Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats
Conclusion:
The results suggest that, regardless of hemodynamic adjustments, the angiotensin II/AT1R/pSrc/ROS/NFκB/COX-2 pathway is involved in the development of MRA inward hypotrophic remodeling and stiffness in ouabain-treated rats. (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
A review on the clinical pharmacokinetics of hydralazine
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - September 27, 2022 Category: Drugs & Pharmacology Authors: Asma Shahzad Qamar Ammara Zamir Sundus Khalid Waseem Ashraf Imran Imran Iltaf Hussain Anees Ur Rehman Hamid Saeed Abdul Majeed Faleh Alqahtani Muhammad Fawad Rasool Source Type: research
Diffuse Alveolar Hemorrhage Secondary to Hydralazine-Induced Antineutrophilic Cytoplasmic Antibody–Associated Vasculitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Hydralazine
(Source: Reactions Weekly)
Source: Reactions Weekly - September 1, 2022 Category: Drugs & Pharmacology Source Type: research
Hypertensive Crisis in Pregnancy
Severe hypertension in pregnancy is a medical emergency, defined as systolic blood pressure (BP) ≥ 160 mm Hg and/or diastolic BP ≥ 110 mm Hg taken 15 minutes to 4 or more hours apart. Outside pregnancy, acute severe hypertension (HTN) is defined as a BP greater than 180/110 to 120 reproducible on 2 occasions. The lower threshold for severe HTN in pregnancy reflects the increased risk for adverse outcomes, particularly maternal stroke and death, and may be a source of under-recognition and treatment delay, particularly in nonobstetrical health care settings. Once a severe hypertension episode is recognized, antihyper...
Source: Obstetrics and Gynecology Clinics - September 1, 2022 Category: OBGYN Authors: Cynthie K. Wautlet, Maria C. Hoffman Source Type: research
Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy
Biomaterials. 2022 Aug 20:121737. doi: 10.1016/j.biomaterials.2022.121737. Online ahead of print.ABSTRACTThe clinical translation of nanomedicines has been impeded by the unfavorable tumor microenvironment (TME), particularly the tortuous vasculature networks, which significantly influence the transport and distribution of nanomedicines into tumors. In this work, a smart pH-responsive bortezomib (BTZ)-loaded polyhydralazine nanoparticle (PHDZ/BTZ) is presented, which has a great capacity to augment the accumulation of BTZ in tumors by dilating tumor blood vessels via specific release of vasodilator hydralazine (HDZ). The L...
Source: Biomaterials - August 28, 2022 Category: Materials Science Authors: Rui Wang Xiaodan Xu Dongdong Li Wei Zhang Xueying Shi Hongxia Xu Jianqiao Hong Shasha Yao Jiwei Liu Zhenli Wei Ying Piao Zhuxian Zhou Youqing Shen Jianbin Tang Source Type: research
Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy
Biomaterials. 2022 Aug 20:121737. doi: 10.1016/j.biomaterials.2022.121737. Online ahead of print.ABSTRACTThe clinical translation of nanomedicines has been impeded by the unfavorable tumor microenvironment (TME), particularly the tortuous vasculature networks, which significantly influence the transport and distribution of nanomedicines into tumors. In this work, a smart pH-responsive bortezomib (BTZ)-loaded polyhydralazine nanoparticle (PHDZ/BTZ) is presented, which has a great capacity to augment the accumulation of BTZ in tumors by dilating tumor blood vessels via specific release of vasodilator hydralazine (HDZ). The L...
Source: Biomaterials - August 28, 2022 Category: Materials Science Authors: Rui Wang Xiaodan Xu Dongdong Li Wei Zhang Xueying Shi Hongxia Xu Jianqiao Hong Shasha Yao Jiwei Liu Zhenli Wei Ying Piao Zhuxian Zhou Youqing Shen Jianbin Tang Source Type: research
Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo
Conclusions These results together suggest that acrolein plays a role in the pathogenesis of DN and could be a diagnostic marker and effective therapeutic target to ameliorate the development of DN.PMID:36001357 | DOI:10.1530/EJE-22-0493 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 24, 2022 Category: Endocrinology Authors: Zhen-Jie Tong Chin-Wei Kuo Po-Cheng Yen Chih-Ching Lin Ming-Tsun Tsai Shing-Hwa Lu Yi-Ping Chang Wen-Sheng Liu Han-Hsing Tsou Hsiao-Wei Cheng Hsiang-Tsui Wang Source Type: research
Antimetastatic Effect of Epigenetic Drugs, Hydralazine and Valproic Acid, in Ras-Transformed NIH 3T3 Cells [Corrigendum]
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - August 3, 2022 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Comparison of Tranexamic acid, Remifentanil, and Hydralazine on the bleeding volume during Dacryocystorhinostomy surgery
CONCLUSION: Our results show that Remifentanil and Hydralazine are more effective than Tranexamic acid in bleeding control.PMID:35891928 | PMC:PMC9301179 (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 27, 2022 Category: Physiology Authors: Darioush Moradi Farsani Hamidreza Shetabi Aryan Rafiee Zadeh Niloofar Saffari Rad Source Type: research
