Letter by Lu et al. regarding article, "Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia"
Hypertens Pregnancy. 2022 Jan 2:1-2. doi: 10.1080/10641955.2021.2024224. Online ahead of print.NO ABSTRACTPMID:34978249 | DOI:10.1080/10641955.2021.2024224 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - January 3, 2022 Category: OBGYN Authors: Zhuo Deng Dan Lu Source Type: research

Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats
CONCLUSIONS: Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.PMID:34933650 | DOI:10.1080/10641955.2021.2013874 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - December 22, 2021 Category: OBGYN Authors: Ying Li Yuanyuan Liu Jinfeng Chen Jian Hu Source Type: research

Antioxidant status in hypertensive disorders of pregnancy
Conclusions: SOD activity decreased whereas total PON1 activity increased during pregnancy with hypertension. Pregnant women with hypertension had higher activities of PON1 and SOD and relative proportion of PON1 on HDL3c subclasses than nonhypertensive ones. PON1 activity and relative proportion of PON1 on HDL3c subclasses exhibited significant association with hypertension in pregnancy.PMID:34903142 | DOI:10.1080/10641955.2021.2013875 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - December 14, 2021 Category: OBGYN Authors: Jasmina Ivani šević Daniela Ardali ć Gorica Banjac Jelena Jana ć Petar Cabunac Jelena Veki ć Aleksandra Zeljkovi ć Vesna Spasojevi ć-Kalimanovska Nata ša Karadžov Orlić Vesna Mandi ć Marković Željko Miković Aleksandra Stefanovi ć Source Type: research

Combined apocyanin and aspirin treatment activates the PI3K/Nrf2/HO-1 signaling pathway and ameliorates preeclampsia symptoms in rats
Conclusion: Overall, our results suggested that combined treatment of apocyanin and aspirin ameliorates the PE symptoms compared with single-dose apocyanin or aspirin in a PE rat model. Also, we demonstrated that activating the PI3K/Nrf2/HO-1 pathway can be a valuable therapeutic target to improve the pregnancy outcomes of PE.PMID:34875953 | DOI:10.1080/10641955.2021.2014518 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - December 8, 2021 Category: OBGYN Authors: Yaru Ju Yan Feng Xiaolin Hou Lixia Wu Huixia Yang Hongjuan Zhang Yan'Na Ma Source Type: research

Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome
Hypertens Pregnancy. 2021 Nov 23:1-8. doi: 10.1080/10641955.2021.2008424. Online ahead of print.ABSTRACTTo evaluate total Th1/Th2 cytokines in CD3+ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3+, INF-g+/CD3+, IL-4+/CD3+, and IL-10+/CD3+, CD4+/CD8+ were determined by flow-cytometry. Preeclampsia (n= 26) and normal pregnancy (n= 25) participants were age and gestational age matched. CD4+ lymphocytes count was higher in preeclampsia, compared with...
Source: Hypertension in Pregnancy - November 23, 2021 Category: OBGYN Authors: Iara Dos Santos Fagundes Eduardo Pletsch Brendler Isadora Nunes Erthal Raquel Jaqueline Eder Ribeiro Rafaela Siviero Caron-Lienert Denise Cantarelli Machado Bartira Erc ília Pinheiro da Costa Carlos Eduardo Poli-de-Figueiredo Source Type: research

Risk of gestational hypertension and preeclampsia in pregnant women with new onset blood pressure of 120-129/ ≤89 mmHg: a meta-analysis of prospective studies
CONCLUSION: Elevated BP and stage 1 hypertension were risk factors of GH and PE occurrence in pregnant women.PMID:34791972 | DOI:10.1080/10641955.2021.1994588 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 18, 2021 Category: OBGYN Authors: Yun Liu Qingfang Meng Source Type: research