Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research
Molecules, Vol. 26, Pages 6856: Structure and Undulations of Escin Adsorption Layer at Water Surface Studied by Molecular Dynamics
Denkov
The saponin escin, extracted from horse chestnut seeds, forms adsorption layers with high viscoelasticity and low gas permeability. Upon deformation, escin adsorption layers often feature surface wrinkles with characteristic wavelength. In previous studies, we investigated the origin of this behavior and found that the substantial surface elasticity of escin layers may be related to a specific combination of short-, medium-, and long-range attractive forces, leading to tight molecular packing in the layers. In the current study, we performed atomistic molecular dynamics simulations of 441 escin molecules in a d...
Source: Molecules - November 13, 2021 Category: Chemistry Authors: Sonya Tsibranska Anela Ivanova Slavka Tcholakova Nikolai Denkov Tags: Article Source Type: research
Molecules, Vol. 26, Pages 5856: Whey Proteins as a Potential Co-Surfactant with Aesculus hippocastanum L. as a Stabilizer in Nanoemulsions Derived from Hempseed Oil
In this study, a whey protein isolate (WPI) from a byproduct of cheese production was used to stabilize a nanoemulsion formulation that contained hempseed oil and the Aesculus hippocastanum L. extract (AHE). A Box–Behnken experimental design was used to set the formulation criteria and the optimal nanoemulsion conditions, used subsequently in follow-up experiments that measured specifically emulsion droplet size distribution, stability tests and visual quality. Regression analysis showed that the concentration of HSO and the interaction between HSO and the WPI were the most significant factors affecting the emulsion poly...
Source: Molecules - September 27, 2021 Category: Chemistry Authors: Wojciech Smu łek Przemys ław Siejak Farahnaz Fathordoobady Łukasz Masewicz Yigong Guo Ma łgorzata Jarzębska David D. Kitts Przemys ław Łukasz Kowalczewski Hanna Maria Baranowska Jerzy Stangierski Anna Szwajca Anubhav Pratap-Singh Maciej Jarz ębski Tags: Article Source Type: research
Estimating the allergenic potential of urban green areas in the city of Madrid (Spain)
AbstractUrban green spaces offer large environmental, social, and economic benefits for the population. However, when species that compose it are chosen, its allergenicity is not usually considered, which poses a risk to the population with pollinosis. In this work, the potential allergenicity index (IUGZA) of five urban parks in the city of Madrid (Spain) has been calculated, in order to assess their allergenic potential and to identify the species that most contribute to increasing it. The results show that three of the parks register an index value sufficient high to cause adverse reactions in the exposed population. Th...
Source: Aerobiologia - August 19, 2021 Category: Environmental Health Source Type: research
Cancers, Vol. 13, Pages 3931: The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis
This study reveals that the natural compound β-escin has a therapeutic potential because of its ability to prevent OvCa dissemination by targeting both cancer and stromal cells in the OvCa tumor microenvironment. (Source: Cancers)
Source: Cancers - August 4, 2021 Category: Cancer & Oncology Authors: Kenny Hart Kordylewicz Lal Shen Kara Chen Grassl Alharbi Pattnaik Watters Patankar Ferrer Lengyel Tags: Article Source Type: research
Molecules, Vol. 26, Pages 3784: Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds
Razzokov
Horse chestnut (Aesculus hippocastanum L.)-derived drugs have shown their potential in biomedical applications. The seed of A. hippocastanum contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, we investigated the chemical components in A. hippocastanum L. grown in Uzbekistan, which has not yet been studied in detail. We identified 30 kinds of triterpene saponins in an extract of A. hippocastanum L. Classifying extracted saponins into eight fractions, we next studied the hypoglycemic and the anti-inflammatory activities of escin and its deriva...
Source: Molecules - June 22, 2021 Category: Chemistry Authors: Avez Sharipov Khurshid Tursunov Sunnatullo Fazliev Bahtigul Azimova Jamoliddin Razzokov Tags: Article Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
