Pathogenesis of Atopic Dermatitis: Current Paradigm.
Authors: Furue M, Ulzii D, Vu YH, Tsuji G, Kido-Nakahara M, Nakahara T Abstract Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such as CCL17, CCL22 and CCL26 is increased in the lesional skin of AD. In addition, IL-4 and IL-13 down-regulate the expression of filaggrin in kerati...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer.
CONCLUSIONS: The frequency of 4-1BBL+ B cells significantly increased following a short time activation, and showed relative and significant associations with tumor grade and estrogen receptor status, respectively. More investigations are required to evaluate the potential of 4-1BBL+ B cells for use in immunotherapy. PMID: 31182685 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients.
CONCLUSIONS: The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100 ECs could be a useful parameter in CD diagnosis and make a decision to put them on a GFD. PMID: 31182686 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications.
CONCLUSION: The membrane-anchoring of FMOD by means of a GPI moiety in leukemic cells supports FMOD as a highly potential diagnostic and therapeutic target in CLL patients. PMID: 31182687 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes.
CONCLUSION: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role. PMID: 31182688 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis.
Authors: Tarokh M, Ghaffari Novin M, Poordast T, Tavana Z, Nazarian H, Norouzian M, Gharesi-Fard B Abstract BACKGROUND: Endometriosis is a chronic inflammatory disease with the growth of endometrial cells out of uterus and in the peritoneal cavity. T cell subsets participate in the establishment and progress of the disease by producing different cytokines. OBJECTIVE: To investigate a group of cytokines related to Th1/Th2/Th17/Treg subsets within both peripheral blood and peritoneal fluid (PF) samples from infertile endometriosis women. METHODS: Peripheral blood and PF samples were collected from 30 infertil...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Evaluation of Exhausted Regulatory T Cells in Preeclampsia.
CONCLUSION: The increased number of PD-1 (CD279) molecules on the Treg cells may play a role in preeclampsia, hence it recommendation as a therapeutic target for the disease. PMID: 31182690 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Reno-Protective Effect of Realgar Nanoparticles on Lupus Nephritis of MRL/Lpr Mice through STAT1.
Authors: Xu W, Chen Z, Shen X, Pi C Abstract BACKGROUND: Realgar, an arsenic tetrasulfide compound, is a highly recognized traditional Chinese medicinal prescription that has been widely used to treat various diseases such as inflammatory diseases. However, there are still some problems in the clinical treatment of Realgar, such as large oral dose and high potential toxicity. OBJECTIVE: To evaluate effects of Realgar nanoparticles on lupus nephritis (LN) in vivo in MRL/lpr mice. METHODS: Ten-week mice were orally administered every day for eight consecutive weeks except the mice of normal model groups. The ...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Roles of Dermcidin, Salusin- α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis.
Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. Iran J Immunol. 2019 Jun;16(2):182-189 Authors: Sağmak Tartar A, Özer Balin Ş, Akbulut A, Yardim M, Aydin S Abstract BACKGROUND: Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. OBJECTIVES: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. METHODS: From 50 patients hospitalized upon diagnosis of acute brucellos...
Source: Iranian Journal of Immunology - June 13, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway.
CONCLUSIONS: ERK and p38 pathways participated in ATRA-activated Treg-Th17 balance adjustment. PMID: 30864551 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Improved Function and Maturation of Dendritic Cells Stimulated by Recombinant pp65 Protein: An in-vitro Design.
CONCLUSIONS: The pp65-treated DCs can induce differentiation and functional activity of the cellular immune system, including Th17, and Th1, but not other major T-cell subsets such as Tregs, and Th2 population. PMID: 30864552 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody.
CONCLUSION: The c2A8 mAb is potentially a valuable tool for targeted immunotherapy of HER2 positive cancers. PMID: 30864553 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Increased Serum Levels of Soluble B7-H4 in Patients with Systemic Lupus Erythematosus.
CONCLUSIONS: The increased level of sB7-H4 in patients suggests that this pathway might be involved in the pathogenesis of SLE. However, the exact mechanism or physiological role of sB7-H4 in SLE pathogenesis remains to be investigated. PMID: 30864554 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Investigation of Interleukin-17 Gene Polymorphisms and Serum Levels in Patients with Basal Cell Carcinoma of the Skin.
Authors: Mohammadipour K, Mansouri R, Salmanpour R, Haghshenas MR, Erfani N Abstract BACKGROUND: Interleukin 17 (IL-17) is a pro-inflammatory cytokine that plays an important role in cancer pathogenesis. OBJECTIVE: To investigate the association of two IL-17 gene polymorphisms (rs2275913 and rs763780), as well as IL-17 serum levels with susceptibility to Basal Cell Carcinoma (BCC) of skin. METHODS: Two hundred subjects with BCC and 200 healthy controls were recruited. DNA was extracted from peripheral blood leukocytes and genotypes were determined using PCR-RFLP methods. Serum levels were assessed by ELISA....
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients.
Authors: Rajabian Z, Kalani F, Taghiloo S, Tehrani M, Rafiei A, Hosseini-Khah Z, Hosseini V, Ajami A Abstract BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are the two forms of inflammatory bowel disease (IBD). Adaptive immune responses involving helper T cells play an important role in developing IBDs. Programmed death (PD)-1 and its ligands namely PD-L1 and PD-L2 are negative costimulatory molecules that control T cell motility and formation of an immune synapse between T cells and antigen-presenting cells (APCs). OBJECTIVE: To investigate the role of PD-L1 and PD-L2 in patients with UC to clar...
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Studying the Association between STAT4 Gene Polymorphism and Susceptibility to Rheumatoid Arthritis Disease: An Updated Meta-Analysis.
CONCLUSIONS: In summary, this study revealed an association between STAT4 gene rs7574865 SNP and risk of RA. PMID: 30864557 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Effect of Entecavir Therapy on Immune Status in Chronic Hepatitis B Patients.
CONCLUSION: IL-10 was a more sensitive effector to ETV-induced inhibition of HBV replication in chronic HBV patients. PMID: 30864558 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age.
Authors: Hogendorf A, Wyka K, Orczyk K, Smolewska E, Mlynarski W Abstract PMID: 30864559 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 15, 2019 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Increased Response of Human T-Lymphocytes by Dendritic Cells Pulsed with HPV16E7 and Pleurotus sajor-caju- β-glucan (PBG).
CONCLUSION: PBG treatment of T-lymphocytes could be a useful option for prophylactic and therapeutic vaccines in cervical cancer. PMID: 30593739 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Lepista sordida Water Extract Enhances the Maturation of Mouse Dendritic Cells in Vitro and in Vivo.
CONCLUSION: These results suggest that WE-LS might have the potential to promote immunity against infection and cancer or to serve as an adjuvant in vaccines and immunotherapies. PMID: 30593740 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Antitumor Immunity Induced by Genetic Immunization with Chitosan Nanoparticle Formulated Adjuvanted for HPV-16 E7 DNA Vaccine.
CONCLUSION: Chitosan nanoparticle is a promising delivery system for DNA vaccine and IL-12 is an effective genetic adjuvant for the induction of strong antitumor immune response. PMID: 30593741 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Chitosan Nanoparticles Loaded with Whole and Soluble Leishmania Antigens, and Evaluation of Their Immunogenecity in a Mouse Model of Leishmaniasis.
CONCLUSION: Nanoparticulate formulations (CHT: SLA and CHT: WLL) are not suitable candidates for preferential induction of a pure Th1-type immune response and immunization against Leishmania infection. However, it might be a good strategy in other infectious diseases where a mixed Th1/Th2 immune response is required. PMID: 30593742 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran.
CONCLUSION: The pattern of allergen-specific IgE showed that Salsola Kali and Lolium perenne are the most common aeroallergens in allergic patients. This finding demonstrates the high frequency of IgE sensitization to outdoor allergens in the southwest of Iran. PMID: 30593743 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

T-helper-17, Regulatory T-helper Cells Related Serum Markers and IL-13 in the Outcome of Polytraumatic Patients with Bacteremia.
CONCLUSION: Sepsis following trauma elicits a heightened immune response in the body and provokes the production of a diverse array of cytokines that is both pro-inflammatory and anti-inflammatory. However, the unique cytokine profile of septic trauma patients is still not well understood. PMID: 30593744 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience.
CONCLUSIONS: Early diagnosis of complement deficiencies can facilitate prevention of life-threatening complications such as severe bacterial infections by considering prophylactic antibiotics and vaccines. In patients with C1 inhibitor deficiency, achieving an acurate early diagnosis will assist in the management and timely treatment of life-threatening attacks such as upper airway obstruction and improve outcomes. PMID: 30593745 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population.
CONCLUSION: This study demonstrates an association between the carrier status of IL-1RN* 2 and CRC and GC in an Iranian population. PMID: 30593746 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 31, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases.
Authors: Wang X, Xu K, Chen S, Li Y, Li M Abstract Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 can join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated protein kinases. Almost all reports showed that IL-37 has remarkable anti-inflammatory activity. IL-37 plays an important role in a variety of inflammatory and autoim...
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome.
CONCLUSION: In summary, Th1 and Th17 bias and reduction of Treg and Th2 cells as regulators of immune responses might be involved in the pathogenesis of PCOS. These results are suggestive of an altered immune response to inflammatory status in PCOS patients, likely causing some complications such as infertility in these patients. PMID: 30246693 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome.
Authors: Amani R, Abbasnezhad A, Hajiani E, Cheraghian B, Abdoli Z, Choghakhori R Abstract BACKGROUND: Given the variations in clinical presentation and physiopathological mechanisms in irritable bowel syndrome (IBS) subtypes, it is an acknowledged fact that the response to treatments can be disparate. OBJECTIVE: To assess the effect of vitamin D on inflammatory cytokines (IL-17, IL-10, TNF-α), and biomarkers of oxidative stress (total antioxidant capacity (TAC), and malondialdehyde (MDA)) among IBS patients. METHODS: A double-blind, randomized, placebo-controlled 6-month intervention study was carrie...
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis.
CONCLUSION: Our results demonstrated that DRB1*01 may be a protective allele against atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation. PMID: 30246695 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Designing and Expression of Recombinant Chimeric Protein Containing CtxB and OmpW from Vibrio Cholerae and Evaluation of Its Immunogenicity.
CONCLUSION: Chimeric construct is able to induce the immune system and provide up to 75% inhibition of toxin activity against 1 LD50 of Vibrio cholerae. PMID: 30246696 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Circulating Levels of Interleukin-10 and -17 in Patients with Cerebral Sinovenous Thrombosis (CSVT) in Acute and Subacute Stages: A Prospective Case-Control Study.
CONCLUSION: This study demonstrated the alteration of IL-10 and IL-17 levels in aseptic non-vasculitic CSVT. The rise in subacute IL-10 can be explained by the assumption that IL-10 is released as an anti-inflammatory response to subside the effects of IL-17 mediated reactions. More importantly, the immediate sampling in the acute stage did not allow enough time for triggering the immune system to produce such mediators. However, a balance was established between IL-10 and IL-17 in the subacute stage to prevent further tissue damage. PMID: 30246697 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Soluble and Particulate Form of Alginates Positively Regulate Immune Response.
CONCLUSION: Alginate materials could affect immune response through different ways, including promoting inflammatory cytokine production, and activating dendritic cells. Therefore, alginate materials, especially in particulate form, have the potential to be applied in inflammation related diseases. PMID: 30246698 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma.
Authors: Zhi Y, Gao P, Li W, Gao F, Zhang J, Lin H, Zhang J Abstract BACKGROUND: CD163-expressing macrophages are involved in the inflammatory response in asthma. OBJECTIVE: To assess sputum and serum soluble CD163 (sCD163) and cytokine levels in patients with asthma. Further discussed was the difference between sCD163 and other classic inflammatory mediators. METHODS: Sputum was successfully induced in asthma patients (n=85) and healthy controls (n=21). Interleukin (IL)-4, IL-5, IL-1β, IL-8, IL-9, IL-6, and sCD163 levels in sputum were measured. CD163+ monocytes in blood were evaluated using flow cyto...
Source: Iranian Journal of Immunology - September 26, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Vaccination with Live Attenuated L. Major and TLR4 Agonist Promotes a Th1 Immune Response and Induces Protection against L. Major Infection in BALB/c Mice.
CONCLUSION: Vaccination with the attenuated L. major along with TLR4 agonist promotes a Th1-mediated immune response which leads to the protection of BALB/c mice against L. major infection. PMID: 29947337 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Anti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model.
CONCLUSION: PMX205 has recognizable anti-inflammatory effects in RAW 264.7 cell inflammation model, a finding which probably opens doors to future investigations on new targets for the prevention and treatment of chronic periodontitis. PMID: 29947338 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

HLA Class I and Class II Genes Distribution of the Iranian Sistanis.
CONCLUSION: These data could be useful for finding better donor matches for organ transplantation among Sistanis or other related Iranian ethnic groups, epidemiological studies of HLA-associated diseases, handling HLA genomics and mapping the migration pattern of different ethnic group. PMID: 29947339 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir.
CONCLUSION: Patients with KIR2DS3 might have negative responses to anti-HBV therapy with ETV and patients with KIR2DL3 and KIR3DS1 might have advantage in the therapy with ETV. PMID: 29947340 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells.
CONCLUSION: Hemin is a potential sterile danger signal molecule that can induce inflammasome activation without directly mediating inflammation damage on microglia. PMID: 29947341 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Identification of hnRNP C1/C2 as an Autoantigen in Patients with Behcet's Disease.
Authors: Hussain M, Xiao J, Zhang Y, Chen P, Du H Abstract BACKGROUND: Ribonucleoproteins particles that form the spliceosomes are among the most frequently targeted molecules of the autoimmune response. In the last few years, autoantibodies against all A/B hnRNP proteins have been found in the sera of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), and serve as diagnostic markers for several rheumatic diseases. However, the functional role of hnRNP C1/C2 in autoimmune diseases is still not clearly understood. OBJECTIVE: To identify hnRNP C1/C...
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes.
CONCLUSION: These results suggest the involvement of AIM2 and mtDNA in the inflammatory process seen in T2D. PMID: 29947343 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients.
CONCLUSION: Our study suggests the second day as the golden time for measuring the serum levels of IL-6. These findings warn us to take more health care actions in patients with higher serum levels of IL-6 on the second day. PMID: 29947344 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - June 28, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

The Significance of B-cell Subsets in Patients with Unclassified Hypogammaglobulinemia and Association with Intravenous Immunoglobulin Replacement Requirement.
CONCLUSION: B-lymphocyte subsets in UCH cases that did not require IVIG replacement were similar to the control group. On the other hand, the percentage of switched memory B-cells in the UCH cases that required IVIG replacement was not different from that of the CVID cases. PMID: 29549228 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model.
CONCLUSION: Overall, the results demonstrated the pro-inflammatory role of endogenous IL-27 and IL-35 along with the over expression of their receptors in chronic joint inflammation. IL-27 and IL-35 antagonists exerted the most anti-inflammatory effects and increased IGF-1 receptor expression. These two antagonists may be potential agents for new treatment strategies in chronic joint inflammatory diseases. PMID: 29549229 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions.
CONCLUSION: Our findings showed that HLA-G overexpression in tumor tissue correlated with poor prognosis in PADC. HLA-G expression is apparently affected by the patient's genetic background and other epigenetic factors rather than by HBV infection. PMID: 29549230 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats.
CONCLUSION: Although, some studies have showed that cinnamon and turmeric supplementation decreased IL-17F under the standard diet, in the presence of high fructose diet and extraweight their effects were reversed and caused an increase in serum level of IL-17F. PMID: 29549231 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Production of Chicken Egg Yolk Antibody (IgY) Against Recombinant Cholera Toxin B Subunit and Evaluation of Its Prophylaxis Potency in Mice.
CONCLUSION: The increase in the number of antibiotic resistant bacteria implies the necessity of finding novel antibiotics. Our results suggest the possibility of passive protection from purified IgY, hence implying that anti CTB-IgY may be useful in the treatment of cholera infections. PMID: 29549232 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women.
Authors: Roomandeh N, Saremi A, Arasteh J, Pak F, Mirmohammadkhani M, Kokhaei P, Zare A Abstract BACKGROUND: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. OBJECTIVE: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. METHODS: Forty-six women with URSA and 28 non-pregnant control women with at least o...
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Age-Related Prostate Specific Antigen Reference Ranges in Healthy Northern Iranian Men.
CONCLUSION: The present study revealed the lowest upper limit of PSA level in all age groups in comparison to populations from different countries. PMID: 29549234 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - March 21, 2018 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

CD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia.
CONCLUSION: Given that the exhaustion phase of T cells can be reversible, targeted blocking of immune inhibitory molecules could be a promising tool to restore the host immune responses against leukemic cells in CLL. PMID: 29276179 [PubMed - in process] (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - December 26, 2017 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research