KeratoScreen: Early Keratoconus Classification With Zernike Polynomial Using Deep Learning
Conclusions:
Deep learning algorithms based on ZCs could be used to screen for early KC and for other corneal ectasia during preoperative screening for corneal refractive surgery. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Basic Investigation Source Type: research
Long-Term Outcomes of Bowman Layer Inlay Transplantation for the Treatment of Progressive Keratoconus
Conclusions:
BL inlay transplantation stabilized KC in most eyes along with preservation of contact lens tolerance up to 8 years postoperatively and may be a successful treatment option, in particular for eyes with progressive advanced KC (Kmax> 69D). (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Short-term Efficacy and Safety of Biological Tear Substitutes and Topical Secretagogues for Dry Eye Disease: A Systematic Review and Network Meta-analysis
Conclusions:
Biological tear substitutes, including autologous serum, autologous platelet lysate, platelet rich plasma, and cord blood serum, might be the most effective treatment among tear promotion eye drops in relieving dry eye symptoms without increasing adverse events. However, there remains uncertainty around these findings because of low/very low certainty of evidence. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Observation of Conjunctiva-Associated Lymphoid Tissue With In Vivo Confocal Microscopy in Healthy Patients and Patients With Meibomian Gland Dysfunction
Purpose:
The purpose of this study was to assess the distribution and morphological variation of conjunctiva-associated lymphoid tissue (CALT) in healthy human subjects and patients with meibomian gland dysfunction (MGD) using laserscanningin vivo confocal microscopy.
Methods:
A total of 34 healthy subjects and 32 patients with MGD were enrolled. All subjects underwent a conventional examination consisting of slitlamp biomicroscopy, tear film break-up time, and the Schirmer test. In vivo microscopy was applied to analyze the morphological changes in the diffuse lymphoid layer and lymphoid follicles in CALT. Conj...
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Outcome of Lamellar Graft Patching for the Treatment of Noninfectious Corneal Perforations
Purpose:
The aims of this study were to evaluate the clinical outcome of lamellar graft patching used for treating noninfectious corneal perforations and to determine the clinical factors affecting tectonic integrity.
Methods:
This retrospective study includes a total of 71 eyes of 67 patients who underwent lamellar graft patching for the treatment of corneal perforations due to persistent epithelial defects secondary to limbal stem cell deficiency (LSCD, 21 eyes; 29.6%), peripheral ulcerative keratitis (17 eyes; 23.9%), neurotrophic keratitis due to herpes simplex keratitis (HSK, 14 eyes; 19.7%), and other caus...
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Use of Topical Cyclosporine 0.1% in Therapeutic Penetrating Keratoplasty for Fungal Keratitis
Conclusions:
Postoperative treatment with topical cyclosporine 0.1% seems to increase graft survival and postoperative vision with reduced risk of recurrence of primary infection in eyes with fungal keratitis undergoing TPK. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Enterobacter cloacae Keratitis: Clinicomicrobiological Profiles, Risk Factors, and Outcomes
Conclusions:
E. cloacae keratitis is a rare clinical entity seen more often in immunocompromised host conditions such as failed corneal transplants with concomitant topical steroids. Most cases healed with medical management. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Pediatric Microbial Keratitis: Identification of Clinical Biomarkers for Prognosis and Outcome of 218 Cases From 2009 to 2019
Purpose:
The aim of this study was to analyze the risk factors, microbiological profile, and treatment efficacy in pediatric microbial keratitis (MK) and to identify clinical biomarkers prognosticating outcome.
Methods:
A retrospective analysis was conducted from patients younger than 16 years with MK-excluding viral, marginal, or interstitial keratitis. Data pertaining to predisposing factors, symptom duration, prior treatment, ulcer characteristics, microbiological profile, time to resolution, and final outcome were recorded. Statistical analysis was performed. The mixed-effects linear regression model with ra...
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Infectious Keratitis Isolates and Susceptibility in Southern California
Conclusions:
In southern California between 2006 and 2019, there was a shift toward Staphylococcus species, with increased CoNS, decreased methicillin-sensitive Staphylococcus aureus, and decreased prevalence of P. aeruginosa. Empiric therapy of vancomycin and a fluoroquinolone or aminoglycoside provides effective antibacterial coverage for predominant bacterial species when culture sensitivities are pending. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Cancer Risk in Patients With Fuchs Endothelial Corneal Dystrophy
Purpose:
The purpose of this study is to quantify cancer risk in patients with Fuchs endothelial corneal dystrophy (FECD).
Methods:
Using the 2014 to 2016 Medicare Limited 5% Data Sets—Carrier Line File, US Medicare fee-for-service beneficiaries (aged 65 years or older) with FECD and cancer were identified through International Classification of Diseases, ninth and 10th Revision diagnostic codes from January 1, 2014, to December 31, 2016. The main outcome measures were odds ratios (ORs) of cancer at various anatomic locations in patients with versus without FECD.
Results:
Of the 1,462,740 Medicare benef...
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Clinical and Molecular Outcomes After Combined Intense Pulsed Light Therapy With Low-Level Light Therapy in Recalcitrant Evaporative Dry Eye Disease With Meibomian Gland Dysfunction
This study evaluates the effects of combined light therapy [intense pulsed light (IPL) and low-level light therapy (LLLT)] on clinical and molecular outcomes in evaporative DED with meibomian gland dysfunction (MGD).
Methods:
This prospective study evaluated 94 eyes (47 subjects) with chronic MGD treated with combined light therapy. Patients underwent a detailed evaluation of MGD and DED using the Ocular Surface Disease Index, dry eye tests—tear breakup time and Schirmer test, ocular surface staining, meibomian gland expressibility scoring, and meibography. Patients underwent a single session of combined light the...
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Corneal Biometric Parameters and Refractive Properties in Microcornea With Normal Axial Length
Conclusions:
Patients with MC and normal axial length possess specific parameters, including significantly smaller corneal diameter and thicker CCT than the patients in the control groups. There were no significant differences in ECD and average keratometry. These parameters should be taken into account in the follow-up and treatment. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
PACK Cross-Linking as Adjuvant Therapy Improves Clinical Outcomes in Culture-Confirmed Bacterial Keratitis
Conclusions:
In our study, PACK-CXLs addition to the standard of care in cases of culture-proven bacterial keratitis had a positive effect on the final visual acuity and time to resolution, compared with the standard-of-care treatment. (Source: Cornea)
Source: Cornea - August 18, 2022 Category: Opthalmology Tags: Clinical Science Source Type: research
Medium-Term Failure of Descemet's Stripping Only and Fuchs’ Dystrophy With Pancorneal Guttae
Conclusions:
Medium-term failure in this clinical setting is further evidence that DSO is likely best offered to patients with central guttae but a clear corneal periphery, indicative of a healthy cell reservoir. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
Bowman Layer Onlay Graft for Recurrent Corneal Erosions in Map–Dot–Fingerprint Dystrophy
Conclusions:
In the described case, the transplantation of an isolated BL graft as an onlay proved to be an effective treatment for painful chronic recurrent erosions in the context of map–dot–fingerprint dystrophy in a patient who had undergone numerous unsuccessful previous treatments. (Source: Cornea)
Source: Cornea - July 20, 2022 Category: Opthalmology Tags: Case Report Source Type: research
