Implementation of CYP2C19 and CYP2D6 genotyping to guide antidepressant use in a large rural health system
CONCLUSION: The implementation and maintenance of Sanford Health's PGx program to guide antidepressant and antianxiety medication use continues to evolve and requires a multipronged approach relying on both human and informatics-based resources.PMID:38546726 | DOI:10.1093/ajhp/zxae083 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - March 28, 2024 Category: Drugs & Pharmacology Authors: Natasha J Petry Joel Van Heukelom April J Schultz Kristen Jacobsen Jordan F Baye Sarah Mills Debbie Figueroa Amanda Massmann Source Type: research
Do decision aids improve clinical practice?
J Prim Health Care. 2024 Mar;16(1):110-111. doi: 10.1071/HC24043.NO ABSTRACTPMID:38546781 | DOI:10.1071/HC24043 (Source: Journal of Primary Health Care)
Source: Journal of Primary Health Care - March 28, 2024 Category: Primary Care Authors: Vanessa Jordan Source Type: research
GSE252088 Single-stranded Pre-methylated 5mC Adapters Uncover the Methylation Profile of Plasma Ultrashort Single-stranded Cell-free DNA
We describe the “5mCAdpBS-Seq” workflow in which pre-methylated 5mC (5-methylcytosine) single-stranded adapters are ligated to heat-denatured cfDNA before bisulfite conversion. This method retains only DNA fragments that are unaltered by bisulfite treatment, resulting in less biased uscfDNA methylation analysis . Using 5mCAdpBS-Seq, uscfDNA had lower levels of DNA methylation (~15%) and was enriched in promoters and CpG islands. Hypomethylated uscfDNA fragments were enriched in upstream transcription start sites (TSSs), and the intensity of enrichment positively affected gene expression of hemopoietic cell s. Using tis...
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
Global epidemiology of epithelial ovarian cancer
Nature Reviews Clinical Oncology, Published online: 28 March 2024; doi:10.1038/s41571-024-00881-3Ovarian cancer, accounting for 4.7% of cancer deaths in women in 2020, remains highly prevalent globally. Nonetheless, owing to changes in environmental exposures, the approach to preventive measures and disease classification, both incidence and mortality have been declining in economically developed countries since the early 2000s. Conversely, parts of Asia and eastern Europe have seen increases in the incidence of ovarian cancer over this period of time. In this Review, the authors summarize the epidemiology of ovarian cance...
Source: Nature Reviews Clinical Oncology - March 28, 2024 Category: Cancer & Oncology Authors: Penelope M. Webb Susan J. Jordan Source Type: research
What does recovery mean to Jordanian mental health service users and their families? A descriptive qualitative study
. (Source: Journal of Mental Health)
Source: Journal of Mental Health - March 28, 2024 Category: Psychiatry Authors: Mohammad S. Abu-MahfouzGordon WellerLisa ClarkeBetsy Thoma Department of Mental Health and Social Work, Middlesex University, London, UKb Department of Nursing, AlMoosa College of Health Sciences, Al Mubarraz, Al-Ahsa, Saudi Arabia Source Type: research
Optimizing precision medicine for second-step depression treatment: a machine learning approach
CONCLUSION: Ensemble machine learning has potential to predict second-step treatment. In this study, predictive performance varied by type of treatment, with greater accuracy in predicting remission in response to behavioral treatments than to pharmacotherapy interventions. Future directions include considering more informative predictor modalities to enhance prediction of second-step treatment response.PMID:38533794 | DOI:10.1017/S0033291724000497 (Source: Psychological Medicine)
Source: Psychological Medicine - March 27, 2024 Category: Psychiatry Authors: Joshua Curtiss Jordan W Smoller Paola Pedrelli Source Type: research
