Diabetes Mellitus and Keratoconus: A Systematic Review and Meta-Analysis
Conclusions:
This meta-analysis indicates that current literature does not support a significant association between diabetes and keratoconus. Further studies with more definite control for confounders and well-designed cohorts or interventions are warranted. (Source: Cornea)
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Repeatability and Agreement of Horizontal Corneal Diameter Measurements Between Scanning-Slit Topography, Dual Rotating Scheimpflug Camera With Placido Disc Tomography, Placido Disc Topography, and Optical Coherence Tomography
Purpose:
The purpose of this study was to assess the repeatability and agreement of horizontal white-to-white (WTW) measurements using 4 different imaging modalities including a slit-scanning elevation topographer, dual rotating Scheimpflug camera and Placido Disc tomographer, Placido Disc topographer, and anterior segment optical coherence (OCT) tomographer.
Methods:
In this prospective study, 33 eyes of 33 healthy subjects were scanned 3 times using each of the Orbscan IIz, Sirius, Nidek OPD III, and DRI OCT Triton devices and WTW measurements were recorded. Repeatability was assessed using the intraclass corr...
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Corynebacterium Keratitis: Pure Versus Mixed Infection and Antibiotic Susceptibility Patterns From Different Tertiary Eye Care Centers
Conclusions:
Ocular surface disorder is the most common risk factor in Corynebacterium keratitis. Although fluoroquinolones are commonly used as first-line therapy in microbial keratitis, the in vitro resistance pattern indicates that these are less likely to be effective in infection with Corynebacterium species. (Source: Cornea)
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Scheimpflug Versus Optical Coherence Tomography to Detect Subclinical Corneal Edema in Fuchs Endothelial Corneal Dystrophy
Purpose:
The purpose of this research was to compare the ability of Scheimpflug and anterior segment optical coherence tomography (OCT) in detecting subclinical corneal edema in patients with Fuchs endothelial corneal dystrophy (FECD) without clinical corneal edema.
Methods:
In this single-center, consecutive case series, 47 eyes of 29 patients with FECD were analyzed. The main outcome measures were anterior/posterior keratometry and central/thinnest corneal thickness. The criteria for subclinical corneal edema were loss of regular isopachs, displacement of the thinnest point of the cornea, and presence of poste...
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Trends in Diagnosed Dry Eye Disease Incidence, 2001 to 2015: A Nationwide Population-Based Study in Taiwan
Conclusions:
The IRs of DED increased from 2001 to 2015 for all demographics, particularly in the 20 to 39 and 50 to 59 years aged male population. These findings highlight the disease burden of DED and are expected to grow substantially. (Source: Cornea)
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Graft Thickness at 6 Months Postoperatively Predicts Long-Term Visual Acuity Outcomes of Descemet Stripping Automated Endothelial Keratoplasty for Fuchs Dystrophy and Moderate Phakic Bullous Keratopathy: A Cohort Study
Purpose:
It remains unclear whether preoperative central graft thickness (CGT) contributes to visual outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK). This retrospective cohort study examined the ability of preoperative and postoperative CGT to predict 12-month best spectacle–corrected visual acuity (BSCVA) after DSAEK for Fuchs endothelial corneal dystrophy/moderate pseudophakic bullous keratopathy/second graft.
Methods:
All consecutive patients who underwent DSAEK in 2015 to 2018 were included. The primary end point was 12-month BSCVA. DSAEK-CGT was measured preoperatively and 6 time...
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Corneal Epithelial Thickness Mapping in the Diagnosis of Ocular Surface Disorders Involving the Corneal Epithelium: A Comparative Study
Conclusions:
The epithelial map pattern recognition combined with quantitative analysis of ET is relevant for the diagnosis of OSDs and for distinguishing various OSDs from each other. Deep learning analysis of big data could lead to the fully automated diagnosis of these disorders. (Source: Cornea)
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Outcomes of Penetrating Keratoplasty After Open Globe Injury
Conclusions:
Despite a high graft survival at 1 year, most of the patients did not regain ambulatory vision. Graft rejection, RD, and endophthalmitis were risk factors for graft failure. These factors should be considered when counseling patients regarding PKP after OGI. (Source: Cornea)
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Update on the Corneal Dystrophies—Genetic Testing and Therapy
Abstract:
One major purpose of the IC3D Corneal Dystrophy Nomenclature Revision was to include genetic information with a goal of facilitating investigation into the pathogenesis, treatment, and perhaps even prevention of the corneal dystrophies, an ambitious goal. Over a decade has passed since the first publication of the IC3D Corneal Dystrophy Nomenclature Revision. Gene therapy is available for an early-onset form of inherited retinal degeneration called Leber congenital amaurosis, but not yet for corneal degenerations. We review the current state of affairs regarding our original ambitious goal. We discuss genetic...
Source: Cornea - October 16, 2022 Category: Opthalmology Tags: Invited Submission Source Type: research
Reply
No abstract available (Source: Cornea)
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Comment on: Comparison of Pterygium Recurrence Rates Between Attending Physicians and Supervised Trainee Residents
No abstract available (Source: Cornea)
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Delivery of Cells to the Cornea Using Synthetic Biomaterials
Abstract:
The cornea is subject to a myriad of ocular conditions often attributed to cell loss or cell dysfunction. Owing to the superficial positioning of tissues composing the anterior segment of the eye, particularly the cornea, regenerative medicine in this region is aided by accessibility as compared with the invasive delivery methods required to reach deep ocular tissues. As such, cell therapies employing the use of carrier substrates have been widely explored. This review covers recent advances made in the delivery of stem cells, corneal epithelial cells, and corneal endothelial cells. Particular focus is placed...
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Review Source Type: research
In Vitro Expansion of Corneal Endothelial Cells for Clinical Application: Current Update
Abstract:
Endothelial dysfunction is one of the leading causes of corneal blindness and one of the common indications for keratoplasty. At present, the standard of treatment involves the replacement of the dysfunctional endothelium with healthy tissue taken from a donor. Because there is a paucity of healthy donor tissues, research on the corneal endothelium has focused primarily on expanding these cells in the laboratory for transplantation in an attempt to reduce the gap between the demand and supply of donor tissues for transplantation. To expand these cells, which are nonmitotic in vivo, various mitogens, substrate...
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Review Source Type: research
Twenty-Two–Year Clinical Outcome of a Case of Endokeratoplasty
Conclusions:
To the best of our knowledge, this is the longest reported outcome for selective endothelial replacement. The patient undergoing endokeratoplasty can achieve an excellent visual acuity and long-term graft survival. (Source: Cornea)
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Atypical Conjunctival Lesion as the Initial Presentation of Granulomatosis With Polyangiitis in an Adolescent Male
Conclusions:
This is the first documented case of a conjunctival mass as the initial presenting feature of pediatric GPA. The presence of granulomatous inflammation on histopathology and recurrences after excision should raise suspicion for GPA in children and adults. (Source: Cornea)
Source: Cornea - September 18, 2022 Category: Opthalmology Tags: Case Report Source Type: research
