GSE236239 Novel spirocyclic dimer, SpiD3, targets critical tumor survival pathways and displays potent preclinical activity in B-cell chronic lymphocytic leukemia
Contributors : Alexandria P Eiken ; Achyuth Kalluchi ; Jordan Rowley ; Dalia El-GamalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic lymphocytic leukemia (CLL) cell survival and growth is fueled by aberrant activation of various pro-survival signaling pathways within tumor niches. Specifically, B-cell receptor (BCR) signaling, toll-like receptor signaling, and supportive cellular interactions drive constitutive activation of NF- κB signaling and transcription of proliferative/pro-survival genes. Directly targeting the NF-κB pathway has been a challenge, however, herein, w...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England
npj Primary Care Respiratory Medicine, Published online: 25 April 2024; doi:10.1038/s41533-024-00362-1The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - April 25, 2024 Category: Primary Care Authors: Erin Barker Jessica Pocock Joe Moss Nick Hex Jordan Rankin Richard Hudson Source Type: research
The Role of Number of Affected Vessels on Radiologic and Clinical Outcomes of Patients with Blunt Cerebrovascular Injury
There is a lack of data on the role of characteristics of injured vessels on the outcomes of patients with blunt cerebrovascular injuries (BCVIs). The aim of this study was to assess the effect of the number (single vs multiple) of injured vessels on outcomes. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 25, 2024 Category: Surgery Authors: Hamidreza Hosseinpour, Louis J. Magnotti, Dih-Dih Huang, Jordan A. Weinberg, Andrew Tang, Omar Hejazi, Collin Stewart, Sai Krishna Bhogadi, Tanya Anand, Bellal Joseph Source Type: research
Early survival benefit of a low-profile endograft in blunt traumatic aortic injury
To demonstrate the safety and effectiveness of a low-profile thoracic endograft (19-23 French) in subjects with blunt traumatic aortic injury. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 25, 2024 Category: Surgery Authors: Benjamin W. Starnes, Ravi R. Rajani, Peter Rossi, Niten Singh, Jaime Benarroch-Gampel, Jae S. Cho, Naiem Nassiri, Matthew R. Smeds, Venkat Kalapatapu, Jordan R. Stern, Nii-Kabu Kabutey, Joel Corvera, RelayPro Investigators Source Type: research
Public Awareness of Palliative Care: A Nationally Representative Sample of Jordanian Adults
Internationally, studies suggest that inadequate comprehension of the concept of palliative care and misconceptions about it hinder the effective use of palliative care, especially in developing nations. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 25, 2024 Category: Palliative Care Authors: Nijmeh AL-Atiyyat, Ahmed Al Ibraheemi, Majdi Rababa, Wafa'a Mousa Othman, Abdallah Abu Khait, Dima Ali Salem Jaradat Source Type: research
Enhancing clinical decision support with genomic tools in breast cancer: A Scottish perspective
CONCLUSIONS: Genomic assays offer the potential for risk-stratified decision making regarding the use of chemotherapy. They can help reduce unnecessary chemotherapy treatment and identify a subgroup of patients with more adverse genomic tumour biology. A recent publication by Health Improvement Scotland (HIS) has updated guidance on use of the RS test for NHS Scotland. It suggests to limit its use to the intermediate risk PREDICT group. Our study shows the impact of the RS test in the low and high risk PREDICT groups. The implementation across Scotland has resulted in a notable shift in practice, leading to a significant r...
Source: Breast - April 24, 2024 Category: Cancer & Oncology Authors: A L Peters P S Hall L B Jordan F Y Soh L Hannington S Makaranka G Urquhart M Vallet D Cartwright H Marashi B Elsberger Source Type: research
COVID-19 outcome trends by vaccination status in Canada, December 2020-January 2022
CONCLUSION: Vaccination remains one of the most important public health interventions, particularly among older adults, to protect against COVID-19 severe outcomes as the pandemic evolves. Routine monitoring of COVID-19 outcomes by vaccination status can identify changes in COVID-19 epidemiology and inform public health action and policy.PMID:38655240 | PMC:PMC11037879 | DOI:10.14745/ccdr.v50i12a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - April 24, 2024 Category: Infectious Diseases Authors: Demy Dam Sharifa Merali Michelle Chen Cameron Coulby Brigitte Ho Mi Fane Felix Bang Jordan Robson Samara David Source Type: research
Black and Latin é parents' perspectives on supporting their children's emotional and physical health
AbstractInformed by integrative models of cultural resilience, the purpose of this study was to (a) explore how parents are promoting their children's emotional and physical health, with a focus on race and ethnic-racial socialization strategies, and (b) identify the barriers and challenges parents are experiencing in supporting their children's health. Ethnically racially matched qualitative interviews were conducted with 33 parents (82% women, 64% Black, 36% Latin é). Results of thematic analysis revealed three overarching themes: (a) Strategies for Promoting Children's Physical and Emotional Health, (b) Challenges Prom...
Source: Journal of Marital and Family Therapy - April 24, 2024 Category: Psychiatry & Psychology Authors: Daniel K. Cooper,
Jayxa K. Alonzo,
Tracey Goldson,
Isabel R. Jordan,
Fatima Jatoi,
Isabella Mallozzi,
Francesca Lupini Tags: ORIGINAL ARTICLE Source Type: research
Cryogenic focus measurement system for a wide-field infrared space telescope
We describe a technique for measuring focus errors in a cryogenic, wide-field, near-infrared space telescope. The measurements are made ... (Source: Applied Optics)
Source: Applied Optics - April 24, 2024 Category: Physics Authors: Samuel S. Condon Stephen Padin James Bock Howard Hui Phillip Korngut Chi Nguyen Jordan Ostby Source Type: research
GSE247147 Systematic identification of transcriptional activation domains from non-transcription factor proteins in plants and yeast
Contributors : Niklas F Hummel ; Jordan Stefani ; Max V Staller ; Patrick M ShihSeries Type : OtherOrganism : Saccharomyces cerevisiaeTranscription factors can promote gene expression through activation domains. Whole-genome screens have systematically mapped activation domains in transcription factors, but not in non-transcription factor proteins (e.g., chromatin regulators, coactivators). To fill this knowledge gap, we employed the activation domain predictor PADDLE to analyze the proteomes of Arabidopsis thaliana and Saccharomyces cerevisiae. We screened 18,000 predicted activation domains from>800 non-transcription fa...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Saccharomyces cerevisiae Source Type: research
GSE253397 scRNA-seq of day 32 p.i. GC B cells induced by experimental Plasmodium infection following the inducible deletion of IL-21 from CD4 T cells on day 16-18
Contributors : Jordan T Johnson ; Noah S ButlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIL-21 is critical for initiating humoral immune responses, but whether sustained IL-21 production by T follicular helper cells regulates the quality or output of memory B cells and plasma cells during an established germinal center response is unknown. Here, we applied scRNA and approaches to determine the heterogeneity of germinal center B cells from Plasmodium infected mice with or without truncated IL-21 expression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Opportunities and Challenges to Build Behavioral Health Crisis Capacity in Rural America
Psychiatr Serv. 2024 Apr 23:appips20230111. doi: 10.1176/appi.ps.20230111. Online ahead of print.ABSTRACTThis column shares lessons learned from a 1-year pilot implementation of a crisis response program deploying crisis professionals to rural parts of Albany County, New York. The data (325 crisis interventions for 191 unique individuals, 57% of cases resolved on the scene) suggest that the program helps fill the crisis services gap in these communities. Police were present on 80% of cases. Educating police to build confidence in the program and providing clearer guidelines on the triage process for dispatchers may be impo...
Source: Psychiatric Services - April 23, 2024 Category: Psychiatry Authors: Tomoko Udo Preston Cody Roberts Jordan Dyett Shannon Mullin Denard Cummings Carmen Morano Source Type: research
Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E < sub > 2 < /sub > synthase-1 (mPGES-1) inhibitors
Bioorg Chem. 2024 Apr 16;147:107383. doi: 10.1016/j.bioorg.2024.107383. Online ahead of print.ABSTRACTSelective inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) is implicated as a new therapeutic modality for the development of new-generation anti-inflammatory drugs. Here, we present the discovery of new and potent inhibitors of human mPGES-1, i.e., compounds 13, 15-25, 29-30 with IC50 values in the range of 5.6-82.3 nM in a cell-free assay of prostaglandin (PG)E2 formation. We also demonstrate that 20 (TG554, IC50 = 5.6 nM) suppresses leukotriene (LT) biosynthesis at low µM concentrations, providing a bench...
Source: Bioorganic Chemistry - April 23, 2024 Category: Chemistry Authors: Tu ğçe Gür Maz Philipp Dahlke Azize Gizem Erg ül Abdurrahman Ol ğaç Paul M Jordan Burcu Çalışkan Oliver Werz Erden Banoglu Source Type: research
