Effects of Long-time Exposure to Lipopolysaccharide on Intestinal Lymph Node Immune Cells and Antibodies Level in Mice.
CONCLUSION: Long-term exposure to low-dose endotoxin had little or no effect on the immune function of the body, suggesting that the endotoxin can be rapidly eliminated by the immune system. Nonetheless, the number of immune cells was reduced in the high-dose group. T- and B-lymphocytes were significantly reduced, resulting in a decrease in immunoglobulin level, and showing a significant immune suppression state. PMID: 32996895 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection.
CONCLUSION: IL-6 and IL-10 are closely associated with the severity and treatment efficacy of BSI, and can help to distinguish between GP-BSI and GN-BSI at an early stage. PMID: 32996896 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Variants in Intron 4 of PD-1 Gene are Associated with the Susceptibility to SLE in an Iranian Population.
CONCLUSION: To the best of our knowledge, this is the first report of the significant association of PD-1 +7499 (G/A) SNP with the SLE susceptibility and the first detection of both polymorphic loci in a population from Iran. However, more investigations are necessary to confirm these findings. PMID: 32996897 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes.
Authors: Ahmadi M, Mahrooz A, Abediankenari S, Hayati Roodbari N Abstract BACKGROUND: According to genome wide association studies, SLC30A8 is among the loci containing SNPs associated with type 2 diabetes (T2D) risk. This gene encodes an islet zinc transporter (ZnT8). OBJECTIVE: To provide new information on the association of the SNP rs11558471 in SLC30A8 gene with IL-17 levels and insulin resistance in an Iranian population with T2D. METHODS: A total of 133 patients with T2D and 128 control subjects were included in this study. Insulin and IL-17 concentrations were determined using ELISA. Insulin and fas...
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Hereditary Angioedema Due to C1-Inhibitor Deficiency in Romania: First National Study, Diagnostic and Treatment Challenges.
CONCLUSION: The significantly lower delay observed in children suggests an improvement in the awareness of C1-INH-HAE among physicians in recent years. The management of HAE in Romania has been somewhat enhanced as the majority of HAE patients have recently gained access to pdC1-INH, rhC1-INH, and bradykinin B2-receptor antagonist. PMID: 32996899 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients.
CONCLUSION: Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group. PMID: 32996900 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

A Patient with CTLA-4 Haploinsufficiency with Multiple Autoimmune Presentations: A Case Report.
Authors: Zaremehrjardi F, Baniadam L, Seif F, Arshi S, Bemanian MH, Shokri S, Rezaeifar A, Fallahpour M, Nabavi M Abstract Increased susceptibility to autoimmunity, malignancy, and allergy in addition to recurrent infections are the main characteristics suggesting for the primary immunodeficiency diseases (PID). CTLA-4 is predominantly expressed on activated and regulatory T-cells, which can bind to CD80/CD86 molecules on antigen-presenting cells as a negative regulator. Here, we describe a 24-year-old male born from consanguineous parents with heterozygous CTLA-4 mutation who presented with multiple autoimmune dis...
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Plasmodium Vivax Malaria: Usual Illness with Dysregulated Immune Profile.
Authors: Dixit S, Garg N, Kotru M, Gupta R Abstract Afebrile Plasmodium vivax disease is believed to be extremely rare; and so is the association of a secondary immune thrombocytopenia due to Plasmodiun vivax malaria. This is a case of malaria presenting in an atypical manner. A middle aged male (31 years) came with occasional bleeding around gums, small petechial haemorrhages over chest and abdomen, and blood in stools for a few months, but no fever. In addition, the cervical lymph nodes were slightly enlarged. Spleen was 3 cm below costal margin. Platelets were found to have markedly decreased with clusters of me...
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Prognostic Significance of Circulating CD28 Negative Suppressor T Cells and Memory B Cells in Patients with Breast Cancer.
CONCLUSION: NK, NKT, lymphocytes, and CD28‒ T cells significantly differed between healthy controls and BC patients. Also, memory B cells were associated with good response to treatment while CD28‒ T cells were associated with shorter RFS. PMID: 32602464 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Toward an Alum Free Mono-Component Monovalent Pertussis Vaccine: A Cytokine Response Assay.
CONCLUSION: Our alum free mono-component monovalent recombinant fusion protein (LLO-PTS1) could bear the capacity to stimulate the release of IFN-γ similar to wP and aP vaccines in the mouse model. Besides, it showed better results in stimulating the release of IL-17 and IL-4 response. This study can be regarded as a platform for further probes in booster pertussis vaccine development. PMID: 32602465 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

In-Silico Analysis and Protective Efficacy of the PcrV Recombinant Vaccine against Pseudomonas Aeruginosa in the Burned and PA-Infected BALB/c Mouse Model.
CONCLUSION: Our results demonstrated that the PcrV protein could be an effective candidate vaccine for the generation of antibody response against P. aeruginosa infection. PMID: 32602466 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Th17 Cytokines and its Correlation with Receptor Activator of Nuclear Factor kappa B Ligand During Orthodontic Tooth Movement.
CONCLUSION: This study provided preliminary evidence that Th17 cytokines may be involved in the regulation of OTM. PMID: 32602467 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Fetuin-A and Interleukine-8 in Children with the Clinical Remission of Type 1 Diabetes.
CONCLUSION: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR. PMID: 32602468 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Exposure of 1800 MHz Radiofrequency with SAR 1,6 W/kg Caused a Significant Reduction in CD4+ T Cells and Release of Cytokines In-Vitro.
CONCLUSION: Exposure to RF-EMF for 60 minutes at 5 cm distance causes a significant reduction in the number of CD4+ T cells, IL-2, IL-10 and IL-17a expressing T cells. PMID: 32602469 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Immune-Related Adverse Events Mimicking Behcet's Disease in a Gastric Cancer Patient Following Camrelizumab Treatment.
CONCLUSION: Severe irAEs occur at a low frequency when anti-PD-1 antibodies are used as monotherapy. Whether anti-PD-1 antibodies combined with systemic chemotherapy increase the incidence of irAEs is not certain. PMID: 32602470 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Letter to the Editor: Coexistence of Autoimmune Lymphoproliferative Syndrome and Familial Mediterranean Fever.
Authors: Aydın Köker S, Gülez N, Rieux-Laucat F, Genel F, Vergin C, Picard C PMID: 32602471 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - July 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis.
CONCLUSION: Evaluation of immune status based on PD-L1 pleural concentration and Th2 to Th1 ratio might predict the risk of MDR-TB occurrence. PMID: 32224537 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

TLR Agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response.
CONCLUSION: These results suggested that rHP-NAP possesses the potential for use as an adjuvant of dendritic cell-based vaccine in anti-melanoma treatment. PMID: 32224538 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Maturation and Function of Murine Dendritic Cells: an In-Vitro Study.
CONCLUSION: Despite improvements in maturity status, pp150-stimulated DCs did not seem to be able to induce Th1 or Th2 immunity. In fact, Th17 and its mediators, IL-17A and IL-22, might be the main inflammatory factors involved in pp150-stimulated DC's mechanism of action. However, it is necessary to conduct further investigations to corroborate these observations. PMID: 32224539 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA.
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
CONCLUSION: Our study showed that Tim-3 might play an important role in the development of AP through regulating the inflammatory response. PMID: 32224541 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effect of Tribulus Terrestris L. on Expression of ICAM-1, VCAM-1, E-Selectin and Proteome Profile of Human Endothelial Cells In-Vitro.
CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. However, the anti-inflammatory effect of aqueous extract was greater than that of saponin fraction. Therefore, TT could be considered as a potential candidate for the treatment or prevention of atherosclerosis. PMID: 32224542 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Protective Potential of Conjugated P. aeruginosa LPS -PLGA Nanoparticles in Mice as a Nanovaccine.
CONCLUSION: The conjugation of the bacterial LPS to the PLGA nanoparticle increased their functional activity by decrease in bacterial dissemination and increase the killing of opsonized bacteria. PMID: 32224543 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

T Regulatory Cell Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia.
CONCLUSION: Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response. PMID: 32224544 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - April 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effects of Dendritic Cell Vaccine Activated with Components of Lieshmania Major on Tumor Specific Response.
CONCLUSION: This study indicates that the use of Leishmania major extract, as well as LPS, can enhance the efficiency of DC-based vaccines and provides a basis for the use of Leishmania major in DC-targeted clinical therapies. PMID: 31885004 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α.
Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α. Iran J Immunol. 2019 Dec;16(4):278-290 Authors: Wang Y, Wu X, Hu Y Abstract BACKGROUND: Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. OBJECTIVE: To investigate the immunomodulatory function of bone marrow mesenchymal stromal cells (MM-BMSCs) on CD8+ T cells. METHODS: Proliferation and cytotoxicity were detected by cell counting kit-8 assay. Cell cycl...
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer.
CONCLUSION: The increase in the percentage of NK and iNKT cells in TDLNs of patients with higher grade of BC might suggest a suppressive phenotype for these cells in breast cancer, which merit more functional investigation. PMID: 31885006 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet's Disease.
CONCLUSION: IL-37 expression increased in NBD patients, and correlated with disease activity. Our data conclude that IL-37 could be a disease marker in NBD, however it requires further studies. PMID: 31885007 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Importance of L. Infantum H2B Recombinant Antigen for Serodiagnosis of Visceral Leishmaniasis.
CONCLUSION: Recombinant H2B antigen expressed in the prokaryotic system had suboptimal performance for the serological diagnosis of VL. It seems that the production and expression of recombinant H2B antigen in a eukaryotic system may enhance the performance of this antigen in the diagnosis of VL in Iran. PMID: 31885008 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis.
Authors: Abbasi R, Zomorodian K, Zare Shahrabadi Z, Saadat F, Nabavizadeh SH, Esmaeilzadeh H, Alyasin S Abstract BACKGROUND: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. OBJECTIVE: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. METHODS: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. ...
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis.
CONCLUSION: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH. PMID: 31885010 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Atypical Omenn Syndrome Due to RAG2 Gene Mutation, a Case Report.
We present a novel case of atypical SCID (SCID manifestations with more than 300 CD3+T cells) caused by RAG 2 gene mutation whose immunophenotype changed to atypical Omenn syndrome (all Omenn syndrome manifestations except rash, eosinophilia, and elevated IgE) over time. Differentiation of leaky SCID, SCID and Omenn syndrome in RAG mutation genes and overlap manifestations is important in treatment plan and prognosis. PMID: 31885011 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - January 1, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages.
CONCLUSION: Hepcidin is able to induce macrophage polarization towards M1 type, and might be utilized as a potential M1 macrophage agonist in clinical practice. PMID: 31552828 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Immunogenic Evaluation of Bivalent Vaccine Candidate against Enterohemorrhagic and Enterotoxigenic Escherichia coli.
CONCLUSIONS: The immunity to both ETEC and EHEC bacteria is significant, and this structure can be considered as a candidate for vaccine production against these bacterial strains. PMID: 31552829 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IpaD-loaded N-trimethyl Chitosan Nanoparticles Can Efficiently Protect Guinea Pigs against Shigella flexneri.
Authors: Akbari MR, Saadati M, Honari H, Ghorbani HM Abstract BACKGROUND: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). OBJECTIVE: To evaluate the efficiency of O-metylated free trimethyl chitosan nanoparticles (TMC NPs) in the oral delivery of NIpaD. METHODS: TMC was synthesized by a two-step method from high molecular weight chitosan. The recombinant NIpaD protein was used as the immunogen. The protei...
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial.
CONCLUSION: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. PMID: 31552831 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer.
CONCLUSION: As the CEA DNA vaccine displayed encouraging antitumor effects, therefore, we suggest that it can be a potential therapeutic modality for colorectal cancer and is worthy of further investigation. PMID: 31552832 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effects of CD133 Silencing on Survival and Migration of HT-29 Colorectal Cancer Cells.
CONCLUSION: siRNA mediated targeting of CD133 could be considered as a promising approach to treat CRC through suppressing the cancerous behavior of tumor cells. PMID: 31552833 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

IgG Avidity Test for Ocular Toxoplasmosis Diagnosis at a Tertiary Center, Northeast of Iran.
CONCLUSION: The result of this study showed that IgM is not a reliable marker of acute disease. Repetition of the serology tests was proposed in cases with clinical manifestations without detectable antibody titer after approximately two weeks. IgG avidity testing results coincided with clinical diagnosis and it could therefore considered to be a reliable method to differentiate between recently acquired and chronic ocular toxoplasmosis. PMID: 31552834 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?
Authors: Barra F, Ferrero S PMID: 31552835 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Pathogenesis of Atopic Dermatitis: Current Paradigm.
Authors: Furue M, Ulzii D, Vu YH, Tsuji G, Kido-Nakahara M, Nakahara T Abstract Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such as CCL17, CCL22 and CCL26 is increased in the lesional skin of AD. In addition, IL-4 and IL-13 down-regulate the expression of filaggrin in kerati...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer.
CONCLUSIONS: The frequency of 4-1BBL+ B cells significantly increased following a short time activation, and showed relative and significant associations with tumor grade and estrogen receptor status, respectively. More investigations are required to evaluate the potential of 4-1BBL+ B cells for use in immunotherapy. PMID: 31182685 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients.
CONCLUSIONS: The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100 ECs could be a useful parameter in CD diagnosis and make a decision to put them on a GFD. PMID: 31182686 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications.
CONCLUSION: The membrane-anchoring of FMOD by means of a GPI moiety in leukemic cells supports FMOD as a highly potential diagnostic and therapeutic target in CLL patients. PMID: 31182687 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes.
CONCLUSION: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role. PMID: 31182688 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis.
Authors: Tarokh M, Ghaffari Novin M, Poordast T, Tavana Z, Nazarian H, Norouzian M, Gharesi-Fard B Abstract BACKGROUND: Endometriosis is a chronic inflammatory disease with the growth of endometrial cells out of uterus and in the peritoneal cavity. T cell subsets participate in the establishment and progress of the disease by producing different cytokines. OBJECTIVE: To investigate a group of cytokines related to Th1/Th2/Th17/Treg subsets within both peripheral blood and peritoneal fluid (PF) samples from infertile endometriosis women. METHODS: Peripheral blood and PF samples were collected from 30 infertil...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Evaluation of Exhausted Regulatory T Cells in Preeclampsia.
CONCLUSION: The increased number of PD-1 (CD279) molecules on the Treg cells may play a role in preeclampsia, hence it recommendation as a therapeutic target for the disease. PMID: 31182690 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Reno-Protective Effect of Realgar Nanoparticles on Lupus Nephritis of MRL/Lpr Mice through STAT1.
Authors: Xu W, Chen Z, Shen X, Pi C Abstract BACKGROUND: Realgar, an arsenic tetrasulfide compound, is a highly recognized traditional Chinese medicinal prescription that has been widely used to treat various diseases such as inflammatory diseases. However, there are still some problems in the clinical treatment of Realgar, such as large oral dose and high potential toxicity. OBJECTIVE: To evaluate effects of Realgar nanoparticles on lupus nephritis (LN) in vivo in MRL/lpr mice. METHODS: Ten-week mice were orally administered every day for eight consecutive weeks except the mice of normal model groups. The ...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Roles of Dermcidin, Salusin- α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis.
Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. Iran J Immunol. 2019 Jun;16(2):182-189 Authors: Sağmak Tartar A, Özer Balin Ş, Akbulut A, Yardim M, Aydin S Abstract BACKGROUND: Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. OBJECTIVES: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. METHODS: From 50 patients hospitalized upon diagnosis of acute brucellos...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway.
CONCLUSIONS: ERK and p38 pathways participated in ATRA-activated Treg-Th17 balance adjustment. PMID: 30864551 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research