Preloaded Descemet Membrane Endothelial Keratoplasty Donor Tissue: Surgical Technique and Early Clinical Results
No abstract available (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Use of a Purpose-Built Impression Cytology Device for Gene Expression Quantification at the Ocular Surface Using Quantitative PCR and Droplet Digital PCR
Conclusions: IC is a recognized technique for ocular surface cell evaluation and protein biomarker quantification but is infrequently used for quantifying gene expression. The EYEPRIM device allows ease of use and impression-to-impression consistency while accurate gene expression data offers a highly specific and sensitive method of disease characterization for clinician scientists to use in diagnosis. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Ocular Surface Stem Cell Transplantation for Treatment of Keratitis–Ichthyosis–Deafness Syndrome
Conclusions: KID syndrome is a rare cause of LSCD. Although OSST can stabilize the surface, long-term treatment of KID syndrome can be challenging. An lr-CLAL may offer further benefit over a KLAL in these eyes because it is HLA- and ABO-matched tissue; it also helps to treat keratoconjunctivitis sicca, often a prominent feature of KID syndrome. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Topical Ganciclovir for Prophylaxis of Cytomegalovirus Endotheliitis in Endothelial Keratoplasty
Conclusions: Long-term topical ganciclovir use can prevent recurrence of CMV-associated graft failure even in immunocompromised hosts without side effects of systemic antivirals. DMEK may have advantages over DSEK in eyes with previous CMV infection and in eyes prone to inflammation. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Descemet's Membrane Biomimetic Microtopography Differentiates Human Mesenchymal Stem Cells Into Corneal Endothelial-Like Cells
Conclusions: Artificial reproduction of Descemet membrane with respect to topography and similar stiffness offers a potential innovative way to bioengineer a functional CEC monolayer from autologous stem cells. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Stenciling-Based “Prick and Print” Technique for Harvesting Shaped Corneal Grafts for Management of Peripheral Corneal Perforations
Conclusions: The stenciling-based prick and print technique for making shaped donor corneal grafts may offer a simple, easy-to-learn surgical technique that can be used to make any shape or pattern of donor corneal grafts without involving the optical center, even in extensive peripheral corneal lesions. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Two Femtosecond Laser LASIK Platforms: Comparison of Evolution of Visual Acuity, Flap Thickness, and Stromal Optical Density
Purpose: To compare postoperative evolution of visual acuity, flap thickness, and stromal optical density during the first 3 months after femtosecond (FS) laser in situ keratomileusis surgery for correction of myopia using the iFS 150-kHz FS laser and LenSx FS laser platforms. Methods: This was a prospective case series. Thirty-nine eyes treated with the iFS 150-kHz FS laser versus 38 refraction-matched eyes treated with the LenSx FS laser platform were included. Visual outcomes, flap morphology, and optical density of the stroma (in both flap and residual stromal bed) were compared at 4 visits during a three-month fo...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Relevance of Swept-Source Anterior Segment Optical Coherence Tomography for Corneal Imaging in Patients With Flap-Related Complications After LASIK
Conclusions: Swept-source AS-OCT is useful not only for diagnosis but also for management of eyes with LASIK flap-related complications by allowing noninvasive, noncontact, real-time acquisition of cross-sectional AS images. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Central Islands and Visual Outcomes of Phototherapeutic Keratectomy Using the Photorefractive Keratectomy Mode
Purpose: To compare the rate of central island (CI) and visual acuity after phototherapeutic keratectomy (PTK) with and without the CI program. Methods: This retrospective study comprised 147 eyes of 89 consecutive patients (mean age ± SD, 71.1 ± 9.6 years) undergoing PTK with and without the anti-CI program [photorefractive keratectomy (PRK) mode and PTK mode] using the VISX Star S4 excimer laser system (Johnson & Johnson Vision, Santa Ana, US) for treatment of band keratopathy (BK) or granular corneal dystrophy (GCD). The rate of CI formation, defined as a steepening area of 3 D, 1.5 mm in diameter...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Concurrent Microbial Keratitis and Nasolacrimal Duct Obstruction: Concordance, Etiopathogenesis, and Outcome
Conclusions: CNS are the most common organisms in concurrent MK and NLDO (58% concordance), in patients with NLDO alone, and as commensals in healthy subjects. Persistence of NLDO may be responsible for a poorer outcome of MK in a concurrent setting. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Cumulative Effects of Smoking and Diabetes Mellitus on Corneal Endothelial Cell Parameters
Conclusions: Although neither only DM nor only smoking has a statistically significant effect on corneal endothelial morphometric properties, coexistence of DM and smoking causes a significant decrease in ECD. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Endothelial Cell Density in Uveal Coloboma Associated With Microcornea
Purpose: To evaluate the relationship between endothelial cell density (ECD) and mean corneal diameter (MCD) in eyes with uveal coloboma associated with microcornea. Methods: Corneal endothelial cell imaging was performed using specular microscopy on 22 eyes of 18 subjects diagnosed with uveal coloboma associated with microcornea. The MCD was noted as the average of horizontal and vertical corneal diameters, which were measured using the ruler tool of the slit-lamp biomicroscope and Castroviejo calipers. Results: Mean age of the study subjects was 29.7 ± 10.4 years (range, 14–46 years). The MCD was 7.3...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping for a 9-mm Zone Using Optical Coherence Tomography
Conclusions: Optical coherence tomography produced excellent repeatability and reproducibility for corneal ET and CT measurements up to a 9-mm zone in normal eyes and eyes with different corneal conditions. The CT measurements in keratoconic eyes were more variable than those in eyes with other corneal conditions. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes
Purpose: To evaluate corneal epithelial thickness (CET) and corneal thickness (CT) in healthy eyes using spectral domain optical coherence tomography. Methods: Thirty-six healthy eyes were imaged using the Cirrus high-definition (HD)-optical coherence tomography device. The average CET and CT were assessed using Cirrus Review Software within predefined concentric corneal ring-shaped zones. Specific regions of CET (superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal, and inferonasal) were also assessed. The difference between zones was compared between males and females. Results: The ave...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Superficial Keratopigmentation: An Alternative Solution for Patients With Cosmetically or Functionally Impaired Eyes
Conclusions: The modern superficial KTP procedure provides the possibility to improve the cosmetic appearance of impaired eyes, as an alternative to evisceration, enucleation, prosthetic contact lenses, or keratoplasty. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Intraocular Light Scatter in Eyes With the Boston Type 1 Keratoprosthesis
Purpose: The Boston keratoprosthesis (KPro) is the most commonly used artificial cornea. It has been proven to be successful for severe corneal disease not amenable to keratoplasty. We have observed our patients reporting debilitating glare despite attaining good visual acuities. This motivated us to objectively measure light scatter in eyes with a KPro. Methods: Light scatter was measured in 21 eyes with the Boston type 1 KPro with a VA of 20/150 or better and was compared with 13 healthy control eyes using the Oculus C-Quant device (Arlington, WA). Eyes were also measured using an occluder contact lens. Results: ...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-Term Results of Femtosecond Laser–Enabled Keratoplasty With Zig-Zag Trephination
Conclusions: The femtosecond laser–generated zig-zag–shaped incision results in lower manifest and topographical astigmatism than the reported average for conventional penetrating keratoplasty. Graft rejection and failure rates are similar to published data for conventional penetrating keratoplasty. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Geometric Properties of Donor Corneas After Mechanical Trephination in Deep Anterior Lamellar Keratoplasty
Purpose: To evaluate the geometry of donor corneal buttons after mechanical trephination and to determine whether there were any possible variables that could influence the accuracy of cutting corneal buttons in deep anterior lamellar keratoplasty. Methods: This cross-sectional study included 85 sclerocorneal buttons that were transplanted during deep anterior lamellar keratoplasty. Donor corneas were punched from the posterior surface. Photographs that most clearly represented the entire edges of the donor corneas were taken from the punched corneas and systematically analyzed using ImageJ software. The univariate an...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Cross-Country Transportation Efficacy and Clinical Outcomes of Preloaded Large-Diameter Ultra-Thin Descemet Stripping Automated Endothelial Keratoplasty Grafts
Conclusions: Large-diameter UT-DSAEK grafts can be prepared and preloaded in the eye bank using the iGlide and transported to the surgical center facilitating surgery for patients undergoing UT-DSAEK, potentially reducing tissue wastage, surgical time, and costs related to surgery. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Precut DMEK Using Dextran-Containing Storage Medium Is Equivalent to Conventional DMEK: A Prospective Pilot Study
Conclusions: This pilot study shows a comparable clinical outcome after DMEK surgery for precut Descemet membrane grafts versus conventionally prepared grafts, using the liquid bubble preparation technique and storage conditions with dextran-containing medium. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Influence of Incision Size on Dry Eye Symptoms in the Small Incision Lenticule Extraction Procedure
Conclusions: There was no difference in dry eye symptoms with 2-, 3-, and 4-mm incisions. In the learning period of SMILE surgery, larger incision sites can be used to make the procedure easier. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Current Practice Patterns and Opinions on the Management of Recent-Onset or Chronic Herpes Zoster Ophthalmicus of Zoster Eye Disease Study Investigators
Conclusions: Approximately half of ZEDS investigators treat HZO with prolonged oral antivirals, in addition to topical steroids, and two-thirds believe that it is effective. Completion of ZEDS is feasible and necessary to determine whether or not these practices are effective. Participation in this study is necessary to obtain evidence to support treatment that many ophthalmologists use and believe is effective. (Source: Cornea)
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Acute Chemical Eye Injury and Limbal Stem Cell Deficiency—A Prospective Study in the United Kingdom
Purpose: To analyze the incidence, nature, outcomes, and complications of acute chemical eye injuries, including the incidence of limbal stem cell deficiency (LSCD) and to compare the 2 main classifications for ocular chemical injuries: Roper-Hall (RH) and Dua. Methods: This is a prospective, consecutive, interventional single-center study between April and October 2009 of all new patients with acute chemical eye injury presenting to the Royal Victoria Infirmary eye emergency department (EED). Results: Of 11,683 patients who attended the EED, 98 patients (110 eyes) presented with acute chemical eye injury (60% male...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading
Purpose: To grade the severity of limbal stem cell deficiency (LSCD) based on the extent of clinical presentation and central corneal basal epithelial cell density (BCD). Methods: This is a retrospective observational comparative study of 48 eyes of 35 patients with LSCD and 9 eyes of 7 normal subjects (controls). Confocal images of the central cornea were acquired. A clinical scoring system was created based on the extent of limbal and corneal surface involvement. LSCD was graded as mild, moderate, and severe stages based on the clinical scores. The degree of BCD reduction was given a score of 0 to 3. Results: Com...
Source: Cornea - December 5, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Herpes Zoster Vaccination: An Urgent Priority
No abstract available (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Is Nanothin Descemet Stripping Automated Endothelial Keratoplasty Comparable to Descemet Membrane Endothelial Keratoplasty?
No abstract available (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Appropriate Sequence of Combined Intracorneal Ring Implantation and Corneal Collagen Cross-Linking in Keratoconus: A Systematic Review and Meta-Analysis
Conclusions: Simultaneous ICRS implantation and CXL may provide better outcomes than staged techniques for improving the corneal shape. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Review Source Type: research

Congenital Corneal Opacities Associated With Trisomy 8 Mosaicism Syndrome
Conclusions: T8mS should be considered in the differential diagnosis for superficial CCOs with blood vessels. Anterior segment OCT can guide management and cytogenetics performed to confirm diagnosis. Systemic associations and, in particular, risk of acute myeloid leukemia and myelodysplastic syndromes warrant prompt diagnosis of this condition. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Corneal Relapse of Peripheral T-Cell Lymphoma Under Systemic Chemotherapy
Conclusions: In this rare case of systemic multinodal peripheral T-cell lymphoma, corneal stromal infiltration was the only ocular manifestation. Prompt corneal biopsy enabled the appropriate diagnosis. Development and persistence of corneal infiltration despite systemic chemotherapy may be a warning sign for resistance to treatment. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review
Conclusions: Isolated corneal Acremonium eumycetoma masquerading as a perforated corneal ulcer with prolapsed uveal tissue is a rare entity. Surgical intervention and appropriate antimicrobial therapy are key to successful outcome. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Case Report Source Type: research

First Report on Detection of Dengue Virus in the Donor Cornea
Conclusions: The data presented in this study recommend the implementation of polymerase chain reaction for detection of DENV and CHIV to analyze excised corneoscleral tissue of a donor with viral hemorrhagic fever. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis
Conclusions: Together, these findings demonstrate that fenretinide may suppress inflammation through reduced neutrophil recruitment and inflammatory cytokine production in A. fumigatus keratitis. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Development of Cell Analysis Software to Evaluate Fibroblastic Changes in Cultivated Corneal Endothelial Cells for Quality Control
Purpose: To develop software to evaluate the fibroblastic morphological changes in cultured human corneal endothelial cells (HCECs) as a quality control measure for use in tissue engineering therapy. Methods: Software was designed to recognize cell borders, to approximate cell shape as an ellipse, and to calculate the aspect ratio of the ellipse as an indicator of severity of the fibroblastic morphological change. Using the designed software, 60 phase contrast images of polygonal HCECs and 60 phase contrast images of fibroblastic HCECs were analyzed. The correlations of the aspect ratio and other parameters (cell dens...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction
Purpose: To evaluate the efficacy of intense pulsed light (IPL) therapy combined with meibomian gland expression (MGX) for refractory meibomian gland dysfunction (MGD) in a prospective study conducted at 3 sites in Japan. Methods: Patients with refractory obstructive MGD were enrolled and underwent 4 to 8 IPL-MGX treatment sessions at 3-week intervals. Clinical assessment included the Standard Patient Evaluation of Eye Dryness questionnaire; noninvasive breakup time of the tear film and interferometric fringe pattern as determined by tear interferometry; lid margin abnormalities, fluorescein breakup time of the tear f...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Collagen I Defect Corneal Profiles in Osteogenesis Imperfecta
Purpose: The goal of this study was to evaluate corneal profiles of patients with osteogenesis imperfecta (OI) due to a collagen I gene mutation. Methods: This was a cross-sectional comparative study. There were 84 eyes from 42 patients with OI types I, III, and IV who were recruited from the OI Clinic at the Clinical Hospital of Porto Alegre, Brazil. All cases presented either COL1A1 or A2 gene mutations. Controls were matched by sex, age, and refractive error. Corneal Scheimpflug tomography was used to determine curvature and thickness parameters in both groups. Results: Quantitative collagen mutations were found...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Association Between Season, Temperature and Causative Organism in Microbial Keratitis in the UK
Purpose: Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK. Methods: Retrospective review of all corneal scrapes from patients with MK presenting to Manchester Royal Eye Hospital, UK, between January 2004 and December 2015. Manchester’s monthly temperature data were obtained from Met Office UK. Analysis was performed using logistic regression. Results: From 4229 corneal scrapes, 1539 organisms grew (90.6% bacteria, 7.1% fungi, and ...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Characteristics and Outcomes of Moraxella Keratitis
Purpose: Changing trends of infective keratitis have been identified worldwide. The aim of this study was to define the clinical associations, characteristics, and outcomes of patients with culture-proven Moraxella keratitis from a large tertiary corneal unit in the United Kingdom. Methods: Patients with confirmed Moraxella isolates presenting between January 2004 and November 2016 were analyzed. Patient-related factors were examined, including patient demographics, date of presentation, clinical presentation, predisposing factors, best-corrected visual acuity (BCVA), treatment plans, and clinical outcomes. Results: ...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Molecular Bioburden of the Lens Storage Case for Contact Lens–Related Keratitis
Conclusions: A heavier bioburden in the lens storage case was associated with a higher risk of CL-related keratitis and infectious keratitis. Inappropriate maintenance of the CL will lead to microbial contamination and transfer the pathogen onto the ocular surface causing keratitis accordingly. The DHA assessment for the lens storage case might provide an alternative way to differentiate infectious from noninfectious CL-related keratitis. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Epidemiology of Persistent Postsurgical Pain Manifesting as Dry Eye-Like Symptoms After Cataract Surgery
Purpose: To evaluate the epidemiology of persistent postsurgical pain (PPP) manifesting as dry eye (DE)-like symptoms 6 months after surgery. Methods: This single-center study included 119 individuals whose cataract surgeries were performed by a single surgeon at the Bascom Palmer Eye Institute and who agreed to participate in a phone survey 6 months after surgery. Patients were divided into 2 groups: the PPP group was defined as those with a Dry Eye Questionnaire-5 score ≥6 and without PPP as those with a Dry Eye Questionnaire-5 score (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Incidence and Risk Factors of Dry Eye in a Spanish Adult Population: 11-Year Follow-Up From the Salnés Eye Study
Purpose: To estimate the incidence of dry eye (DE) and to evaluate risk factors in an adult cohort in Spain. Methods: The Salnés Eye Study (SES) was a cross-sectional population-based study of 654 subjects conducted from 2005 to 2006. After 11 years, 264 individuals (65.8% response rate) participated in SES 2. The incidence cohort consisted of 209 subjects not diagnosed with DE in SES 1 [mean age (SD) 67.6 years (±10.1), range: 51–92, women 69.4%]. DE was defined as the simultaneous presence of symptoms and at least 1 sign. A Schirmer test score ≤5 mm, tear film breakup time ≤10 seconds, rose...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy
Conclusions: CET and corneal epithelial microvilli are new parameters with which to evaluate early stages of corneal epithelial changes during glaucoma therapy. In advanced stages of corneal epithelial damage, SEM evaluation reveals ultrastructural epithelial changes that may not be observed on CET measurements. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Post-Laser In Situ Keratomileusis Epithelial Ingrowth: Treatment, Recurrence, and Long-Term Results
Conclusions: Scraping alone provides significantly better initial visual outcomes but higher EI recurrence rates compared with scrape–suturing. Long-term visual outcomes are comparable between 2 techniques. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Correlation of Demarcation Line Depth With Medium-Term Efficacy of Different Corneal Collagen Cross-Linking Protocols in Keratoconus
Purpose: To compare demarcation line depth (DD) and topographic changes among different corneal collagen cross-linking (CXL) protocols and to evaluate the relation of DD with medium-term efficacy of CXL in halting progression of keratoconus. Methods: The study included 124 patients (mean age 19 ± 4.8 years) with progressive keratoconus who underwent conventional (3 mW/cm2/30 min), accelerated (18 mW/cm2/5 min), or transepithelial (TE) CXL (3 mW/cm2/30 min) and followed up for at least 2 years. Baseline and final corneal topographic parameters and DD determined with anterior segment optical coherence tomography ...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Refractive Stability After Deep Anterior Lamellar Keratoplasty for Keratoconus
Conclusions: Refraction stabilized 6 months after complete DALK suture removal. Therefore, postponing refractive surgery until this time is advisable to manage post-DALK refractive errors. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Development of a Reference Model for Keratoconus Progression Prediction Based on Characterization of the Course of Nonsurgically Treated Cases
Purpose: To evaluate and characterize long-term clinical changes in keratoconus cases not requiring surgical treatment because of the absence of clinically significant visual degradation and to design a predictive model for the progression rate. Methods: This retrospective longitudinal study enrolled 68 nonsurgically treated keratoconic eyes of 46 patients (age range, 18–66 years), with a follow-up period of 6 years ± 12 months. Visual, refractive, topographic, and aberrometric changes were evaluated, detecting the abnormal levels of longitudinal changes in each clinical variable analyzed (percentiles 10%...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Penetrating Keratoplasty Using the Femtosecond Laser: A Comparison of Postoperative Visual Acuity and Astigmatism by Suture Pattern
Purpose: To compare the effect of 3 common suturing techniques on eyes that received femtosecond laser-enabled penetrating keratoplasty (FLEK) with a zig-zag configuration at the Gavin Herbert Eye Institute, University of California- Irvine, California. Methods: This is a retrospective chart review of a series of 319 eyes of 286 patients who underwent FLEK with a zig-zag configuration. One hundred fifty-seven eyes had running sutures, 136 eyes had simple interrupted sutures, and 26 eyes had combined sutures (single running and simple interrupted). The main outcome measures were uncorrected distance visual acuity, best...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Does Same-Day Postoperative Increased Intraocular Pressure Affect Endothelial Cell Density After Descemet Membrane Endothelial Keratoplasty?
Conclusions: Increased IOP at 2 hours is common after DMEK, but does not seem to influence early endothelial cell survival. One-month ECD was influenced by donor counts and combined cataract surgery. (Source: Cornea)
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemetorhexis Without Endothelial Keratoplasty Versus DMEK for Treatment of Fuchs Endothelial Corneal Dystrophy
Purpose: To compare the visual outcomes and associated morbidity of patients with Fuchs endothelial corneal dystrophy who were treated with either Descemet membrane endothelial keratoplasty (DMEK) or descemetorhexis without endothelial keratoplasty (DWEK). Methods: This is a retrospective comparative cohort study of 27 eyes with mild to moderate Fuchs dystrophy (with corneal guttae/edema limited to the central cornea with relatively clear periphery) that were treated at the University of Pittsburgh Medical Center from 2015 to 2017 with either DMEK (n = 15) or DWEK (n = 12). Descemetorhexis was performed by removing th...
Source: Cornea - November 6, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research