Pre-existing medical disorders as risk factors for preeclampsia: an exploratory case-control study.
Conclusions: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia. PMID: 31530202 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 20, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The relationship between maternal characteristics and carotid intima-media thickness using an automated ultrasound technique.
Conclusion: In healthy pregnancy, we reported CIMT was related to BMI and maternal age but not parity or gestational age. PMID: 31535936 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 20, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Negative association between serum adropin and hypertensive disorders complicating pregnancy.
Authors: Lin D, Yong J, Ni S, Ou W, Tan X Abstract Objective: Study the association of adropin and hypertensive disorders complicating pregnancy (HDCP). Methods: Patients with HDCP were matched with normotensive women (47 pairs). Adropin concentrations were detected by enzyme-linked immunosorbent assay. Results: Compared with the controls, the serum adropin levels were lower in the HDCP group (P
Source: Hypertension in Pregnancy - August 25, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

CoQ10 alleviate preeclampsia symptoms by enhancing the function of mitochondria in the placenta of pregnant rats with preeclampsia.
Authors: Xu X, Pan JR, Zhang YZ Abstract Objective: To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy alleviate preeclampsia symptoms and the underlying mechanism in the rats with preeclampsia. Methods: Forty-five pregnant Wistar rats were equally divided into three groups randomly and received subcutaneous saline injection (control group, n = 15) or 200 mg/kg L-NAME injection to induce preeclampsia symptoms (PE group, n = 30). The PE rats were treated by distilled water (PE+DW group, n = 15) and CoQ10 (PE+CoQ10 group, n = 15) on day 15 to 21 of gestation randomly. Physiological character...
Source: Hypertension in Pregnancy - August 3, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Identification of key transcription factors in preeclampsia.
Authors: Wang J, Liu H, Guo Y, Zhou C, Qi T Abstract Objective: The aim of this study was to identify important transcription factors (TFs) in preeclampsia. Methods: Fisher's test was applied to identify differentially expressed pathways. Functional principal component analysis (FPCA) was applied to identify differential expressed genes (DEGs). Topological characterizations of TFs were analyzed to identify key TFs. Results: From the DEG group, 37 genes were identified as TFs, and a total of 10 significant TFs with adjusted p
Source: Hypertension in Pregnancy - August 1, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.
Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring. PMID: 31364410 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - August 1, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Role of vitamin D in influencing angiogenesis in preeclampsia.
Authors: Nema J, Sundrani D, Joshi S Abstract Objective: Vitamin D plays a key role during pregnancy and is involved in implantation and maintenance of pregnancy. Its deficiency is associated with pregnancy complications like preeclampsia, characterized by abnormal angiogenesis.Method: The current article summarises studies examining the role of vitamin D in pregnancy, with special emphasis on preeclampsia.Results and conclusion: An imbalance in pro- and anti-angiogenic factors is reported in women with preeclampsia. Cell culture studies have demonstrated that vitamin D can influence the process of angiogenesis. Ho...
Source: Hypertension in Pregnancy - July 26, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia.
Authors: Yonekura Collier AR, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA Abstract The immune complement system protects against pathogens; however, excess activation results in disease like hemolytic uremic syndrome, a clinical imitator of preeclampsia. Vascular endothelial factor (VEGF) protects against aberrant complement activation and is inhibited by soluble fms-like tyrosine kinase-1 (sFLT1) in other organs. We hypothesize that sFLT1 promotes complement-mediated placental damage through VEGF inhibition in preeclampsia. Objective: Quantify placental complement activity and sFLT1 expressi...
Source: Hypertension in Pregnancy - July 14, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics.
Conclusion: PE pathogenesis is related to lipid metabolism and inflammation, and proteins related to these pathways are potential early diagnostic markers for PE.PSG2 may be a marker of PE. PMID: 31284791 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 11, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The association between abnormal coagulation testing in preeclampsia, adverse pregnancy outcomes, and placental histopathology.
Conclusion: ACP in pregnancies complicated by preeclampsia was not associated with any of the studied outcomes. Our data question the usefulness of routine coagulation tests in the initial assessment of women presenting with preeclampsia. PMID: 31271326 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 5, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Neuropathological complications associated with hypertensive disorders of pregnancy.
Conclusion: A strong plea is made for the early detection of high blood pressure, its immediate control with rapid acting anti-hypertensive agents if necessary and timeous delivery of fetus as the exact pathogenesis of preeclampsia remains unknown. PMID: 31213115 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 21, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation.
Conclusion: Plasma concentrations of E2 and Ang II decreased after delivery. The plasma concentrations of E2 and Ang II were correlated with each other. PMID: 31204528 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 19, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women.
Authors: Yuksel S, Ozyurek SE, Acar DK, Ozdemir C, Guler S, Kiyak H, Gedikbasi A Abstract Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P
Source: Hypertension in Pregnancy - May 30, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Investigation of Elevation as a Risk Factor for Hypertensive Disorders of Pregnancy Among Colorado Women between 2007 and 2015.
Authors: PMID: 31104530 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 22, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.
Authors: Curtin K, Theilen LH, Fraser A, Smith KR, Varner MW, Hageman GS Abstract BACKGROUND: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). METHODS: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. FINDINGS: Women with HDP exhibite...
Source: Hypertension in Pregnancy - April 13, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The importance of proteinuria in preeclampsia and its predictive role in maternal and neonatal outcomes.
Authors: Tanacan A, Fadiloglu E, Beksac MS Abstract OBJECTIVE: To evaluate impact of 24-h proteinuria level in preeclampsia on maternal/perinatal outcomes. METHODS: Singleton pregnancies with preeclampsia delivered after 24 weeks of gestation were included. Patients were divided into mild (0.3 to
Source: Hypertension in Pregnancy - April 5, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The association between calcium supplement and preeclampsia and gestational hypertension: a systematic review and meta-analysis of randomized trials.
Authors: Sun X, Li H, He X, Li M, Yan P, Xun Y, Lu C, Yang K, Zhang X Abstract OBJECTIVES: The purpose of this study is to investigate whether calcium supplement with or without other drugs could reduce the risk of preeclampsia and gestational hypertension based on existed evidence, and to clarify whether there is discrepant effect among different population and using different dose. METHODS: PubMed, Cochrane library, and EMBASE database were searched. Two authors independently screened all records and extracted data. The meta-analysis was performed to calculate risk ratios and 95% CIs using random-effects mode...
Source: Hypertension in Pregnancy - April 3, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin.
CONCLUSION: VD treatment reduced Chemerin level, and blood pressure in DOCA rat model of PE. PMID: 30922121 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 30, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia.
CONCLUSION: Urinary protein carbonyl level is elevated in preeclampsia but plays a minor role in proteins misfolding. PMID: 30913931 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 29, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.
Authors: Lamain-de Ruiter M, Kwee A, Naaktgeboren CA, Louhanepessy RD, De Groot I, Evers IM, Groenendaal F, Hering YR, Huisjes AJM, Kirpestein C, Monincx WM, Schielen PCJI, Van 't Zelfde A, Van Oirschot CM, Vankan-Buitelaar SA, Vonk MAAW, Wiegers TA, Zwart JJ, Moons KGM, Franx A, Koster MPH Abstract OBJECTIVE: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). METHODS: Women
Source: Hypertension in Pregnancy - March 21, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Incidence and outcomes of eclampsia: a single-center 30-year study.
Authors: Uludag SZ, Gokmen Karasu AF, Kutuk MS, Takmaz T Abstract OBJECTIVE: We aimed to determine the incidence of eclampsia at Erciyes University Hospital which is a tertiary referral center situated at central Anatolia. Additionally, we investigated eclampsia-associated maternal and perinatal outcomes for the 30-year study period. METHODS: A retrospective review was performed for all women who were diagnosed with eclampsia and admitted to the Erciyes University Medical School, Department of Obstetrics and Gynecology from January 1985 to December 2015. Improvement in management gained over time was determined...
Source: Hypertension in Pregnancy - March 20, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlates of neutrophil/lymphocyte, platelet/lymphocyte, and platelet/neutrophil ratios of neonates of women with hypertensive disease of pregnancy with neonatal birth outcomes.
CONCLUSION: PLR and NLR in neonates of hypertensive mothers are found to be markedly lower than those of controls, the degree of which is affected by the severity of hypertension. Also, lower PLR is associated with lower APGAR scores. Therefore, severity of high blood pressure and lower PLR may be determinants of poor birth outcome. PMID: 30835575 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 7, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Circulating HO-1 levels are not associated with plasma sFLT-1 and GTn HMOX1 polymorphism in preeclampsia.
CONCLUSION: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GTn polymorphism. PMID: 30835584 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 7, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Dysregulation of circulating sTie2 and sHER2 in HIV-infected women with preeclampsia.
CONCLUSION: Irrespective of HIV status, reduced concentrations of sTie2 were evident in preeclampsia (PE) reflecting a dysregulation of the angiogenic process. sHER2 was similar between pregnancy types, attributable to the oxidative stressed microenvironment which promotes dysregulation of the MAPK and P13K/Akt signaling. HIV status did not influence sTie2 and sHER2 expression, reflecting the immune reconstitution of highly active antiretroviral therapy. sTie2 and sHER2 were not influenced by PE comorbid with HIV infection. PMID: 30836796 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 7, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia.
Conclusion: Increased circulating TMAO downregulates IL-10 and promotes vascular inflammation and oxidative stress, contributing to endothelial dysfunction and hypertension in PE. PMID: 30821524 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 4, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis.
CONCLUSION: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease. PMID: 30794002 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 24, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.
CONCLUSION: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation. PMID: 30760065 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 16, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

T lymphocytes in the third trimester decidua in preeclampsia.
Authors: Milosevic-Stevanovic J, Krstic M, Stefanovic M, Zivadinovic R, Vukomanovic P, Trajkovic-Dinic SP, Stojnev S Abstract OBJECTIVE: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia. METHODS: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. RESULTS: The group with preeclampsia included a significantly higher number of CD3+ (p
Source: Hypertension in Pregnancy - February 14, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia.
CONCLUSION: It is explained how altered expression of the lncRNAs and abnormal regulation of them affect the risk of preeclampsia. However, the interaction between various lncRNAs and coordinate regulation of them in health and failure of such coordinative mechanisms in diseases such as preeclampsia need to be elucidated. PMID: 30707634 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 3, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

A meta-analysis of tumor necrosis factor- α and FAS/FASL polymorphisms with risk of pre-eclampsia.
In this study, we aimed to evaluate the association between TNF-α -308 A/G, -850 C/T, -238 A/G, FAS -670 A/G, and FASL -844 C/T and PE risk using a meta-analysis. Pubmed, EBSCO, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched up to April 10th 2018. Summarized odds ratios (ORs) with 95% confidence intervals (CIs) for the association between the five polymorphisms and PE risk were computed using a fixed or random effects model. The TNF-α -308 GA and GA/AA genotypes were associated with increased risks of PE in Asians (heterozygous comparison: OR = 2.68, 95% CI, ...
Source: Hypertension in Pregnancy - January 5, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlation between uterine artery Doppler and the sFlt-1/PlGF ratio in different phenotypes of placental dysfunction.
CONCLUSION: In PDD, the sFlt-1/PlGF ratio and UtA Doppler indexes increase proportionally. Correlations between the sFlt-1/PlGF ratio and UtA Doppler indexes might help to distinguish between PDDs with and without impaired placentation. However, further studies are needed to explore the correlations in different phenotypes of PDD. PMID: 30485134 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - December 1, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Investigation of elevation as a risk factor for hypertensive disorders of pregnancy among Colorado women between 2007 and 2015.
CONCLUSION: Women living at high or moderate elevation do not have higher odds of HDP. PMID: 30384782 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease.
Authors: Tayyar AT, Tayyar A, Kozali S, Karakus R, Eser A, Abide Yayla C, Yalcin ET, Dag I, Eroglu M Abstract OBJECTIVE: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. METHODS: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. RESULTS: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p 
Source: Hypertension in Pregnancy - November 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum neopterin levels in women with preeclampsia: a systematic review.
Authors: Pergialiotis V, Karampetsou N, Zoumpourlis P, Papantoniou N, Thomakos N, Daskalakis G Abstract OBJECTIVE: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Several studies suggest its association with preeclampsia and the purpose of the present study is to evaluate this assumption. METHODS: We searched the Medline (1992-2018), Scopus (1993-2018) and Google Scholar (1993-2018) databases. All articles that evaluated serum neopterin levels in patients with preeclampsia were held eligible for inclusion, regardless of the...
Source: Hypertension in Pregnancy - October 13, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal levels of growth differentiation factor-15 in patients with preeclampsia.
CONCLUSION: Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia. PMID: 30295110 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 10, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Peripheral arterial tonometry and angiogenic biomarkers in preeclampsia.
CONCLUSION: Peripheral arterial analysis did provide additional information beyond serum biomarkers in the diagnosis of PE. PMID: 30282501 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 6, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serial profile of flow-mediated dilatation in primigravida for prediction of preeclampsia and gestational hypertension.
Authors: Malhotra AS, Goel P, Chaudhary A, Kochhar S, Kaur G, Bhagat A Abstract OBJECTIVE: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE). METHODS: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. RESULTS: Significant fall in FMD was observed from first trimester to third trimester but decrease in FMD in GH/PE gr...
Source: Hypertension in Pregnancy - October 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy.
Authors: Aldika Akbar MI, Herdiyantini M, Aryananda RA, CIninta N, Wardhana MP, Gumilar KE, Wicaksono B, Ernawati, Sulistyono A, Aditiawarman, Joewono HT, Nadir Abdullah, Dekker G, Dachlan EG, Dikman Angsar M Abstract OBJECTIVE: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). METHODS: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cas...
Source: Hypertension in Pregnancy - October 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output.
Authors: Niemczyk NA, Catov JM, Desai MM, McClure CK, Roberts JM, Sekikawa A, Tepper PG, Barinas-Mitchell E Abstract OBJECTIVE: To assess brachial artery distensibility and associated factors in healthy primigravidas. METHODS: We assessed brachial artery distensibility using the DynaPulse 5,000A in 37 women each trimester, and 6-8 weeks and 1-5 years postpartum. Associations with physical and cardiometabolic measures were considered. RESULTS: Mean (SE) brachial artery distensibility (%Δ/mmHg) decreased (stiffened) from 7.50 (0.20) 12-14 weeks to 6.93 (0.22) 36-38 weeks (p 
Source: Hypertension in Pregnancy - September 27, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Arterial stiffness during controlled ovarian hyperstimulation and early pregnancy in women exposed to assisted reproduction.
CONCLUSION: During COH for IVF treatment, DPA showed no changes in arterial stiffness during the follicular phase or in early pregnancy, but increased arterial stiffness in central and peripheral arteries in the early luteal phase. The result suggests a hormonal hemodynamic activation counteracting the effects of estrogen. PMID: 30238809 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 23, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study.
Authors: Abbas AM, Fikry EM, Mostafa TS, Shaltout AS, El-Baz MAH Abstract OBJECTIVE: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications. METHODS: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Age-, parity-, and gestational age-matched women had approached to participate in the study as a control group (Group III). Serum sFlt-1 levels ...
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between hypertensive disorders complicating pregnancy and risk of placenta accreta: a meta-analysis and systematic review.
CONCLUSIONS: Our meta-analysis demonstrated that the risk of placenta accreta is reduced in women with hypertensive disorders complicating pregnancy. Further well-designed studies are warranted to testify the result and explored any potential mechanism association between hypertensive disorders complicating pregnancy and placenta accreta. PMID: 30040502 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes.
Authors: Li B, Lin L, Yang H, Zhu Y, Wei Y, Li X, Chen D, Zhao X, Cui S, Ding H, Ding G, Meng H, Wei H, Sun X, Xin H Abstract BACKGROUND: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population. STUDY DESIGN: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Urinary clusterin and glutathione-s-transferase levels in HIV positive normotensive and preeclamptic pregnancies.
CONCLUSION: HIV infection affects the activity of urinary CLU protein in HIV positive preeclampsia. However, the cytoprotective role of these proteins neutralizes the oxidative radicals associated with preeclampsia development through complement response in HIV infection. PMID: 30024772 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 21, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.
Authors: Keshavarzi F, Mehdizadeh S, Khazaie H, Ghadami MR Abstract OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP)> 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (...
Source: Hypertension in Pregnancy - July 21, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Uterine artery flow velocity waveforms before and after delivery in hypertensive disorders of pregnancy near term.
Authors: Duncan JR, Tobiasz AM, Bursac Z, Rios-Doria EV, Schenone MH, Mari G Abstract OBJECTIVE: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term. METHODS: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Our primary outcome was to compare the UtAPI-AP and UtAPI-PP between subjects with HTNP (g...
Source: Hypertension in Pregnancy - July 20, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum magnesium level in the first trimester of pregnancy as a predictor of pre-eclampsia - a pilot study.
Authors: Čabarkapa V, Bogavac M, Jakovljević A, Pezo L, Nikolić A, Belopavlović Z, Mirjana D Abstract OBJECTIVES: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE). METHODS: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 3...
Source: Hypertension in Pregnancy - July 20, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension.
Authors: Marrs CC, Rahman M, Dixon L, Olson G Abstract Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Logistic regression was conducted to determine the association of elevated UA with PP HTN. Five hundred and fifty-six women met criteria. An UA level ≥ 5.2 mg/dL was associated with immediate PP HTN (adjusted odds ratio 2.44, 95% CI 1.63-3.64). The association was stronger among overweight an...
Source: Hypertension in Pregnancy - July 18, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk.
CONCLUSION: Second trimester MPV and serum uric acid alone or in combination could be used as a useful biochemical markers for prediction of PE based on their validity, simplicity, and availability. PMID: 29893156 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 14, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Morphological and structural changes of umbilical veins and clinical significance in preeclampsia.
CONCLUSIONS: These results indicate that umbilical vein of preeclampsia cases has a thickened tunica media from smooth muscle proliferation, which may be an adapted reaction to hypertension. Altogether, this study demonstrates that morphological changes in umbilical veins adversely affect fetal development in preeclampsia cases. PMID: 29733777 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 9, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research