Mini-DSAEK for Macro Corneal Perforations
Conclusions: Mini-Descemet stripping–automated endothelial keratoplasty technique can be an alternative approach to avoid poor visual outcomes of tectonic keratoplasty in paracentral perforations. It also offers host tissue preservation in eyes with high risk of rejection for tectonic grafts. (Source: Cornea)
Source: Cornea - July 15, 2021 Category: Opthalmology Tags: Techniques Source Type: research

Mini-Descemet Stripping–Automated Endothelial Keratoplasty for Macro Corneal Perforations
Conclusions: Mini-Descemet stripping–automated endothelial keratoplasty technique can be an alternative approach to avoid poor visual outcomes of tectonic keratoplasty in paracentral perforations. It also offers host tissue preservation in eyes with high risk of rejection for tectonic grafts. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Techniques Source Type: research

A Novel Technique for Donor Insertion and Unfolding in Descemet Membrane Endothelial Keratoplasty
Conclusions: Our novel technique of donor DM insertion allows easy donor insertion and unfolding, thereby simplifying the DMEK procedure. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Techniques Source Type: research

Keratoplasty Rejection After the BNT162b2 messenger RNA Vaccine
Conclusions: The BNT162b2 mRNA vaccine may be have been associated with a low-risk corneal graft rejection that responded well to topical and systemic steroids. Treating physicians should be aware of this potential complication and patients should be advised to report any visual changes after vaccination. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Late Corneal Stromal Deposits After COVID-19
We present 2 cases of striking stromal corneal infiltrates months after COVID-19 infection. While we cannot prove that these infiltrates are caused by or directly related to COVID-19, we did not find any other plausible cause that could explain these ophthalmic signs. In these cases, the ongoing process was detected in relatively early stages due to scheduled visits with patients and responded positively to prednisolone acetate 1% ophthalmic suspension. However, we do not know the response to treatment in more advanced cases. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Solitary Conjunctivocorneal Plasmacytoma Arising After Cataract Surgery
Conclusions: To our knowledge, this is the first case of plasmacytoma in the literature to involve the cornea. This case was not associated with systemic disease. Surgical excision and brachytherapy remain options for cases without corneal involvement. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Severe Keratitis and Corneal Perforation by Paenibacillus glucanolyticus
Conclusions: This is the first reported ocular case of P. glucanolyticus demonstrating its bacterial virulence and pathogenic potential when infecting the cornea. Rapid identification with newer technology enable us to accurately identify these opportunistic bacteria and may give a more favorable visual outcome as correct sensitivities lead to timely treatment administration. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Treatment of Dry Eye from Laser-Assisted In Situ Keratomileusis With Recombinant Human Nerve Growth Factor (Cenegermin)
Conclusions: Although recombinant human nerve growth factor seems to be effective in short term for neurotrophic keratitis secondary to laser-assisted in situ keratomileusis surgery, alternative dosing for patients with this patient population should be considered to achieve long-lasting resolution. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Herpes Simplex Virus–Related Conjunctivitis Resistant to Aciclovir: A Case Report and Review of the Literature
Conclusions: This is a rare case of isolated conjunctivitis due to herpes virus type 2, in an human immunodeficiency virus-positive patient, which was found to be resistant to ACV. Drug-resistant HSV is likely to emerge as an important clinical entity in the future, increasing the need for new drugs with novel mechanisms of action. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Transient Reticular Cystic Corneal Epithelial Edema With Topical Netarsudil: A Case Series and Review
Conclusions: Although rho-kinase inhibitors have been suggested to improve endothelial function, we have documented worsening epithelial cysts in a subset of patients with pre-existing corneal edema. These effects of netarsudil were transient and resolved after discontinuing treatment within 2 weeks in most patients. We hypothesize that the incidence of this adverse finding is more common than previously believed. Nevertheless, large-scale studies are needed to accurately report on the incidence and clinical significance of this novel finding. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Role of Reverse Transcriptase Polymerase Chain Reaction in Cornea Donors During the COVID-19 Pandemic
Conclusions: NP samples of cornea donors dying due to causes other than coronavirus disease-19 were positive for SARS-CoV-2 on RT-PCR. This implicates that donors could be having asymptomatic/undetected coronavirus disease infection. We recommend adding the routine testing of NP samples of all cornea donors in the eye banking protocol in this ongoing SARS-CoV-2 pandemic. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Basic Investigation Source Type: research

Rose Bengal Photodynamic Antimicrobial Therapy: A Pilot Safety Study
Conclusions: RB-PDAT with 0.1% RB is a safe procedure. There was no difference clinically and on histopathology compared with control groups. In eyes where RB dye is retained in the corneal stroma after 1 month of treatment, oxidative stress is not evidenced at long term. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Basic Investigation Source Type: research

Trypan-Assisted Automated Endothelial Cell Loss Measurements Compared With Specular Microscopy
Purpose: The aims of this study were 1) to compare area of cell loss (ACL) on trypan staining with ACL on specular imaging and 2) to evaluate the use of automated software for measuring ACL on trypan staining. Methods: Donor corneas with transplant-grade endothelium were mechanically injured with an 18-gauge cannula and a Fogla deep anterior lamellar keratoplasty dissector tip to create an easily identifiable “bullseye” pattern of cell death. Each cornea was then stained with trypan blue 0.06% for 90 seconds and imaged at 2× magnification. ACL on staining was measured using manual (ImageJ, Nati...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Basic Investigation Source Type: research

Younger Donor Tissue in Descemet Membrane Endothelial Keratoplasty Surgery: Clinical Outcomes
Purpose: To determine whether using younger donor tissue for Descemet membrane endothelial keratoplasty (DMEK) surgery influences clinical outcomes. Methods: Scroll tightness, unscrolling time, rebubble rate, and preoperative and 3- and 6-month postoperative endothelial cell density (ECD) and endothelial cell loss (ECL) were compared for 661 DMEK grafts prepared from younger (aged younger than 50 yrs, n = 81) and older donors (aged 50 yrs or older, n = 580) with Student t test, χ2 test, or Mann–Whitney U test. Results: There was no difference in overall unscrolling time (younger donors: 3.1 &plu...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Impact of the COVID-19 Pandemic on Keratoplasty and Corneal Eye Banking
Conclusions: Despite a reduction in referrals and eligible corneal transplant donors at a single eye bank, there was a surplus of surgically suitable corneal tissue during the first wave of the COVID-19 pandemic. Eye banks should consider routine postmortem COVID-19 testing to identify asymptomatic infected donors although the risk of transmission of COVID-19 from infected donors is unknown. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Topical Erythropoietin as a Novel Treatment for Necrotizing Scleritis After Pterygium Surgery: A Pilot Study
Conclusions: Topical erythropoietin might be a safe and an effective method for treating cases of necrotizing scleritis that manifests immediately after pterygium surgery. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty in Toxic Anterior Segment Syndrome: A Case Series
Purpose: To evaluate the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients with toxic anterior segment syndrome (TASS). Methods: Thirteen eyes of 13 patients who underwent DMEK for endothelial decompensation secondary to TASS were retrospectively reviewed. A comprehensive ocular examination including best-corrected visual acuity (BCVA), slitlamp biomicroscopy, intraocular pressure measurement, fundus evaluation, and measurement of central corneal thickness were performed in all patients at preoperatively and postoperatively. Results: There were 8 men and 5 women, with an average ag...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report
Conclusions: The unexpected coincidence of pterygium and OSSN is frequent, although varies depending on the geographical location. We recommend performing a histopathology analysis on every pterygium removed. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Prevalence of Ocular Demodicosis in an Older Population and Its Association With Symptoms and Signs of Dry Eye
Conclusions: Demodex is highly prevalent in an older population with DE. Symptom of itching and CD were the findings most specific for Demodex. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Effects of Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea–Hypopnea Syndrome on Corneal Morphological Characteristics
Conclusions: Better oxygenation during sleep, resulting from increased CPAP adherence, had a significant influence on corneal endothelium, providing an improvement in corneal polymegathism and pleomorphism, with a potential return of CV and %Hex to their normal values. Greater improvement in polymegathism was observed in patients with greater proportion of NREM sleep. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Stripping Endothelial Keratoplasty Outcomes in Patients With Rheumatoid Arthritis
Purpose: To review the graft and visual outcomes in a series of patients with rheumatoid arthritis (RA) who underwent Descemet stripping endothelial keratoplasty (DSEK). Methods: In this case series, the electronic medical records at Wills Eye Hospital were queried for cases of patients with RA who underwent DSEK between January 1, 2009 and September 1, 2018. Charts were reviewed to obtain demographic data, medical history, ocular history, surgical variables, graft survival, and visual acuity outcomes. Results: During the study period, 22 transplants performed in 18 eyes of 15 patients with RA were eligib...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Evaluation of Ocular Surface and Meibomian Glands in Patients With Scleroderma
Purpose: To evaluate the prevalence of dry eye and meibomian gland dysfunction in patients with scleroderma. Methods: A total of 32 patients with scleroderma (study group) and 31 healthy subjects (control group) were enrolled. Besides routine ophthalmologic evaluation, Schirmer 1 test, tear break-up time, tear osmolarity, ocular surface staining with fluorescein (Oxford score), and Ocular Surface Disease Index (OSDI) score, meibomian gland dysfunction evaluation (foamy tears, telangiectasia of the eyelid, eyelid contour abnormalities, and meibomian plugs), and meibography were performed. Results: Sixty-fo...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Descemet Membrane Endothelial Keratoplasty in Congenital Hereditary Endothelial Dystrophy: Initial Experiences
Conclusions: DMEK may be a viable option in phakic eyes with CHED. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Limbal Stem Cell Deficiency Associated With Herpes Keratitis
Conclusions: Our data suggest that HK may be a risk factor for development of LSCD. Patients with HK should be monitored for the development of LSCD to reduce the risk of chronic ocular surface morbidity. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Use of Panel-Reactive Antibody Testing in the Planning and Management of Ocular Surface Stem Cell Transplantation
Purpose: Panel-reactive antibody (PRA) testing has been widely adopted in solid organ transplantation for risk assessment in potential allograft recipients but has not been studied in the context of ophthalmic transplantation. The purpose of this study is to evaluate outcomes in patients undergoing ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) relative to preoperative PRA level. Methods: This is retrospective chart review of all eyes with documented PRA level that underwent OSST for LSCD between May 2000 and March 2019 at a single institution. Eyes with stable ocular surf...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Evaluation of Electrolysis for Reis-Bücklers Corneal Dystrophies and In Vivo Histological Analysis Using Anterior Segment Optical Coherence Tomography
Conclusions: Corneal electrolysis is an excellent treatment option for corneal opacities caused by RBCD. Corneal electrolysis improves visual acuity without changing corneal thickness or refraction. Therefore, repeat corneal electrolysis over the years might be a preferred long-term treatment strategy for RBCD. Moreover, AS-OCT is suitable for evaluating the effectiveness of this treatment and might be useful during postoperative follow-up. (Source: Cornea)
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Conjunctival Vessels in Diabetes Using Functional Slit Lamp Biomicroscopy
This study used functional slit lamp biomicroscopy (FSLB) to quantify conjunctival microvessel parameters in individuals with and without diabetes and examined whether these metrics could be used as surrogate markers of diabetes-related complications. Methods: A cross-sectional study of 98 controls (C), 13 individuals with diabetes without complications (D–C), and 21 with diabetes and related complications (D+C), which included retinopathy, nephropathy, neuropathy, and cardiovascular-, peripheral vascular-, and cerebrovascular diseases, was performed. Bulbar conjunctival metrics (venule diameter, length, axial...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Herpes Zoster: A Brief Definitive Review
Abstract: This brief definitive review of herpes zoster (HZ) will cover the current state of knowledge and questions that remain to be answered regarding HZ in general and HZ ophthalmicus in particular. A question-and-answer format will be used to address various important topics related to this common and serious disease. Questions to be addressed relate to common misconceptions, contagiousness of infection, unknowns regarding pathogenesis, rising incidence, risk factors and complications, relationship with temporal arteritis, vaccination, and current and future antiviral treatment. In addition, the importance of the ...
Source: Cornea - July 8, 2021 Category: Opthalmology Tags: Invited Submission Source Type: research

Beware of Polymegathism
No abstract available (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Letters to the Editor Source Type: research

COVID-19 Pandemic Impact on Epidemic Keratoconjunctivitis
No abstract available (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Clinical Metagenomic Next-Generation Sequencing has the Potential to Reduce Costs in the Management of Microbial Keratitis Patients
No abstract available (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Empirical and Normative Research in Ethics in Eye Banking
No abstract available (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Do Eye Bank Models and Competitive Practice Affect International Cornea Allocation?
Conclusion: We mapped the pathways for corneas involved in export and import from the point of recovery to their point of transplantation. Although generalist in nature and limited by the paucity of the existing literature, our article outlines that different business models, partnerships, and applied methods influence corneal export and import. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Review Source Type: research

Corneal Donor Characteristics and Descemet Membrane Endothelial Keratoplasty Success: A Scoping Review
Conclusions: Further research into the area is warranted to better understand how donor characteristics impact preoperative DMEK graft preparation and intraoperative graft manipulation. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Review Source Type: research

Acute Benign Paroxysmal Positional Vertigo After Endothelial Keratoplasty–A Unique Cause of Postoperative Nausea and Headache
Conclusions: BPPV is a benign but rare complication of nonotologic surgery and has not been previously reported with ophthalmic surgery. The overlap in symptomatology between BPPV and other serious and potentially vision-threatening causes of postoperative nausea and headache, such as pupillary block glaucoma, makes this a relevant etiology to consider in the spectrum of postendothelial keratoplasty complications. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Supra-Descemetic Venting Incision in the Management of Spontaneous Descemet Membrane Detachment in an Old Penetrating Keratoplasty Graft
Conclusions: Late spontaneous DMD of the graft after PKP is very uncommon and must be differentiated from acute graft rejection. Anterior segment optical coherence tomography may help to diagnose this entity that can be managed successfully despite late intervention. The addition of a venting incision that drains fluid from the supra-Descemetic space can increase the chance of success of descemetopexy when compared with descemetopexy with air or gas alone. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Diffuse Lamellar Keratitis in a Patient Undergoing Collagen Corneal Cross-Linking 18 Years After Laser In Situ Keratomileusis Surgery
Conclusions: DLK is a potential sight-threatening complication of refractive surgery that can occur at any time in the postoperative period, even years after the procedure. Undergoing a subsequent corneal procedure that may disrupt or promote inflammation within the surgical flap–stromal interface, such as corneal collagen cross-linking, is a recognized risk factor for the development of DLK. This case suggests that patients with any history of LASIK surgery undergoing corneal cross-linking or other lamellar corneal surgeries may benefit from closer follow-up (eg, daily) than patients with no history of LASIK. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

“Doughnut” Amniotic Membrane Transplantation With Penetrating Keratoplasty for Vernal Keratoconjunctivitis With Limbal Stem Cell Disease
Conclusions: Severe VKC can cause ocular surface disease including LSCD with corneal scarring, especially in early-onset limbal form of VKC. The modified technique of AMT (doughnut AMT) along with PK can successfully visually rehabilitate and address partial LSCD in such patients. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Wound Healing of Descemet Membrane After Penetrating Keratoplasty and Its Relevance for Descemet Membrane Endothelial Keratoplasty Surgeons
Abstract: Compared with penetrating keratoplasty (PK), Descemet membrane endothelial keratoplasty (DMEK) is characterized as lower risk for complications such as immunological graft reaction and faster and better postoperative visual recovery. In patients with endothelial graft failure after PK, DMEK can be used to regenerate PK graft transparency. The surgical technique for DMEK in this specific situation is still under debate, particularly regarding stripping of Descemet membrane (DM) from the failed PK and diameter of the DMEK graft. Here we report a case of a 75-year-old female patient with a failed graft 16 years ...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Alkali Burn Over a LASIK Flap
Conclusions: A chemical burn over a LASIK flap poses a challenge for managing corticosteroids, which are required to prevent diffuse lamellar keratitis but can also contribute to keratolysis beyond the first week after an alkali injury. Oral corticosteroid therapy may be beneficial in this situation, with a low threshold to lift the LASIK flap and debride the interface if inflammation occurs. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Case Report: Suspected Donor Transmission of Acanthamoeba Keratitis After Deep Anterior Lamellar Keratoplasty
Conclusions: Several signs led us to believe that this case was donor-derived. There was little opportunity for graft exposure to the amoeba, and deep amoebic cysts and trophozoites were present on postoperative week 1—a highly unusual time course and depth of invasion for primary amoebic infection. In addition, pathological analysis revealed cysts only within the confines of the donor tissue and none in the recipient; Acanthamoeba cysts would have been present in the recipient rim tissue if the infection originated from the patient himself. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Pilot Study of Corneal Clearance With the Use of a Rho-Kinase Inhibitor After Descemetorhexis Without Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy
Purpose: To investigate corneal clearance time using a topical rho-kinase inhibitor, netarsudil, after descemetorhexis without endothelial keratoplasty (DWEK). Methods: Twenty eyes from 10 patients with Fuchs endothelial corneal dystrophy had DWEK with cataract surgery. For the first eye of each participant, netarsudil was administered immediately after surgery until corneal clearance. For the second eye, netarsudil was withheld 2 weeks beyond the time for corneal clearance of the first eye and then administered only if corneal edema was still present. Interpatient and intrapatient comparisons were made for pach...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Basic Investigation Source Type: research

Ink Retention and Endothelial Cell Viability After the Application of an Orientation Stamp Over an Air Bubble During Descemet Membrane Endothelial Keratoplasty Graft Preparation
Conclusions: The application of an orientation stamp to a DMEK graft over an air bubble in an eye bank setting results in a single, solid orientation mark that is readily visible within the period in which most eye bank-prepared tissue is used. This technique produces no further ECL compared with the methods where the orientation stamp is applied through a stromal window. Eye bank technicians and surgeons can be confident that this modified preparation technique results in transplant-quality DMEK grafts with the additional benefit of conserving the stromal cap for use in other anterior lamellar procedures, thereby maki...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Basic Investigation Source Type: research

Improved Outcome of Pythium Keratitis With a Combined Triple Drug Regimen of Linezolid and Azithromycin
Conclusions: The dual topical drug regimen with oral linezolid has good cure rates (over 80%) for Pythium keratitis over prolonged duration. It is recommended to persevere with medical therapy even in large infiltrates because more than two thirds resolved. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Refractive Outcomes After Descemet Membrane Endothelial Keratoplasty + Cataract/Intraocular Lens Triple Procedure: A Fellow Eye Comparison
Purpose: Descemet membrane endothelial keratoplasty is often combined with phacoemulsification and intraocular lens implantation (DMEK + cataract/IOL triple procedure) in phakic patients. This procedure results in a refractive shift that is difficult to predict. The aim of this study was to evaluate the hypothesis that the refractive shift in the second eye follows the shift in the first eye. Methods: In this retrospective, single-center, consecutive case series, the refractive outcomes of 254 eyes of 127 patients who underwent DMEK + cataract/IOL triple procedure in both eyes for Fuchs endothelial corneal dystr...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Prevalence and Risk Factors Associated With Corneal Perforation in Chronic Ocular Graft-Versus-Host-Disease
Purpose: To determine the prevalence and risk factors associated with corneal perforation in patients with chronic ocular graft-versus-host disease (oGVHD). Methods: We reviewed the case records of 405 patients diagnosed with chronic oGVHD over 8 years at a single academic center and assessed the prevalence of corneal perforation in the cohort. We reviewed patient demographics, indication for and type of hematopoietic stem cell transplantation (HSCT), time elapsed between HSCT and perforation, and clinical characteristics including oGVHD severity scores, ocular comorbidities, and topical medications at the time ...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Ocular Discomfort and Quality of Life Among Patients in the Dry Eye Assessment and Management Study
Conclusions: Among patients in the Dry Eye Assessment and Management study, worse ocular discomfort was associated with worse overall DED symptoms and interfered to a greater degree with activities of daily living. Ocular discomfort is an important part of the assessment of patients with DED. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Mini-Scleral Lenses Improve Vision-Related Quality of Life in Keratoconus
Purpose: To evaluate the effects of mini-scleral lenses on visual acuity (VA) and visual functioning in patients with keratoconus. Methods: This prospective, interventional study examined the effects of mini-scleral lenses on VA and visual functioning in patients with keratoconus. Patients younger than 18 years or with a history of refractive surgery or corneal graft surgery were excluded. Patients were fitted with mini-Misa lenses, Senso mini-scleral lenses, or Zenlens mini-scleral lenses. Outcome measures were scleral lens–corrected VA and vision-related quality of life as assessed with the National Eye ...
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Corneal Biomechanical Properties and Corneal Tomography Between Customized and Accelerated Corneal Crosslinking in Eyes with Keratoconus
Conclusions: C-CXL might improve the biomechanical properties and irregular shape of the cornea from the early postoperative period to a greater extent than A-CXL. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research

Phenotypic Characterization of Corneal Epithelium in Long-Term Follow-Up of Patients Post-Autologous Cultivated Oral Mucosal Epithelial Transplantation
Conclusions: In long-term follow-up of COMET, epithelium of successful patients demonstrated cornea-like phenotype, whereas failed cases revealed mainly conjunctival phenotype. However, there were evidences that oral mucosal epithelial cells remained across the cornea in both successful and failed COMET as detected by IVCM and ICIF. (Source: Cornea)
Source: Cornea - June 10, 2021 Category: Opthalmology Tags: Clinical Science Source Type: research