Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors
CONCLUSION: In this work we implemented MFPCA to identify variation in movement patterns during sitting bouts, and showed that these patterns were associated with cardiovascular health. Unlike existing methods, MFPCA does not require pre-specified cut-points to define activity intensity, and thus offers a novel powerful statistical tool to elucidate variation in SB patterns and health.TRIAL REGISTRATION: ClinicalTrials.gov NCT03473145; Registered 22 March 2018; https://clinicaltrials.gov/ct2/show/NCT03473145 ; International Registered Report Identifier (IRRID): DERR1-10.2196/28684.PMID:38671485 | DOI:10.1186/s12966-024-015...
Source: Health Physics - April 26, 2024 Category: Physics Authors: Rong W Zablocki Sheri J Hartman Chongzhi Di Jingjing Zou Jordan A Carlson Paul R Hibbing Dori E Rosenberg Mikael Anne Greenwood-Hickman Lindsay Dillon Andrea Z LaCroix Loki Natarajan Source Type: research
Medical Malpractice Cases Involving Medical Students
CONCLUSIONS: Medical malpractice claims involving medical students are rare but commonly relate to medical decision-making, procedural complication, and poor communication, with a lack of supervision being frequently cited. These results can be used to guide students and supervising physicians on how to avoid scenarios that may increase vulnerability to medical malpractice lawsuits.PMID:38669133 | DOI:10.1097/ACM.0000000000005746 (Source: Pain Physician)
Source: Pain Physician - April 26, 2024 Category: Anesthesiology Authors: Jordan R Pollock Eric Shappell Benjamin J Sandefur M Lane Moore Rachel A Lindor Source Type: research
Variable CGRP family peptide signaling durations and the structural determinants thereof
Biochem Pharmacol. 2024 Apr 24:116235. doi: 10.1016/j.bcp.2024.116235. Online ahead of print.ABSTRACTCalcitonin gene-related peptides alpha and beta (αCGRP, βCGRP), adrenomedullin (AM), and adrenomedullin 2/intermedin (AM2/IMD) function in pain signaling, neuroimmune communication, and regulation of the cardiovascular and lymphatic systems by activating either of two class B GPCRs, CLR and CTR, in complex with a RAMP1, -2, or -3 modulatory subunit. Inspired by our recent discovery that AM2/IMD(1-47) activation of CLR-RAMP3 elicits long duration cAMP signaling, here we used a live-cell cAMP biosensor assay to characterize...
Source: Biochemical Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Katie M Babin Sandra E Gostynska Jordan A Karim Augen A Pioszak Source Type: research
Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice
CONCLUSION: Hydroxychloroquine inhibited hemolysis-induced arterial thrombosis ex-vivo and improved pulmonary perfusion in hemin-treated mice, supporting a potential benefit of its use as an adjuvant therapy in hemolytic diseases to limit arterial thrombosis and to improve organ perfusion.PMID:38670315 | DOI:10.1016/j.jtha.2024.04.008 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 26, 2024 Category: Hematology Authors: Joshua H Bourne Gina Perrella Juma El-Awaisi Lauren V Terry Veronika Tinkova Rebecca L Hogg Poppy Gant Beata Grygielska Neena Kalia Dean Kavanagh Alexander Brill Jordan D Dimitrov Steve P Watson Julie Rayes Source Type: research
Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors
CONCLUSION: In this work we implemented MFPCA to identify variation in movement patterns during sitting bouts, and showed that these patterns were associated with cardiovascular health. Unlike existing methods, MFPCA does not require pre-specified cut-points to define activity intensity, and thus offers a novel powerful statistical tool to elucidate variation in SB patterns and health.TRIAL REGISTRATION: ClinicalTrials.gov NCT03473145; Registered 22 March 2018; https://clinicaltrials.gov/ct2/show/NCT03473145 ; International Registered Report Identifier (IRRID): DERR1-10.2196/28684.PMID:38671485 | PMC:PMC11055353 | DOI:10.1...
Source: Health Physics - April 26, 2024 Category: Physics Authors: Rong W Zablocki Sheri J Hartman Chongzhi Di Jingjing Zou Jordan A Carlson Paul R Hibbing Dori E Rosenberg Mikael Anne Greenwood-Hickman Lindsay Dillon Andrea Z LaCroix Loki Natarajan Source Type: research
Variable CGRP family peptide signaling durations and the structural determinants thereof
Biochem Pharmacol. 2024 Apr 24;224:116235. doi: 10.1016/j.bcp.2024.116235. Online ahead of print.ABSTRACTCalcitonin gene-related peptides alpha and beta (αCGRP, βCGRP), adrenomedullin (AM), and adrenomedullin 2/intermedin (AM2/IMD) function in pain signaling, neuroimmune communication, and regulation of the cardiovascular and lymphatic systems by activating either of two class B GPCRs, CLR and CTR, in complex with a RAMP1, -2, or -3 modulatory subunit. Inspired by our recent discovery that AM2/IMD(1-47) activation of CLR-RAMP3 elicits long duration cAMP signaling, here we used a live-cell cAMP biosensor assay to characte...
Source: Biochemical Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Katie M Babin Sandra E Gostynska Jordan A Karim Augen A Pioszak Source Type: research
GSE236239 Novel spirocyclic dimer, SpiD3, targets critical tumor survival pathways and displays potent preclinical activity in B-cell chronic lymphocytic leukemia
Contributors : Alexandria P Eiken ; Achyuth Kalluchi ; Jordan Rowley ; Dalia El-GamalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic lymphocytic leukemia (CLL) cell survival and growth is fueled by aberrant activation of various pro-survival signaling pathways within tumor niches. Specifically, B-cell receptor (BCR) signaling, toll-like receptor signaling, and supportive cellular interactions drive constitutive activation of NF- κB signaling and transcription of proliferative/pro-survival genes. Directly targeting the NF-κB pathway has been a challenge, however, herein, w...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors
Sedentary behavior (SB) is a recognized risk factor for many chronic diseases. ActiGraph and activPAL are two commonly used wearable accelerometers in SB research. The former measures body movement and the lat... (Source: International Journal of Behavioral Nutrition and Physical Activity)
Source: International Journal of Behavioral Nutrition and Physical Activity - April 26, 2024 Category: Nutrition Authors: Rong W. Zablocki, Sheri J. Hartman, Chongzhi Di, Jingjing Zou, Jordan A. Carlson, Paul R. Hibbing, Dori E. Rosenberg, Mikael Anne Greenwood-Hickman, Lindsay Dillon, Andrea Z. LaCroix and Loki Natarajan Tags: Research Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England
This study carried out a multivariable regression analysis of publicly available data and found that deprivation is associated with a statistically significant increase in the proportion of patients receiving an OCS prescription for asthma or COPD at a GP practice level (p < 0.001). The model estimated that the proportion of prescriptions is 1.88% (95% CI 1.83% to 1.92%) and 2.84% (95% CI 2.70% to 2.98%) for the least deprived GP practice and the most deprived GP practice, respectively. This study lays the groundwork for future research using individual patient level data to consider the impact of variation in OCS presc...
Source: Primary Care - April 25, 2024 Category: Primary Care Authors: Erin Barker Jessica Pocock Joe Moss Nick Hex Jordan Rankin Richard Hudson Source Type: research
Don't SNARC me now! Intraindividual variability of cognitive phenomena - Insights from the Ironman paradigm
Cognition. 2024 Apr 24;248:105781. doi: 10.1016/j.cognition.2024.105781. Online ahead of print.ABSTRACTTwo implicit generalizations are often made from group-level studies in cognitive experimental psychology and their common statistical analysis in the general linear model: (1) Group-level phenomena are assumed to be present in every participant with variations between participants being often treated as random error in data analyses; (2) phenomena are assumed to be stable over time. In this preregistered study, we investigated the validity of these generalizations in the commonly used parity judgment task. In the propose...
Source: Cognition - April 25, 2024 Category: Neurology Authors: Lilly Roth Verena Jordan Stefania Schwarz Klaus Willmes Hans-Christoph Nuerk Jean-Philippe van Dijck Krzysztof Cipora Source Type: research
The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England
This study carried out a multivariable regression analysis of publicly available data and found that deprivation is associated with a statistically significant increase in the proportion of patients receiving an OCS prescription for asthma or COPD at a GP practice level (p < 0.001). The model estimated that the proportion of prescriptions is 1.88% (95% CI 1.83% to 1.92%) and 2.84% (95% CI 2.70% to 2.98%) for the least deprived GP practice and the most deprived GP practice, respectively. This study lays the groundwork for future research using individual patient level data to consider the impact of variation in OCS presc...
Source: Respiratory Care - April 25, 2024 Category: Respiratory Medicine Authors: Erin Barker Jessica Pocock Joe Moss Nick Hex Jordan Rankin Richard Hudson Source Type: research
Beyond the Human Genome Project: The Age of Complete Human Genome Sequences and Pangenome References
Annu Rev Genomics Hum Genet. 2024 Apr 25. doi: 10.1146/annurev-genom-021623-081639. Online ahead of print.ABSTRACTThe Human Genome Project was an enormous accomplishment, providing a foundation for countless explorations into the genetics and genomics of the human species. Yet for many years, the human genome reference sequence remained incomplete and lacked representation of human genetic diversity. Recently, two major advances have emerged to address these shortcomings: complete gap-free human genome sequences, such as the one developed by the Telomere-to-Telomere Consortium, and high-quality pangenomes, such as the one ...
Source: Annual Review of Genomics and Human Genetics - April 25, 2024 Category: Genetics & Stem Cells Authors: Dylan J Taylor Jordan M Eizenga Qiuhui Li Arun Das Katharine M Jenike Eimear E Kenny Karen H Miga Jean Monlong Rajiv C McCoy Benedict Paten Michael C Schatz Source Type: research
Don't SNARC me now! Intraindividual variability of cognitive phenomena - Insights from the Ironman paradigm
Cognition. 2024 Apr 24;248:105781. doi: 10.1016/j.cognition.2024.105781. Online ahead of print.ABSTRACTTwo implicit generalizations are often made from group-level studies in cognitive experimental psychology and their common statistical analysis in the general linear model: (1) Group-level phenomena are assumed to be present in every participant with variations between participants being often treated as random error in data analyses; (2) phenomena are assumed to be stable over time. In this preregistered study, we investigated the validity of these generalizations in the commonly used parity judgment task. In the propose...
Source: Cognition - April 25, 2024 Category: Neurology Authors: Lilly Roth Verena Jordan Stefania Schwarz Klaus Willmes Hans-Christoph Nuerk Jean-Philippe van Dijck Krzysztof Cipora Source Type: research
