ROCK Inhibitor (Ripasudil) as Coadjuvant After Descemetorhexis Without an Endothelial Graft
No abstract available (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Cellular Therapy With Human Autologous Adipose-Derived Adult Stem Cells for Advanced Keratoconus
No abstract available (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Importance of Axial Length and Functional Corneal Endothelial Cells in Descemet Membrane Endothelial Keratoplasty
No abstract available (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Parents of Patients With Congenital Hereditary Endothelial Dystrophy Should Be Evaluated for Fuchs Endothelial Corneal Dystrophy
No abstract available (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Gaps in Current Knowledge and Priorities for Future Research in Dry Eye
Conclusions: We identified gaps pertaining to treatment options for dry eye. Future clinical research on the management of dry eye should strongly consider these prioritized questions. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Review Source Type: research

Single-Pass 4-Throw Pupilloplasty for Pre-Descemet Endothelial Keratoplasty
Conclusions: SFT serves an effective technique for performing pupilloplasty in PDEK cases without the presence of a knot in the anterior chamber that poses a risk of mechanical damage to the donor graft. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

“Bubble-in-the-Roll” Technique Using the Endoject DMEK Injector: Influence of the Air Bubble on Endothelial Cell Loss
Conclusions: The bubble-in-the-roll technique for injection and unfolding of the graft is a safe method for graft delivery into the anterior chamber guaranteeing orientation of the graft without harming the endothelium. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Combined Conjunctival Limbal Autografts and Living-Related Conjunctival Limbal Allografts for Severe Unilateral Ocular Surface Failure
Conclusions: Certain etiologies of limbal stem cell deficiency also lead to significant conjunctival (and goblet cell) deficiency. Combined CLAU and lr-CLAL procedures maximize the amount of healthy limbal stem cells with conjunctiva while also minimizing the antigenic burden as all transplanted tissue potentially can be a complete (or near-complete), compatible HLA and crossmatch. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Severe Corneal Disorders Developed After Brimonidine Tartrate Ophthalmic Solution Use
Conclusions: We encountered 2 cases of corneal and conjunctival complications that developed as side effects after BT eye-drop use, thus indicating that strict attention should be paid to the possibility of side effects after initiation of antiglaucoma eye-drop use. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Posterior Amorphous Corneal Dystrophy Associated With Keratoglobus: A Case Report
Conclusions: In this case report, we illustrate progressive corneal ectasia in a patient with PACD. Although both conditions may represent changes in the structure and integrity of corneal collagen, whether an association exists between the 2 conditions is unknown. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Descemet Membrane Endothelial Keratoplasty Patch for Persistent Corneal Hydrops
Conclusions: DMEK, although technically challenging, can be considered for patients with persistent hydrops with preservation of corneal clarity and contour in areas of the uninvolved cornea. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Adjuvant Stromal Amphotericin B Injection for Late-Onset DMEK Infection
Conclusions: Medical therapy, including systemic and intrastromal application, is a viable initial treatment option for late-onset, presumed yeast interface keratitis in patients who have undergone DMEK. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Aberrant Patterns of Key Epithelial Basement Membrane Components in Keratoconus
Conclusions: These results indicate the activation of keratocytes into the fibroblast and myofibroblast wound phenotypes and the potential source of corneal scarring commonly observed in keratoconic corneas. Our data also support the hypothesis of dysregulated collagen synthesis and breakdown in the keratoconic cornea, in particular, the BM, and suggest a role for the BM in initiation and progression of keratoconus. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Promotion of Corneal Epithelial Wound Healing in Diabetic Rats by the Fibronectin-Derived Peptide PHSRN
Purpose: Topical application of the fibronectin-derived peptide PHSRN facilitates corneal epithelial wound healing in healthy animals and in patients with nonhealing epithelial defects. We have now examined the effect of PHSRN eye drops on the healing of corneal epithelial wounds in diabetic rats. Methods: Wistar rats were injected intraperitoneally with streptozotocin to induce diabetes or with a vehicle as a control. Four weeks after confirmation of the corresponding presence or absence of glycosuria, a 3-mm-diameter portion of the corneal epithelium of the right eye was excised and eye drops containing PHSRN (200 μM...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Effect of Multipurpose Solution Combined With Autophagy Inhibitors on Adhesion of Acanthamoeba trophozoites to Silicone Hydrogel Contact Lenses
Conclusions: MPS combined with 3-methyladenine or chloroquine reduced the adhesion rate of AC trophozoites rather than MPS containing only polyhexamethylene biguanide. Appropriate concentrations of autophagy inhibitors, 3-methyladenine and chloroquine, added to commercial MPS should be considered to decrease the clinical rate of Acanthamoeba keratitis. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Descemet Membrane Thickening as a Sign for the Diagnosis of Corneal Graft Rejection: An Ex Vivo Study
Purpose: To disclose, using an ex vivo study, the histopathological mechanism behind in vivo thickening of the endothelium/Descemet membrane complex (En/DM) observed in rejected corneal grafts (RCGs). Methods: Descemet membrane (DM), endothelium, and retrocorneal membranes make up the total En/DM thickness. These layers are not differentiable by high-definition optical coherence tomography; therefore, the source of thickening is unclear from an in vivo perspective. A retrospective ex vivo study (from September 2015 to December 2015) was conducted to measure the thicknesses of DM, endothelium, and retrocorneal membrane in ...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Bacterial Keratitis in Toronto: A 16-Year Review of the Microorganisms Isolated and the Resistance Patterns Observed
Purpose: To review the incidence, distribution, current trends, and resistance patterns of bacterial keratitis isolates in Toronto over the past 16 years. Methods: Microbiology records of suspected bacterial keratitis that underwent a diagnostic corneal scraping and cultures from January 1, 2000, through December 31, 2015, were retrospectively reviewed. The distribution of the main isolated pathogens and in vitro laboratory minimum inhibitory concentration testing results were used to identify resistance patterns. Results: A total of 2330 corneal scrapings were taken over 16 years. A pathogen was recovered in 1335 sample...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Oral Voriconazole Versus Oral Ketoconazole as an Adjunct to Topical Natamycin in Severe Fungal Keratitis: A Randomized Controlled Trial
Conclusions: Although the duration and percentage of healing was similar in both groups, oral VCZ attained a significantly better tear film concentration with a smaller scar size and better BSCVA compared with oral KCZ. Thus, oral VCZ may be preferred over oral KCZ in severe fungal keratitis. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of the Center and Flex-Center Methods of Corneal Endothelial Cell Analysis in the Presence of Guttae
Purpose: To compare endothelial cell analysis by the center and flex-center methods in corneas with guttae of differing severity and to determine the minimum countable cell number for using only the flex-center method. Methods: Forty-seven eyes with corneal guttae and 50 age-matched normal controls were enrolled in the study. Three images were captured in each central cornea with the noncontact specular microscope. Endothelial cell density (ECD), coefficient of variation (CV), and percentage of hexagonal cells (HEX) were analyzed by trained graders, using both center and flex-center methods. Results: Consistent ECD and H...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Lamina Cribrosa Thickness in Patients With Keratoconus
Purpose: To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls. Methods: This was a cross-sectional, observational study comprising 45 patients with keratoconus and 56 healthy subjects. Analysis of LC imaging was performed using spectral domain optical coherence tomography. Data collected included spherical equivalent, central corneal thickness, axial length, intraocular pressure, and keratometry. Results: Eyes with keratoconus had significantly thinner LC...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Accelerated Epi-On Versus Standard Epi-Off Corneal Collagen Cross-Linking for Progressive Keratoconus in Pediatric Patients
Conclusions: Accelerated epi-on CXL and standard epi-off CXL are safe and effective for stopping the progression of keratoconus at 12 months postoperatively. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Tomographic Changes After UV Cross-Linking for Corneal Ectasia (1-Year Results)
Conclusions: One year after UV cross-linking, the observation of stable CDVA and thinnest point thickness, together with reduced Kmax suggests no ectasia progression within the study period in these cases. Although HOAs showed a trend toward improvement, corneal densitometry remained elevated. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Conventional Corneal Collagen Cross-Linking Versus Transepithelial Diluted Alcohol and Iontophoresis-Assisted Corneal Cross-Linking in Progressive Keratoconus
Purpose: To compare clinical outcomes of conventional corneal cross-linking (C-CXL) and diluted alcohol and iontophoresis-assisted corneal cross-linking (DAI-CXL) for the treatment of progressive keratoconus (KC). Methods: Ninety-three eyes of 80 patients with KC were treated by C-CXL (n = 47) or DAI-CXL (n = 46). Visual acuity, keratometry, KC indexes, pachymetry, and aberrations were recorded before treatment and 1, 3, 6, and 12 months after treatment. The demarcation line was assessed 1 month after treatment. Results: A significant improvement in visual acuity was observed at month 3 and month 6 after DAI-CXL and C-CX...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Meibomian Gland Dysfunction Associated With Periocular Radiotherapy
Purpose: To investigate the influence of periocular radiotherapy on meibomian glands. Methods: We evaluated 28 patients (40 eyes) who received radiotherapy (RT group) for conjunctival or orbital lymphoma and 30 age-matched control subjects (60 eyes). Subjects underwent slit-lamp examination of the eyelids, Schirmer test, meibography, and evaluation of tear film breakup time (TBUT), Ocular Surface Disease Index (OSDI) scores, meibomian glands evaluation (meiboscore, meibum expressibility, and lid margin abnormality scores), and tear film lipid layer thickness using an ocular surface interferometer. These parameters were co...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Dark Endothelial Spots After Descemet Membrane Endothelial Keratoplasty May Appear as Recurrent Fuchs Dystrophy or Herald Graft Failure or Rejection
Conclusions: Dark endothelial spots after DMEK for FED may not represent a recurrent disease, but tissue irregularities just anterior to the graft. However, if associated with changes in endothelial cell morphology, nuclear activation and/or ECD decrease, dark discolorations may reflect “cellular stress” heralding secondary graft failure or (subclinical) allograft rejection. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Learning DMEK From YouTube
Conclusions: Although formal training is desirable, good results can be obtained by an anterior segment surgeon learning DMEK, including graft preparation, without it. DMEK should no longer be considered a procedure with a long learning curve in routine cases. (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Multicenter Study of 6-Month Clinical Outcomes After Descemet Membrane Endothelial Keratoplasty
Purpose: To report the 6-month clinical outcomes of a large cohort of Descemet membrane endothelial keratoplasty (DMEK) eyes operated by 55 starting or experienced surgeons. Methods: This is a retrospective, multicenter, interventional, cohort study with a total of 2485 eyes. Best-corrected visual acuity (BCVA), endothelial cell density (ECD) decrease, and intra- and post-operative complications were evaluated. Three groups based on case order were compared: group I (cases 1–24), group II (cases 25–99), and group III (cases ≥100). Forty-nine percent of the surgeons were in their learning curve ( (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Standardizing Descemet Membrane Endothelial Keratoplasty Graft Preparation Method in the Eye Bank—Experience of 527 Descemet Membrane Endothelial Keratoplasty Tissues
Purpose: To share the experience and provide a standardized protocol for Descemet membrane endothelial keratoplasty (DMEK) graft preparation. Methods: A retrospective study based on 527 prestripped DMEK tissues that were prepared between 2014 and 2017. The experience of using different instruments and techniques has been described, and a standardized technique for preparing DMEK grafts has been identified. The tissues in general were prepared by superficially tapping the endothelial side with a Moria trephine (9.5 mm diameter). The plane of cleavage was identified using a cleavage hook, and the DMEK graft was deadhered fr...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Minimizing Graft Preparation Failure in Descemet Membrane Endothelial Keratoplasty
Conclusions: Various DMEK graft preparation techniques may provide failure rates of (Source: Cornea)
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Meta-Analysis of Postoperative Outcome Parameters Comparing Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty
Purpose: This meta-analysis compares Descemet membrane endothelial keratoplasty (DMEK) with Descemet stripping automated endothelial keratoplasty (DSAEK) to evaluate their strength and weakness profiles. Design: Meta-analysis. Methods: We performed a meta-analysis and searched the peer-reviewed literature in PubMed, Cochrane Library, Web of Science, and Embase following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Prospective and retrospective trials performing and comparing DMEK and DSAEK were included. Effects were calculated as odds ratios or standardized mean differences. R...
Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Visual Outcomes After SMILE, LASEK, and LASEK Combined With Corneal Cross-Linking for High Myopic Correction
No abstract available (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Efficacy and z* Formula for Minimum Corneal Thickness in Ultraviolet Light Cross-Linking
No abstract available (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Systematic Review and Meta-Analysis of Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Endothelial Keratoplasty/Descemet Stripping Automated Endothelial Keratoplasty
Purpose: To review and compare the published reports of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping endothelial keratoplasty/Descemet stripping automated endothelial keratoplasty (DSEK/DSAEK) procedures with regard to endothelial cell density/loss, best spectacle-corrected visual acuity, central corneal thickness, subjective outcomes (patient's reported satisfaction/preference), and postoperative complications. Methods: A thorough search was conducted in the databases including AMED, EMBASE, Cochrane Database of Systematic Reviews, and MEDLINE without date restrictions. Systematic reviews, met...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Review Source Type: research

New Graft Insertion Device for Descemet Stripping Automated Endothelial Keratoplasty
Conclusions: The newly developed DSAEK inserter is a simple and useful tool for endothelial graft delivery, lessening intraoperative mechanical stress on the graft tissue. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Techniques Source Type: research

Therapeutic Femtosecond Laser-Assisted Lamellar Keratectomy for Multidrug-Resistant Nocardia Keratitis
Conclusions: Multidrug-resistant N. asteroides keratitis can be difficult to manage even with appropriate antibiotic therapy based on drug sensitivity testing. Femtosecond laser-assisted resections may facilitate treatment in these cases by safely and precisely debulking infected tissue and enhancing penetration of topical medications. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers
Conclusions: Topical insulin may be a simple and effective treatment for refractory neurotrophic corneal ulcers. Further study is required to determine the clinical efficacy and side effect profile of insulin drops. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Favorable Outcome in Coccidioides Endophthalmitis—A Combined Medical and Surgical Treatment Approach
Conclusions: A combined medical and surgical approach resulted in a favorable visual outcome and avoided the need for enucleation. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Recovery From Amiodarone-Induced Cornea Verticillata by Application of Topical Heparin
Conclusions: In patients using amiodarone, clearing of cornea verticillata may be achieved by topical use of unpreserved eye drops of a sterile, phosphate-free solution of 0.1% sodium hyaluronate with 1300 IU/mL heparin sodium. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Donor-Derived Conjunctival-Limbal Melanoma After a Keratolimbal Allograft
Conclusions: We present a case of conjunctival–limbal melanoma after a KLAL from a donor who had a history of metastatic melanoma. In response to this case, the US eye banking guidelines were amended to include stricter parameters for vascularized ocular tissue transplantation. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Case Report Source Type: research

Alkali Burn Induced Corneal Spontaneous Pain and Activated Neuropathic Pain Matrix in the Central Nervous System in Mice
Conclusions: Alkali burn could cause corneal spontaneous pain and activate the neuropathic pain matrix in the central nervous system. Furthermore, activation of ERK in the ACC is required for alkali burn induced corneal spontaneous pain. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Prestained and Preloaded DMEK Grafts: An Evaluation of Tissue Quality and Stain Retention
Conclusions: It is possible to prestain and preload DMEK grafts without inducing additional endothelial cell loss. Consideration should be given to the interval between staining and surgery because stain can fade. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Corneal Stiffening by a Bacteriochlorophyll Derivative With Dextran and Near-Infrared Light: Effect of Shortening Irradiation Time up to 1 Minute
Purpose: The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. Methods: One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in this study. Fifty-two eyes (ex vivo n = 34, in vivo n = 18) were mechanically deepithelialized, treated topically with WST-D, and irradiated at 10 mW/cm2 using a diode laser at 755 nm for 1, 5, or 30 minutes. Untreated fellow eyes served as controls. Corneoscleral rings were removed immediately after treatme...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Development of Cell Analysis Software for Cultivated Corneal Endothelial Cells
Conclusions: The software described here provides morphometric information from phase contrast images, and it enables subjective and noninvasive quality assessment for tissue engineering therapy of the corneal endothelium. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research

Self-Retained Amniotic Membrane Combined With Antiviral Therapy for Herpetic Epithelial Keratitis
Conclusions: The PKS in conjunction with oral acyclovir facilitates the ease of early intervention to accelerate restoration of a normal corneal epithelium in herpetic epithelial keratitis. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Learning Curve of Small Incision Lenticule Extraction: Challenges and Complications
Conclusions: The learning curve of SMILE is surgically challenging. Lenticule dissection and extraction is the most difficult step and leads to a multitude of complications. Most complications that result in delayed visual recovery are observed in the initial 50 cases. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Agreement of Corneal Diameter Measurements Obtained by a Swept-source Biometer and a Scheimpflug-based Topographer
Conclusions: According to the results of this study, the IOLMaster 700 may overestimate the WTW distance measurements by up to 0.78 mm compared with the Pentacam HR, so these 2 devices should not be used interchangeably for this purpose. The agreement is somehow weaker for eyes with WTW distances of 11.50 mm or less than those with WTW distances greater than 11.50 mm. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Simulated Keratometry Versus Total Corneal Power by Ray Tracing: A Comparison in Prediction Accuracy of Intraocular Lens Power
Purpose: To investigate the relationship between corneal powers measured by simulated keratometry (Sim-K) and ray tracing and understand whether their difference influences intraocular lens (IOL) power calculation. Methods: In a first sample of healthy eyes, corneal curvature was measured using a rotating Scheimpflug camera (Sirius, CSO). Sim-K was obtained from anterior corneal curvature using the 1.3375 keratometric index. Ray tracing was performed through both corneal surfaces to calculate the total corneal power (TCP). The difference between Sim-K and TCP was correlated with various parameters. In a second sample of p...
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research

Releasable Single Suture for Primary Pterygium Excision With a Conjunctival Autograft
Conclusions: Releasable single suture may offer a good and simple alternative, which uses the gold standard technique of the CAG with exclusion of suture-related complications. (Source: Cornea)
Source: Cornea - October 10, 2017 Category: Opthalmology Tags: Clinical Science Source Type: research