E-187 Pipeline embolization stent for treatment of giant supraclinoid aneurysms: a case series
ConclusionThe Pipeline embolization device is a novel technique that can be utilized for treatment of giant cerebrovascular aneurysms with emerging evidence of immediate and long-term success. Further patient enrollment and clinical trials will be required to assess its efficacy in comparison to other endovascular and surgical approaches for the treatment of giant aneurysms.Disclosures M. Fana: None. O. Alsrouji: None. M. Rehman: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fana, M., Alsrouji, O., Rehman, M. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay
Bioorg Med Chem Lett. 2022 Jul 9:128883. doi: 10.1016/j.bmcl.2022.128883. Online ahead of print.ABSTRACTGlutamate oxaloacetate transaminase 1 (GOT1) plays a key role in aberrant glutamine metabolism. GOT1 suppression can arrest tumor growth and prevent the development of cancer, indicating GOT1 as a potential anticancer target. Reported GOT1 inhibitors, on the other hand, are quite restricted. Here, we developed and optimized a coupling reaction-based high-throughput screening assay for the discovery of GOT1 inhibitors. By using this screening assay, we found that the cardiovascular drug hydralazine hydrochloride inhibited...
Source: Bioorganic and Medicinal Chemistry Letters - July 12, 2022 Category: Chemistry Authors: Qiqi Wu Zhongya Sun Zhifeng Chen Jingqiu Liu Hong Ding Cheng Luo Mingliang Wang Daohai Du Source Type: research
The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay
Bioorg Med Chem Lett. 2022 Jul 9:128883. doi: 10.1016/j.bmcl.2022.128883. Online ahead of print.ABSTRACTGlutamate oxaloacetate transaminase 1 (GOT1) plays a key role in aberrant glutamine metabolism. GOT1 suppression can arrest tumor growth and prevent the development of cancer, indicating GOT1 as a potential anticancer target. Reported GOT1 inhibitors, on the other hand, are quite restricted. Here, we developed and optimized a coupling reaction-based high-throughput screening assay for the discovery of GOT1 inhibitors. By using this screening assay, we found that the cardiovascular drug hydralazine hydrochloride inhibited...
Source: Bioorganic and Medicinal Chemistry Letters - July 12, 2022 Category: Chemistry Authors: Qiqi Wu Zhongya Sun Zhifeng Chen Jingqiu Liu Hong Ding Cheng Luo Mingliang Wang Daohai Du Source Type: research
Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
In conclusion, hydralazine protected renal proximal tubular epithelial cells against the insults of high glucose and prevented renal damage via XO/NADPH oxidase inhibition and Nrf-2/HO-1 activation, suggesting the comprehensive antioxidation and anti-inflammation mechanisms for the management of DN.PMID:35623171 | DOI:10.1016/j.biopha.2022.113139 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2022 Category: Drugs & Pharmacology Authors: Ting-Ting Chang Chih-Hung Chiang Ching Chen Su-Chu Lin Hsin-Jou Lee Jaw-Wen Chen Source Type: research
Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
In conclusion, hydralazine protected renal proximal tubular epithelial cells against the insults of high glucose and prevented renal damage via XO/NADPH oxidase inhibition and Nrf-2/HO-1 activation, suggesting the comprehensive antioxidation and anti-inflammation mechanisms for the management of DN.PMID:35623171 | DOI:10.1016/j.biopha.2022.113139 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2022 Category: Drugs & Pharmacology Authors: Ting-Ting Chang Chih-Hung Chiang Ching Chen Su-Chu Lin Hsin-Jou Lee Jaw-Wen Chen Source Type: research
Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
In conclusion, hydralazine protected renal proximal tubular epithelial cells against the insults of high glucose and prevented renal damage via XO/NADPH oxidase inhibition and Nrf-2/HO-1 activation, suggesting the comprehensive antioxidation and anti-inflammation mechanisms for the management of DN.PMID:35623171 | DOI:10.1016/j.biopha.2022.113139 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2022 Category: Drugs & Pharmacology Authors: Ting-Ting Chang Chih-Hung Chiang Ching Chen Su-Chu Lin Hsin-Jou Lee Jaw-Wen Chen Source Type: research
Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
In conclusion, hydralazine protected renal proximal tubular epithelial cells against the insults of high glucose and prevented renal damage via XO/NADPH oxidase inhibition and Nrf-2/HO-1 activation, suggesting the comprehensive antioxidation and anti-inflammation mechanisms for the management of DN.PMID:35623171 | DOI:10.1016/j.biopha.2022.113139 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2022 Category: Drugs & Pharmacology Authors: Ting-Ting Chang Chih-Hung Chiang Ching Chen Su-Chu Lin Hsin-Jou Lee Jaw-Wen Chen Source Type: research
Glucagon-like peptide-1 receptor agonist, liraglutide, attenuated retinal thickening in spontaneously diabetic Torii fatty rats
This study aims to investigate the effect of the glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) liraglutide on retinal pathological findings as compared with insulin and hydralazine using an animal... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - May 6, 2022 Category: Opthalmology Authors: Kazuho Inoue, Shohei Yamada, Seiko Hoshino, Minoru Watanabe, Kenjiro Kimura and Atsuko Kamijo-Ikemori Tags: Research Source Type: research
Hydralazine-induced vasculitis presenting with ocular manifestations
CONCLUSIONS AND IMPORTANCE: To our knowledge, this report is the first case of hydralazine-induced vasculitis initially presenting with ocular manifestations.PMID:35464686 | PMC:PMC9020102 | DOI:10.1016/j.ajoc.2022.101515 (Source: Herpes)
Source: Herpes - April 25, 2022 Category: Infectious Diseases Authors: Vivian S Hawn Thomas A Vo David Flomenbaum Richard P Gibralter Source Type: research
