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No abstract available (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Corrected and reprinted letter Source Type: research

Pythium Insidiosum Keratitis: Histopathology and Rapid Novel Diagnostic Staining Technique
No abstract available (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Keratoconus and Personality—A Review
Conclusions: We hypothesize that the stage of life at which keratoconus commonly presents plays a crucial role in personality and coping mechanism development that significantly affects behavioral patterns and the relationship with caregivers. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Review Source Type: research

Recognizing and Managing Bullous Descemet Detachment Secondary to Accidental Hydroseparation During Phacoemulsification/Cataract Surgery by Relaxing Descemetotomy
Conclusions: Rarely stromal hydration performed with an irrigating cannula positioned too close to the posterior stroma can result in hydroseparation of DM creating BDD, seen intraoperatively as a fluid wave propagating across the posterior aspect of the cornea. Large folds, free mobility, and DM tear classically seen with rhegmatogenous Descemet detachment are not seen clinically or on ASOCT in BDD. Pneumodescemetopexy alone cannot resolve BDD because without a DM tear, SDF cannot evacuate. Combining relaxing Descemetotomy with pneumodescemetopexy allows SDF to drain internally and Descemet detachment to resolve. This t...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Role of Hemidivisional Corneal Topographic Astigmatisms (CorTs) in the Regularization and Reduction of Irregular Astigmatism
Conclusions: HemiCorTs allow for the design of hemidivisional corneal treatments of asymmetric nonorthogonal astigmatism. Such treatments should be suitable in the routine treatment of commonly occurring irregular astigmatism, while also allowing the spherical refractive error to be treated concurrently. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Selective Endothelial Removal for Peters Anomaly
Conclusions: Selective endothelial removal can potentially be used to treat cases of type 1 Peters anomaly. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Gout Keratitis: A Case of Peripheral Ulcerative Keratitis Secondary to Gout With a Review of the Literature
Conclusions: Gout is the most common type of inflammatory arthritis in adults with rising incidence and prevalence. Ocular findings in gout are common, but patients are usually asymptomatic. Monosodium urate crystal deposition has been reported to occur in various parts of the eye, with and without ocular inflammation. Crystal deposition in the cornea is extremely rare and may be a cause of peripheral ulcerative keratitis. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease
Conclusions: The clinical presentation of unilateral, posterior interstitial keratitis may be a rare manifestation of herpes simplex virus keratitis. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Outcomes of Corneal Cross-Linking Correlate With Cone-Specific Lysyl Oxidase Expression in Patients With Keratoconus
Conclusions: Our study demonstrates that preoperative levels of molecular factors such as LOX, MMP9, and COL IVA1 aid in understanding CXL outcomes at the tissue level. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Corneal Cross-Linking With Verteporfin and Nonthermal Laser Therapy
Purpose: To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo. Methods: Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined treatment of verteporfin with nonthermal laser therapy for 1 sequence (V+NTL1) or 6 sequences (V+NTL6) of 1 minute of NTL exposure. Positive controls were pretreated with 0.1% riboflavin/20% dextran every 3 to 5 minutes for 30 minutes and irradiated with ultraviolet light type A (λ = 370 nm, irr...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Femtosecond Laser-Assisted Small Incision Endokeratophakia Using a Xenogeneic Lenticule in Rhesus Monkeys
Purpose: To evaluate the feasibility and safety of xenogeneic endokeratophakia in rhesus monkeys and to explore the effects of a concave lenticule on refractive power. Methods: Three adult New Zealand white rabbits and 6 healthy rhesus monkeys were used. The xenogenic concave grafts were created from the rabbits using a modified small incision lenticule extraction technique; after being cryopreserved in glycerol for 1 week, the grafts were implanted into the monkey recipient corneas. Spherical equivalent (SE), central corneal thickness, and keratometry curvature were assessed preoperatively, 1 week, 1, 4 and 6 months ...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Persistence of the Cone on the Posterior Corneal Surface Affecting Corneal Aberration Changes After Intracorneal Ring Segment Implantation in Patients With Keratoconus
Purpose: To analyze the changes in anterior and posterior corneal surfaces and aberrations in patients who underwent intracorneal ring segment (ICRS) implantation for the treatment of keratoconus. Methods: Eighty-nine eyes of 59 patients with keratoconus who underwent ICRS implantation were analyzed. All eyes were evaluated using a tomography system combining a Placido disc and Scheimpflug photography before and at least 6 months after surgery. Total, anterior, and posterior corneal aberrations, anterior and posterior sagittal and tangential anterior and posterior curve analysis, keratometry (K), minimum corneal thick...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Changes in Central Corneal Thickness During Corneal Collagen Cross-Linking, Using Isotonic Riboflavin Solutions With and Without Dextran, in the Treatment of Progressive Keratoconus
Purpose: To compare intraoperative changes in central corneal thickness (CCT) during corneal cross-linking, using 2 different isotonic riboflavin solutions either with dextran or with hydroxy propyl methylcellulose, in the treatment of progressive keratoconus. Methods: In this retrospective study, we analyzed records of corneal thickness measurements, taken during various steps of cross-linking. Cross-linking was performed using either isotonic riboflavin with dextran (group A) or isotonic riboflavin with hydroxy propyl methylcellulose (without dextran) (group B). CCT measurements were recorded before and after epithe...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size
Conclusions: Variability exists when measuring corneal ulcers, even among ophthalmologists. Photography and computerized methods for quantifying the ulcer size could reduce variability while remaining accurate and impact quantitative measurement endpoints. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical Features, Antibiotic Susceptibility Profile, and Outcomes of Infectious Keratitis Caused by Stenotrophomonas maltophilia
Conclusions: Infectious keratitis due to S. maltophilia presents a treatment challenge because of its resistance to aminoglycosides and cephalosporins, which are typically used for empiric broad-spectrum gram-negative coverage as fortified solutions. Fluoroquinolones and polymyxin B/trimethoprim should be considered instead in cases of S. maltophilia infection. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Therapeutic Effects of Lamellar Keratoplasty on Terrien Marginal Degeneration
Purpose: To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD). Methods: Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated. Results: Mean age of the patients was 50.4 ± 16.8 years. The follow-up period was 2.5 ± 0.9 years. The uncorrected distance visual acu...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy
In this study, we determined changes in corneal optical properties associated with induced corneal edema. Methods: Twenty-three phakic eyes (23 participants) with FECD (grades 1–6, modified Krachmer scale) and 8 normal eyes (8 participants) were examined by Scheimpflug photography. Central corneal thickness, high-order aberrations from anterior and posterior corneal surfaces, and backscatter from the anterior, mid-, and posterior cornea were determined from the Scheimpflug images. A low-oxygen permeable contact lens was placed on the eye, and eyes were closed for 2 hours, after which the lens was removed and Schei...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Topical Tacrolimus as Adjuvant Therapy to Corticosteroids in Acute Endothelial Graft Rejection After Penetrating Keratoplasty: A Randomized Controlled Trial
Conclusions: Topical tacrolimus 0.05% as an adjunct to steroids can hasten the resolution of endothelial rejection of a PKP graft and potentially decreases the recurrence of rejection. However, it may not improve rejection reversal success. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Reconsidering Sequential Double Running Suture Removal After Penetrating Keratoplasty: A Prospective Randomized Study Comparing Excimer Laser and Motor Trephination
Purpose: We assessed the impact of sequential double running suture removal on corneal curvature after penetrating keratoplasty (PK), comparing mechanical and nonmechanical excimer laser trephination. Methods: PK was performed in 134 patients (mean age 51 ± 18 yrs) using either the excimer laser [excimer, n = 60 (37 keratoconus and 23 Fuchs dystrophy)] or motor trephination [control, n = 74 (44 keratoconus and 30 Fuchs dystrophy)] and a double running cross-stitch suture. Refractometry, Zeiss keratometry, and Tomey corneal topography were performed before removal of the first suture (15.2 ± 4.2 mo) and i...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Characterization of Corneal Endothelial Injury During Penetrating Keratoplasty
Purpose: To characterize corneal endothelial injury during penetrating keratoplasty in a controlled wet laboratory environment using human tissue. To identify potential areas or steps within surgery in which insult to the corneal endothelium may be most affected by trauma during routine penetrating keratoplasty. Methods: Human donor corneas (n = 12) with intact endothelium underwent experimental penetrating keratoplasty. Endothelial injury was evaluated after each suture quartile using trypan staining, a validated modality for assessing endothelial injury. Insult was quantified using high-resolution photography and co...
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Corneal Transplantation in New Zealand 2000 to 2009
Conclusions: In this study of 941 consecutive, principally penetrating, corneal transplants, adverse events were found to be more common than typically reported. In an era in which PKP is increasingly substituted by lamellar surgery, this provides useful insight into operative and postoperative adverse events in penetrating surgery. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Visual Outcomes and Aberrometric Changes With Topography-Guided Photorefractive Keratectomy Treatment of Irregular Astigmatism After Penetrating Keratoplasty
Conclusions: Twelve months postoperatively, the BSCVA improved significantly, the lines of vision increased, and astigmatism, corneal best-fit sphere, mean keratometry, corneal thickness, corneal root mean square total, and corneal spherical aberrations decreased. TG-PRK with MMC is a good alternative for correcting post-PKP cases with irregular astigmatism with elevated higher-order aberrations. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Incidence of Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty
Conclusions: Although CME frequently occurred after DMEK, no CME risk factors were identified. In addition, CME did not significantly affect long-term visual outcomes when it was appropriately treated. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Sulfur Hexafluoride (SF6) and Air Tamponade in Noniridectomized Descemet Membrane Endothelial Keratoplasty
Conclusions: Use of air with it being readily available and short acting is a good method of Descemet membrane tamponade in noniridectomized DMEK. (Source: Cornea)
Source: Cornea - February 7, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Cornea Peer Reviewers for 2017
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Azithromycin in the Management of Pythium insidiosum Keratitis
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Corneal Endothelial and Myotonic Dystrophy
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Limbal Stem Cell Preservation During Proton Beam Irradiation for Diffuse Iris Melanoma
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Artificial Anterior Chamber Pressure and Corneal Thinning Rate in UT-DSAEK
No abstract available (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein
Conclusions: Corneal lymphatic vessels can be easily imaged in vivo in the murine model using intrastromal fluorescein injection. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Partitioning an Artificial Anterior Chamber With a Latex Diaphragm to Simulate Anterior and Posterior Segment Pressure Dynamics: The “DMEK Practice Stage,” Where Surgeons Can Rehearse the “DMEK Dance”
Conclusions: We present a novel in vitro model of the human eye that more closely mimics the anterior and posterior segment pressure dynamics of in vivo DMEK surgery than average human and animal cadaveric globes. The model is easy to assemble, inexpensive, and applicable to a range of teaching environments. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Techniques Source Type: research

Three Hundred Sixty-Degree Fuchs Superficial Marginal Keratitis Managed With Annular Lamellar Keratoplasty
Conclusions: We report an extensive case of Fuchs superficial marginal keratitis treated with 360-degree annular lamellar keratoplasty. This technique provides tectonic support to decrease the likelihood of future perforation while also improving vision by modifying the ectatic cornea. Anterior segment optical coherence tomography may be a helpful tool preoperatively to avoid severely thinned areas (eg, during pseduopterygium removal) and to ensure complete removal of the ectatic cornea. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome
Conclusions: Filamentary keratitis is a chronic, recurrent condition that can be challenging to treat. Effective management requires careful consideration of possible predisposing causes, especially in refractory cases. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Benign Reactive Lymphoid Hyperplasia of the Conjunctiva Treated With Cyclosporine
Conclusions: This report represents the first case of benign ocular RLH responsive to topical cyclosporine therapy. We believe that cyclosporine could play a role in treating patients with benign ocular RLH and warrants further investigation to evaluate its full efficacy. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Severe Phenotype of Keratitis–Ichthyosis–Deafness Syndrome With Presumed Ocular Surface Squamous Neoplasia
Conclusions: KID syndrome is a very rare disease that has been reported with an incremental incidence of squamous cell carcinoma of the mucous membranes and skin (12%–15%). Here, we presented a case of severe systemic KID syndrome with ocular surface squamous neoplasia. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Case Report Source Type: research

Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities
Conclusion: A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Special Article Source Type: research

High Permeability and Intercellular Space Widening With Brimonidine Tartrate Eye Drops in Cultured Stratified Human Corneal Epithelial Sheets
Conclusions: The toxicity of 0.1% brimonidine containing sodium chlorite for HCES was lower than that of ophthalmic preparations containing BAC. Reduction of the barrier function occurred after HCES were exposed to brimonidine because of widening of intercellular junctions. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Can Appropriate Systemic Treatment Help Protect the Cornea in Patients With Rheumatoid Arthritis? A Multidisciplinary Approach to Autoimmune Ocular Involvement
Conclusions: There was no clear correlation between RA-NPIs and pathologic corneal findings in our study. DMARDs treatment may help maintain corneal integrity in our patients and prevented collagenolytic manifestations of RA. Other medications such as azathioprine should be used carefully, as endothelial damage may potentially occur. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Diagnostic Evaluation of Co-Occurrence of Acanthamoeba and Fungi in Keratitis: A Preliminary Report
Conclusions: Acanthamoeba can coexist with other forms of microbial keratitis. The frequency of infection coexistent or otherwise is higher than reported, and the possibility of coinfection must be considered especially in unresponsive cases. Including nonnutrient agar and confocal microscopy in all cases of keratitis would perhaps translate into better treatment strategies and outcomes. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Meibomian Glands and Ocular Surface Changes After Closure of Meibomian Gland Orifices in Rabbits
Conclusions: Meibomian gland orifice closure reduced corneal wetting property and induced meibomian gland duct dilation accompanied by shrinkage of secretory acini. Meibography could not detect early changes in the meibomian gland after closure of the orifice. Therefore, when the orifice is obstructed, more active treatments are needed before structural changes occur. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Sealing of Corneal Lacerations Using Photoactivated Rose Bengal Dye and Amniotic Membrane
Conclusions: The results of these studies established that a light-activated method to cross-link AM to the cornea can be used for sealing complex penetrating wounds in the cornea and sclera with minimal inflammation or secondary effects. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Basic Investigation Source Type: research

Ocular Surface Alterations in the Context of Corneal In Vivo Confocal Microscopic Characteristics in Patients With Fibromyalgia
Purpose: To quantify the morphology of corneal basal epithelium and subbasal nerves and to evaluate the ocular surface alterations in patients with fibromyalgia (FM). Methods: Patients with FM (n = 34) and healthy controls (n = 42) were enrolled. All participants underwent ocular surface tests in the following order: corneal sensitivity, tear film breakup time, lissamine green staining, Schirmer test, and the Ocular Surface Disease Index questionnaire. Basal epithelial cells and subbasal nerves were evaluated using in vivo confocal microscopy (IVCM). Demographic characteristics, Visual Analog Scale for Pain (VAS), Ame...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Comparison of Pterygium Recurrence Rates Among Different Races and Ethnicities After Primary Pterygium Excision by Surgeons in Training
Conclusions: Hispanic and black patients are more likely to experience pterygium recurrence after AMG than CAG. White patients are less likely than Hispanic or black patients to experience recurrence regardless of the surgical technique. To reduce the likelihood of recurrence, surgeons may consider race and ethnicity when selecting their operative technique. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Pilot Study Comparing Topical Anesthetic Agents in Pterygium Surgery: Subconjunctival Injection Versus 2% Lidocaine Gel Versus 5% Lidocaine Gel
Purpose: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. Methods: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure. The primary outcome was pain, which was experienced during and after surgery. The assessment was done using a 10-point linear analog scale at predete...
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research

Amniotic Membrane Grafts to Reduce Pterygium Recurrence
Conclusions: Adjunctive use of AMT and short exposure of MMC can reduce recurrence after pterygium surgery. The procedure is less tedious and less time consuming, resulting in early recovery while saving the conjunctiva for future surgeries. (Source: Cornea)
Source: Cornea - January 17, 2018 Category: Opthalmology Tags: Clinical Science Source Type: research