Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research

Recombinant Production and One-Step Purification of IL-1Ra in Escherichia coli and Evaluation of its IL-1 Antagonizing Efficacy
CONCLUSION: In this study, biologically active soluble rIL1-Ra was successfully produced with high purity through a one-step procedure. This method can reduce the cost and time of production for this protein and might be applicable other biological products.PMID:34190695 | DOI:10.22034/iji.2021.89103.1929 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Roya Adelnia Fatemeh Shafiee Source Type: research

Camrelizumab plus Zoledronic Acid Showed Sustained Efficacy in a Patient with Cranial and Spinal Metastases from Lung Adenocarcinoma
Iran J Immunol. 2021 Jun;18(2):131-135. doi: 10.22034/iji.2021.87760.1828.ABSTRACTThe role of anti-programmed cell death protein-1 (PD-1) antibody camrelizumab in brain metastases (BMs) from lung adenocarcinoma is uncertain. Herein, for the first time, we report the efficacy of camrelizumab in a patient with chemotherapy-refractory BMs from lung adenocarcinoma. A 49-year-old male non-smoker was admitted with cough and back pain. Primary lung adenocarcinoma with brain and spinal metastases was diagnosed. The specimen from CT-guided lung biopsy showed a positive expression of PD-L1 (~20%).The BMs were enlarged after first-li...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Chu Zhang Guangmao Yu Miao Zhang Wenbin Wu Source Type: research

High Level of IgG4 in a Patient with Extensive Pulmonary Involvement
Iran J Immunol. 2021 Jun;18(2):136-140. doi: 10.22034/iji.2021.88789.1907.ABSTRACTImmunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disease that has been proposed as a separate entity since the beginning of this century. The disease is often manifested by increased serum IgG4 levels and certain histopathological manifestations. The patient mentioned in this article is a 29-year-old man from Tajikistan, who has had a chronic cough since the beginning of 2018 without a previous history of the disease. At first, he was diagnosed with pneumonia for a long time and then underwent a lung biopsy due to ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Mohammad Hassan Bemanian Sima Bahrami Saba Arshi Afshin Rezaeifar Mohammad Nabavi Morteza Fallahpour Sima Shokri Source Type: research

Distinguishing Isolated Lymphoid Extramedullary Blast Crisis and Secondary Non-Hodgkin Lymphoma in Chronic Myelogenous Leukemia: a Case Report and Review of the Literature
In this study, we presented a patient with an unusual presentation of CML transformation as a rapid growth of generalized lymphadenopathy that appeared 5 months after the initial diagnosis of CML. The patient underwent the left supraclavicular lymph node biopsy and repeat bone marrow aspiration. The revealed CD3+, terminal deoxynucleotidyl transferase (TdT)+, CD5+, CD23+, myeloperoxidase (MPO)-, CD20-, cyclin D1-, CD10-, which was consistent with the diagnosis of T-cell lymphoblastic lymphoma (T-LBL). Fluorescence in situ hybridization (FISH) verified the BCR-ABL rearrangement, and T-cell EBC of CML was finally diagnosed. ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Tingting Wang Li Fu Na Wei Xiaoge Zhou Xiaodan Zheng Li Li Zhao Wang Source Type: research

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research

Recombinant Production and One-Step Purification of IL-1Ra in Escherichia coli and Evaluation of its IL-1 Antagonizing Efficacy
CONCLUSION: In this study, biologically active soluble rIL1-Ra was successfully produced with high purity through a one-step procedure. This method can reduce the cost and time of production for this protein and might be applicable other biological products.PMID:34190695 | DOI:10.22034/iji.2021.89103.1929 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Roya Adelnia Fatemeh Shafiee Source Type: research

Camrelizumab plus Zoledronic Acid Showed Sustained Efficacy in a Patient with Cranial and Spinal Metastases from Lung Adenocarcinoma
Iran J Immunol. 2021 Jun;18(2):131-135. doi: 10.22034/iji.2021.87760.1828.ABSTRACTThe role of anti-programmed cell death protein-1 (PD-1) antibody camrelizumab in brain metastases (BMs) from lung adenocarcinoma is uncertain. Herein, for the first time, we report the efficacy of camrelizumab in a patient with chemotherapy-refractory BMs from lung adenocarcinoma. A 49-year-old male non-smoker was admitted with cough and back pain. Primary lung adenocarcinoma with brain and spinal metastases was diagnosed. The specimen from CT-guided lung biopsy showed a positive expression of PD-L1 (~20%).The BMs were enlarged after first-li...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Chu Zhang Guangmao Yu Miao Zhang Wenbin Wu Source Type: research

High Level of IgG4 in a Patient with Extensive Pulmonary Involvement
Iran J Immunol. 2021 Jun;18(2):136-140. doi: 10.22034/iji.2021.88789.1907.ABSTRACTImmunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disease that has been proposed as a separate entity since the beginning of this century. The disease is often manifested by increased serum IgG4 levels and certain histopathological manifestations. The patient mentioned in this article is a 29-year-old man from Tajikistan, who has had a chronic cough since the beginning of 2018 without a previous history of the disease. At first, he was diagnosed with pneumonia for a long time and then underwent a lung biopsy due to ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Mohammad Hassan Bemanian Sima Bahrami Saba Arshi Afshin Rezaeifar Mohammad Nabavi Morteza Fallahpour Sima Shokri Source Type: research

Distinguishing Isolated Lymphoid Extramedullary Blast Crisis and Secondary Non-Hodgkin Lymphoma in Chronic Myelogenous Leukemia: a Case Report and Review of the Literature
In this study, we presented a patient with an unusual presentation of CML transformation as a rapid growth of generalized lymphadenopathy that appeared 5 months after the initial diagnosis of CML. The patient underwent the left supraclavicular lymph node biopsy and repeat bone marrow aspiration. The revealed CD3+, terminal deoxynucleotidyl transferase (TdT)+, CD5+, CD23+, myeloperoxidase (MPO)-, CD20-, cyclin D1-, CD10-, which was consistent with the diagnosis of T-cell lymphoblastic lymphoma (T-LBL). Fluorescence in situ hybridization (FISH) verified the BCR-ABL rearrangement, and T-cell EBC of CML was finally diagnosed. ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Tingting Wang Li Fu Na Wei Xiaoge Zhou Xiaodan Zheng Li Li Zhao Wang Source Type: research

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research

Recombinant Production and One-Step Purification of IL-1Ra in Escherichia coli and Evaluation of its IL-1 Antagonizing Efficacy
CONCLUSION: In this study, biologically active soluble rIL1-Ra was successfully produced with high purity through a one-step procedure. This method can reduce the cost and time of production for this protein and might be applicable other biological products.PMID:34190695 | DOI:10.22034/iji.2021.89103.1929 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Roya Adelnia Fatemeh Shafiee Source Type: research

Camrelizumab plus Zoledronic Acid Showed Sustained Efficacy in a Patient with Cranial and Spinal Metastases from Lung Adenocarcinoma
Iran J Immunol. 2021 Jun;18(2):131-135. doi: 10.22034/iji.2021.87760.1828.ABSTRACTThe role of anti-programmed cell death protein-1 (PD-1) antibody camrelizumab in brain metastases (BMs) from lung adenocarcinoma is uncertain. Herein, for the first time, we report the efficacy of camrelizumab in a patient with chemotherapy-refractory BMs from lung adenocarcinoma. A 49-year-old male non-smoker was admitted with cough and back pain. Primary lung adenocarcinoma with brain and spinal metastases was diagnosed. The specimen from CT-guided lung biopsy showed a positive expression of PD-L1 (~20%).The BMs were enlarged after first-li...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Chu Zhang Guangmao Yu Miao Zhang Wenbin Wu Source Type: research

High Level of IgG4 in a Patient with Extensive Pulmonary Involvement
Iran J Immunol. 2021 Jun;18(2):136-140. doi: 10.22034/iji.2021.88789.1907.ABSTRACTImmunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disease that has been proposed as a separate entity since the beginning of this century. The disease is often manifested by increased serum IgG4 levels and certain histopathological manifestations. The patient mentioned in this article is a 29-year-old man from Tajikistan, who has had a chronic cough since the beginning of 2018 without a previous history of the disease. At first, he was diagnosed with pneumonia for a long time and then underwent a lung biopsy due to ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Mohammad Hassan Bemanian Sima Bahrami Saba Arshi Afshin Rezaeifar Mohammad Nabavi Morteza Fallahpour Sima Shokri Source Type: research

Distinguishing Isolated Lymphoid Extramedullary Blast Crisis and Secondary Non-Hodgkin Lymphoma in Chronic Myelogenous Leukemia: a Case Report and Review of the Literature
In this study, we presented a patient with an unusual presentation of CML transformation as a rapid growth of generalized lymphadenopathy that appeared 5 months after the initial diagnosis of CML. The patient underwent the left supraclavicular lymph node biopsy and repeat bone marrow aspiration. The revealed CD3+, terminal deoxynucleotidyl transferase (TdT)+, CD5+, CD23+, myeloperoxidase (MPO)-, CD20-, cyclin D1-, CD10-, which was consistent with the diagnosis of T-cell lymphoblastic lymphoma (T-LBL). Fluorescence in situ hybridization (FISH) verified the BCR-ABL rearrangement, and T-cell EBC of CML was finally diagnosed. ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Tingting Wang Li Fu Na Wei Xiaoge Zhou Xiaodan Zheng Li Li Zhao Wang Source Type: research

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research

Recombinant Production and One-Step Purification of IL-1Ra in Escherichia coli and Evaluation of its IL-1 Antagonizing Efficacy
CONCLUSION: In this study, biologically active soluble rIL1-Ra was successfully produced with high purity through a one-step procedure. This method can reduce the cost and time of production for this protein and might be applicable other biological products.PMID:34190695 | DOI:10.22034/iji.2021.89103.1929 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Roya Adelnia Fatemeh Shafiee Source Type: research

Camrelizumab plus Zoledronic Acid Showed Sustained Efficacy in a Patient with Cranial and Spinal Metastases from Lung Adenocarcinoma
Iran J Immunol. 2021 Jun;18(2):131-135. doi: 10.22034/iji.2021.87760.1828.ABSTRACTThe role of anti-programmed cell death protein-1 (PD-1) antibody camrelizumab in brain metastases (BMs) from lung adenocarcinoma is uncertain. Herein, for the first time, we report the efficacy of camrelizumab in a patient with chemotherapy-refractory BMs from lung adenocarcinoma. A 49-year-old male non-smoker was admitted with cough and back pain. Primary lung adenocarcinoma with brain and spinal metastases was diagnosed. The specimen from CT-guided lung biopsy showed a positive expression of PD-L1 (~20%).The BMs were enlarged after first-li...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Chu Zhang Guangmao Yu Miao Zhang Wenbin Wu Source Type: research

High Level of IgG4 in a Patient with Extensive Pulmonary Involvement
Iran J Immunol. 2021 Jun;18(2):136-140. doi: 10.22034/iji.2021.88789.1907.ABSTRACTImmunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disease that has been proposed as a separate entity since the beginning of this century. The disease is often manifested by increased serum IgG4 levels and certain histopathological manifestations. The patient mentioned in this article is a 29-year-old man from Tajikistan, who has had a chronic cough since the beginning of 2018 without a previous history of the disease. At first, he was diagnosed with pneumonia for a long time and then underwent a lung biopsy due to ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Mohammad Hassan Bemanian Sima Bahrami Saba Arshi Afshin Rezaeifar Mohammad Nabavi Morteza Fallahpour Sima Shokri Source Type: research

Distinguishing Isolated Lymphoid Extramedullary Blast Crisis and Secondary Non-Hodgkin Lymphoma in Chronic Myelogenous Leukemia: a Case Report and Review of the Literature
In this study, we presented a patient with an unusual presentation of CML transformation as a rapid growth of generalized lymphadenopathy that appeared 5 months after the initial diagnosis of CML. The patient underwent the left supraclavicular lymph node biopsy and repeat bone marrow aspiration. The revealed CD3+, terminal deoxynucleotidyl transferase (TdT)+, CD5+, CD23+, myeloperoxidase (MPO)-, CD20-, cyclin D1-, CD10-, which was consistent with the diagnosis of T-cell lymphoblastic lymphoma (T-LBL). Fluorescence in situ hybridization (FISH) verified the BCR-ABL rearrangement, and T-cell EBC of CML was finally diagnosed. ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Tingting Wang Li Fu Na Wei Xiaoge Zhou Xiaodan Zheng Li Li Zhao Wang Source Type: research

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research

Recombinant Production and One-Step Purification of IL-1Ra in Escherichia coli and Evaluation of its IL-1 Antagonizing Efficacy
CONCLUSION: In this study, biologically active soluble rIL1-Ra was successfully produced with high purity through a one-step procedure. This method can reduce the cost and time of production for this protein and might be applicable other biological products.PMID:34190695 | DOI:10.22034/iji.2021.89103.1929 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Roya Adelnia Fatemeh Shafiee Source Type: research

Camrelizumab plus Zoledronic Acid Showed Sustained Efficacy in a Patient with Cranial and Spinal Metastases from Lung Adenocarcinoma
Iran J Immunol. 2021 Jun;18(2):131-135. doi: 10.22034/iji.2021.87760.1828.ABSTRACTThe role of anti-programmed cell death protein-1 (PD-1) antibody camrelizumab in brain metastases (BMs) from lung adenocarcinoma is uncertain. Herein, for the first time, we report the efficacy of camrelizumab in a patient with chemotherapy-refractory BMs from lung adenocarcinoma. A 49-year-old male non-smoker was admitted with cough and back pain. Primary lung adenocarcinoma with brain and spinal metastases was diagnosed. The specimen from CT-guided lung biopsy showed a positive expression of PD-L1 (~20%).The BMs were enlarged after first-li...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Chu Zhang Guangmao Yu Miao Zhang Wenbin Wu Source Type: research

High Level of IgG4 in a Patient with Extensive Pulmonary Involvement
Iran J Immunol. 2021 Jun;18(2):136-140. doi: 10.22034/iji.2021.88789.1907.ABSTRACTImmunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disease that has been proposed as a separate entity since the beginning of this century. The disease is often manifested by increased serum IgG4 levels and certain histopathological manifestations. The patient mentioned in this article is a 29-year-old man from Tajikistan, who has had a chronic cough since the beginning of 2018 without a previous history of the disease. At first, he was diagnosed with pneumonia for a long time and then underwent a lung biopsy due to ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Mohammad Hassan Bemanian Sima Bahrami Saba Arshi Afshin Rezaeifar Mohammad Nabavi Morteza Fallahpour Sima Shokri Source Type: research

Distinguishing Isolated Lymphoid Extramedullary Blast Crisis and Secondary Non-Hodgkin Lymphoma in Chronic Myelogenous Leukemia: a Case Report and Review of the Literature
In this study, we presented a patient with an unusual presentation of CML transformation as a rapid growth of generalized lymphadenopathy that appeared 5 months after the initial diagnosis of CML. The patient underwent the left supraclavicular lymph node biopsy and repeat bone marrow aspiration. The revealed CD3+, terminal deoxynucleotidyl transferase (TdT)+, CD5+, CD23+, myeloperoxidase (MPO)-, CD20-, cyclin D1-, CD10-, which was consistent with the diagnosis of T-cell lymphoblastic lymphoma (T-LBL). Fluorescence in situ hybridization (FISH) verified the BCR-ABL rearrangement, and T-cell EBC of CML was finally diagnosed. ...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Tingting Wang Li Fu Na Wei Xiaoge Zhou Xiaodan Zheng Li Li Zhao Wang Source Type: research

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Fatemeh Mashhadiabbas Masoume Fayazi-Boroujeni Akram Alizadeh Mahshid Namdari Seyed Abbas Mirzaei Source Type: research

VEGF-A, HGF and bFGF are Involved in IL-17A-mediated Migration and Capillary-like Vessel Formation of Vascular Endothelial Cells
CONCLUSION: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.PMID:34190691 | DOI:10.22034/iji.2021.91214.2059 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Muneo Numasaki Koyu Ito Source Type: research

Diospyros Peregrina Fruit Preparation Mediated Immunomodulation of Lymphocytes Isolated From The Blood of Breast Cancer Patients
CONCLUSION: DFP increases the expression levels of TH1 specific network genes which in turn help in evoking tumor protective immunity.PMID:34190692 | DOI:10.22034/iji.2021.85430.1710 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ahana Guha Roy Aitijhya Ghosh Kasturi Sinha Basundhara Mitra Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research

Effect of Bortezomib Regimens and Daratumumab Monotherapy on Cellular Immunity in Multiple Myeloma Patients
CONCLUSION: Bortezomib had a negative influence on subsets of T cells, while Daratumumab positively affected T cells subsets. In both treatments, NK cells decreased significantly. These results suggested that DARA is more specific to target myeloma cells than Bortezomib. Also, DARA expanded T cells especially CD3+ T cells and CD4+ T cells.PMID:34190693 | DOI:10.22034/iji.2021.87547.1812 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Ashraf Kakoo Taban Rasheed Mustafa Al-Attar Source Type: research

IL-17 Genetic Variations Increase The Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection
CONCLUSION: Our findings suggest that A allele and GA genotype at IL-17A rs2275913 (G197A), as well as A allele and AA genotype at IL-17F rs763780 (A7488G) locus, might be associated with increased risk of C/HCC among patients with hepatitis B virus infection.PMID:34190694 | DOI:10.22034/iji.2021.88020.1852 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 30, 2021 Category: Allergy & Immunology Authors: Abolfazl Gheshlaghi Mohammad Reza Haghshenas Ali Reza Safarpour Seyed Younes Hosseini Mohammad Reza Fattahi Jamal Sarvari Source Type: research