Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation
ConclusionHydralazine, an acrolein scavenger, significantly mitigated SCI-induced inflammation and oxidative stressin vivo, modulated macrophage activation, and consequently promoted the structural and functional recovery of the injured CNS. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - August 10, 2023 Category: Research Source Type: research
Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance
Iran J Immunol. 2023 Aug 7;3(20). doi: 10.22034/iji.2023.97585.2522. Online ahead of print.ABSTRACTTwo central questions in COVID-19 treatment which should be considered are: "How does the imbalance of the complement system affect the therapeutic approaches?" and "Do we consider complement inhibitors in therapeutic protocols?". The complement system is a double-edged sword since it may either promote immune responses against COVID-19 or contribute to destructive inflammation in the host. Therefore, it is crucial to regulate this system with complement inhibitors. In this manuscript, we discuss the molecular mechanisms of c...
Source: Iranian Journal of Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Mehdi Torabizadeh Helia Modaresi Asfeh Zeinab Deris Zayeri Cerdan Dominique Hashem Kazemi Najmaldin Saki Source Type: research
