Genetic rearrangements in Pseudomonas amygdali pathovar aesculi shape coronatine plasmids
In this study, we have sequenced and analyzed the complete genome sequences of four Pseudomonas amygdali pv. aesculi (Pae), which infect European horse chestnut trees (Aesculus hippocastanum) and belong to phylogroup 3 of the P. syringae species complex. The four investigated genomes contain six groups of plasmids that all encode pathogenicity factors. Effector genes were found to be mostly associated with insertion sequence elements, suggesting that virulence genes are generally mobilized and potentially undergo horizontal gene transfer after transfer to a conjugative plasmid. We show that the biosynthetic gene cluster en...
Source: Infection, Genetics and Evolution - August 4, 2023 Category: Genetics & Stem Cells Authors: Tue Kj ærgaard Nielsen Caroline S Winther-Have Iben Margrete Thomsen Robert W Jackson Mojgan Rabiey Rosanna Catherine Hennessy Frederik Bak Witold Kot Mette Haubjerg Nicolaisen Alexander Byth Carstens Lars Hestbjerg Hansen Source Type: research
Genetic rearrangements in Pseudomonas amygdali pathovar aesculi shape coronatine plasmids
In this study, we have sequenced and analyzed the complete genome sequences of four Pseudomonas amygdali pv. aesculi (Pae), which infect European horse chestnut trees (Aesculus hippocastanum) and belong to phylogroup 3 of the P. syringae species complex. The four investigated genomes contain six groups of plasmids that all encode pathogenicity factors. Effector genes were found to be mostly associated with insertion sequence elements, suggesting that virulence genes are generally mobilized and potentially undergo horizontal gene transfer after transfer to a conjugative plasmid. We show that the biosynthetic gene cluster en...
Source: Infection, Genetics and Evolution - August 4, 2023 Category: Genetics & Stem Cells Authors: Tue Kj ærgaard Nielsen Caroline S Winther-Have Iben Margrete Thomsen Robert W Jackson Mojgan Rabiey Rosanna Catherine Hennessy Frederik Bak Witold Kot Mette Haubjerg Nicolaisen Alexander Byth Carstens Lars Hestbjerg Hansen Source Type: research
The Role of Defensins as Pollen and Food Allergens
We present and critically review the allergenic relevance of pollen and food defensins. The recently identified Api g 7 from celeriac and other allergens potentially involved inArtemisia pollen-related food allergies are discussed and related to clinical severity and allergen stability. To specifyArtemisia pollen-related food allergies, we propose the term “defensin-related food allergies” to account for defensin-polyproline–linked protein-associated food syndromes.SummaryThere is increasing evidence that defensins are the causative molecules in several mugwort pollen-associated food allergies. A small number of stud...
Source: Current Allergy and Asthma Reports - May 13, 2023 Category: Allergy & Immunology Source Type: research
Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis
ConclusionsLCMS report confirms the presence of quercetin and rutin in AH seeds ethanolic extract. The therapeutic effect of AH seeds extract against indomethacin-induced ulcer in rat model indicated the regenerated membrane integrity, with improved cellular functions and mucus thickness. Further, improved antioxidant enzyme level would help to reduce PGE2 biosynthesis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - April 20, 2023 Category: Internal Medicine Source Type: research
Molecules, Vol. 28, Pages 2087: Horse Chestnut Saponins & ndash;Escins, Isoescins, Transescins, and Desacylescins
Molecules, Vol. 28, Pages 2087: Horse Chestnut Saponins–Escins, Isoescins, Transescins, and Desacylescins
Molecules doi: 10.3390/molecules28052087
Authors:
Philippe Savarino
Emmanuel Colson
Julien André
Pascal Gerbaux
Escins constitute an abundant family of saponins (saponosides) and are the most active components in Aesculum hippocastanum (horse chestnut—HC) seeds. They are of great pharmaceutical interest as a short-term treatment for venous insufficiency. Numerous escin congeners (slightly different compositions), as well as numerous regio-and stereo-isomers, are extractable from H...
Source: Molecules - February 23, 2023 Category: Chemistry Authors: Philippe Savarino Emmanuel Colson Julien Andr é Pascal Gerbaux Tags: Article Source Type: research
Peripheral Edema: Evaluation and Management in Primary Care
Am Fam Physician. 2022 Nov;106(5):557-564.ABSTRACTEdema is a common clinical sign that may indicate numerous pathologies. As a sequela of imbalanced capillary hemodynamics, edema is an accumulation of fluid in the interstitial compartment. The chronicity and laterality of the edema guide evaluation. Medications (e.g., antihypertensives, anti-inflammatory drugs, hormones) can contribute to edema. Evaluation should begin with obtaining a basic metabolic panel, liver function tests, thyroid function testing, brain natriuretic peptide levels, and a urine protein/creatinine ratio. Validated decision rules, such as the Wells and...
Source: American Family Physician - November 15, 2022 Category: Primary Care Authors: Hiten Patel Christopher Skok Anthony DeMarco Source Type: research
Peripheral Edema: Evaluation and Management in Primary Care
Am Fam Physician. 2022 Nov;106(5):557-564.ABSTRACTEdema is a common clinical sign that may indicate numerous pathologies. As a sequela of imbalanced capillary hemodynamics, edema is an accumulation of fluid in the interstitial compartment. The chronicity and laterality of the edema guide evaluation. Medications (e.g., antihypertensives, anti-inflammatory drugs, hormones) can contribute to edema. Evaluation should begin with obtaining a basic metabolic panel, liver function tests, thyroid function testing, brain natriuretic peptide levels, and a urine protein/creatinine ratio. Validated decision rules, such as the Wells and...
Source: American Family Physician - November 15, 2022 Category: Primary Care Authors: Hiten Patel Christopher Skok Anthony DeMarco Source Type: research
Molecules, Vol. 27, Pages 5471: The Secondary Metabolites Profile in Horse Chestnut Leaves Infested with Horse-Chestnut Leaf Miner
Marta Dmitruk
Natural defensive substances synthesized by plants that could replace synthetic pesticides in the protection of plants against insect invasions are constantly being sought. The study assessed changes in the qualitative and quantitative composition of secondary metabolites in horse chestnut leaves collected in different locations and differing in the sensitivity of the plant to the invasion by the horse-chestnut leaf miner. An attempt was made to identify compounds that are most responsible for the increased plant resistance to this threat. Additionally, changes in the anatomy of chestnut leaves affected ...
Source: Molecules - August 25, 2022 Category: Chemistry Authors: Ma łgorzata Materska Marzena Pabich Monika Sachadyn-Kr ól Agata Konarska El żbieta Weryszko-Chmielewska Barbara Chilczuk Monika Staszowska-Karkut Izabella Jackowska Marta Dmitruk Tags: Article Source Type: research
Assessment of Antimicrobial Activity of Ethanolic and Aqueous Extracts of < em > Aesculus hippocastanum < /em > L. (Horse Chestnut) Bark against Bacteria Isolated from Urine of Patients Diagnosed Positive to Urinary Tract Infections
Front Biosci (Schol Ed). 2022 Apr 2;14(2):11. doi: 10.31083/j.fbs1402011.ABSTRACTThe search for new antimicrobials is essential to address the worldwide issue of antibiotic resistance. The present work aimed at assessing the antimicrobial activity of Aesculus hippocastanum L. (horse chestnut) bark against bacteria involved in urinary tract infections (UTIs). Bioactive compounds were extracted from A. hippocastanum bark using water and ethanol as solvents. The extracts were tested against 10 clinical uropathogenic strains including five Gram-positive and five Gram-negative bacteria. Staphylococcus aureus ATCC 6538 and Esche...
Source: Frontiers in Bioscience - Scholar - June 22, 2022 Category: Biomedical Science Authors: Khar'kov Y Konstantinovitch Mbarga M J Arsene Martynenkova V Aliya Podoprigora I Viktorovna Volina G Elena Madina M Azova Ait A Amira Source Type: research
