Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice

CONCLUSION: Hydroxychloroquine inhibited hemolysis-induced arterial thrombosis ex-vivo and improved pulmonary perfusion in hemin-treated mice, supporting a potential benefit of its use as an adjuvant therapy in hemolytic diseases to limit arterial thrombosis and to improve organ perfusion.PMID:38670315 | DOI:10.1016/j.jtha.2024.04.008

Source: Thrombosis and Haemostasis - April 26, 2024 Category: Hematology Authors: Joshua H Bourne Gina Perrella Juma El-Awaisi Lauren V Terry Veronika Tinkova Rebecca L Hogg Poppy Gant Beata Grygielska Neena Kalia Dean Kavanagh Alexander Brill Jordan D Dimitrov Steve P Watson Julie Rayes Source Type: research