Biosynthesis of silver nanoparticles using leaf extract of Aesculus hippocastanum (horse chestnut): Evaluation of their antibacterial, antioxidant and drug release system activities
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): Fatma Öztürk Küp, Seval Çoşkunçay, Fatih DumanAbstractBiosynthesis of metal nanoparticles is expected as a cost efficient and ecofriendly option in the research study. Therefore, the aqueous extracts made from leaf of Aesculus hippocastanum (horse chestnut) were used as the reducing factors to synthesize silver nanoparticles (AgNPs) and their antioxidant, antibacterial and the application of resveratrol combined AgNPs as efficient delivery vehicles have also been evaluated. The biosynthesized AgNPs were characterized by ...
Source: Materials Science and Engineering: C - November 14, 2019 Category: Materials Science Source Type: research
Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathway.
In this study, we aimed to evaluate the effect of escin on APAP-induced liver injury in mice. Mice were intraperitoneally administrated with APAP (300 mg/kg) or an equal volume of saline (control), followed by a treatment with various concentrations of escin (0, 0.5, 1, 2 and 4 mg/kg) for 30 min. The animals were sacrificed 16 h following APAP administration for serum and liver tissue assay. Escin treatment attenuated the damage of APAP-induced liver injury in a dose-dependent manner (0.5-4 mg/kg). Escin also attenuated the hepatic myeloperoxidase (MPO) activity and hepatic pro-inflammatory cytokines (i.e., TNF-α, IL-1β,...
Source: American Journal of Translational Research - September 11, 2019 Category: Research Tags: Am J Transl Res Source Type: research
Leaves of common urban tree species ( Aesculus hippocastanum , Acer platanoides , Betula pendula and Tilia cordata ) as a measure of particle and particle-bound pollution: a 4-year study
AbstractMagnetic biomonitoring using tree leaves has been proven as a proxy for airborne particle matter (PM) pollution. Since the leaf entrapment of PM is species-specific, in this study, four tree species common in urban areas of Europe and wider (Aesculus hippocastanum,Acer platanoides,Betula pendula andTilia cordata) were investigated to evaluate which biomonitor enables consistent ‘signal’ to particle and particle-bound toxic elements. The tree leaves were sampled in the central urban and suburban parks in Belgrade (Serbia) in May and September from 2011 until 2014. Magnetic PM fractions in the samples were quanti...
Source: Air Quality, Atmosphere and Health - July 26, 2019 Category: Environmental Health Source Type: research
Aesculus hippocastanum L. extract as a potential emulsion stabilizer
This study presents the investigations on Aesculus hippocastanum L. (AHL) bark extract as a potential antibacterial emulsion stabilizer. The tested crude extract of AHL contained 4.7% saponins, which are considered as the main group of extract components responsible for its surface-active properties. Two series of plant extracts were prepared: the first one (crude) was obtained immediately after the extraction procedure, and the second one was obtained by filtration of crude extract through a syringe filter (200 nm). The emulsifying properties of crude and filtered extracts were compared according to their surface-active...
Source: Food Hydrocolloids - July 25, 2019 Category: Food Science Source Type: research
In vitro determination of prebiotic potential of aqueous extract of horse chestnut by-product
Publication date: Available online 28 May 2019Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Joanna Przyborska, Michael C. Hall, Mary Concannon (Source: Bioactive Carbohydrates and Dietary Fibre)
Source: Bioactive Carbohydrates and Dietary Fibre - May 29, 2019 Category: Food Science Source Type: research
Survival and growth of embryo axes of temperate trees after two decades of cryo-storage.
In this study we evaluated in vitro viability and ex vitro growth of embryo axes of a species that is short-lived in seed bank conditions (Juglans nigra) and two recalcitrant seeded species (Aesculus hippocastanum and A. glabra) that were stored 11-23 years in LN. Viability of J. nigra axes did not decrease significantly after 23 years and produced normal-appearing plantlets. Similarly, viability of A. hippocastanum axes did not decrease after 23 years. However, A. glabra axes showed a significant decline in viability after 23 years, from 80% when freshly harvested to 33%. These results demonstrate that LN storage can pres...
Source: Cryobiology - April 21, 2019 Category: Biology Authors: Ballesteros D, Pence VC Tags: Cryobiology Source Type: research
Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (Camelus dromedarius)
This study was supported by grants from Alpaca Research Foundation (ARF) 2009–2011 and Morris Animal Foundation (MAF) D09LA-004, D14LA-005. The authors highly appreciate donations to ARF and MAF by Leslie Herzog of Herzog Alpacas. FA was supported by Qassim University, Saudi Arabia.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The handling Editor and reviewer PO-tW declared their involvement as co-editors in the Research Topic, and confirm the absence of an...
Source: Frontiers in Genetics - April 15, 2019 Category: Genetics & Stem Cells Source Type: research
Biological activity of Aesculus hippocastanum flower extracts on vascular endothelial cells cultured in vitro
In conclusion, HF extract exhibits anti-hyaluronidase activity, antimicrobial properties, and reduces ROS production. These observations may partly justify the use of HF in supporting wound healing.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research
Natural barrigenol–like triterpenoids: A comprehensive review of their contributions to medicinal chemistry
Publication date: May 2019Source: Phytochemistry, Volume 161Author(s): Xinxin Zhang, Song Zhang, Yiren Yang, Da Wang, Huiyuan GaoAbstractBarrigenol-like triterpenoids (BATs), which contain an unusual oleanane substituted by many hydroxyl groups as the skeleton, are subdivided into five subtypes: barrigenol A1, barrigenol A2, barrigenol R1, barringtogenol C, and 16-deoxybarringtogenol C. The variations in acyl derivatives, hydroxyl groups, and carbohydrate chains in their structures have enhanced the diversity of BATs. Moreover, the stable polyhydroxy-replaced pentacyclic skeleton provides an ideal platform for structural m...
Source: Phytochemistry - February 27, 2019 Category: Chemistry Source Type: research
Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo
In this study, we demonstrate that β-escin and AH have virucidal and antiviral activities against RSV, as well as NF-κB, AP-1 and cytokine modulating activities in RSV infected epithelial and macrophage cell lines in vitro. Besides, in a murine model of pulmonary RSV infection, AH treatment improves the course of acute disease, evidenced by decreased weight loss, reduced RSV lung titers, and attenuated airway inflammation. In contrast, even though β-escin showed, similarly to AH, antiviral and immunomodulatory properties in vitro, it neither reduces viral titers nor attenuates lung injury in vivo. Thus, our data demonst...
Source: Antiviral Therapy - February 1, 2019 Category: Virology Source Type: research
Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo.
In this study, we demonstrate that β-escin and AH have virucidal and antiviral activities against RSV, as well as NF-κB, AP-1 and cytokine modulating activities in RSV infected epithelial and macrophage cell lines in vitro. Besides, in a murine model of pulmonary RSV infection, AH treatment improves the course of acute disease, evidenced by decreased weight loss, reduced RSV lung titers, and attenuated airway inflammation. In contrast, even though β-escin showed, similarly to AH, antiviral and immunomodulatory properties in vitro, it neither reduces viral titers nor attenuates lung injury in vivo. Thus, our data demonst...
Source: Antiviral Research - January 31, 2019 Category: Virology Authors: Salinas FM, Vázquez L, Gentilini MV, O Donohoe A, Regueira E, Nabaes Jodar MS, Viegas M, Michelini FM, Hermida G, Alché LE, Bueno CA Tags: Antiviral Res Source Type: research
In vitro anthelmintic activity and safety of different plant species against the ovine gastrointestinal nematode Teladorsagia circumcincta
Publication date: Available online 4 January 2019Source: Research in Veterinary ScienceAuthor(s): Myriam Esteban-Ballesteros, Jaime Sanchis, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, Francisco A. Rojo-Vázquez, Camino González-Lanza, María Martínez-ValladaresAbstractThe present study was conducted to evaluate the in vitro anthelmintic activity and safety of methanolic and aqueous extracts of 9 plants against the ovine GIN Teladorsagia circumcincta. Initially the ovicidal efficacy of all extracts was tested at 50 mg/ml and at 1%, this last concentration for the methanolic extract of Elettaria cardamomum, by the Eg...
Source: Research in Veterinary Science - January 5, 2019 Category: Veterinary Research Source Type: research
Rutosides for treatment of post-thrombotic syndrome.
CONCLUSIONS: There was no evidence that rutosides were superior to the use of placebo or ECS. Overall, there is currently limited low-quality evidence that 'venoactive' or 'phlebotonic' remedies such as rutosides reduce symptoms of PTS. Mild side effects were noted in one study. The three studies included in this review provide no evidence to support the use of rutosides in the treatment of PTS.
PMID: 30406640 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 8, 2018 Category: General Medicine Authors: Morling JR, Broderick C, Yeoh SE, Kolbach DN Tags: Cochrane Database Syst Rev Source Type: research
Rutosides for prevention of post-thrombotic syndrome.
CONCLUSIONS: As there were no studies identified in this review there is currently insufficient evidence to determine the effectiveness and safety of rutosides for prevention of PTS in patients with DVT. Some studies suggest that rutosides may provide short-term relief of PTS symptoms. However, there is nothing published on their use as a preventative therapy for PTS. High quality randomised controlled trials of rutoside versus any alternative are required to build the evidence base in this area.
PMID: 30406639 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 8, 2018 Category: General Medicine Authors: Morling JR, Yeoh SE, Kolbach DN Tags: Cochrane Database Syst Rev Source Type: research
A validated 1H qNMR method for direct and simultaneous quantification of esculin, fraxin and (-)-epicatechin in Hippocastani cortex.
A validated 1H qNMR method for direct and simultaneous quantification of esculin, fraxin and (-)-epicatechin in Hippocastani cortex.
Talanta. 2019 Jan 15;192:263-269
Authors: Owczarek A, Kłys A, Olszewska MA
Abstract
A fast and precise qNMR method was developed for quantification of major bioactive constituents in the bark of horse chestnut and dry extracts prepared thereof. The method was optimised using 600 MHz spectrometer, and the final acquisition parameters (90°-pulse, acquisition time - 3.0 s, relaxation delay - 27 s, number of transients - 16) allowed for performi...
Source: Talanta - October 24, 2018 Category: Chemistry Authors: Owczarek A, Kłys A, Olszewska MA Tags: Talanta Source Type: research
