Presbyopic Corneal Inlay Extrusion Consequent to Sterile Keratolysis: Surgical Revision and Long-Term Management
Conclusions:
Some refractive synthetic corneal inlays have been recalled because they may result in significant corneal haze. We present herein a case of severe keratolysis that necessitated surgical explantation and further document long-term care for eventual visual rehabilitation. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Analysis of SARS-CoV-2 in Corneal Tissue of Deceased Asymptomatic Novel Coronavirus Disease 2019 Donors
Conclusions:
In line with previous studies, our study also reflects the absence of SARS-CoV-2 viral mRNA in corneal tissues of clinically asymptomatic deceased COVID-19 donors, thereby indicating a probable low risk of transmission of the SARS-CoV-2 virus through the transplantation of corneas from donors who tested positive for, but were asymptomatic for COVID-19. In addition, further studies on the subject should include histopathological examination because of the false positive and negative rates of molecular tests. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Effect of Increasing Povidone-Iodine Exposure on Corneal Epithelium and Impact on Donor Rim Cultures
Conclusions:
These results indicate that new donor preparation methods with an additional 5 minutes of PVP-I exposure do not affect tissue quality, reduce positive rim cultures, and lead to lower incidence of postoperative infection. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Comprehensive Analysis of circRNA-Associated-ceRNA Networks in Human Corneal Endothelial Dysfunction
Conclusions:
CircRNAs are significantly dysregulated in HCECs under oxidative stress. The circRNA-associated-ceRNA networks are closely related to HCEC functions. Targeting these networks might provide novel therapies for CE dysfunction. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Comparison of Graft Outcomes Reusing Original Intermediate-Term Cold Storage Solution for Entire Corneal Donor Storage Period With Exchanged Fresh Storage Solution After Donor Preparation in the Cornea Preservation Time Study
Conclusions:
The use of the original intermediate-term cold storage solution did not reduce the 3-year graft success rate compared with exchanging with fresh solution after lenticule preparation for Descemet stripping automated endothelial keratoplasty, while the frequency of positive donor rim cultures did not significantly differ between groups. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
COVID-19 Vaccination May Not Increase Rates of Corneal Graft Rejection
Conclusions:
No notable increase in rates of corneal graft rejection was noted in year 2021 when COVID-19 vaccination was broadly implemented. The apparent temporal relationship between COVID vaccination and corneal graft rejection may not represent a causative association. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Combined Corneal Transplant, Glaucoma Drainage Implantation, and Pars Plana Vitrectomy Outcomes in a Pediatric Population
Conclusions:
Combined keratoplasty, GDI, and PPV seems to be effective in the management of complex pediatric eye disease. However, owing to the high risk of complications in this vulnerable patient population, careful consideration must be taken when determining a patient's surgical candidacy for combined cornea/glaucoma/retina procedures. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Posterior Corneal Curvature Changes After Pre-Descemet's Endothelial Keratoplasty: A Prospective Analysis
Purpose:
To assess the changes in the posterior corneal curvature after pre-Descemet's endothelial keratoplasty (PDEK) and correlate with the visual outcomes.
Methods:
Eyes with pseudophakic bullous keratopathy, aphakic bullous keratopathy, and Fuchs dystrophy undergoing PDEK were included. The main outcome measures were the topography (OrbscanIIz, Bausch and Lomb) indices—total corneal power (TCP) in diopters (D), radius of the posterior curvature (mm), and best-fit sphere of the posterior corneal surface (BFS in D) at preoperative and postoperative 1 month, 3 months, and 6 months.
Results:
Overall, 43...
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
A Randomized Controlled Trial Comparing Microthin Descemet Stripping Automated Endothelial Keratoplasty With Descemet Membrane Endothelial Keratoplasty: Two-Year Report
Conclusions:
In summary, the trial showed no significant difference in BSCVA at 24 months between the DMEK and MT-DSAEK groups. Both techniques continued to demonstrate comparable outcomes for complication rates, endothelial cell loss, and patient-reported vQoL scores.
Trial Registration:
ISRCTN10578843. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Acute Hydrops After Bowman Layer Transplantation for Keratoconus May Indicate that Descemet Membrane Rupture Is Secondary to Hydrops
Conclusions:
Hydrops formation in keratoconic corneas after midstromal BL transplantation may indicate that a break in Descemet membrane is secondary to hydrops development (and not vice versa). With a midstromal BL graft in situ limiting hydrops dimensions, resolution of the hydrops seemed relatively quick with recovery to prehydrops visual acuity in most eyes. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Management of Late Descemet's Membrane Detachment After Penetrating Keratoplasty in Keratoconus
Conclusions:
This case series provides evidence that DMEK is a viable option in eyes with spontaneous DM detachment after PK. Visual outcome is limited by the persisting high astigmatism in the ectatic cornea. Illustrated by a small series of patients, the results of DMEK in this condition are presented and new findings about the pathophysiology are given. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Prevalence and Impact of Cornea Guttata in the Graft After Penetrating Keratoplasty in Germany
Purpose:
The aim of this study was to analyze the prevalence and severity of corneal guttata (CG) in grafts after penetrating keratoplasty (PKP) and to determine its clinical significance.
Methods:
This retrospective study included 1758 PKP performed in 1522 patients. In total, 6662 postoperative endothelial images revealed the prevalence and severity of CG (divided into categories G0 without CG and G1-G3 with increasing severity). Origin of the graft, postoperative corneal thickness, visual acuity, pleomorphism, polymegethism, and endothelial cell density (ECD) were analyzed.
Results:
CG was detected in ...
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Reproducibility and Reliability of Subbasal Corneal Nerve Parameters of the Inferior Whorl in the Neurotoxic and Healthy Cornea
Conclusions:
Although the overall interobserver reliability was excellent for the central corneal and inferior whorl parameters, there was lower intraobserver reliability for the inferior whorl parameters for complex morphological patterns. To improve reliability, more sophisticated wide-field imaging of the inferior whorl may be needed. (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Selective Endothelialectomy in Peters Anomaly: A Novel Surgical Technique and Its Clinical Outcomes in Children
This study describes the surgical outcomes of selective endothelialectomy in Peters anomaly (SEPA), a relatively new technique to manage Peters anomaly (PA).
Methods:
This study included 34 eyes of 28 children who had a visually significant posterior corneal defect due to PA and underwent SEPA between 2012 and 2019. A selective endothelialectomy from the posterior corneal defect was performed while preserving Descemet membrane. The primary outcome measure was the resolution of corneal opacification. The secondary outcome measures were functional vision, complications, and risk factors for failure.
Results:
At...
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Strategies to Address Shortages of Intermediate-Term Cold Donor Corneal Storage Solution
No abstract available (Source: Cornea)
Source: Cornea - November 13, 2022 Category: Opthalmology Tags: Editorial Source Type: research
