laser-assisted in situ keratomileusis refractive surgery using a femtosecond laser (IntraLase FS150) were prospectively included in the study. Flap thickness was set to 115 μm. Corneal flap thickness was measured using the direct method—ie, ultrasound pachymetry immediately after flap construction in the presence of cavitation bubbles—and indirect methods, with subtraction of intraoperative post-lift corneal thickness measured using ultrasound pachy...
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Corneal Epithelial Remodeling Over 2 Years in LASIK Versus SMILE: A Contralateral Eye Study
Conclusions: Both LASIK and SMILE resulted in significant epithelial thickening. This response seemed to be surprisingly quite similar between the 2 different techniques. This study suggests that epithelial remodeling may correlate with relative curvature changes resulting after both techniques, rather than the obvious difference of subepithelial corneal denervation changes. (Source: Cornea)
Source: Cornea - February 5, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research