The Integrated Healing Program: Outcomes Associated with a New Intensive Interdisciplinary Pain Program (IIPT) for Teens in Wisconsin
The “Integrated Healing Program” was developed through a novel partnership amongst Children’s Wisconsin, Rogers Behavioral Health, and the Medical College of Wisconsin. The purpose of this study was to evaluate patient-reported outcomes associated with this new IIPT program. The Program was design ed as a Partial Hospitalization Program with integrated physical therapy and medical support. Participants must be 13-18 years and have a medical condition resulting in functional impairment with a decline in health, physical, and emotional quality of life that is exacerbated by psychological factor s. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kimberly Anderson Khan, Keri R. Hainsworth, Kevin E. Berridge, Dalton Kick, Kristine Kim, Gregory Evangelatos, Amanda Quesnell, Michael Collins, Katherine Freimark, Jordan Snetslaar, Jill Wenzel, Steven J. Weisman Source Type: research
Psychometrics of a Fear-Avoidance Measure Adapted for Youth with Concussion: Fear of Concussive Symptoms Questionnaire (FOCSQ)
Fear-avoidance is a risk factor for chronic pain, and recent research suggests fear-avoidance might play a role in prolonged concussion recovery, but standardized measures of fear-avoidance focus on pain rather than broader concussive symptoms. We adapted the Fear of Pain Questionnaire (FOPQ), changing “pain” to “concussive symptoms” and generating parent-proxy and youth-report versions, calling the new scale the Fear of Concussive Symptoms Questionnaire (FOCSQ). We assessed psychometrics of this scale with a sample of N=110 youth with concussion (mean age = 15.1 years, 58% female, 70% Non -Hispanic White, 15% Hisp...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sara Chrisman, Chuan Zhou, Beth Bollinger, Jordan Sahlberg, Jason Mendoza, Alison Brooks, Fred Rivara, Tonya Palermo Source Type: research
Investigating Neurometabolites and Pain in Fibromyalgia
Fibromyalgia (FM) is a complex, chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. The exact cause of FM remains elusive, with factors like abnormal pain processing and central nervous system sensitization implicated in its pathophysiology. One hypothesis is that the immune system is frequently activated, prompting microglia to initiate a central inflammatory state. The purpose of this study was to use whole-brain magnetic resonance spectroscopic imaging (MRSI) to investigate whether abnormal inflammation in the central nervous system may be asso...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Indonesia A. Jordan, Sophia Fox, Matthew McDaniel, Jarred Younger Source Type: research
81 Evaluation of neoadjuvant chemo-immunotherapy for operable non-small cell lung cancer: clinical outcomes and impact on service delivery
Checkmate 816 has established a new standard of care for operable NSCLC, combining neoadjuvant nivolumab with 3 cycles of platinum-based chemotherapy, granted approval in the UK in March 2023. This represents a shift in practice from traditional adjuvant treatment, with implications for patient care and service delivery. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Taher Abu, Alexius John, Faisal Rehman, Charlotte Milner-Watts, David McMahon, Thubeena Manickavasagar, Elizabeth Cartwright, Nadia Yousaf, Domingo Vicente Cano Gil, Carol Tan, Jeremy Smelt, Ian Hunt, Simon Jordan, Sofina Begum, Jaishree Bhosle, Anna Minc Tags: NSCLC Systemic Treatment Source Type: research
61 The first-in-class peroxiredoxin 3 (PRX3) inhibitor RSO-021 modulates the mesenchymal and immune phenotype in mesothelioma
RSO-021 is a first-in-class PRX3 inhibitor currently being investigated in a first-in-human phase 1/2 clinical trial called MITOPE, which is currently recruiting patients with malignant pleural effusion (MPE) arising from mesothelioma or other solid tumors (NCT05278975). Mesothelioma cells rely on buffering of mitochondrial oxidative stress through the expression and activity of mitochondrial PRX3, which is covalently inactivated by RSO-021. Inactivation of PRX3 by RSO-021 leads to increased oxidative stress and tumor cell death. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Brian Cunniff, Terri Messier, Victoria Gibson, David Seward, Essa Baitei, Peter Wells Jordan, Charlotte Poile, Joanna Dzialo, Aleksandra Bzura, Kudzayi Kutywayo, Apostolos Nakas, George Naumov, Dean Fennell Tags: Mesothelioma Source Type: research
208 SynthEtic LEthal Cancer Therapy in mesothelioma (SELECTmeso): a molecularly stratified multi-arm phase II platform trial for patients with relapsed malignant mesothelioma
Mesothelioma is a rare cancer caused by exposure to asbestos typically affecting the pleura or pericardium. Prognosis remains dismal yet targeted therapies are lacking. Advances have revealed a preponderance of tumour suppressors in mesothelioma, which may present new opportunities to develop treatments. The SELECTmeso trial platform, coordinated by the Cancer Research UK Southampton Clinical Trials Unit, has been developed to leverage new insights into synthetic lethal biology to improve treatment outcomes. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Kayleigh Hill, Dean Fennell, Anna Song, Robin Wickens, Judith Cave, Andrea Corkhill, Jens Hahne, Michelle Lattimore, Peter Wells-Jordan, Nada Nusrat, Sean Dulloo, Charlotte Poile, Gareth Griffiths Tags: Trials in progress Source Type: research
Midwives' attitudes toward the use of cardiotocograph (CTG) machines in labor units: A study in Jordan
CONCLUSION: This study provides new insights into the attitudes of Jordanian midwives towards CTG use in labor units. These suggest that it is critical to conduct training courses for registered midwives to help them develop and/or regain confidence and competence with respect to various key aspects of intrapartum care, including intermittent auscultation and the appropriate use of CTG.PMID:38555829 | DOI:10.1016/j.midw.2024.103978 (Source: Midwifery)
Source: Midwifery - March 31, 2024 Category: Midwifery Authors: Reem Hatamleh Nemeh Al-Akour Suha M Maharmeh Maha Atout Source Type: research
Midwives' attitudes toward the use of cardiotocograph (CTG) machines in labor units: A study in Jordan
CONCLUSION: This study provides new insights into the attitudes of Jordanian midwives towards CTG use in labor units. These suggest that it is critical to conduct training courses for registered midwives to help them develop and/or regain confidence and competence with respect to various key aspects of intrapartum care, including intermittent auscultation and the appropriate use of CTG.PMID:38555829 | DOI:10.1016/j.midw.2024.103978 (Source: Midwifery)
Source: Midwifery - March 31, 2024 Category: Midwifery Authors: Reem Hatamleh Nemeh Al-Akour Suha M Maharmeh Maha Atout Source Type: research
Midwives' attitudes toward the use of cardiotocograph (CTG) machines in labor units: A study in Jordan
CONCLUSION: This study provides new insights into the attitudes of Jordanian midwives towards CTG use in labor units. These suggest that it is critical to conduct training courses for registered midwives to help them develop and/or regain confidence and competence with respect to various key aspects of intrapartum care, including intermittent auscultation and the appropriate use of CTG.PMID:38555829 | DOI:10.1016/j.midw.2024.103978 (Source: Midwifery)
Source: Midwifery - March 31, 2024 Category: Midwifery Authors: Reem Hatamleh Nemeh Al-Akour Suha M Maharmeh Maha Atout Source Type: research
Midwives' attitudes toward the use of cardiotocograph (CTG) machines in labor units: A study in Jordan
CONCLUSION: This study provides new insights into the attitudes of Jordanian midwives towards CTG use in labor units. These suggest that it is critical to conduct training courses for registered midwives to help them develop and/or regain confidence and competence with respect to various key aspects of intrapartum care, including intermittent auscultation and the appropriate use of CTG.PMID:38555829 | DOI:10.1016/j.midw.2024.103978 (Source: Midwifery)
Source: Midwifery - March 31, 2024 Category: Midwifery Authors: Reem Hatamleh Nemeh Al-Akour Suha M Maharmeh Maha Atout Source Type: research
Long-term characterization of cognitive phenotypes in children with seizures over 36 months
CONCLUSIONS: This study demonstrates the presence of diverse latent cognitive trajectory phenotypes over 36 months in youth with new-onset seizures that are associated with a stable neuropsychological and academic performance longitudinally.PMID:38554647 | DOI:10.1016/j.yebeh.2024.109742 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 30, 2024 Category: Neurology Authors: Jordan Eisner Danielle Harvey David Dunn Jana Jones Anna Byars Philip Fastenau Joan Austin Bruce Hermann Temitayo Oyegbile-Chidi Source Type: research
GSE243695 Plasma amino acids regulate pancreatic acinar cell proliferation and size via mTORC1 and YAP/TAZ signaling pathways
Contributors : Chunhua Dai ; Yulong Gong ; Yue Zhang ; Amber Bradley ; Zihan Tang ; Katelyn Sellick ; Shristi Shrestha ; Erick Spears ; Brittney A Covington ; Jade Stanley ; Regina Jenkins ; Tiffany M Richardson ; Rebekah A Brantley ; Katie Coate ; Diane C Saunders ; Jordan Wrights ; Marcela Brissova ; Danielle Dean ; Alvin C Powers ; Wenbiao ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreas volume or mass varies more than 3-fold among adult humans. The heterogeneity is likely the result of genetics, diseases, and nutrition. Dietary protein intake and blood a...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE261418 Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote re-epithelialization of diabetic wounds
Contributors : Ellen K White ; Aayushi Uberoi ; Jamie Ting-Chun Pan ; Jordan T Ort ; Amy E Campbell ; Sof ía M Murga-Garrido ; Jordan C Harris ; Preeti Bhanap ; Monica Wei ; Nélida Robles ; Sue E Gardner ; Elizabeth A GriceSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, and infection. We previously showed that aspects of the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial ...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Histories of neighborhood socioeconomic status contribute to race differences in later-life cognition
DISCUSSION: Disinvestment in neighborhoods may be particularly salient in race disparities in cognitive function.HIGHLIGHTS: Race is implicated in the likelihood of living in more disadvantaged neighborhoods. Historical trends in neighborhood disadvantage are associated with cognitive function in older adulthood. Identifying patterns of neighborhood change may inform neighborhood-level interventions.PMID:38552138 | DOI:10.1002/alz.13786 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 29, 2024 Category: Psychiatry Authors: Ketlyne Sol Emily P Morris Ji Hyun Lee Afsara B Zaheed Jordan D Palms Kiana Scambray Philippa Clarke Laura B Zahodne Source Type: research
Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of atherosclerosis and arteriosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:38552474 | DOI:10.1016/j.atherosclerosis.2024.117521 (Source: Atherosclerosis)
Source: Atherosclerosis - March 29, 2024 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research
