In vitro permeation studies of phenolics from horse chestnut seed gels prepared with different polyacrylic acid polymer derivatives.
Abstract
The aim of this study was to investigate the effects of polyacrylic acid polymers (Ultrez 10, Ultrez 20, Carbopol 980, and Carbopol 940) on the viscosity and the in vitro permeation of phenolic compounds from the gel prepared from natural horse chestnut seed extract. Experiments were performed in the presence and in the absence of peppermint oil (Mentha piperita). Our results showed that peppermint oil decreased the viscosity of the gels and permeation of phenolic compounds from all gel samples. Results show that the highest content of phenolic compounds (1.758 μg cm-2) permeated in vitro from ge...
Source: Acta Pharmaceutica - May 29, 2015 Category: Drugs & Pharmacology Authors: Zelbienė E, Draksiene G, Savickas A, Kopustinskiene D, Masteikova R, Bernatoniene J Tags: Acta Pharm Source Type: research
A Burst of miRNA Innovation in the Early Evolution of Butterflies and Moths
MicroRNAs (miRNAs) are involved in posttranscriptional regulation of gene expression. Because several miRNAs are known to affect the stability or translation of developmental regulatory genes, the origin of novel miRNAs may have contributed to the evolution of developmental processes and morphology. Lepidoptera (butterflies and moths) is a species-rich clade with a well-established phylogeny and abundant genomic resources, thereby representing an ideal system in which to study miRNA evolution. We sequenced small RNA libraries from developmental stages of two divergent lepidopterans, Cameraria ohridella (Horse chestnut Leaf...
Source: Molecular Biology and Evolution - April 23, 2015 Category: Molecular Biology Authors: Quah, S., Hui, J. H. L., Holland, P. W. H. Tags: Discoveries Source Type: research
The Influence of Herbal Medicine on Platelet Function and Coagulation: A Narrative Review
Semin Thromb HemostDOI: 10.1055/s-0035-1549089Cardiovascular disease (CVD) is the leading cause of death worldwide. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of CVD and can play a role in modifying CVD progression, particularly in platelet function, and have the potential of altering platelet function tests, as well as some coagulation parameters. Herbal medicines, such as feverfew, garlic, ginger, ginseng, motherwort, St John's wort, and willow bark, were found to reduce platelet aggregation. In vitro studies show p...
Source: Seminars in Thrombosis and Hemostasis - April 3, 2015 Category: Hematology Authors: McEwen, Bradley J. Source Type: research
Horse‐chestnut (Aesculus hippocastanum) seed extract for venous leg ulceration: a comparative multiple case study of healers and non‐healers
ConclusionsA number of variables were identified as having an influence on the trajectory of venous ulcer healing among patients treated with HCSE. Further investigation is needed to validate these findings. (Source: Focus on Alternative and Complementary Therapies)
Source: Focus on Alternative and Complementary Therapies - September 26, 2014 Category: Complementary Medicine Authors: Matthew J Leach Tags: Original Article Source Type: research
Impulsive spatial control of invading pests by generalist predators
We model the conditions for pest eradication in a reaction–diffusion system made of a prey and a generalist predator through spatial impulsive control within a bounded domain. The motivating example is the control of the invasive horse chestnut leafminer moth through the yearly destruction of leaves in autumn, in which both the pest and its parasitoids overwinter. The model is made of two integro-partial differential equations, the integral portion describing the within-year immigration from the whole domain. The problem of pest eradication is strongly related to some appropriate eigenvalue problems. Basic properties...
Source: Mathematical Medicine and Biology - September 9, 2014 Category: Biomedical Science Authors: Aniţa, S., Casas, J., Suppo, C. Tags: Articles Source Type: research
Influence of extrahent on antioxidant capacity of Aesculus hippocastanum seeds.
In this study, the optimisation of horse chestnut seed extraction was performed to determine the best extraction solvent in the recovery of pharmacologically active escin from raw material. All extracts were obtained by accelerated solvent extraction and were analysed for their antioxidant potential (DPPH test), phenolic content (Folin-Ciocalteu (FC) assay) and escin content (ESI-TOF-MS extracts profiling). Methanol was found to recover the highest amount of escin from the plant matrix as well as to produce the most active antiradical solutions rich in polyphenols. Radical scavenging properties of methanol extracts were ca...
Source: Natural Product Research - August 11, 2014 Category: Biochemistry Authors: Kukula-Koch W, Kędzierski B, Głowniak K Tags: Nat Prod Res Source Type: research
Bacteria-Phage Interactions across Time and Space: Merging Local Adaptation and Time-Shift Experiments to Understand Phage Evolution *
Abstract
Abstract The study of parasite local adaptation to host populations offers important insight into the spatial scale of host-parasite interactions. For parasites adapting to local hosts, the process is continually driven by change in the host population, in response to either the parasite or alternative selection pressures. In the case of reciprocal coevolutionary change, this adaptation should generate a pattern whereby parasites are most fit against hosts from the recent past (which have not yet responded to parasite-mediated selection) and least fit against future host populations (with increase...
Source: The American Naturalist - July 27, 2014 Category: Biology Authors: Koskella B Tags: Am Nat Source Type: research
Escin Suppresses Migration and Invasion Involving the Alteration of CXCL16/CXCR6 Axis in Human Gastric Adenocarcinoma AGS Cells.
Abstract
Escin, a natural mixture of triterpene saponins isolated from horse chestnut, has been reported to possess anticancer activity in many human cancer cells. However, the effect of escin on the metastasis has not been studied. The present study examined the effect of escin on the migration and invasion of AGS human gastric cancer cells. To examine the effects of escin on metastatic capacities of gastric cancer cells, AGS cells were cultured in the presence of 0-4 μmol/L escin. Escin inhibited cell migration and invasion in AGS cells. However, escin did not affect the viability of these cells at the...
Source: Nutrition and Cancer - June 9, 2014 Category: Cancer & Oncology Authors: Lee HS, Hong JE, Kim EJ, Kim SH Tags: Nutr Cancer Source Type: research
A Rapid Method for Total Β‐Escin Analysis in Dry, Hydroalcoholic and Hydroglycolic Extracts of Aesculus hippocastanum L. by Capillary Zone Electrophoresis
ConclusionA fast and reliable methodology for determination of total β‐escin was successfully validated and applied on extracts of A. hippocastanum L. demonstrating its usefulness to quality control of medicines containing this plant species. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Phytochemical Analysis)
Source: Phytochemical Analysis - March 18, 2013 Category: Biochemistry Authors: Lidiane S. Dutra, Magda N. Leite, Marcos A. F. Brandão, Priscila Aparecida Almeida, Fernando A. S. Vaz, Marcone A. L. Oliveira Tags: Research Article Source Type: research
Horse chestnut extract: Rupture of a renal angiomyolipoma: case report
(Source: Reactions)
Source: Reactions - February 6, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
