Comment on: “Comparison of Graft Thickness Measured by an Eye Bank With Graft Thickness Measured After Descemet Stripping Automated Endothelial Keratoplasty”
No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Perioperative Corneal Abrasions After Nonocular Surgery: A Systematic Review
Conclusions: Standardized ocular protection, reporting, and education initiatives were found to maximally decrease rates of perioperative corneal abrasions after nonocular surgery. However, no gold standard currently exists for intraoperative ocular protection. More research needs to be conducted on specific prevention strategies and content of educational initiatives in hopes of standard development across facilities nationwide. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Review Source Type: research

Implementation of a Quality Index for Improvement of Quantification of Corneal Nerves in Corneal Confocal Microcopy Images: A Multicenter Study
Purpose: Corneal confocal microscopy (CCM) is an imaging method to detect loss of nerve fibers in the cornea. The impact of image quality on the CCM parameters has not been investigated. We developed a quality index (QI) with 3 stages for CCM images and compared the influence of the image quality on the quantification of corneal nerve parameters using 2 modes of analysis in healthy volunteers and patients with known peripheral neuropathy. Methods: Images of 75 participants were a posteriori analyzed, including 25 each in 3 image quality groups (QI 1–QI 3). Corneal nerve fiber length (CNFL) was analyzed using aut...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Multimodal Imaging Report of Crystalline Keratopathy in Relapsing Polychondritis
Conclusion: A central keratopathy is not typically reported in patients with RP. In this case report, we describe a unique diffuse bilateral nummular mid-stromal crystalline keratitis that extends into the central cornea and further define it using multimodal imaging. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis
Conclusions: This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient. Further clinical evidence would be needed to possibly incorporate this medication in the antiamoebic armamentarium. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea
Conclusions: Corneal GPR18 activation induced both chemotaxis and proliferation in corneal epithelial cells in vitro and impacted wound healing. GPR18 may contribute to the maintenance of corneal integrity. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Effect of Optisol Supplementation With 0.255 μg/mL Amphotericin B on Elimination of Yeast at 5°C
Conclusions: AmpB at a concentration of 0.255 μg/mL in Optisol-GS at cold storage (2°C–8°C) over 48 hours did not eliminate yeast from corneal tissue. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa
Conclusions: Asfotase alfa was invariably associated with development of mild focal conjunctival calcification, likely through disinhibition of hydroxyapatite crystal propagation. The calcifications were not symptomatic or vision-threatening and should not preclude enzyme replacement therapy for patients with this rare and often debilitating disease. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography
Conclusions: OCTA can be useful to visualize CoNV, which may be valuable in assessing corneal graft rejection. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Expressible Meibomian Glands Have Occult Fixed Obstructions: Findings From Meibomian Gland Probing to Restore Intraductal Integrity
Purpose: To describe and quantify findings of intraductal obstruction during probing expressible and nonexpressible meibomian glands (MGs) in patients with obstructive meibomian gland dysfunction using a 1-mm intraductal MG probe. Methods: A retrospective study of probe findings from 108 consecutive patients. Nonparametric tests using SPSS software 25.0 to explore relationships between expressibility and probe findings. Results: Of 11,776 probed glands of 404 lids, 84% showed mechanical resistance (MR) and 16% showed no resistance (NR). Fixed, firm, focal unyielding resistance (FFFUR) occurred in 79.5% of obstructe...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Changes in Endothelial Cell Count Up to Three Years After Implantation of Toric Implantable Collamer Lenses
Purpose: To determine the temporal effect of toric implantable collamer lens (TICL) implantation and location on corneal endothelial cell density (ECD) over a period of 36 months after surgery. Methods: ECD [number of cells per square millimeter estimated using the Specular Microscope SP-1P (Topcon Europe Medical B.V., Netherlands)] data were collected from cases deemed suitable for the TICL (VTICMO, VTICM5; STAAR Surgical, Nidau, Switzerland). The preoperative refractive error (sphere and cylinder) ranged from −1.00 to −22.25 diopter sphere and from −0.50 to −5.50 diopter cylinder. ECD was eva...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Causes and Management Outcomes of Acquired Corneal Opacity in a Preschool Age (0–5 Years) Group: A Hospital-Based Study
Conclusions: Chemical injury and keratomalacia are the major causes of acquired corneal opacity in preschool age groups in India and are associated with poor visual prognosis. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Riboflavin Solution With Hydroxypropyl Methylcellulose and Eyelid Speculum on Pachymetry Changes During Accelerated Collagen Crosslinking
Purpose: To assess corneal thickness changes with isotonic riboflavin (RF) solution with hydroxylpropyl methylcellulose in patients undergoing accelerated corneal collagen crosslinking (CXL) with and without an eyelid speculum. Methods: Fifty-two eyes of 48 patients with progressive keratoconus were enrolled in this study. The patients in this study were divided into 2 groups: in group 1 an eyelid speculum was removed during 20-minute RF (0.1%) + hydroxylpropyl methylcellulose (Mediocross M; Avedro Inc, Waltham, MA) instillation, and in group 2 the eyelid speculum was retained in place during the entire CXL procedure....
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Iontophoretic Transepithelial Collagen Cross-Linking Versus Epithelium-Off Collagen Cross-Linking in Pediatric Patients: 3-Year Follow-Up
Conclusions: In pediatric patients, 3 years after treatment, epi-off CXL halted keratoconus progression in 75% of eyes, whereas I-ON CXL seemed to slow down keratoconus progression in 50% of eyes, mainly in those with highest Kmax and paracentral cone. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

The Outcome of Scleral Lens Fitting for Keratoconus With Resolved Corneal Hydrops
Conclusions: Scleral lenses are effective for providing satisfactory visual acuity after corneal hydrops in keratoconus. A scleral lens trial is advised before listing patients for graft surgery. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Trends in Research Related to Keratoconus From 2009 to 2018: A Bibliometric and Knowledge Mapping Analysis
Conclusions: On the basis of the data extracted from the Web of Science Core Collection, the quantity and quality of publications on keratoconus were assessed using bibliometric techniques. The cited references and research hotspots could provide insights into keratoconus research as well as valuable information to cornea specialists for performing research in this field and discovering potential collaborators. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-Term Follow-up of Intrastromal Corneal Ring Segment Implantation in Pediatric Keratoconus
This study included patients with keratoconus aged 18 years or younger who had received Ferrara-type ICRS implantation. The uncorrected and corrected distance visual acuities, residual refractive errors, and root mean square for coma-like aberration were recorded preoperatively and at 6 months, 1, 3, and 5 years postoperatively. Results: One hundred eighteen eyes of 88 patients (mean age 16.1 ± 1.89; range 10–18) were studied. All patients were examined at a 6-month follow-up after ICRS implantation, and at the 12-, 36-, and 60-month follow-ups, 97, 71, and 23 eyes were evaluated, respectively. Mean uncorre...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcomes of Corneal Transplantation Using Donor Corneas Retrieved From Snakebite Victims
Conclusions: The donor corneas retrieved from snakebite victims are apparently safe and suitable for transplantation, and screening for such donor corneas should include a thorough examination of ocular adnexa to rule out local envenomation before corneal retrieval in addition to the routine evaluation protocol. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Factors Affecting Corneal Organ Culture Contamination: A 6-year Study at the New South Wales Tissue Bank
Conclusions: A relatively low contamination rate of 2.5% observed in our study reflects the stringent laboratory protocols, strict donor selection criteria, and high level of experience among staff at the Lions NSW Eye Bank. Our study demonstrated that the season of collection had a strong association with the rate of organ culture contamination. Because Candida species contributed the largest percentage of contamination, specific measures to reduce and eliminate fungal proliferation should be considered by eye banks particularly in warm seasons. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcomes of a Modified Technique for Successful Pneumatic Dissection in Pediatric Eyes With Corneal Scars
Conclusions: Despite impaired corneal transparency and increased tissue consistency, a modified DALK technique allows successful pneumatic dissection in an extremely high percentage of scarred pediatric eyes. Visual results compare favorably with those obtained in children after penetrating keratoplasty, while vision threatening complications are minimized. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Risk Factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty
Purpose: To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes. Methods: In this retrospective, interventional, consecutive case series, 77 eyes of 65 patients who underwent DMEK were evaluated; in 53 eyes, cataract surgery was performed 1 month before DMEK (staged DMEK), and 24 eyes underwent DMEK alone (simple DMEK). Central retinal thickness, incidence of CME, postoperative best-corrected visual acuity, central corneal thickness, and corneal endothelial cell density were assessed at 1, 3, and 6 months after surgery. Multiple regressi...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Tomography Changes and Refractive Outcomes After Descemet Stripping Without Endothelial Keratoplasty
Conclusions: DWEK induces an increased central posterior float localized to the site of Descemet membrane stripping, confirming the need for centralized stripping. Irregular astigmatism can occur after DWEK but is typically minimal and occurs more commonly in the setting of preoperative irregular astigmatism. DWEK induces about a 0.5 D hyperopic shift, which should be considered when determining intraocular lens power with simultaneous surgery. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty
Conclusions: F-DMEK showed good efficacy with reduced detachment, rebubble, and cell-loss rates, compared with M-DMEK. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty Outcomes During the Initial Learning Curve of Cornea Fellows
Conclusions: Establishing DMEK in a fellowship program was successful with the supervision of an experienced DMEK surgeon. Even without the facility of a prestripped DMEK graft by an eye bank and with no backup tissue, no surgery was canceled because of graft preparation failure. Good visual outcomes were achieved with satisfactory ECD at 6-month follow-up, with an acceptable complication rate. Even the 3 eyes that failed to clear the cornea evolved well after secondary endothelial keratoplasty by the cornea fellows. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy
Conclusions: Our large German cohort demonstrated a significant association between the risk allele G in rs613872 and FECD, irrespective of TNR expansion, although this risk allele was more frequent in FECD cases with TNR expansion than without. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Response to “Variability of Tear Osmolarity Measurements With a Point-of-Care System in Healthy Subjects—Systematic Review”
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Management of Type 2 Bubble Formed During Big-Bubble Deep Anterior Lamellar Keratoplasty
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Letter to the Editor re: “Corneal Collagen Cross-linking with Riboflavin and Ultraviolet A Light for Pediatric Keratoconus: Ten-Year Results”
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Femtosecond Laser Surgery in Ophthalmology
No abstract available (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Book Review Source Type: research

Water Exposure and the Risk of Contact Lens–Related Disease
Conclusions: Consensus among stakeholders about water and CL care is needed. Guidelines should unequivocally advocate for the avoidance of any water exposure including handling CLs with wet hands, rinsing CLs or storage cases in tap water, showering while wearing CLs and swimming with CLs without wearing goggles. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Review Source Type: research

Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions
Conclusions: Improved understanding of the complex interactions of riboflavin, ultraviolet A energy and oxygen in corneal CXL may provide a successful route to transepithelial corneal CXL. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Review Source Type: research

Fibrin Glue–Assisted Closure of Macroperforation in Predescemetic Deep Anterior Lamellar Keratoplasty With a Donor Obtained From Small Incision Lenticule Extraction
Conclusions: A donor lenticule from SMILE surgery is a useful adjunct to seal macroperforations in deep anterior lamellar keratoplasty because the thin uniform lamellar tissue is easily applied using fibrin glue and gives uniform and good apposition on both host and donor sides. It can be used immediately without further preparation unlike hand-fashioned patch grafts. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Management of Descemet Membrane's Folds After Deep Anterior Lamellar Keratoplasty: Descemet Membrane—Tucking Technique
Conclusions: DALK is the procedure of choice for the surgical treatment of corneal stromal diseases with a healthy endothelium, such as keratoconus. DM folds are a possible complication after DALK in patients with advanced corneal ectasia, arising from the compression of the redundant host DM by the donor graft, once it is sutured to the recipient. DM folds after DALK, when they involve the visual axis, cause permanent visual disturbances DM tucking allows the displacement of the central DM folds toward the graft margin, where they do not affect the patient's quality of vision. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Double-Line Reflection Pattern as a Simple Method to Determine Graft Orientation of Descemet Membrane Endothelial Keratoplasty
Conclusions: This method of confirming correct graft orientation requires no additional procedures, equipment, or manipulation of the donor tissue and can be used in conjunction with other marking methods already described. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Corneal Biofilm Plaques: A Novel Clinical Presentation
Conclusions: Corneal plaques are a very rare clinical presentation of corneal biofilms that allow prolonged survival of microorganisms even in the absence of prosthetic material and clinical signs or symptoms of corneal active inflammation and/or infection. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Descemet Membrane Endothelial Keratoplasty Using Tissues From Donors With a History of Radial Keratotomy
Conclusions: Two patients received successful DMEK grafts using tissues from donors with a history of RK. Careful eye bank screening and processing of RK donor tissues has thus far yielded similar outcomes in our recipient patients to what would be expected using tissues from donors without a history of RK. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Coincidental Occurrence of Schnyder Corneal Dystrophy and Posterior Polymorphous Corneal Dystrophy Type 3
Conclusions: This case illustrates the coincidental occurrence of 2 rare and genetically distinct corneal dystrophies in a single patient. Furthermore, it highlights the need to perform comprehensive phenotyping in combination with appropriate genetic diagnostic testing to achieve an accurate diagnosis. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Optical Coherence Tomography Assessment of the Cornea During Corneal Swelling: Should the Term “Descemet Membrane Folds” Be Reconsidered?
Conclusions: Folds in DM associated with corneal edema originate in the middle and posterior stroma and are secondarily transmitted into DM. On the basis of the stromal origin of these anatomic changes, “stromal folds” should be considered a more accurate term to replace “Descemet membrane folds.” (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Peripheral Endothelial Cell Density in Descemet Membrane Endothelial Keratoplasty Grafts
Purpose: To compare the variation in corneal endothelial cell density (ECD) from the center to the periphery in unpeeled and peeled donor corneas and to determine the impact of eccentric trephining on total endothelial cells in Descemet membrane endothelial keratoplasty (DMEK) grafts. Methods: Mated donor cornea pairs were obtained. One cornea from each pair was peeled for DMEK, whereas the other was left unpeeled. Alizarin Red was used to stain the endothelial cells. High-resolution images at fixed magnification were obtained for the center, midperiphery (2.5 mm from the center), and the periphery (5 mm from the cent...
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Blood Vessels and Lymphatic Vessels in the Cornea and Iris After Penetrating Keratoplasty
Conclusions: Our findings suggest that the iris–ciliary body could amplify immune signals and in part promote initiation of immune rejection after keratoplasty by providing a pathway for macrophages, which might participate in corneal lymphangiogenesis. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Seroprevalence of Anti-HIV-1, Anti-HIV-2, Hepatitis B Surface Antigen, and Anti-HCV in Eye Donors in a Tertiary Eye Hospital, Chennai, India, in the Past 13 years (2005–2017)
Conclusions: This retrospective study indicates that there is a trend of reduction in the seropositivity for HIV, HBV, and HCV among eye donors in Chennai over the last decade. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Keratoconus Corneal Posterior Surface Characterization According to the Degree of Visual Limitation
Purpose: To characterize posterior corneal surface features in patients with keratoconus and healthy controls and correlate them with the severity of the disease according to visual limitation. Methods: Retrospective, comparative, clinical study including 477 cases, 374 keratoconic eyes and 103 healthy corneas. Patients were classified according to the degree of visual limitation. The corneal posterior surface including shape indices and keratoconus screening indices was evaluated using the rotating Scheimpflug camera and Placido disc topographer. Results: Dioptric power of the posterior corneal surface increases l...
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Small Incision Lenticule Extraction Surgery With and Without Cyclotorsion Error Correction for Patients With Astigmatism
Conclusions: SMILE surgery combined with cyclotorsion error compensation yielded a significant improvement in surgical outcomes regarding safety, efficiency, and predictability for patients with astigmatism. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Identification of a Novel ZNF469 Mutation in a Pakistani Family With Brittle Cornea Syndrome
Conclusions: This is the first report of a ZNF469 homozygous mutation causing a BCS phenotype in a consanguineous Pakistani family. Our data extend the mutation spectrum of ZNF469 variants implicated in BCS. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens
Conclusions: This large-scale assessment (n = 244) is the first demonstration of efficacy for CL delivery of a therapeutic for ocular allergy. Results are comparable to direct topical drug delivery and suggest that the lens/ketotifen combination can provide a means of simultaneous vision correction and treatment for CL wearers with ocular allergies. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of Chemokine mRNA Expression to Assess Allergic Inflammation of the Ocular Surface in Chronic Allergic Conjunctival Diseases
Conclusions: At least 2 kinds of inflammatory reactions, IL-1α- and CXCL8-associated inflammation and CCL24- and IL-16-associated inflammation, may be involved in the exacerbation of chronic ACDs. (Source: Cornea)
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

The Use of Conjunctival Staining to Measure Ocular Surface Inflammation in Patients With Dry Eye
This study evaluated 28 patients with Sjögren syndrome (SS) DED, 28 patients with non-SS DED, and 10 controls. The messenger ribonucleic acid (mRNA) expression of inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, interferon (IFN)-γ, IL-17, and matrix metalloproteinase 9 (MMP9) from conjunctival epithelium was investigated by real-time polymerase chain reaction. Protein expression was confirmed by immunofluorescence staining. Correlations were evaluated between the mRNA expression of inflammatory cytokines and clinical DED parameters such as ocular surface disease index...
Source: Cornea - May 15, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research