Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation
ConclusionHydralazine, an acrolein scavenger, significantly mitigated SCI-induced inflammation and oxidative stressin vivo, modulated macrophage activation, and consequently promoted the structural and functional recovery of the injured CNS. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - August 10, 2023 Category: Research Source Type: research
Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance
Iran J Immunol. 2023 Aug 7;3(20). doi: 10.22034/iji.2023.97585.2522. Online ahead of print.ABSTRACTTwo central questions in COVID-19 treatment which should be considered are: "How does the imbalance of the complement system affect the therapeutic approaches?" and "Do we consider complement inhibitors in therapeutic protocols?". The complement system is a double-edged sword since it may either promote immune responses against COVID-19 or contribute to destructive inflammation in the host. Therefore, it is crucial to regulate this system with complement inhibitors. In this manuscript, we discuss the molecular mechanisms of c...
Source: Iranian Journal of Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Mehdi Torabizadeh Helia Modaresi Asfeh Zeinab Deris Zayeri Cerdan Dominique Hashem Kazemi Najmaldin Saki Source Type: research
Epidemiological Profile of Neonates in Hearing Screening at a Maternity of a Tertiary Hospital in the state of Santa Catarina, Brazil
Conclusion False positives (62.8%) in the first test showed a value higher than the ideal goal; those who did not undergo the NHS (1.9%) and who needed evaluation by a specialist, due to failure in the retest (1.5%), are within the quality goals defined by the Joint Committee on Infant Hearing (JCIH) in 2007. [...] Thieme Revinter Publicações Ltda. Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, BrazilArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - August 4, 2023 Category: ENT & OMF Authors: Diego Gimenes Lopes, Juan Disconzi Dallegrave, Carolina Hellmann Delfino, Nadine Lauxen, R úbia Marcelino, Taise Eduardo Monteiro Zappelini, Carlos Tags: Original Research Source Type: research
Synergistic effect of hydralazine associated with triazoles on Candida spp. in planktonic cells
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - August 4, 2023 Category: Microbiology Authors: Francisca BSA do Nascimento L ívia GA Valente Sá Jo ão B de Andrade Neto Let ícia S Sampaio Helaine A Queiroz Lisandra J Silva Vit ória PF Cabral Daniel S Rodrigues Sidsayde C Pereira Bruno C Cavalcanti Jacilene Silva Emmanuel S Marinho Helcio S Sant Source Type: research
Overlapping drug ‐induced vasculitis, ANCA‐associated vasculitis, and lupus nephritis caused by low‐dose hydralazine
ConclusionsAlthough a few cases of simultaneous antibody-associated vasculitis and drug-induced lupus nephritis secondary to hydralazine use have been reported, this case is singular. Similar findings were previously reported with doses of 50 –100 mg two to three times daily over 1–5 years. In our patient, a dose of only 10 mg twice daily for a year caused a severe disease presentation. This brings to light the combination of different vasculitides that can coexist and the potentially life-threatening adverse effects of low-dos e hydralazine that should be kept in mind. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 15, 2023 Category: Rheumatology Authors: M. Bhatnagar,
A. Agaronov,
E. Sarkisyan,
I. Sotoudeh Deilamy,
D. Pepito,
H. Akhondi Tags: APLAR GRAND ROUND CASE Source Type: research
IJERPH, Vol. 20, Pages 6153: Prevalence of Hypertensive Disorders, Antihypertensive Therapy and Pregnancy Outcomes among Pregnant Women: A Retrospective Review of Cases at Tamale Teaching Hospital, Ghana
lu Nlooto
Hypertensive disorders associated with pregnancy are a major health concern and a leading cause of maternal indisposition and transience. The main objective of this study was to assess the prevalence of hypertension in pregnancy as well as antihypertensive therapy and pregnancy outcomes among pregnant women at Tamale Teaching Hospital (TTH) in Ghana. This was a retrospective study conducted using data from the folders of pregnant hypertensive patients. The study was conducted at the maternity ward of TTH from 1 June 2018 to 31 May 2019. Participants were all pregnant women with a diagnosis of hypertensive dis...
Source: International Journal of Environmental Research and Public Health - June 16, 2023 Category: Environmental Health Authors: Amos Adapalala Bugri Solomon Kwabena Gumanga Peter Yamoah Ebenezer Kwabena Frimpong Manimbulu Nlooto Tags: Article Source Type: research
Increased plasma renin by vasodilators promotes the progression of abdominal aortic aneurysm
Conclusion and relevance: The plasma renin level and plasma renin activity are positively associated with AAA development. Direct vasodilators aggravated experimental AAA progression, which raised cautionary concerns about their applications in AAA disease. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety of Valproic Acid in Myelodysplastic Syndrome and Acute Myeloid Leukemia; a Narrative Review
Drug Res (Stuttg). 2023 May 23. doi: 10.1055/a-2088-3718. Online ahead of print.ABSTRACTLoads of new therapeutic regimes have been turned up to manage Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly in elderly patients who are unfit for intensive chemotherapy. Despite accumulating research, the best MDS and AML management approach is indeterminate. Myelodysplastic syndrome implies a group of various hematopoietic stem cell disorders that may progress to acute myeloid leukemia. These disorders are more frequent in older adults. To the high rate of morbidity and abundant toxicities related to th...
Source: Cell Research - May 23, 2023 Category: Cytology Authors: Navid Omidkhoda Sina Mahdiani Sara Samadi Hossein Rahimi Amir Hooshang Mohammadpour Source Type: research
Efficacy and Safety of Valproic Acid in Myelodysplastic Syndrome and
Acute Myeloid Leukemia; a Narrative Review
Drug Res (Stuttg) DOI: 10.1055/a-2088-3718Loads of new therapeutic regimes have been turned up to manage Myelodysplastic
syndrome (MDS) and acute myeloid leukemia (AML), particularly in elderly
patients who are unfit for intensive chemotherapy. Despite accumulating
research, the best MDS and AML management approach is indeterminate.
Myelodysplastic syndrome implies a group of various hematopoietic stem cell
disorders that may progress to acute myeloid leukemia. These disorders are more
frequent in older adults. To the high rate of morbidity and abundant toxicities...
Source: Drug Research - May 23, 2023 Category: Drugs & Pharmacology Authors: Omidkhoda, Navid Mahdiani, Sina Samadi, Sara Rahimi, Hossein Mohammadpour, Amir Hooshang Tags: Review Source Type: research
Po-05-062 gaps in care for heart failure patients indicated for device therapy
Guideline-directed medical therapy (GDMT) has been the foundation of treatment in heart failure (HF) with reduced ejection fraction (HFrEF). The use of beta-blockers (BB), angiotensin-converting enzyme inhibitors (ACE-I), angiotensin receptor blockers (ARB), angiotensin and neprilysin inhibitors (ARNI), mineralocorticoid receptor antagonists (MRA), the combination of hydralazine and isosorbide dinitrate, and implantation of implantable cardioverter-defibrillators (ICDs) without/with cardiac resynchronization therapy (CRT-D) have been shown to improve outcomes. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Aamir Ahmed, Anne Marti, Dana Soderlund, Anne B. Curtis Source Type: research
Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women
Conclusion: The results of this study show that Labetalol is more effective as compared to Hydralazine in terms of reducing the systolic and diastolic blood pressure and number of doses (Drugs) for in patients with severe preeclampsia.Keywords: Preeclampsia; bolus dose; Hydralazine; Labetalol. (Source: African Health Sciences)
Source: African Health Sciences - April 6, 2023 Category: African Health Authors: Mauzma Kausar, Samia Husain, Rubina Hussain Source Type: research
The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof
ConclusionWe conclude that the assumption that these drugs can be used with little consequence to the aldosterone-to-renin cannot be substantiated. While it is possible that they are indeed the best option when full antihypertensive drug cessation is infeasible, the potential effects of these drugs must still be taken into account when interpreting the aldosterone-to-renin ratio. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 1, 2023 Category: Cardiology Source Type: research
Drug- Induced Lupus in Association with Ethosuximide Therapy in an 11-Year-Old Child
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a multifactorial pathogenesis. Genetic, epidemiological, and environmental factors influence the susceptibility to develop SLE. Certain drugs can also trigger SLE, and these agents may unmask clinically silent SLE, and induce flares or lupus-like syndromes (1). Collectively, these syndromes are referred to as drug-induced lupus (DIL). Drugs that are classically associated with DIL include minocycline, procainamide, hydralazine, and quinidine but strong associations with other drugs such as ethosuximide are increasingly being recognized (2, 3). (So...
Source: Pediatric Neurology - March 22, 2023 Category: Neurology Authors: Rajvee Sanghavi, Sukesh Sukumaran Tags: Correspondence Source Type: research
Drug-Induced Lupus in Association With Ethosuximide Therapy in an 11-Year-Old Child
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a multifactorial pathogenesis. Genetic, epidemiologic, and environmental factors influence the susceptibility to develop SLE. Certain drugs can also trigger SLE, and these agents may unmask clinically silent SLE, and induce flares or lupuslike syndromes.1 Collectively, these syndromes are referred to as drug-induced lupus (DIL). Drugs that are classically associated with DIL include minocycline, procainamide, hydralazine, and quinidine, but strong associations with other drugs such as ethosuximide are increasingly being recognized. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 22, 2023 Category: Neurology Authors: Rajvee Sanghavi, Sukesh Sukumaran Tags: Correspondence Source Type: research
