Patients' perspective on aspirin during pregnancy: a survey.
CONCLUSION: Half of the women with a history of HDP were aware of the risk-reducing effect of aspirin in a consecutive pregnancy. PMID: 32564638 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 24, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum apelin and galectin-3 in preeclampsia in Iraq.
CONCLUSION: In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia. PMID: 32538210 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 17, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Relationship between ABO blood groups and preeclampsia.
Conclusion: Blood group O decreased the risk of late-onset preeclampsia while it increased the risk of early-onset preeclampsia. PMID: 32525417 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 13, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Predictive value of early second trimester maternal serum cyclophilin A concentrations in women complicated with preeclampsia: a preliminary case-control study.
CONCLUSION: Cyclophilin A may be a valuable predictor for pregnant women who subsequently develop preeclampsia in their pregnancies. PMID: 32507068 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 10, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies.
Conclusion ACE I/D polymorphism may protect against the development of PE. PMID: 32484368 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 4, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort.
CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia. PMID: 32479208 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 3, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Complications and outcomes of SARS-CoV-2 in pregnancy: where and what is the evidence?
CONCLUSION: Limited data on COVID-19 during preganacy, associated with a wide variation in the methodology make accurate data interpretation difficult. PMID: 32456489 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 29, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cystatin C as an indicator of renal damage in pre-eclampsia.
Conclusion: Serum cystatin C level maybe a significant marker of pre-eclampsia. PMID: 32427499 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 21, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Impact of physical activity and traumatic exposure on occurrence of gestational hypertension: a survey of pregnant women in an armed-conflict region in Nigeria.
Conclusion: Despite exposed to traumatic events, physical activity is associated with normotensive pregnancy in an armed conflict region. PMID: 32419529 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 19, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension.
Conclusion: Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension.the incidence of preeclampsia was greater in methyldopa group. PMID: 32420783 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 19, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Carbetocin versus oxytocin for prevention of postpartum hemorrhage in hypertensive women undergoing elective cesarean section.
Authors: Ibrahim ZM, Sayed Ahmed WA, Abd El-Hamid EM, Taha OT, Elbahie AM Abstract Objective: Assess the efficacy and safety of carbetocin, versus oxytocin in the prevention of postpartum hemorrhage in hypertensive women.Study design: A randomized clinical trial.Setting: Obstetrics and Gynecology Department of Suez Canal University Hospital.Patients: One hundred and sixty hypertensive pregnant women who underwent CS.Interventions: Patients were randomized to receive either 10 IU oxytocin or 100 μg carbetocin. Primary outcomes included estimated blood loss, blood transfusion, hemoglobin (HB), and hematocrit ...
Source: Hypertension in Pregnancy - May 19, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Exploring the beneficial effects and possible mechanisms of repeated episodes of whole-body hypoxic perconditioning in rat model of preeclampsia.
Conclusion: WHPC attenuates L-NAME-induced PE-like symptoms due to increase in CBS activity and H2S-production. PMID: 32397773 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 15, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats.
Authors: Rozkova I, Brusentsev E, Igonina T, Ragaeva D, Petrova O, Tikhonova MA, Akopyan AA, Amstislavskaya TG, Antonov YV, Amstislavsky S Abstract The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activi...
Source: Hypertension in Pregnancy - May 15, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Fetal gender, serum human chorionic gonadotropin, and testosterone in women with preeclampsia.
Conclusion: The mechanism of preeclampsia could be androgen-mediated. There is a significant correlation between serum HCG and testosterone and preeclampsia. PMID: 32406308 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 15, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Factors contributing to late stillbirth among women with pregnancy hypertension in a developing country.
Authors: Kumar M, Vajala R, Bhutia P, Singh A Abstract Objective: To investigate the factors associated with late stillbirth among women with hypertensive disorders of pregnancy (HDP).Material and Methods: The clinical details of women with HDP having late stillbirth were compared with controls having livebirth.Results: Total 208 cases and 288 controls were included in the study. Inadequate antenatal visits (p
Source: Hypertension in Pregnancy - May 14, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum levels of uric acid may have a potential role in the management of immediate delivery or prolongation of pregnancy in severe preeclampsia.
Conclusion: UA levels could be a potential management biomarker for immediate or delayed delivery in severe preeclampsia. However, the higher risk of stillbirth must be considered in delayed delivery.Conclusion: UA levels could be a potential management biomarker for immediate or delayed delivery in severe preeclampsia. However, the higher risk of stillbirth must be considered in delayed delivery. PMID: 32345065 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 1, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The diagnostic value and regulatory mechanism of miR-200a targeting ZEB1 in pregnancy-induced hypertension.
Conclusion: MiR-200a was upregulated in PIH patients, andinhibition of miR-200a may improve disease progression, as it could facilitatetrophoblastproliferation, migration and invasionandinhibitapoptosisby targeting ZEB1. PMID: 32345067 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 1, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Antenatal and postpartum comparison of HD-OCT findings of macula, retinal nerve fiber layer, ganglion cell density between severe preeclampsia patients and healthy pregnant woman.
Authors: Tok A, Beyoğlu A Abstract Aim: To investigate the effects of severe preeclampsia on the retinal nerve fiber layer (RNFL), macula thickness and ganglion cell density in pregnancy and postpartum, using High Definition Optical Coherence Tomography (HD-OCT).Material and Method: The study group included 28 stable pregnant patients diagnosed with severe preeclampsia and the control group, 28 age and gestational week-matched healthy pregnant women. HD-OCT measurements were taken by the same researcher using a Cirrus HD-OCT device and were repeated at 8 weeks postpartum.Results:The mean systolic pressure, di...
Source: Hypertension in Pregnancy - April 29, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Magnesium intoxication in women with preeclampsia with severe features treated with magnesium sulfate.
Conclusion: Mg intoxication is associated with a increased risk of maternal and perinatal mortality and morbidity. PMID: 32336169 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 28, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Shortened postpartum magnesium sulfate treatment vs traditional 24h for severe preeclampsia: a systematic review and meta-analysis of randomized trials.
Conclusions: Shortened postpartum magnesium sulfate treatment was as effective as traditional 24 h magnesium sulfate in seizure prevention and total complications. But flushing and needed for prolonged treatment in the shortened groups warrants further research. PMID: 32338165 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 28, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis.
Conclusion: The present study supports the concept that ICP is associated with the risk of GDM and preeclampsia. PMID: 32326772 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 25, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis.
Conclusions: IL9 and IL9R contribute to the pathogenesis of preeclampsia. IL9/IL9R signaling provides a new potential therapeutic target for preventing preeclampsia. PMID: 32329646 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 25, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

A çaí (Euterpe oleracea Mart) seed extract protects against maternal vascular dysfunction, hypertension, and fetal growth restriction in experimental preeclampsia.
Conclusion: ASE protected against maternal cardiovascular changes and IUGR in the L-NAME-induced PE. The protective effect of ASE may be partly explained by its antioxidant property. PMID: 32306786 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 22, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Concordance-analysis and evaluation of different diagnostic algorithms used in first trimester screening for late-onset preeclampsia.
Authors: Schaller S, Knippel AJ, Verde PE, Kozlowski P Abstract Objective: Concordance-analysis and evaluation of existing algorithms detecting late-onset preeclampsia during first trimester screeningMethods: Retrospective cohort study investigating risk algorithms of late-onset preeclampsia during first trimester screening in a German prenatal center. Three previously developed algorithms including anamnestic factors (Apriori) and biophysical markers (BioM) were investigated by using detection rates (DR) with fixed FPR 10% and fixed cutoff>1:100. Furthermore, we set up a concordance-analysis of test results in ...
Source: Hypertension in Pregnancy - April 22, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable Thrombophilia.
Authors: Schonewille NN, Abheiden CNH, Bokslag A, Thijs A, De Groot CJM, De Vries JIP, De Boer MA Abstract Aim of this study was to compare cardiovascular risk in women with and without inheritable thrombophilia after hypertensive disorders of pregnancy (HDP). Blood pressure, anthropometrics and blood samples were measured 9-13 years after early-onset ( 25 kg/m2 (43.8% vs. 53.1%, OR 0.69 95% CI (0.24-2.00)) or metabolic syndrome (18.8% vs. 13.3%, OR 1.51 95% CI (0.38-6.02)) were found. These data show similar cardiovascular risk profile in women with and without inheritable thrombophilia. PMID: 32297536 [PubMed...
Source: Hypertension in Pregnancy - April 18, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis.
Conclusion: ApoE polymorphism might not be associated with the risk of PE. PMID: 32290718 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 17, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Prehypertension prior to pregnancy is associated with hypertensive disorders of pregnancy and postpartum metabolic syndrome in Chinese women.
Conclusion: Women with pre-pregnancy prehypertension may benefit from the more intensive monitor for HDP and postpartum metabolic syndrome. PMID: 32267178 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 9, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Predictive possibility of the transverse cerebellar diameter to abdominal circumference ratio for small-for-gestational-age fetus suspected as a cause of maternal placental syndromes: a retrospective cohort study.
Conclusions: Accurate risk stratification using the TCD/AC ratio could assist in managing patients with small-for-gestational-age fetuses at risk of developing MPS-associated adverse outcomes. PMID: 32248714 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 8, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry.
Conclusion: The genotyped rs505802 and rs1014290 are significantly associated with pre-eclampsia. PMID: 32255363 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 8, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Reference ranges and trajectories for blood pressure in pregnancy: findings from a follow-up study based on China Maternal and Newborn's Health Monitoring System.
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 5, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Is gestational hypertension associated with affective temperaments?
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Source: Hypertension in Pregnancy - April 5, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Expression and role of ERAP1 in placental tissues of preeclampsia.
Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia. PMID: 32239976 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 4, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Interleukin-35 inhibits human umbilical vein endothelial cell injury induced by sera from pre-eclampsia patients by up-regulating S100A8 protein expression.
Authors: Li M, Qian L, Yu J, Zou Y Abstract Objectives: The protective effects of interleukin(IL)-35 against injury to human umbilical vein endothelial cells (HUVECs) induced by the serum of pre-eclampsia patients were analyzed.Methods: This cross-sectional study included 24 patients with pre-eclampsia (PE) and 24 normotensive pregnant women.Results: Compared to normotensive pregnant women, patients with pre-eclampsia had lower IL-35 levels (P
Source: Hypertension in Pregnancy - March 25, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida.
Conclusion:  sFlt-1/PlGF ratio at 16-18 weeks of gestation in elderly gravida has a high sensitivity for predicting preeclampsia, especially early onset preeclampsia. PMID: 32202171 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 25, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The value of fetal Doppler indices as predictors of perinatal outcome in women with preeclampsia with severe features.
Authors: El-Demiry NM, Maged AM, Gaafar HM, ElAnwary S, Shaltout A, Ibrahim S, El-Didy HM, Elsherbini MM Abstract Objective: To evaluate the diagnostic performance of Doppler sonography of umbilical artery (UA), fetal middle cerebral artery (MCA), ductus venosus (DV) & umbilical vein (UV) for prediction of adverse perinatal outcome.Material and Methods: A prospective cohort study conducted on 60 women diagnosed  with preeclampsia with severe features divided into two groups based on adverse perinatal outcome.Results: Statistically Significant differences were demonstrated UA PI (1.28 ± 0.23 vs. 0.96 ± 0.21, P
Source: Hypertension in Pregnancy - February 27, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies.
Conclusion: The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome. PMID: 32069132 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 20, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Reappraisal of the relationship between 24-hour proteinuria and preeclampsia in terms of the maternal and perinatal outcomes.
Conclusion: Proteinuria levels may aid in diagnosing preeclampsia and indicating early intervention. The revised guidelines do not suggest that proteinuria encountered during pregnancy is clinically insignificant. PMID: 32037908 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 12, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women.
Authors: Ahmed SF, Ali MM, Kheiri S, Elzaki SEG, Adam I Abstract Purpose: To assess the associations between preeclampsia, methylenetetrahydrofolate reductase (MTHFR) C677T, and reduced folate carrier-1 (RFC-1) G80A gene polymorphism in Sudanese women.Methods: A matched (for age and parity) case-control study was conducted in a tertiary hospital (Saad Abualila) in Khartoum, Sudan during February to September 2018. The cases were women with preeclampsia and healthy pregnant women were the controls (160 women in each arm of the study). Genotyping for MTHFR C677T and RFC-1 G80A was performed by polymerase chain reacti...
Source: Hypertension in Pregnancy - February 7, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study.
Conclusions: Family history of pre-eclampsia increased the risk of PE. The impact of family history of cardiovascular disease on pre-eclampsia was more conservative, but serves to support the hypothesis that pre-eclampsia may reflect the premature exposure of underlying cardiovascular dysfunction, precipitated by the stress test of pregnancy. PMID: 31910697 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - January 9, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal serum perlecan levels in women with preeclampsia.
Conclusion: Our findings suggest that preeclamptic women with severe features have higher serum perlecan levels than women with preeclampsia. PMID: 31899995 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - January 6, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Plasma concentrations of tissue kallikrein in normal and preeclamptic pregnancies.
Conclusion: Lower maternal plasma TK may be a risk marker that reflects the severity of preeclampsia. PMID: 31880472 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - December 29, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Treatment of severe hypertension during pregnancy: we still do not know what the best option is.
Authors: Wertaschnigg D, Wang R, Reddy M, Costa FDS, Mol BWJ, Rolnik DL Abstract Intracranial hemorrhage and stroke are primary causes of maternal mortality in pregnancies affected by hypertensive disorders. As such antihypertensive therapy plays a crucial role in the management of severe hypertension. However, the target level to achieve the best outcome for both - mother and fetus - is still unclear. Moreover, given the lack of well-designed randomized controlled trials with standardized key outcomes, the current choice of antihypertensive medications depends rather on clinicians' preference. Furthermore, data on...
Source: Hypertension in Pregnancy - December 29, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia in women with pregestational diabetes - a cohort study.
Conclusions: In women with pregestational diabetes, some risk factors may predict PE, similar to those found in non-diabetic pregnant women. Two non-modifiable factors (type of diabetes and chronic hypertension) and two modifiable ones (systolic blood pressure levels and gestational weight gain) were found relevant in this cohort. A policy of close monitoring of blood pressure and weight gain, aiming adequate weight gain, may be added to current recommended measures. The high prevalence of PE in women with prepregnancy diabetes, especially those with initial pregnancy systolic blood pressure>124 mmHg, supports a policy ...
Source: Hypertension in Pregnancy - December 27, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Management of hypertension in pregnancy: a descriptive report of two clinic practices.
Conclusion: Inconsistencies exist in current treatment and documentation of hypertension in pregnancy. PMID: 31777293 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 30, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal asthma and the risk of hypertensive disorders of pregnancy: a systematic review and meta-analysis of cohort studies.
Conclusion: The meta-analysis illustrated that asthma was significantly increased risk of hypertension during pregnancy. PMID: 31762345 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 27, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Immunohistochemical localization of heme oxygenase-1 and bilirubin/biopyrrin of heme metabolites as antioxidants in human placenta with preeclampsia.
Conclusions: The degree of these expressions tended to relate to the onset of PE. This suggests that the heme catabolic pathway induced by oxidative stress plays an important role in the pathophysiology of PE. PMID: 31718385 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 15, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

First trimester screening for preeclampsia - a systematic review.
FIRST TRIMESTER SCREENING FOR PREECLAMPSIA - A SYSTEMATIC REVIEW. Hypertens Pregnancy. 2019 Oct 31;:1-11 Authors: Mosimann B, Amylidi-Mohr SK, Surbek D, Raio L Abstract Objective: To increase the detection rate of preterm preeclampsia (PE) first trimester combined screening tests are being developed. The aim of this review is to create an overview of the currently investigated screening markers, algorithms and their validations.Methods: Comprehensive review of the literature concerning first trimester screening for PEResults and conclusions: Studies investigating a total of 160 biochemical, 6 biophysic...
Source: Hypertension in Pregnancy - November 2, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction.
Authors: Hendrix MLE, Palm KCM, Van Kuijk SMJ, Bekers O, Spaanderman MEA, Bons JAP, Al-Nasiry S Abstract Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p
Source: Hypertension in Pregnancy - September 29, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Polymorphisms within vitamin D binding protein gene within a Preeclamptic South African population.
Authors: Naidoo Y, Moodley J, Ramsuran V, Naicker T Abstract Objectives: The vitamin D binding protein encoded by the GC gene contains two single nucleotide polymorphisms (rs4588 and rs7041) that have been associated with disease outcome, these include periodontitis coronary heart disease and hypertension. In pregnancy, these SNPs influence vitamin D metabolism that could result in hypertensive disorders such as PE. The etiology of PE, still remains elusive. The aim of this study was to evaluate the distribution of rs4588 and rs7041 within the GC gene among PE and normotensive pregnant women, residing in Durban, Kw...
Source: Hypertension in Pregnancy - September 29, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Managing hypertensive disorders during pregnancy in low resource settings.
Authors: Ramavhoya IT, Maputle MS, Lebese RT, Ramathuba DU, Netshikweta LM Abstract Background: Maternal deaths caused by hypertensive disorders are preventable. The purpose was to assess midwives' perceived knowledge and skills on the implementation of maternal health guidelines when managing hypertensive disorders during pregnancy. Methods: Quantitative, cross-sectional method was used. Population comprised of 200 midwives. Data was collected through self-report questionnaires and analysed through Statistical Package for Social Sciences 24. Results: Midwives (63.5%) possessed knowledge and skills of implementing ...
Source: Hypertension in Pregnancy - September 27, 2019 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research