Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size
Conclusions: Variability exists when measuring corneal ulcers, even among ophthalmologists. Photography and computerized methods for quantifying the ulcer size could reduce variability while remaining accurate and impact quantitative measurement endpoints. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Features, Antibiotic Susceptibility Profile, and Outcomes of Infectious Keratitis Caused by Stenotrophomonas maltophilia
Conclusions: Infectious keratitis due to S. maltophilia presents a treatment challenge because of its resistance to aminoglycosides and cephalosporins, which are typically used for empiric broad-spectrum gram-negative coverage as fortified solutions. Fluoroquinolones and polymyxin B/trimethoprim should be considered instead in cases of S. maltophilia infection. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Therapeutic Effects of Lamellar Keratoplasty on Terrien Marginal Degeneration
Purpose: To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD). Methods: Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated. Results: Mean age of the patients was 50.4 ± 16.8 years. The follow-up period was 2.5 ± 0.9 years. The uncorrected distance visual acu...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy
In this study, we determined changes in corneal optical properties associated with induced corneal edema. Methods: Twenty-three phakic eyes (23 participants) with FECD (grades 1–6, modified Krachmer scale) and 8 normal eyes (8 participants) were examined by Scheimpflug photography. Central corneal thickness, high-order aberrations from anterior and posterior corneal surfaces, and backscatter from the anterior, mid-, and posterior cornea were determined from the Scheimpflug images. A low-oxygen permeable contact lens was placed on the eye, and eyes were closed for 2 hours, after which the lens was removed and Schei...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Topical Tacrolimus as Adjuvant Therapy to Corticosteroids in Acute Endothelial Graft Rejection After Penetrating Keratoplasty: A Randomized Controlled Trial
Conclusions: Topical tacrolimus 0.05% as an adjunct to steroids can hasten the resolution of endothelial rejection of a PKP graft and potentially decreases the recurrence of rejection. However, it may not improve rejection reversal success. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Reconsidering Sequential Double Running Suture Removal After Penetrating Keratoplasty: A Prospective Randomized Study Comparing Excimer Laser and Motor Trephination
Purpose: We assessed the impact of sequential double running suture removal on corneal curvature after penetrating keratoplasty (PK), comparing mechanical and nonmechanical excimer laser trephination. Methods: PK was performed in 134 patients (mean age 51 ± 18 yrs) using either the excimer laser [excimer, n = 60 (37 keratoconus and 23 Fuchs dystrophy)] or motor trephination [control, n = 74 (44 keratoconus and 30 Fuchs dystrophy)] and a double running cross-stitch suture. Refractometry, Zeiss keratometry, and Tomey corneal topography were performed before removal of the first suture (15.2 ± 4.2 mo) and i...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Characterization of Corneal Endothelial Injury During Penetrating Keratoplasty
Purpose: To characterize corneal endothelial injury during penetrating keratoplasty in a controlled wet laboratory environment using human tissue. To identify potential areas or steps within surgery in which insult to the corneal endothelium may be most affected by trauma during routine penetrating keratoplasty. Methods: Human donor corneas (n = 12) with intact endothelium underwent experimental penetrating keratoplasty. Endothelial injury was evaluated after each suture quartile using trypan staining, a validated modality for assessing endothelial injury. Insult was quantified using high-resolution photography and co...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Transplantation in New Zealand 2000 to 2009
Conclusions: In this study of 941 consecutive, principally penetrating, corneal transplants, adverse events were found to be more common than typically reported. In an era in which PKP is increasingly substituted by lamellar surgery, this provides useful insight into operative and postoperative adverse events in penetrating surgery. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Visual Outcomes and Aberrometric Changes With Topography-Guided Photorefractive Keratectomy Treatment of Irregular Astigmatism After Penetrating Keratoplasty
Conclusions: Twelve months postoperatively, the BSCVA improved significantly, the lines of vision increased, and astigmatism, corneal best-fit sphere, mean keratometry, corneal thickness, corneal root mean square total, and corneal spherical aberrations decreased. TG-PRK with MMC is a good alternative for correcting post-PKP cases with irregular astigmatism with elevated higher-order aberrations. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Incidence of Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty
Conclusions: Although CME frequently occurred after DMEK, no CME risk factors were identified. In addition, CME did not significantly affect long-term visual outcomes when it was appropriately treated. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Sulfur Hexafluoride (SF6) and Air Tamponade in Noniridectomized Descemet Membrane Endothelial Keratoplasty
Conclusions: Use of air with it being readily available and short acting is a good method of Descemet membrane tamponade in noniridectomized DMEK. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Cornea Peer Reviewers for 2017
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Azithromycin in the Management of Pythium insidiosum Keratitis
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Corneal Endothelial and Myotonic Dystrophy
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Limbal Stem Cell Preservation During Proton Beam Irradiation for Diffuse Iris Melanoma
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Artificial Anterior Chamber Pressure and Corneal Thinning Rate in UT-DSAEK
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein
Conclusions: Corneal lymphatic vessels can be easily imaged in vivo in the murine model using intrastromal fluorescein injection. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Partitioning an Artificial Anterior Chamber With a Latex Diaphragm to Simulate Anterior and Posterior Segment Pressure Dynamics: The “DMEK Practice Stage,” Where Surgeons Can Rehearse the “DMEK Dance”
Conclusions: We present a novel in vitro model of the human eye that more closely mimics the anterior and posterior segment pressure dynamics of in vivo DMEK surgery than average human and animal cadaveric globes. The model is easy to assemble, inexpensive, and applicable to a range of teaching environments. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Three Hundred Sixty-Degree Fuchs Superficial Marginal Keratitis Managed With Annular Lamellar Keratoplasty
Conclusions: We report an extensive case of Fuchs superficial marginal keratitis treated with 360-degree annular lamellar keratoplasty. This technique provides tectonic support to decrease the likelihood of future perforation while also improving vision by modifying the ectatic cornea. Anterior segment optical coherence tomography may be a helpful tool preoperatively to avoid severely thinned areas (eg, during pseduopterygium removal) and to ensure complete removal of the ectatic cornea. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome
Conclusions: Filamentary keratitis is a chronic, recurrent condition that can be challenging to treat. Effective management requires careful consideration of possible predisposing causes, especially in refractory cases. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Benign Reactive Lymphoid Hyperplasia of the Conjunctiva Treated With Cyclosporine
Conclusions: This report represents the first case of benign ocular RLH responsive to topical cyclosporine therapy. We believe that cyclosporine could play a role in treating patients with benign ocular RLH and warrants further investigation to evaluate its full efficacy. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Severe Phenotype of Keratitis–Ichthyosis–Deafness Syndrome With Presumed Ocular Surface Squamous Neoplasia
Conclusions: KID syndrome is a very rare disease that has been reported with an incremental incidence of squamous cell carcinoma of the mucous membranes and skin (12%–15%). Here, we presented a case of severe systemic KID syndrome with ocular surface squamous neoplasia. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities
Conclusion: A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Special Article Source Type: research

High Permeability and Intercellular Space Widening With Brimonidine Tartrate Eye Drops in Cultured Stratified Human Corneal Epithelial Sheets
Conclusions: The toxicity of 0.1% brimonidine containing sodium chlorite for HCES was lower than that of ophthalmic preparations containing BAC. Reduction of the barrier function occurred after HCES were exposed to brimonidine because of widening of intercellular junctions. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Can Appropriate Systemic Treatment Help Protect the Cornea in Patients With Rheumatoid Arthritis? A Multidisciplinary Approach to Autoimmune Ocular Involvement
Conclusions: There was no clear correlation between RA-NPIs and pathologic corneal findings in our study. DMARDs treatment may help maintain corneal integrity in our patients and prevented collagenolytic manifestations of RA. Other medications such as azathioprine should be used carefully, as endothelial damage may potentially occur. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Diagnostic Evaluation of Co-Occurrence of Acanthamoeba and Fungi in Keratitis: A Preliminary Report
Conclusions: Acanthamoeba can coexist with other forms of microbial keratitis. The frequency of infection coexistent or otherwise is higher than reported, and the possibility of coinfection must be considered especially in unresponsive cases. Including nonnutrient agar and confocal microscopy in all cases of keratitis would perhaps translate into better treatment strategies and outcomes. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Meibomian Glands and Ocular Surface Changes After Closure of Meibomian Gland Orifices in Rabbits
Conclusions: Meibomian gland orifice closure reduced corneal wetting property and induced meibomian gland duct dilation accompanied by shrinkage of secretory acini. Meibography could not detect early changes in the meibomian gland after closure of the orifice. Therefore, when the orifice is obstructed, more active treatments are needed before structural changes occur. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Sealing of Corneal Lacerations Using Photoactivated Rose Bengal Dye and Amniotic Membrane
Conclusions: The results of these studies established that a light-activated method to cross-link AM to the cornea can be used for sealing complex penetrating wounds in the cornea and sclera with minimal inflammation or secondary effects. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Ocular Surface Alterations in the Context of Corneal In Vivo Confocal Microscopic Characteristics in Patients With Fibromyalgia
Purpose: To quantify the morphology of corneal basal epithelium and subbasal nerves and to evaluate the ocular surface alterations in patients with fibromyalgia (FM). Methods: Patients with FM (n = 34) and healthy controls (n = 42) were enrolled. All participants underwent ocular surface tests in the following order: corneal sensitivity, tear film breakup time, lissamine green staining, Schirmer test, and the Ocular Surface Disease Index questionnaire. Basal epithelial cells and subbasal nerves were evaluated using in vivo confocal microscopy (IVCM). Demographic characteristics, Visual Analog Scale for Pain (VAS), Ame...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Pterygium Recurrence Rates Among Different Races and Ethnicities After Primary Pterygium Excision by Surgeons in Training
Conclusions: Hispanic and black patients are more likely to experience pterygium recurrence after AMG than CAG. White patients are less likely than Hispanic or black patients to experience recurrence regardless of the surgical technique. To reduce the likelihood of recurrence, surgeons may consider race and ethnicity when selecting their operative technique. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Pilot Study Comparing Topical Anesthetic Agents in Pterygium Surgery: Subconjunctival Injection Versus 2% Lidocaine Gel Versus 5% Lidocaine Gel
Purpose: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. Methods: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure. The primary outcome was pain, which was experienced during and after surgery. The assessment was done using a 10-point linear analog scale at predete...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Amniotic Membrane Grafts to Reduce Pterygium Recurrence
Conclusions: Adjunctive use of AMT and short exposure of MMC can reduce recurrence after pterygium surgery. The procedure is less tedious and less time consuming, resulting in early recovery while saving the conjunctiva for future surgeries. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Adjustment of Intrastromal Corneal Ring Segments After Unsuccessful Implantation in Keratoconic Eyes
Purpose: To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. Methods: A retrospective nonrandomized case series was conducted including consecutive eyes of patients with keratoconus that underwent ICRS adjustment after an unsuccessful visual outcome. Patients were divided into 2 groups: group 1 was made up of patients with Intacs ICRSs that were exchanged for the Ferrara ICRS type, and group ...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of the Reliability and Repeatability of Scheimpflug System Measurement in Keratoconus
Conclusions: The level of repeatability of the measurements obtained with a Pentacam HR confirms the usefulness of this system for the diagnosis of keratoconus. Nevertheless, it has certain limitations for monitoring individual progression of keratoconus and planning intrastromal corneal ring segment insertion. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis
Conclusions: Surgical excision of refractory giant papillae followed by MMG does have its advantages in reducing their corneal complications, and it should be considered early in the management of exuberant refractory giant papillae. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Topical Tacrolimus 0.03% for Maintenance Therapy in Steroid-Dependent, Recurrent Phlyctenular Keratoconjunctivitis
Conclusions: Topical tacrolimus 0.03% was effective in maintaining long-term remission in patients with recurrent, steroid-dependent PKC. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Microbial Keratitis After Accelerated Corneal Collagen Cross-Linking in Keratoconus
Purpose: To assess the pattern of microbial keratitis after accelerated corneal collagen cross-linkage (aCXL) in patients with keratoconus. Method: The medical records of cases of keratoconus that underwent aCXL from June 2014 to May 2017 were reviewed. Cases that developed microbial keratitis after aCXL were included in the study. The clinical, microbiological profile and the treatment outcomes were evaluated. Results: Of 532 eyes that underwent aCXL, 7 cases developed microbial keratitis during the study period. Median age at presentation was 11 years (range 8–17). Association with vernal keratoconjunctivit...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Role of Confocal Microscopy in the Diagnosis of Pythium insidiosum Keratitis
Conclusions: P.insidiosum keratitis is a severe progressive infectious corneal disease that causes vision loss in most patients. Confocal microscopy may provide rapid in vivo visualization of P. insidiosum hyphae in corneal tissues, but it cannot distinguish P. insidiosum from other fungal keratitides. Culture identification with zoospore induction or polymerase chain reaction remains the most reliable means to confirm the diagnosis of P. insidiosum keratitis. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Outcome of Therapeutic Keratoplasty in Hopeless Microbial Keratitis Cases Otherwise Advised Evisceration
Conclusions: Primary evisceration is best avoided in infections limited to the anterior segment. Even in hopeless cases, every eye deserves a fair chance. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Retroprosthetic Membrane Formation in Boston Keratoprosthesis: A Case–Control-Matched Comparison of Titanium Versus PMMA Backplate
Conclusions: Titanium backplate KPros do not significantly reduce RPM formation compared with PMMA backplate KPros in a case–control-matched setting. A larger prospective study is warranted to evaluate comparative long-term performance and guide newer designs. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Transfer: Ultimate Outcome
Conclusions: Ultimately, regardless of the etiology of endothelial dysfunction, DMET fails to provide satisfactory results in the long term; durable corneal clearance may therefore require the presence of a nearly completely attached Descemet graft. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Predictive Factors for Corneal Clearance After Descemetorhexis Without Endothelial Keratoplasty
Conclusions: DWEK when performed with a Descemetorhexis technique results in corneal clearance in the majority of cases regardless of baseline demographics, with clearance typically 3 months after the procedure. Further studies are needed to investigate environmental factors, such as possible growth factors in the anterior chamber, that may influence clearing in these cases. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Cornea Peer Reviewers for 2017
No abstract available (Source: Cornea)
Source: Cornea - January 9, 2018 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 9, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Azithromycin in the Management of Pythium insidiosum Keratitis
No abstract available (Source: Cornea)
Source: Cornea - January 9, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 9, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research