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No abstract available (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Evaluating a Simpler Method of Noncontact Infrared Meibography Using Still Photography
No abstract available (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

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No abstract available (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis
No abstract available (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Use of Topical Steroids in Conjunctivitis: A Review of the Evidence
Conclusions: Corticosteroids, in combination with anti-infectives, could be a promising treatment option for acute conjunctivitis subject to development of further evidence on their effectiveness and safety in conjunctivitis treatment. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Review Source Type: research

Microscope-Integrated Optical Coherence Tomography-Guided Drainage of Acute Corneal Hydrops in Keratoconus Combined With Suturing and Gas-Aided Reattachment of Descemet Membrane
Conclusions: MI-OCT guided micropuncture of stromal edema combined with compression sutures and SF6 tamponade is a new therapeutic option in acute corneal hydrops with small Descemet membrane defects. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Long-Term Stability With the Athens Protocol (Topography-Guided Partial PRK Combined With Cross-Linking) in Pediatric Patients With Keratoconus
Purpose: To evaluate the safety, efficacy, and stability of topography-guided partial PRK combined with corneal cross-linking (CXL) (the Athens Protocol [AP]) in pediatric patients with keratoconus over a 4-year follow-up period. Methods: This prospective study included 39 keratoconic eyes of 21 patients younger than 18 years with clinical and imaging evidence of keratoconus progression. Partial topography-guided excimer laser ablation in conjunction with high-fluence CXL was performed in all patients according to the AP. Uncorrected distance visual acuity, corrected distance visual acuity, refraction, keratometry, en...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Mini-Descemet Membrane Endothelial Keratoplasty for the Early Treatment of Acute Corneal Hydrops in Keratoconus
Conclusions: Mini-DMEK could be helpful in patients with larger defects and detachments of DM in very ectatic corneas in the acute phase of corneal hydrops in acute keratoconus. These patients may not be successfully treated by intracameral gas application alone or in combination with pre-Descemetal sutures. Further investigations are needed to identify factors helping to decide on the best surgical approach in hydrops in acute keratoconus. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Corneal Edema Associated With Systemic Dopaminergic Agents
Conclusions: Methylphenidate, ropinirole, and resiniferatoxin have different mechanisms of actions but have a common end point leading to increased dopamine. We believe that these agents are linked with the reversible corneal edema seen in our 3 patients. This strongly correlates with previous studies that have linked amantadine, a drug that blocks dopamine reuptake, to reversible corneal edema. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Corneal Perforation After Corneal Cross-Linking in Keratoconus Associated With Potentially Pathogenic ZNF469 Mutations
Purpose: To report a case of bilateral and repetitive corneal perforations after corneal cross-linking (CXL) for keratoconus in a woman harboring potentially pathogenic variants in the ZNF469 gene and to characterize the keratoconus phenotype in this woman and her daughter who shared the same ZNF469 mutations. Methods: Clinical characterization of the proband and her daughter followed by sequencing of the genes associated with brittle cornea syndrome, ZNF469 and PRDM5, in both individuals. Results: An Ashkenazi Jewish woman in her sixth decade presented with diffuse corneal thinning and progressive steepening consi...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Lateral Antebrachial Cutaneous Nerve as Autologous Graft for Mini-Invasive Corneal Neurotization (MICORNE)
Conclusions: We report the first case of MICORNE, a novel surgical technique of corneal neurotization in a herpetic patient with NK. Despite the potential risk of viral recurrence, our patient showed dramatic improvement in corneal sensation and visual acuity. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Safety of Long-Term Storage and Shipping of Prestripped, Prestained, and Preloaded Descemet Membrane Endothelial Keratoplasty Tissue
Purpose: The purpose of this study was to determine the safety of long-term storage and shipping of prestripped, prestained, and preloaded Descemet membrane endothelial keratoplasty (p3DMEK) grafts. Methods: A total of 33 cadaveric corneas were prestripped, prestained, and preloaded using modified Jones tube injectors as p3DMEK. The corneas were masked to groups that were prepared (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Stability and Sterility of Extemporaneously Prepared Nonpreserved Cefazolin, Ceftazidime, Vancomycin, Amphotericin B, and Methylprednisolone Eye Drops
Conclusions: The NoMR group showed that the drug significantly degraded rapidly for cefazolin, ceftazidime, and amphotericin B. Implementation of MR could decrease the predicted loss of concentration per day for cefazolin and ceftazidime. In vitro antimicrobial activity and sterility were retained for 28 days. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

N-chlorotaurine Inactivates Acanthamoeba and Candida albicans in the Porcine Ex Vivo Corneal Infection Model
Conclusions: NCT inactivates A. castellanii and C. albicans in corneal tissue. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Changes in Corneal Wound Healing and Graft Biomechanics After Primary Penetrating Keratoplasty Versus Repeat Penetrating Keratoplasty
Purpose: To evaluate and compare the influence of the wound healing process at the graft edge on corneal biomechanics after primary penetrating keratoplasty (PK) and repeat PK. Methods: This retrospective comparative study included 95 eyes: 35 eyes of 35 patients had PK, 40 eyes of 40 patients underwent repeat PK, and 20 eyes of 20 normal subjects served as the control group. The ocular response analyzer was used to measure and compare corneal hysteresis and corneal resistance factor among the study groups at least 6 months after all sutures were removed. In vivo confocal microscopy was used to study the corneal wound...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Central Corneal Thickness in Childhood Cataract
Conclusions: In children, CCT is likely independent of cataract morphology. This implies that factors other than preoperative malformation are more likely related to elevated CCT observed in children with aphakia and pseudophakia. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Scheimpflug Imaging of the Danish Cohort of Patients With Wilson Disease
Conclusions: ImageJ-based analysis of Pentacam images has a high sensitivity in detecting Kayser–Fleischer rings and can be used as a diagnostic procedure for Wilson disease and may be a tool to monitor the disease in an objective manner. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Long-Term Results of Accelerated Corneal Cross-Linking in Adolescent Patients With Keratoconus
Conclusions: After an average follow-up of 56 months, progression was determined in 20% of the eyes despite appropriate treatment. In the last visit, progression was found to be associated with K1, K2, CCT, TTPC, and age. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Scleral Lenses on Corneal Topography in Keratoconus: A Case Series of Cross-Linked Versus Non–Cross-Linked Eyes
Purpose: To evaluate the changes in anterior corneal topography induced by short-time wear of scleral contact lenses (SLs) in keratoconic subjects with and without a history of corneal cross-linking (CXL). Methods: Nine keratoconic patients (14 eyes) were fitted with 18.5 mm SLs for optical rehabilitation. Subjects were divided into 2 groups: 7 eyes without a history of CXL (Non-CXL group) and 7 with a history of CXL (CXL group). Corneal topography was performed at baseline and after 2 and 5 hours of lens wear. The differences for simulated flat (Kflat), steep (Ksteep) and maximal (Kmax) corneal curvatures, central co...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Transepithelial Phototherapeutic Keratectomy Followed by Corneal Collagen Crosslinking for the Treatment of Pellucid Marginal Degeneration: Long-term Results
Purpose: To evaluate visual, refractive, topographic, and aberrometric outcomes of transepithelial phototherapeutic keratectomy (PTK) + corneal collagen crosslinking in the treatment of pellucid marginal degeneration. Methods: This retrospective study includes 20 eyes of 15 patients with pellucid marginal degeneration treated with transepithelial PTK + accelerated corneal collagen crosslinking. Visual acuity, refraction, topographic keratometry, pachymetry, and aberrations were recorded pretreatment and 6, 12, 24, and 36 months after treatment. Results: Stabilization in visual acuity was observed throughout the 36 ...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Anterior Chamber Rebubbling With Perfluoropropane (C3F8) After Failed Rebubbling Attempts for Persistent Descemet Membrane Endothelial Keratoplasty Graft Detachments
Conclusions: Tamponade using nonexpansile 10% C3F8 gas can attach partially detached DMEK grafts after the failure of previous air- or SF6-assisted rebubbling attempts. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Graft Shift Direction on Graft Detachment and Endothelial Cell Survival After Descemet Membrane Endothelial Keratoplasty
Conclusions: Graft shift direction in DMEK, especially inferior graft shift, affected the postoperative graft detachment rate. Superior graft shift had a beneficial effect on postoperative corneal endothelial values. These data suggest that inferior graft shift should be avoided in DMEK. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Changes in Corneal Biomechanical Properties After Descemet Membrane Endothelial Keratoplasty
Conclusions: DMEK affects both measured corneal biomechanical properties in patients with FECD: CH and CRF. This has to be taken into account for the accuracy of intraocular pressure measurements. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Subtenon Bupivacaine for Postoperative Pain in Patients Undergoing Pterygium Excision: A Double-Blinded Randomized Control Trial
Purpose: Patients undergoing primary pterygium excision with autologous conjunctival autograft and human tissue adhesive in New Zealand, currently receive subconjunctival anesthesia with oral postoperative analgesia for pain. Our aim was to investigate the potential added benefit of intraoperative subtenon bupivacaine to this regimen. Methods: A double-blinded, placebo-controlled, randomized trial was conducted at 2 centers. All patients received topical and subconjunctival anesthesia intraoperatively, with standardized oral analgesia as required postoperatively. Participants were allocated to receive subtenon bupivac...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Safety and Efficacy of Supratarsal Triamcinolone for Treatment of Vernal Keratoconjunctivitis in Ireland
Purpose: To describe the clinical features, risk factors, and treatment outcomes after supratarsal injection of triamcinolone for vernal keratoconjunctivitis (VKC). Methods: A retrospective review of all patients treated with supratarsal triamcinolone for VKC between February 2002 and May 2017 at the Royal Victoria Eye and Ear Hospital and Our Lady's Children Hospital Crumlin, Dublin, Ireland, was performed. Results: Twenty-five patients, 46 eyes, and 145 injections were included for analysis. The mean age at first injection was 9.1 ± 5.7 years. Ninety-six percent of the patients were male. A seasonal variat...
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Tuck-In Tenon Patch Graft in Corneal Perforation
Conclusions: TPG is a safe, simple, inexpensive, and an effective technique for the management of corneal perforations. The advantages include the autologous nature of the graft, cost effectiveness, and easy availability. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Toxic Keratitis After Application of Custard Apple Seed for Head Lice Infestation
Conclusions: Health education about the harmful effect of this traditional practice for head lice infestation will prevent further similar events. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Anterior Segment Optical Coherence Tomography Images in Microsporidial Keratoconjunctivitis
Conclusions: AS-OCT represents an alternative, noninvasive tool to diagnose microsporidial keratoconjunctivitis, especially if corneal scraping is not possible. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Microbial Keratitis in Stevens–Johnson Syndrome: A Prospective Study
Conclusions: Infective keratitis in SJS is common, and unlike routine cases, surgical intervention is often required. However, the antibiotic sensitivity pattern suggests that resistance is not that high. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Medication Burden for Patients With Bacterial Keratitis
Conclusions: Older patients and those with positive cultures incur the most medication burden in treatment of BK. Providers should be aware of medication usage and cost burden as it may affect compliance with treatment. (Source: Cornea)
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Reply
No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on: “Descemet Membrane Endothelial Keratoplasty After Failed Penetrating Keratoplasty”
No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

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No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on: “Micropulse Transscleral Cyclophotocoagulation in Keratoplasty Eyes”
No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

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No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Comment on: “Comparison of Graft Thickness Measured by an Eye Bank With Graft Thickness Measured After Descemet Stripping Automated Endothelial Keratoplasty”
No abstract available (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Perioperative Corneal Abrasions After Nonocular Surgery: A Systematic Review
Conclusions: Standardized ocular protection, reporting, and education initiatives were found to maximally decrease rates of perioperative corneal abrasions after nonocular surgery. However, no gold standard currently exists for intraoperative ocular protection. More research needs to be conducted on specific prevention strategies and content of educational initiatives in hopes of standard development across facilities nationwide. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Review Source Type: research

Implementation of a Quality Index for Improvement of Quantification of Corneal Nerves in Corneal Confocal Microcopy Images: A Multicenter Study
Purpose: Corneal confocal microscopy (CCM) is an imaging method to detect loss of nerve fibers in the cornea. The impact of image quality on the CCM parameters has not been investigated. We developed a quality index (QI) with 3 stages for CCM images and compared the influence of the image quality on the quantification of corneal nerve parameters using 2 modes of analysis in healthy volunteers and patients with known peripheral neuropathy. Methods: Images of 75 participants were a posteriori analyzed, including 25 each in 3 image quality groups (QI 1–QI 3). Corneal nerve fiber length (CNFL) was analyzed using aut...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Techniques Source Type: research

Multimodal Imaging Report of Crystalline Keratopathy in Relapsing Polychondritis
Conclusion: A central keratopathy is not typically reported in patients with RP. In this case report, we describe a unique diffuse bilateral nummular mid-stromal crystalline keratitis that extends into the central cornea and further define it using multimodal imaging. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis
Conclusions: This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient. Further clinical evidence would be needed to possibly incorporate this medication in the antiamoebic armamentarium. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea
Conclusions: Corneal GPR18 activation induced both chemotaxis and proliferation in corneal epithelial cells in vitro and impacted wound healing. GPR18 may contribute to the maintenance of corneal integrity. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Effect of Optisol Supplementation With 0.255 μg/mL Amphotericin B on Elimination of Yeast at 5°C
Conclusions: AmpB at a concentration of 0.255 μg/mL in Optisol-GS at cold storage (2°C–8°C) over 48 hours did not eliminate yeast from corneal tissue. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Basic Investigation Source Type: research

Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa
Conclusions: Asfotase alfa was invariably associated with development of mild focal conjunctival calcification, likely through disinhibition of hydroxyapatite crystal propagation. The calcifications were not symptomatic or vision-threatening and should not preclude enzyme replacement therapy for patients with this rare and often debilitating disease. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography
Conclusions: OCTA can be useful to visualize CoNV, which may be valuable in assessing corneal graft rejection. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Expressible Meibomian Glands Have Occult Fixed Obstructions: Findings From Meibomian Gland Probing to Restore Intraductal Integrity
Purpose: To describe and quantify findings of intraductal obstruction during probing expressible and nonexpressible meibomian glands (MGs) in patients with obstructive meibomian gland dysfunction using a 1-mm intraductal MG probe. Methods: A retrospective study of probe findings from 108 consecutive patients. Nonparametric tests using SPSS software 25.0 to explore relationships between expressibility and probe findings. Results: Of 11,776 probed glands of 404 lids, 84% showed mechanical resistance (MR) and 16% showed no resistance (NR). Fixed, firm, focal unyielding resistance (FFFUR) occurred in 79.5% of obstructe...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Changes in Endothelial Cell Count Up to Three Years After Implantation of Toric Implantable Collamer Lenses
Purpose: To determine the temporal effect of toric implantable collamer lens (TICL) implantation and location on corneal endothelial cell density (ECD) over a period of 36 months after surgery. Methods: ECD [number of cells per square millimeter estimated using the Specular Microscope SP-1P (Topcon Europe Medical B.V., Netherlands)] data were collected from cases deemed suitable for the TICL (VTICMO, VTICM5; STAAR Surgical, Nidau, Switzerland). The preoperative refractive error (sphere and cylinder) ranged from −1.00 to −22.25 diopter sphere and from −0.50 to −5.50 diopter cylinder. ECD was eva...
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Causes and Management Outcomes of Acquired Corneal Opacity in a Preschool Age (0–5 Years) Group: A Hospital-Based Study
Conclusions: Chemical injury and keratomalacia are the major causes of acquired corneal opacity in preschool age groups in India and are associated with poor visual prognosis. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Effect of Riboflavin Solution With Hydroxypropyl Methylcellulose and Eyelid Speculum on Pachymetry Changes During Accelerated Collagen Crosslinking
Purpose: To assess corneal thickness changes with isotonic riboflavin (RF) solution with hydroxylpropyl methylcellulose in patients undergoing accelerated corneal collagen crosslinking (CXL) with and without an eyelid speculum. Methods: Fifty-two eyes of 48 patients with progressive keratoconus were enrolled in this study. The patients in this study were divided into 2 groups: in group 1 an eyelid speculum was removed during 20-minute RF (0.1%) + hydroxylpropyl methylcellulose (Mediocross M; Avedro Inc, Waltham, MA) instillation, and in group 2 the eyelid speculum was retained in place during the entire CXL procedure....
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Iontophoretic Transepithelial Collagen Cross-Linking Versus Epithelium-Off Collagen Cross-Linking in Pediatric Patients: 3-Year Follow-Up
Conclusions: In pediatric patients, 3 years after treatment, epi-off CXL halted keratoconus progression in 75% of eyes, whereas I-ON CXL seemed to slow down keratoconus progression in 50% of eyes, mainly in those with highest Kmax and paracentral cone. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

The Outcome of Scleral Lens Fitting for Keratoconus With Resolved Corneal Hydrops
Conclusions: Scleral lenses are effective for providing satisfactory visual acuity after corneal hydrops in keratoconus. A scleral lens trial is advised before listing patients for graft surgery. (Source: Cornea)
Source: Cornea - June 7, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research