Hydralazine-induced vasculitis presenting with ocular manifestations
CONCLUSIONS AND IMPORTANCE: To our knowledge, this report is the first case of hydralazine-induced vasculitis initially presenting with ocular manifestations.PMID:35464686 | PMC:PMC9020102 | DOI:10.1016/j.ajoc.2022.101515 (Source: Herpes)
Source: Herpes - April 25, 2022 Category: Infectious Diseases Authors: Vivian S Hawn Thomas A Vo David Flomenbaum Richard P Gibralter Source Type: research
GSE188349 Transcriptomic response in the heart and kidney to different types of antihypertensive drug administration [kidney]
Contributors : Fumihiko Takeuchi ; Norihiro KatoSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTo unravel antihypertensive drug-induced gene expression changes that are potentially related to the amelioration of end-organ damages, we performed in vivo phenotypic evaluation and transcriptomic analysis on the heart and the kidney, with administration of antihypertensive drugs to two inbred strains of (i.e., hypertensive and normotensive) rats. We chose to use six antihypertensive classes: enalapril (angiotensin converting enzyme inhibitor), candesartan (angiotensin receptor blocker), hydrochlorothia...
Source: GEO: Gene Expression Omnibus - April 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
GSE188348 Transcriptomic response in the heart and kidney to different types of antihypertensive drug administration [heart]
Contributors : Fumihiko Takeuchi ; Norihiro KatoSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTo unravel antihypertensive drug-induced gene expression changes that are potentially related to the amelioration of end-organ damages, we performed in vivo phenotypic evaluation and transcriptomic analysis on the heart and the kidney, with administration of antihypertensive drugs to two inbred strains of (i.e., hypertensive and normotensive) rats. We chose to use six antihypertensive classes: enalapril (angiotensin converting enzyme inhibitor), candesartan (angiotensin receptor blocker), hydrochlorothia...
Source: GEO: Gene Expression Omnibus - April 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation
Free Radic Biol Med. 2022 Apr 7:S0891-5849(22)00149-6. doi: 10.1016/j.freeradbiomed.2022.04.003. Online ahead of print.ABSTRACTOxidative stress has been shown to play a critical pathogenic role in functional loss after spinal cord injury (SCI). As a direct result of oxidative stress, lipid peroxidation-derived aldehydes have emerged as key culprits that sustain secondary injury and contribute significantly to pathological outcomes. Acrolein, a neurotoxin, has been shown to be elevated in SCI and can result in post-SCI neurological deficits. Reducing acrolein has therefore emerged as a novel and effective therapeutic strate...
Source: Free Radical Biology and Medicine - April 10, 2022 Category: Biology Authors: Seth A Herr Spencer S Gardeen Philip S Low Riyi Shi Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Coronavirus Disease 2019 and Hypertension: How Anti-Hypertensive Drugs Affect COVID-19 Medications and Vice Versa
CONCLUSION: This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents and caution must be exercised when these medications are being used simultaneously.PMID:35382727 | DOI:10.2174/1574886317666220405121319 (Source: Current Drug Safety)
Source: Current Drug Safety - April 6, 2022 Category: Drugs & Pharmacology Authors: Aida Doostkam Alireza Hosseinpour Kamyar Iravani Leila Malekmakan Abdolreza Haghpanah Fatemeh Masjedi Zeinab Karimi Hossein Rouzbeh Jamshid Roozbeh Source Type: research
Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials
CONCLUSION: These findings demonstrated the superiority of oral nifedipine 50,60,90 mg, especially oral nifedipine 50 mg tablets, in the treatment of severe hypertension during pregnancy than IV labetalol 300 mg, while oral nifedipine 60,90 mg also showed superiority in the successful treatment rate of severe hypertension during pregnancy than IV hydralazine 15,25 mg. However, the limitations of the underlying data indicate that future large-scale and rigorous RCTs are needed to confirm such findings.PMID:35361052 | DOI:10.1080/10641955.2022.2056196 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 1, 2022 Category: OBGYN Authors: Hui-Zhen Wu Yuan Cheng Ding Yu Ji-Bin Li Yun-Fa Jiang Zhong-Ning Zhu Source Type: research
