Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice
In conclusion, this paper demonstrates that esculin protects liver injury induced by LPS/D-Gal via inhibiting inflammatory and oxidative responses. (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - October 5, 2018 Category: Infectious Diseases Source Type: research
Inhibition of Migration and Invasion in Melanoma Cells by β-Escin via the ERK/NF-κB Signaling Pathway.
Abstract
β-Escin, a natural triterpene saponin was extracted from Aesculus hippocastanum seeds, which have been widely used to treat inflammation in traditional medicine. In an effort to study the possible anti-tumor effects of β-escin, we performed wound healing, invasion, and adhesion assays to examine the effects of β-escin on cell migration, invasion, and angiogenesis. Our results revealed that β-escin inhibits cell migration as well as motility in B16F10 and SK-MEL5 cells in a dose-dependent manner. RT-PCR and Western blot analysis showed that β-escin increased TIMP-1, -2 while significantly down...
Source: Biological and Pharmaceutical Bulletin - October 4, 2018 Category: Drugs & Pharmacology Authors: Kwak H, An H, Alam MB, Choi WS, Lee SY, Lee SH Tags: Biol Pharm Bull Source Type: research
Virucidal, antiviral and immunomodulatory activities of β‐escin and Aesculus hippocastanum extract
Journal of Pharmacy and Pharmacology, EarlyView. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 31, 2018 Category: Drugs & Pharmacology Authors: Flavia M. Michelini
,
Laura E. Alch é
,
Carlos A. Bueno Source Type: research
Optimization of ultrasonic assisted extraction of fatty acids from Aesculus hippocastanum fruit by response surface methodology
Publication date: 15 January 2019Source: Food Chemistry, Volume 271Author(s): Shadan Amiri, Azadeh Shakeri, Mahmoud Reza Sohrabi, Sepideh Khalajzadeh, Ensieh GhasemiAbstractThe effectiveness of ultrasound-assisted extraction (UAE) of Aesculus hippocastanum fruit oil was investigated using methanol as a solvent. The study compared extraction yields using UAE and methanol with soxhlet. The effects of three extraction parameters, namely temperature, time and the ratio of solvent (volume) to plant material (weight) were optimized using both a Box–Behnken design (BBD) and response surface methodology (RSM). The highest extrac...
Source: Food Chemistry - August 10, 2018 Category: Food Science Source Type: research
Nano-encapsulation of catechin in starch nanoparticles: Characterization, release behavior and bioactivity retention during simulated in-vitro digestion
Publication date: 1 January 2019Source: Food Chemistry, Volume 270Author(s): Mudasir Ahmad, Priti Mudgil, Adil Gani, Fathalla Hamed, F.A. Masoodi, Sajid MaqsoodAbstractNovel starch-based nanoparticles from three sources: horse chestnut (HSC), water chestnut (WSC) and lotus stem (LSC) were prepared for nano-encapsulation of catechin. Average particle size of HSC, WSC and LSC based nano-particles were 322.7, 559.2 and 615.6 nm with encapsulation efficiency of 59.09, 48.30, and 55.00% and negative zeta potential of −18.05, −21.5 and −18.05 mv, respectively. Structural, physical and thermal properties were characteri...
Source: Food Chemistry - July 18, 2018 Category: Food Science Source Type: research
Nano encapsulation of catechin in starch nanoparticles: Characterization; release behavior and bioactivity retention during in-vitro digestion
Publication date: Available online 5 July 2018Source: Food ChemistryAuthor(s): Mudasir Ahmad, Priti Mudgil, Adil Gani, Fathalla Hamed, Farooq A. Masoodi, Sajid MaqsoodAbstractNovel starch-based nanoparticles from three sources: horse chestnut (HSC), water chestnut (WSC) and lotus stem (LSC) were prepared for nano-encapsulation of catechin. Average particle size of HSC, WSC and LSC based nano-particles were 322.7, 559.2 and 615.6 nm with encapsulation efficiency of 59.09, 48.30, and 55.00% and negative zeta potential of -18.05, -21.5 and -18.05 mv, respectively. Structural, physical and thermal properties were characterized...
Source: Food Chemistry - July 14, 2018 Category: Food Science Source Type: research
Antioxidant activity evaluation of dried herbal extracts: an electroanalytical approach
ABSTRACT The prevention of chronic and degenerative diseases, is a health concern deeply associated with oxidative stress. Such progressive phenomena can be avoided through exogenous antioxidant intake, which set up a reductant cascade, mopping up damaging free radicals. Medicinal herbs are commonly associated with high antioxidant potential, and hence their health benefits. The commerce of dried herbal extracts movements a big portion of developing countries economy. The determination of medicinal herbs the antioxidant activity capacity is of utmost importance. The assessment of antioxidant activity in phytotherapics is m...
Source: Revista Brasileira de Farmacognosia - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Separation and determination of coumarins including furanocoumarins using micellar electrokinetic capillary chromatography.
Abstract
The conditions of micellar electrokinetic capillary chromatography for separation and simultaneous measurement of coumarins (coumarin, scoparone, isoscopoletin, esculin, esculetin, umbelliferone) including furanocoumarins (xanthotoxin, byakangelicin, isopimpinellin, bergapten, phellopterin, xanthotoxol) have been elaborated. The influence of different parameters, such as the pH of the buffer, sodium cholate (SC) or methanol concentration in the buffer, on the migration time, peak resolution, peak asymmetry, and number of theoretical plates was investigated. The optimum separation of the compounds ...
Source: Talanta - June 2, 2018 Category: Chemistry Authors: Dresler S, Bogucka-Kocka A, Kováčik J, Kubrak T, Strzemski M, Wójciak-Kosior M, Rysiak A, Sowa I Tags: Talanta Source Type: research
Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/ γH2AX pathway.
In conclusion, our results demonstrate that p62 regulates ATM/γH2AX pathway-mediated escin-induced DNA damage and apoptosis.
PMID: 29849127 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 31, 2018 Category: Drugs & Pharmacology Authors: Wang Z, Chen Q, Li B, Xie JM, Yang XD, Zhao K, Wu Y, Ye ZY, Chen ZR, Qin ZH, Xing CG Tags: Acta Pharmacol Sin Source Type: research
Novel Colloidal Microstructures of β-Escin and the Liposomal
Components Cholesterol and DPPC
In this study, β-escin,
a monodesmosidic triterpene saponin from horse chestnut, was investigated in
terms of its interaction with liposomal components (cholesterol,
dipalmitoylphosphatidylcholine) by Langmuir film balance studies and with regard
to particle formation visualized by transmission electron microscopy. A strong
interaction of β-escin with cholesterol was observed by Langmuir
isotherms due to the intercalation of the saponin into the monolayer, whereas no
interaction occurred with dipalmitoylphosphatidylcholine. Transmission electron
...
Source: Planta Medica - May 24, 2018 Category: Drugs & Pharmacology Authors: de Groot, Carolin M üsken, Mathias M üller-Goymann, Christel C. Tags: Original Papers Source Type: research
Molecular targets and anti-cancer potential of escin
Escin is a mixture of triterpenoid saponins extracted from the horse chestnut tree, Aesculus hippocastanum. Its potent anti-inflammatory and anti-odematous properties makes it a choice of therapy against chronic venous insufficiency and odema. More recently, escin is being actively investigated for its potential activity against diverse cancers. It exhibits anti-cancer effects in many cancer cell models including lung adenocarcinoma, hepatocellular carcinoma and leukemia. Escin also attenuates tumor growth and metastases in various in vivo models. (Source: Cancer Letters)
Source: Cancer Letters - February 20, 2018 Category: Cancer & Oncology Authors: Dorothy H.J. Cheong, Frank Arfuso, Gautam Sethi, Lingzhi Wang, Kam Man Hui, Alan Prem Kumar, Thai Tran Tags: Mini-review Source Type: research
In planta bioassay on the effects of endophytic Beauveria strains against larvae of horse-chestnut leaf miner (Cameraria ohridella)
In this study, laboratory bioassays were conducted to determine the ability of local Beauveria strains to colonize horse-chestnut leaves endophytically and test their antagonistic activity against C. ohridella in colonized leaves. Two strains of Beauveria bassiana (AM_EF0111 isolated from horse-chestnut leaf tissue and AM_EP0715 isolated from a C. ohridella pupa) and one strain of B. pseudobassiana (AM_SO1015 obtained from soil) were used for in planta bioassays. The selected strains demonstrated high virulence to leaf miner pupae after a topical treatment with spore suspensions. LC50 ranged between 2.49 and 3.19 × 106 co...
Source: Biological Control - February 14, 2018 Category: Biology Source Type: research
Molecules, Vol. 23, Pages 197: β-Escin Effectively Modulates HUVECS Proliferation and Tube Formation
In conclusion, β-escin affects endothelial cells as a negative mediator of angiogenesis in vitro and in vivo and may therefore be considered as a promising candidate for further research elucidating its underlying mechanism of action. (Source: Molecules)
Source: Molecules - January 17, 2018 Category: Chemistry Authors: Lenka Varinsk á Lenka F áber Martin Kello Eva Petrovov á Ľudmila Balážová Peter Sol ár Mat úš Čoma Peter Urdz ík J án Mojžiš Emil Švajdlenka Pavel Mu čaji Peter G ál Tags: Article Source Type: research
In-vitro Antioxidant Activities of the Ethanolic Extracts of Some Contained-Allantoin Plants
In conclusion, allantoin shows antioxidant properties and it has positive the effect on total antioxidant capacity. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - February 28, 2017 Category: Drugs & Pharmacology Source Type: research
Antioxidant activities and structural characterization of flavonol O-glycosides from seeds of Japanese horse chestnut (Aesculus turbinata BLUME)
Publication date: 1 August 2017 Source:Food Chemistry, Volume 228 Author(s): Hideto Kimura, Satoshi Ogawa, Tomoe Ishihara, Mahoko Maruoka, Shota Tokuyama-Nakai, Mitsuo Jisaka, Kazushige Yokota We attempted to evaluate the contents and distribution of antioxidants in the whole seeds, seed shells, and peeled seeds of the Japanese horse chestnut. The seed shells exhibited the highest antioxidant activities due to the presence of highly polymeric proanthocyanidins as we have reported recently. On the other hand, the peeled seeds predominantly contained flavonols such as quercetin and kaempferol at a high level of 66.7...
Source: Food Chemistry - February 13, 2017 Category: Food Science Source Type: research
