Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis.
CONCLUSION: Evaluation of immune status based on PD-L1 pleural concentration and Th2 to Th1 ratio might predict the risk of MDR-TB occurrence. PMID: 32224537 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

TLR Agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response.
CONCLUSION: These results suggested that rHP-NAP possesses the potential for use as an adjuvant of dendritic cell-based vaccine in anti-melanoma treatment. PMID: 32224538 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Maturation and Function of Murine Dendritic Cells: an In-Vitro Study.
CONCLUSION: Despite improvements in maturity status, pp150-stimulated DCs did not seem to be able to induce Th1 or Th2 immunity. In fact, Th17 and its mediators, IL-17A and IL-22, might be the main inflammatory factors involved in pp150-stimulated DC's mechanism of action. However, it is necessary to conduct further investigations to corroborate these observations. PMID: 32224539 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA.
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
CONCLUSION: Our study showed that Tim-3 might play an important role in the development of AP through regulating the inflammatory response. PMID: 32224541 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effect of Tribulus Terrestris L. on Expression of ICAM-1, VCAM-1, E-Selectin and Proteome Profile of Human Endothelial Cells In-Vitro.
CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. However, the anti-inflammatory effect of aqueous extract was greater than that of saponin fraction. Therefore, TT could be considered as a potential candidate for the treatment or prevention of atherosclerosis. PMID: 32224542 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Protective Potential of Conjugated P. aeruginosa LPS -PLGA Nanoparticles in Mice as a Nanovaccine.
CONCLUSION: The conjugation of the bacterial LPS to the PLGA nanoparticle increased their functional activity by decrease in bacterial dissemination and increase the killing of opsonized bacteria. PMID: 32224543 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

T Regulatory Cell Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia.
CONCLUSION: Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response. PMID: 32224544 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effects of Dendritic Cell Vaccine Activated with Components of Lieshmania Major on Tumor Specific Response.
CONCLUSION: This study indicates that the use of Leishmania major extract, as well as LPS, can enhance the efficiency of DC-based vaccines and provides a basis for the use of Leishmania major in DC-targeted clinical therapies. PMID: 31885004 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α.
Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α. Iran J Immunol. 2019 Dec;16(4):278-290 Authors: Wang Y, Wu X, Hu Y Abstract BACKGROUND: Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. OBJECTIVE: To investigate the immunomodulatory function of bone marrow mesenchymal stromal cells (MM-BMSCs) on CD8+ T cells. METHODS: Proliferation and cytotoxicity were detected by cell counting kit-8 assay. Cell cycl...
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer.
CONCLUSION: The increase in the percentage of NK and iNKT cells in TDLNs of patients with higher grade of BC might suggest a suppressive phenotype for these cells in breast cancer, which merit more functional investigation. PMID: 31885006 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet's Disease.
CONCLUSION: IL-37 expression increased in NBD patients, and correlated with disease activity. Our data conclude that IL-37 could be a disease marker in NBD, however it requires further studies. PMID: 31885007 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Importance of L. Infantum H2B Recombinant Antigen for Serodiagnosis of Visceral Leishmaniasis.
CONCLUSION: Recombinant H2B antigen expressed in the prokaryotic system had suboptimal performance for the serological diagnosis of VL. It seems that the production and expression of recombinant H2B antigen in a eukaryotic system may enhance the performance of this antigen in the diagnosis of VL in Iran. PMID: 31885008 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis.
Authors: Abbasi R, Zomorodian K, Zare Shahrabadi Z, Saadat F, Nabavizadeh SH, Esmaeilzadeh H, Alyasin S Abstract BACKGROUND: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. OBJECTIVE: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. METHODS: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. ...
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis.
CONCLUSION: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH. PMID: 31885010 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Atypical Omenn Syndrome Due to RAG2 Gene Mutation, a Case Report.
We present a novel case of atypical SCID (SCID manifestations with more than 300 CD3+T cells) caused by RAG 2 gene mutation whose immunophenotype changed to atypical Omenn syndrome (all Omenn syndrome manifestations except rash, eosinophilia, and elevated IgE) over time. Differentiation of leaky SCID, SCID and Omenn syndrome in RAG mutation genes and overlap manifestations is important in treatment plan and prognosis. PMID: 31885011 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages.
CONCLUSION: Hepcidin is able to induce macrophage polarization towards M1 type, and might be utilized as a potential M1 macrophage agonist in clinical practice. PMID: 31552828 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Immunogenic Evaluation of Bivalent Vaccine Candidate against Enterohemorrhagic and Enterotoxigenic Escherichia coli.
CONCLUSIONS: The immunity to both ETEC and EHEC bacteria is significant, and this structure can be considered as a candidate for vaccine production against these bacterial strains. PMID: 31552829 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IpaD-loaded N-trimethyl Chitosan Nanoparticles Can Efficiently Protect Guinea Pigs against Shigella flexneri.
Authors: Akbari MR, Saadati M, Honari H, Ghorbani HM Abstract BACKGROUND: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). OBJECTIVE: To evaluate the efficiency of O-metylated free trimethyl chitosan nanoparticles (TMC NPs) in the oral delivery of NIpaD. METHODS: TMC was synthesized by a two-step method from high molecular weight chitosan. The recombinant NIpaD protein was used as the immunogen. The protei...
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial.
CONCLUSION: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. PMID: 31552831 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer.
CONCLUSION: As the CEA DNA vaccine displayed encouraging antitumor effects, therefore, we suggest that it can be a potential therapeutic modality for colorectal cancer and is worthy of further investigation. PMID: 31552832 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effects of CD133 Silencing on Survival and Migration of HT-29 Colorectal Cancer Cells.
CONCLUSION: siRNA mediated targeting of CD133 could be considered as a promising approach to treat CRC through suppressing the cancerous behavior of tumor cells. PMID: 31552833 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IgG Avidity Test for Ocular Toxoplasmosis Diagnosis at a Tertiary Center, Northeast of Iran.
CONCLUSION: The result of this study showed that IgM is not a reliable marker of acute disease. Repetition of the serology tests was proposed in cases with clinical manifestations without detectable antibody titer after approximately two weeks. IgG avidity testing results coincided with clinical diagnosis and it could therefore considered to be a reliable method to differentiate between recently acquired and chronic ocular toxoplasmosis. PMID: 31552834 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?
Authors: Barra F, Ferrero S PMID: 31552835 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Pathogenesis of Atopic Dermatitis: Current Paradigm.
Authors: Furue M, Ulzii D, Vu YH, Tsuji G, Kido-Nakahara M, Nakahara T Abstract Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such as CCL17, CCL22 and CCL26 is increased in the lesional skin of AD. In addition, IL-4 and IL-13 down-regulate the expression of filaggrin in kerati...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer.
CONCLUSIONS: The frequency of 4-1BBL+ B cells significantly increased following a short time activation, and showed relative and significant associations with tumor grade and estrogen receptor status, respectively. More investigations are required to evaluate the potential of 4-1BBL+ B cells for use in immunotherapy. PMID: 31182685 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients.
CONCLUSIONS: The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100 ECs could be a useful parameter in CD diagnosis and make a decision to put them on a GFD. PMID: 31182686 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications.
CONCLUSION: The membrane-anchoring of FMOD by means of a GPI moiety in leukemic cells supports FMOD as a highly potential diagnostic and therapeutic target in CLL patients. PMID: 31182687 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes.
CONCLUSION: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role. PMID: 31182688 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis.
Authors: Tarokh M, Ghaffari Novin M, Poordast T, Tavana Z, Nazarian H, Norouzian M, Gharesi-Fard B Abstract BACKGROUND: Endometriosis is a chronic inflammatory disease with the growth of endometrial cells out of uterus and in the peritoneal cavity. T cell subsets participate in the establishment and progress of the disease by producing different cytokines. OBJECTIVE: To investigate a group of cytokines related to Th1/Th2/Th17/Treg subsets within both peripheral blood and peritoneal fluid (PF) samples from infertile endometriosis women. METHODS: Peripheral blood and PF samples were collected from 30 infertil...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Evaluation of Exhausted Regulatory T Cells in Preeclampsia.
CONCLUSION: The increased number of PD-1 (CD279) molecules on the Treg cells may play a role in preeclampsia, hence it recommendation as a therapeutic target for the disease. PMID: 31182690 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Reno-Protective Effect of Realgar Nanoparticles on Lupus Nephritis of MRL/Lpr Mice through STAT1.
Authors: Xu W, Chen Z, Shen X, Pi C Abstract BACKGROUND: Realgar, an arsenic tetrasulfide compound, is a highly recognized traditional Chinese medicinal prescription that has been widely used to treat various diseases such as inflammatory diseases. However, there are still some problems in the clinical treatment of Realgar, such as large oral dose and high potential toxicity. OBJECTIVE: To evaluate effects of Realgar nanoparticles on lupus nephritis (LN) in vivo in MRL/lpr mice. METHODS: Ten-week mice were orally administered every day for eight consecutive weeks except the mice of normal model groups. The ...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Roles of Dermcidin, Salusin- α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis.
Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. Iran J Immunol. 2019 Jun;16(2):182-189 Authors: Sağmak Tartar A, Özer Balin Ş, Akbulut A, Yardim M, Aydin S Abstract BACKGROUND: Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. OBJECTIVES: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. METHODS: From 50 patients hospitalized upon diagnosis of acute brucellos...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway.
CONCLUSIONS: ERK and p38 pathways participated in ATRA-activated Treg-Th17 balance adjustment. PMID: 30864551 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Improved Function and Maturation of Dendritic Cells Stimulated by Recombinant pp65 Protein: An in-vitro Design.
CONCLUSIONS: The pp65-treated DCs can induce differentiation and functional activity of the cellular immune system, including Th17, and Th1, but not other major T-cell subsets such as Tregs, and Th2 population. PMID: 30864552 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody.
CONCLUSION: The c2A8 mAb is potentially a valuable tool for targeted immunotherapy of HER2 positive cancers. PMID: 30864553 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Increased Serum Levels of Soluble B7-H4 in Patients with Systemic Lupus Erythematosus.
CONCLUSIONS: The increased level of sB7-H4 in patients suggests that this pathway might be involved in the pathogenesis of SLE. However, the exact mechanism or physiological role of sB7-H4 in SLE pathogenesis remains to be investigated. PMID: 30864554 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Investigation of Interleukin-17 Gene Polymorphisms and Serum Levels in Patients with Basal Cell Carcinoma of the Skin.
Authors: Mohammadipour K, Mansouri R, Salmanpour R, Haghshenas MR, Erfani N Abstract BACKGROUND: Interleukin 17 (IL-17) is a pro-inflammatory cytokine that plays an important role in cancer pathogenesis. OBJECTIVE: To investigate the association of two IL-17 gene polymorphisms (rs2275913 and rs763780), as well as IL-17 serum levels with susceptibility to Basal Cell Carcinoma (BCC) of skin. METHODS: Two hundred subjects with BCC and 200 healthy controls were recruited. DNA was extracted from peripheral blood leukocytes and genotypes were determined using PCR-RFLP methods. Serum levels were assessed by ELISA....
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients.
Authors: Rajabian Z, Kalani F, Taghiloo S, Tehrani M, Rafiei A, Hosseini-Khah Z, Hosseini V, Ajami A Abstract BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are the two forms of inflammatory bowel disease (IBD). Adaptive immune responses involving helper T cells play an important role in developing IBDs. Programmed death (PD)-1 and its ligands namely PD-L1 and PD-L2 are negative costimulatory molecules that control T cell motility and formation of an immune synapse between T cells and antigen-presenting cells (APCs). OBJECTIVE: To investigate the role of PD-L1 and PD-L2 in patients with UC to clar...
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Studying the Association between STAT4 Gene Polymorphism and Susceptibility to Rheumatoid Arthritis Disease: An Updated Meta-Analysis.
CONCLUSIONS: In summary, this study revealed an association between STAT4 gene rs7574865 SNP and risk of RA. PMID: 30864557 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Effect of Entecavir Therapy on Immune Status in Chronic Hepatitis B Patients.
CONCLUSION: IL-10 was a more sensitive effector to ETV-induced inhibition of HBV replication in chronic HBV patients. PMID: 30864558 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age.
Authors: Hogendorf A, Wyka K, Orczyk K, Smolewska E, Mlynarski W Abstract PMID: 30864559 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Increased Response of Human T-Lymphocytes by Dendritic Cells Pulsed with HPV16E7 and Pleurotus sajor-caju- β-glucan (PBG).
CONCLUSION: PBG treatment of T-lymphocytes could be a useful option for prophylactic and therapeutic vaccines in cervical cancer. PMID: 30593739 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Lepista sordida Water Extract Enhances the Maturation of Mouse Dendritic Cells in Vitro and in Vivo.
CONCLUSION: These results suggest that WE-LS might have the potential to promote immunity against infection and cancer or to serve as an adjuvant in vaccines and immunotherapies. PMID: 30593740 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Antitumor Immunity Induced by Genetic Immunization with Chitosan Nanoparticle Formulated Adjuvanted for HPV-16 E7 DNA Vaccine.
CONCLUSION: Chitosan nanoparticle is a promising delivery system for DNA vaccine and IL-12 is an effective genetic adjuvant for the induction of strong antitumor immune response. PMID: 30593741 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Chitosan Nanoparticles Loaded with Whole and Soluble Leishmania Antigens, and Evaluation of Their Immunogenecity in a Mouse Model of Leishmaniasis.
CONCLUSION: Nanoparticulate formulations (CHT: SLA and CHT: WLL) are not suitable candidates for preferential induction of a pure Th1-type immune response and immunization against Leishmania infection. However, it might be a good strategy in other infectious diseases where a mixed Th1/Th2 immune response is required. PMID: 30593742 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran.
CONCLUSION: The pattern of allergen-specific IgE showed that Salsola Kali and Lolium perenne are the most common aeroallergens in allergic patients. This finding demonstrates the high frequency of IgE sensitization to outdoor allergens in the southwest of Iran. PMID: 30593743 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

T-helper-17, Regulatory T-helper Cells Related Serum Markers and IL-13 in the Outcome of Polytraumatic Patients with Bacteremia.
CONCLUSION: Sepsis following trauma elicits a heightened immune response in the body and provokes the production of a diverse array of cytokines that is both pro-inflammatory and anti-inflammatory. However, the unique cytokine profile of septic trauma patients is still not well understood. PMID: 30593744 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience.
CONCLUSIONS: Early diagnosis of complement deficiencies can facilitate prevention of life-threatening complications such as severe bacterial infections by considering prophylactic antibiotics and vaccines. In patients with C1 inhibitor deficiency, achieving an acurate early diagnosis will assist in the management and timely treatment of life-threatening attacks such as upper airway obstruction and improve outcomes. PMID: 30593745 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population.
CONCLUSION: This study demonstrates an association between the carrier status of IL-1RN* 2 and CRC and GC in an Iranian population. PMID: 30593746 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research