Cell-type dependent regulation of pluripotency and chromatin remodeling genes by hydralazine
CONCLUSIONS: Our data provide evidence that HYD regulates the expression of OCT4 and NANOG pluripotency genes as well as ARID1A and ARID2 genes, two members of the SWI/SNF chromatin remodeling complex family, in normal human dermal fibroblasts.PMID:36927767 | PMC:PMC10021945 | DOI:10.1186/s13287-023-03268-w (Source: Cell Research)
Source: Cell Research - March 17, 2023 Category: Cytology Authors: Alain Aguirre-V ázquez Fabiola Castorena-Torres Beatriz Silva-Ram írez Katia Pe ñuelas-Urquides Mar ía Elena Camacho-Moll Luis A Salazar-Olivo Iv án Velasco Mario Berm údez de León Source Type: research
Coordination of hydralazine with Cu < sup > 2+ < /sup > at acidic pH promotes its oxidative degradation at neutral pH
In this study, we examined interactions of HL with Cu2+ ions in conditions that mimic pH shift in the digestive tract using UV-Vis, Raman and EPR spectroscopy, cyclic voltammetry and oximetry. In the acidic solution, Cu2+ formed a stable mononuclear complex with two bidentate coordinated HL molecules. On the other hand, at neutral pH, Cu2+ initiated oxidation and degradation of HL. The degradation was more rapid in the HL-Cu2+ system that was initially prepared at acidic pH and then shifted to neutral pH. The formation of the complex at acidic pH increases the availability of Cu2+ for redox reactions after the shift to neu...
Source: Journal of Inorganic Biochemistry - March 17, 2023 Category: Biochemistry Authors: Jelena Kora ć Jačić Danica Bajuk-Bogdanovi ć Sla đana Savić Bojana Bo žić Cvijan Ivan Spasojevi ć Milica R Milenkovi ć Source Type: research
Identification and validation of ferroptosis-related hub genes in obstructive sleep apnea syndrome
ConclusionsOur findings revealed that the genes HIF1A and ATM are highly expressed in OSAS, and can serve as biomarkers and targets for OSAS. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 2, 2023 Category: Neurology Source Type: research
Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury
In this study, we targeted BMDMs to explore the influence of hydralazine on immune cells in a mouse model of SCI, and also investigated the contribution of polarized BMDMs to hydralazine-induced neurological function recovery after SCI in male mice. The adult male mice underwent T10 spinal cord compression. The results showed that in addition to improving motor function and hypersensitivity, hydralazine relieved SCI-induced spontaneous pain and emotional response, which is a newly discovered function of hydralazine. Hydralazine inhibited the recruitments of pro-inflammatory BMDMs and educated infiltrated BMDMs to a more re...
Source: Experimental Neurology - March 1, 2023 Category: Neurology Authors: Xin Quan Caiyong Yu Zhongmin Fan Tong Wu Chuchu Qi Haoying Zhang Shengxi Wu Xi Wang Source Type: research
Hydralazine-augmented contrast ultrasound imaging improves the detection of hepatocellular carcinoma
CONCLUSION: Vascular blood flow modulation by hydralazine enhances the visibility of HCC. HyCUS offers a potential problem-solving method for detecting HCC when B-mode and CUS are unsuccessful, especially with background fibro-cirrhotic liver disease. Future evaluation of the approach in humans will determine its translatability for clinical applications. This article is protected by copyright. All rights reserved.PMID:36680519 | DOI:10.1002/mp.16232 (Source: Cancer Control)
Source: Cancer Control - January 21, 2023 Category: Cancer & Oncology Authors: Laith R Sultan Mrigendra B Karmacharya Maryam Al-Hasani Theodore W Cary Chandra M Sehgal Source Type: research
Potential Impacts of Hydralazine as a Novel Antioxidant on Cardiovascular and Renal Disease-Beyond Vasodilation and Blood Pressure Lowering
Antioxidants (Basel). 2022 Nov 11;11(11):2224. doi: 10.3390/antiox11112224.ABSTRACTHydralazine is a traditional antihypertensive drug that was developed several decades ago. Its most well-known effect is blood pressure lowering by arterial vasodilation. While mainly used an adjunct treatment for clinical hypertension or chronic heart failure, this old drug has also shown potential as a repurposing drug for the atherosclerosis vascular disease and various kidney diseases. Recent experimental studies suggest that hydralazine exerts antioxidative, anti-apoptotic, and HIF-1α stabilization effects for angiogenesis and vascular...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Ting-Ting Chang Jaw-Wen Chen Source Type: research
Potential Impacts of Hydralazine as a Novel Antioxidant on Cardiovascular and Renal Disease-Beyond Vasodilation and Blood Pressure Lowering
Antioxidants (Basel). 2022 Nov 11;11(11):2224. doi: 10.3390/antiox11112224.ABSTRACTHydralazine is a traditional antihypertensive drug that was developed several decades ago. Its most well-known effect is blood pressure lowering by arterial vasodilation. While mainly used an adjunct treatment for clinical hypertension or chronic heart failure, this old drug has also shown potential as a repurposing drug for the atherosclerosis vascular disease and various kidney diseases. Recent experimental studies suggest that hydralazine exerts antioxidative, anti-apoptotic, and HIF-1α stabilization effects for angiogenesis and vascular...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Ting-Ting Chang Jaw-Wen Chen Source Type: research
Effect of the Non-N-Methyl-D-aspartate Receptor of the Glutamatergic System of the Pedunculopontine Tegmental Nucleus on Cardiovascular Responses in Normotensive and Hydralazine-Induced Hypotensive Rats
CONCLUSION: Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.PMID:36393823 | PMC:PMC9651188 | DOI:10.4103/abr.abr_14_21 (Source: Biomed Res)
Source: Biomed Res - November 17, 2022 Category: Research Authors: Mohammad Reza Hosseiniravesh Vida Hojati Reza Mohebbati Abolfazl Khajavirad Hooman Shajiee Mohammad Naser Shafei Source Type: research
Effect of the Non-N-Methyl-D-aspartate Receptor of the Glutamatergic System of the Pedunculopontine Tegmental Nucleus on Cardiovascular Responses in Normotensive and Hydralazine-Induced Hypotensive Rats
CONCLUSION: Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.PMID:36393823 | PMC:PMC9651188 | DOI:10.4103/abr.abr_14_21 (Source: Biomed Res)
Source: Biomed Res - November 17, 2022 Category: Research Authors: Mohammad Reza Hosseiniravesh Vida Hojati Reza Mohebbati Abolfazl Khajavirad Hooman Shajiee Mohammad Naser Shafei Source Type: research
Successful conservative management of left ventricular assist device candidates
ConclusionsNotwithstanding the small size of our cohort, our results suggest that LVAD implantation could be safely deferred in the majority of LVAD candidates. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 16, 2022 Category: Cardiology Authors: Ofer Havakuk,
Aviram Hochstadt,
Sapir Sadon,
Michal Laurel Perl,
Ben Sadeh,
Assi Milwidsky,
Orly Ran Sapir,
Yoav Granot,
Lior Lupu,
Erez Levi,
Ariel Farkash,
Yanai Ben Gal,
Shmuel Banai,
Yan Topilsky Tags: Original Article Source Type: research
Hydralazine-Associated Pulmonary-Renal Syndrome
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
Hypertension is Linked to Enhanced Lymphatic Contractile Response via RGS16/RhoA/ROCK Pathway
In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14-week-old) spontaneously hypertensive rats (SHRs) exhibited increased agonist-mediated contraction compared with age-matched Wistar-Kyoto (WKY) rats, whereas lymphatic contractions in younger (4-week-old) SHRs, exhibiting normal blood pressure, were no different compared with age-matched control rats. Tight regulation of blood pressure with antihypertensive drugs (hydrochlorothiazide/hydralazine) did not prevent the augmented lymphatic contraction in adult SHRs; ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Masashi Mukohda Risuke Mizuno Fumiyo Saito Toshiyasu Matsui Hiroshi Ozaki Source Type: research
