Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
CONCLUSIONS: Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.PMID:33983078 | DOI:10.1177/02683555211015020 (Source: Phlebology)
Source: Phlebology - May 13, 2021 Category: Internal Medicine Authors: Giuseppe Pompilio Andrew Nicolaides Stavros K Kakkos Davide Integlia Source Type: research
Estimating the allergenic potential of urban green areas in the city of Madrid (Spain)
AbstractUrban green spaces offer large environmental, social, and economic benefits for the population. However, when species that compose it are chosen, its allergenicity is not usually considered, which poses a risk to the population with pollinosis. In this work, the potential allergenicity index (IUGZA) of five urban parks in the city of Madrid (Spain) has been calculated, in order to assess their allergenic potential and to identify the species that most contribute to increasing it. The results show that three of the parks register an index value sufficient high to cause adverse reactions in the exposed population. Th...
Source: Aerobiologia - April 24, 2021 Category: Environmental Health Source Type: research
Surface activity of the oat, horse chestnut, cowherb, soybean, quinoa and soapwort extracts – Is it only due to saponins?
Publication date: May 2021Source: Colloid and Interface Science Communications, Volume 42Author(s): Ilona Góral, Anna Stochmal, Kamil Wojciechowski (Source: Colloids and Interface Science Communications)
Source: Colloids and Interface Science Communications - March 31, 2021 Category: Nanotechnology Source Type: research
Escin inhibits angiogenesis by suppressing interleukin ‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines
In conclusion, escin could be used as a novel molecular therapy for PaCa.PMID:33760162 | DOI:10.3892/or.2021.8006 (Source: Oncology Reports)
Source: Oncology Reports - March 24, 2021 Category: Cancer & Oncology Authors: Kan Omi Yoichi Matsuo Goro Ueda Yoshinaga Aoyama Tomokatsu Kato Yuichi Hayashi Hiroyuki Imafuji Kenta Saito Ken Tsuboi Mamoru Morimoto Ryo Ogawa Hiroki Takahashi Shuji Takiguchi Source Type: research
Escin inhibits angiogenesis by suppressing interleukin ‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines
In conclusion, escin could be used as a novel molecular therapy for PaCa.PMID:33760162 | PMC:PMC7962110 | DOI:10.3892/or.2021.8006 (Source: Oncology Reports)
Source: Oncology Reports - March 24, 2021 Category: Cancer & Oncology Authors: Kan Omi Yoichi Matsuo Goro Ueda Yoshinaga Aoyama Tomokatsu Kato Yuichi Hayashi Hiroyuki Imafuji Kenta Saito Ken Tsuboi Mamoru Morimoto Ryo Ogawa Hiroki Takahashi Shuji Takiguchi Source Type: research
[Conservative treatment of varicose veins].
Authors: Stücker M
Abstract
The treatment of varicose veins is supposed to eliminate congestive symptoms and edema, heal skin complications and prevent complications. Surgical procedures, endovenous thermal procedures, endovenous chemical procedures and conservative measures are used for treatment. Often the invasive and conservative procedures are combined. A precise examination of the varicose veins is required for therapy planning; duplex sonography is the gold standard. Conservative therapy focuses on compression therapy with compression bandages and with compression stockings. Medical adaptive compr...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - January 23, 2021 Category: Dermatology Tags: Hautarzt Source Type: research
Aescin - a natural soap for the formation of lipid nanodiscs with tunable size
Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/D0SM02043E, PaperRamsia Geisler, Martin Cramer Pedersen, Natalie Preisig, Yvonne Hannappel, Sylvain Prevost, Rajeev Dattani, Lise Arleth, Thomas Hellweg The saponin β-aescin from the seed extract of the horse chestnut tree Aesculus hippocastanum has demonstrated a beneficial role in clinical therapy which is in part related to its strong... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)
Source: RSC - Soft Matter latest articles - December 16, 2020 Category: Chemistry Authors: Ramsia Geisler Source Type: research
Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency.
Abstract
Chronic venous insufficiency (CVI) is a common disorder associated with a variety of symptoms in later disease stages; despite the high prevalence of this pathology, suitable pharmaceutical therapies have not been explored to date. In this context, it was recently reported that a chronic increase in venous wall stress or biomechanical stretch is sufficient to cause development of varicose veins. Recent evidence demonstrate that flavonoids are natural substances that convey the circulatory system functionality, playing a key role in blood flow. Particularly, troxerutin, diosmin and horse chestnut e...
Source: Vascular Pharmacology - December 2, 2020 Category: Drugs & Pharmacology Authors: Casili G, Lanza M, Campolo M, Messina S, Scuderi S, Ardizzone A, Filippone A, Paterniti I, Cuzzocrea S, Esposito E Tags: Vascul Pharmacol Source Type: research
A Literature Review of Pharmacological Agents to Improve Venous Leg Ulcer Healing.
Authors: Kitchens BP, Snyder RJ, Cuffy CA
Abstract
Compression therapy is the gold standard treatment for venous leg ulcers (VLUs); however, with adjunctive pharmacological therapies and poor patient adherence using compressive dressings, clinicians are looking to find the advantage in treating VLUs. This literature review focuses on the efficacy of pharmacological agents, quality of life using agents in addition to compression therapy, and cost effectiveness to indicate the best outcomes for pharmacological treatment of VLUs. The following available venotonic, hemorheologic, and fibrinolytic agents were r...
Source: Wounds - November 12, 2020 Category: General Medicine Tags: Wounds Source Type: research
