Potential Impacts of Hydralazine as a Novel Antioxidant on Cardiovascular and Renal Disease-Beyond Vasodilation and Blood Pressure Lowering
Antioxidants (Basel). 2022 Nov 11;11(11):2224. doi: 10.3390/antiox11112224.ABSTRACTHydralazine is a traditional antihypertensive drug that was developed several decades ago. Its most well-known effect is blood pressure lowering by arterial vasodilation. While mainly used an adjunct treatment for clinical hypertension or chronic heart failure, this old drug has also shown potential as a repurposing drug for the atherosclerosis vascular disease and various kidney diseases. Recent experimental studies suggest that hydralazine exerts antioxidative, anti-apoptotic, and HIF-1α stabilization effects for angiogenesis and vascular...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Ting-Ting Chang Jaw-Wen Chen Source Type: research

Potential Impacts of Hydralazine as a Novel Antioxidant on Cardiovascular and Renal Disease-Beyond Vasodilation and Blood Pressure Lowering
Antioxidants (Basel). 2022 Nov 11;11(11):2224. doi: 10.3390/antiox11112224.ABSTRACTHydralazine is a traditional antihypertensive drug that was developed several decades ago. Its most well-known effect is blood pressure lowering by arterial vasodilation. While mainly used an adjunct treatment for clinical hypertension or chronic heart failure, this old drug has also shown potential as a repurposing drug for the atherosclerosis vascular disease and various kidney diseases. Recent experimental studies suggest that hydralazine exerts antioxidative, anti-apoptotic, and HIF-1α stabilization effects for angiogenesis and vascular...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Ting-Ting Chang Jaw-Wen Chen Source Type: research

Effect of the Non-N-Methyl-D-aspartate Receptor of the Glutamatergic System of the Pedunculopontine Tegmental Nucleus on Cardiovascular Responses in Normotensive and Hydralazine-Induced Hypotensive Rats
CONCLUSION: Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.PMID:36393823 | PMC:PMC9651188 | DOI:10.4103/abr.abr_14_21 (Source: Biomed Res)
Source: Biomed Res - November 17, 2022 Category: Research Authors: Mohammad Reza Hosseiniravesh Vida Hojati Reza Mohebbati Abolfazl Khajavirad Hooman Shajiee Mohammad Naser Shafei Source Type: research

Effect of the Non-N-Methyl-D-aspartate Receptor of the Glutamatergic System of the Pedunculopontine Tegmental Nucleus on Cardiovascular Responses in Normotensive and Hydralazine-Induced Hypotensive Rats
CONCLUSION: Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.PMID:36393823 | PMC:PMC9651188 | DOI:10.4103/abr.abr_14_21 (Source: Biomed Res)
Source: Biomed Res - November 17, 2022 Category: Research Authors: Mohammad Reza Hosseiniravesh Vida Hojati Reza Mohebbati Abolfazl Khajavirad Hooman Shajiee Mohammad Naser Shafei Source Type: research

Successful conservative management of left ventricular assist device candidates
ConclusionsNotwithstanding the small size of our cohort, our results suggest that LVAD implantation could be safely deferred in the majority of LVAD candidates. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 16, 2022 Category: Cardiology Authors: Ofer Havakuk, Aviram Hochstadt, Sapir Sadon, Michal Laurel Perl, Ben Sadeh, Assi Milwidsky, Orly Ran Sapir, Yoav Granot, Lior Lupu, Erez Levi, Ariel Farkash, Yanai Ben Gal, Shmuel Banai, Yan Topilsky Tags: Original Article Source Type: research

Hydralazine-Associated Pulmonary-Renal Syndrome
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research

Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats
Conclusion: The results suggest that, regardless of hemodynamic adjustments, the angiotensin II/AT1R/pSrc/ROS/NFκB/COX-2 pathway is involved in the development of MRA inward hypotrophic remodeling and stiffness in ouabain-treated rats. (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

A review on the clinical pharmacokinetics of hydralazine
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - September 27, 2022 Category: Drugs & Pharmacology Authors: Asma Shahzad Qamar Ammara Zamir Sundus Khalid Waseem Ashraf Imran Imran Iltaf Hussain Anees Ur Rehman Hamid Saeed Abdul Majeed Faleh Alqahtani Muhammad Fawad Rasool Source Type: research

Diffuse Alveolar Hemorrhage Secondary to Hydralazine-Induced Antineutrophilic Cytoplasmic Antibody–Associated Vasculitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research