Construction of a NT-3 sustained-release system cross-linked with an acellular spinal cord scaffold and its effects on differentiation of cultured bone marrow mesenchymal stem cells
ConclusionAs a composite scaffold, an NT-3 sustained-release system cross-linked with an acellular spinal cord scaffold has potential applications for tissue engineering.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - June 24, 2019 Category: Materials Science Source Type: research

Localization of cells using magnetized patterned thin films
In this study, the nasopharyngeal carcinoma cell line was cultured in a superparamagnetic iron oxide nanoparticle aqueous solution with a concentration of 1 μg/mL by using magnetic labeling technology. The cells took up superparamagnetic nanoparticles through the endocytosis process, which caused the cells to become magnetic and manipulable by a magnetic field gradient. Each cell contained 5.266 × 106 superparamagnetic nanoparticles, as determined using the magnetophoresis method. A specific domain configuration and its related distribution of magnetic poles in a patterned thin film were obtained after apply...
Source: Materials Science and Engineering: C - June 24, 2019 Category: Materials Science Source Type: research

Laser surface texturing of Ti-6Al-4V by nanosecond laser: Surface characterization, Ti-oxide layer analysis and its electrical insulation performance
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): C.G. Moura, O. Carvalho, L.M.V. Gonçalves, M.F. Cerqueira, R. Nascimento, F. SilvaAbstractThe development of smart biomedical implants with intrinsic communication system between sensors and actuators, or between implant and patient, remains a challenge for scientific community. Titanium and its alloys, especially Ti6Al4V, are the most used materials in the implant's fabrication. The present work is concerned with implant internal communication printing process and presents a detailed study on titanium alloy (Ti6Al4V) s...
Source: Materials Science and Engineering: C - June 24, 2019 Category: Materials Science Source Type: research

Facile preparation of biocompatible macroporous chitosan hydrogel by hydrothermal reaction of a mixture of chitosan-succinic acid-urea
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Prabha Govindaraj, Narayanan Abathodharanan, Kartik Ravishankar, Dhamodharan RaghavachariAbstractThe facile preparation of macroporous, super water absorbing, biocompatible hydrogels of chitosan involving the hydrothermal reaction of a mixture of chitosan (CH), succinic acid (SA) and urea (UR), all of which are sustainable materials, is reported. The structure of the dry CHSAUR was ascertained by CP MAS-SS NMR spectroscopy, Fourier transform infrared (FTIR) spectroscopy, powder x-ray diffraction analysis (PXRD), and thermograv...
Source: Materials Science and Engineering: C - June 22, 2019 Category: Materials Science Source Type: research

Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Wenfeng Wei, Xiaoyuan Zhang, Shan Zhang, Gang Wei, Zhiqiang SuAbstractCurrently, a lot of efforts have been applied to diagnosis and treat tumors through the fabrication of highly-efficient and multi-functional nanomaterials. Superior to other methods, photothermal therapy (PTT) has been demonstrated as a noninvasive, controllable, and targeted strategy to eliminate tumor cells. The use of functional biomedical and bioactive nanomaterials can enhance the photothermal performances and meanwhile integrate with favorable function...
Source: Materials Science and Engineering: C - June 22, 2019 Category: Materials Science Source Type: research

Surface potential and charges impact on cell responses on biomaterials interfaces for medical applications
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Sara Metwally, Urszula StachewiczAbstractSurface charge on biomaterials is emerging as a crucial determinant of regulating cells responses impacting cells signaling in tissue treatment. The dynamic cell - material interaction is a complex process where surface properties in biomaterials are one of the most influencing parameters considering especially geometry, stiffness and surface charge. Therefore, a lot of effort in tissue engineering is focused on surface modifications with roughness and various coatings to control the su...
Source: Materials Science and Engineering: C - June 22, 2019 Category: Materials Science Source Type: research

Hydrothermal-assisted synthesis of highly crystalline titania–copper oxide binary systems with enhanced antibacterial properties
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Adam Kubiak, Katarzyna Siwińska-Ciesielczyk, Joanna Goscianska, Anna Dobrowolska, Elżbieta Gabała, Katarzyna Czaczyk, Teofil JesionowskiAbstractBinary oxide systems containing TiO2 and CuO were synthesized using hydrothermal treatment and shown to have enhanced antibacterial properties. A detailed investigation was made of the effect of the molar ratio of components (TiO2:CuO = 7:3, 5:5, 3:7, 1:9) on the physicochemical parameters and antibacterial activity. Analysis of morphology (SEM, TEM and HRTEM) confirmed the pres...
Source: Materials Science and Engineering: C - June 22, 2019 Category: Materials Science Source Type: research

Synthesize and characterization of binary grafted psyllium for removing toxic mercury (II) ions from aqueous solution
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Deepak Kumar, Jyoti Pandey, Nida Khan, Pramendra Kumar, Patit P. KunduAbstractAcrylamide and acrylonitrile were grafted on psyllium employing ceric ammonium nitrate (CAN) as initiator under N2 atmosphere to get an adsorbent of mercury ions. The synthesized adsorbent was optimized by varying synthetic parameters viz. monomer concentration, reaction time, temperature, initiator concentration, etc. to obtain the maximum yield of the grafted product as well as maximum adsorption of ionic mercury. The synthesized adsorbent was char...
Source: Materials Science and Engineering: C - June 21, 2019 Category: Materials Science Source Type: research

Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Shadie Hatamie, Mohammad Mahdi Ahadian, Mahsa Soufi Zomorod, Shukoofeh Torabi, Ali Babaie, Simzar Hosseinzadeh, Masoud Soleimani, Niloofar Hatami, Zung-Hang WeiAbstractMetal-organic framework (MOF) based graphene oxide (GO) recently merits of attention because of the relative correspondence of GO with metal ions and organic binding linkers. Furthermore, introducing the GO to the Co-MOF to make a new nanoporous hybrid have are improved the selectivity and stability of the Co-MOF. Here the graphene oxide/cobalt metal organic fra...
Source: Materials Science and Engineering: C - June 21, 2019 Category: Materials Science Source Type: research

Starch microsponges for enhanced retention and efficacy of topical sunscreen
In this study, an innovative sunscreen formulation was developed based on starch microsponges as a key carrier encapsulating an organic sunscreen benzophenone‑3. The developed starch microsponges were characterized by scanning electron microscopy and nitrogen adsorption/desorption analysis. The results showed that starch microsponges possessed a high BET surface area (85.45 m2/g) with spherical porous morphology with pore size
Source: Materials Science and Engineering: C - June 21, 2019 Category: Materials Science Source Type: research

In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Stefania R. Cicco, Danilo Vona, Gabriella Leone, Elvira De Giglio, Maria A. Bonifacio, Stefania Cometa, Saverio Fiore, Fabio Palumbo, Roberta Ragni, Gianluca M. FarinolaAbstractBisphosphonates are a class of drugs widely used in the clinical treatment of disorders of bone metabolism, such as osteoporosis, fibrous dysplasia, myeloma and bone metastases. Because of the negative side effects caused by oral administration of bisphosphonates, various silica mesoporous materials have been investigated for a confined and controlled r...
Source: Materials Science and Engineering: C - June 21, 2019 Category: Materials Science Source Type: research

Silk fibroin-poly(lactic acid) biocomposites: Effect of protein-synthetic polymer interactions and miscibility on material properties and biological responses
This study provided a useful platform for understanding the fabrication strategies of protein-synthetic polymer composites that have direct biomedical and green chemistry applications.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Facile fabrication of cytocompatible polyester fiber composite incorporated via photocatalytic nano copper ferrite/myristic-lauric fatty acids coating with antibacterial and hydrophobic performances
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Ali Bashiri Rezaie, Majid Montazer, Mahnaz Mahmoudi RadAbstractBenign polymeric and textile based materials having multifaceted features such as antibacterial performance, hydrophobic property and photocatalytic activity are highly interesting from the both human health and environment observations. Herein, a cytocompatible polyester fiber composite incorporated via photocatalytic nano copper ferrite/myristic-lauric fatty acids coating with antibacterial and hydrophobic performances was prepared through one-pot facile fabricat...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Nanocomposite foams based on flexible biobased thermoplastic polyurethane and ZnO nanoparticles as potential wound dressing materials
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Aleksandra Bužarovska, Sorina Dinescu, Andreea D. Lazar, Mirela Serban, Gratiela G. Pircalabioru, Marieta Costache, Chiara Gualandi, Luc AvérousAbstractIn the present study biobased and soft thermoplastic polyurethane (TPU), obtained by polymerization from fatty acids, was used to produce TPU/ZnO nanocomposite foams by thermally induced phase separation method (TIPS). The produced foams were characterized and evaluated regarding their potential uses as wound dressing materials. The structure and morphology of the prepa...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Magnetic nanoparticles decorated with PEGylated curcumin as dual targeted drug delivery: Synthesis, toxicity and biocompatibility study
In this study, PEGylated curcumin was used as the surface modification of magnetic nanoparticles (MNP@PEG-Cur) in order to simultaneously take advantage of magnetic targeting characteristic of nanoparticles and PEG conjugated drug. Curcumin was conjugated through EDC/NHS chemistry to the PEG hydroxyl functional groups, and then physically decorated on the surface of magnetic nanoparticles (MNP). The analysis of the conjugate and nanoparticles by FT-IR, 1HNMR, FE-SEM, TEM, EDX, TGA and VSM confirmed the successful synthesis and proper physicochemical properties of MNP@PEG-Cur nanoparticles. The carrier showed pH dependent d...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Direct electrochemistry of glucose oxidase based on one step electrodeposition of reduced graphene oxide incorporating polymerized l-lysine and its application in glucose sensing
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Dongdong Zhang, Xia Chen, Weina Ma, Tianfeng Yang, Dandan Li, Bingling Dai, Yanmin ZhangAbstractThe direct electron transfer and enzyme catalytic activity were investigated in electrochemical biosensor based on glucose oxidase (GOx) and electrochemical reduced graphene oxide-poly-(l-lysine) (ERGO-PLL) hybrid composite film embedded in a biocompatible matrix of Nafion. The ERGO-PLL was fabricated onto glassy carbon electrode (GCE) through one step electrodeposition of RGO incorporating PLL from graphene oxide-l-lysine aqueous d...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Osteoblast studied on gelatin based biomaterials in rabbit Bone Bioengineering
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Namrata Yadav, Pradeep SrivastavaAbstractThe bone-derived-osteoblast seeded biomaterials scaffold in tissue engineering, have displayed prominence in the treatment of the osseous medical condition. In vitro osteogenesis of rabbit osteoblast cell (rOb) from bone tissue (rT) and MSC-derived rOb from bone marrow (rM) on Gelatin-Hydroxyapatite (HG) based biomaterials was investigated. In this work, lyophilized biomaterial was prepared by the addition of amorphous chitosan (‘C’) to ‘H’ dispersed in ‘G&...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

A three-dimensional (3D) printed biomimetic hierarchical scaffold with a covalent modular release system for osteogenesis
In this study, we designed an osteoid, biomimetic, hierarchical, porous HA ceramic 3D printed scaffold (3DPs). Further incorporation of a covalent, modular, controlled release system (CMR), based on Watson-Crick's complementary oligonucleotides, and was added to carry a bone morphogenetic protein-2 (BMP2) peptide. The choice of a HA biomimetic scaffold housing BMP2 protein fragments was selected to successfully promote osteogenesis both in vitro and in vivo. Scanning electron microscopy, micro-computed tomography analysis and computer fluid dynamics simulations of the 3DPs showed a uniform biomimetic hierarchical structure...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Selective detection of Escherichia coli caused UTIs with surface imprinted plasmonic nanoscale sensor
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Sinem Diken Gür, Monireh Bakhshpour, Adil DenizliAbstractThe aim of the present study was developing a surface plasmon resonance (SPR) nanosensor to detect Escherichia coli (E. coli) for the diagnosis of urinary tract infections by using surface imprinted Au nanoparticles (AuNPs) as a recognition element. In order to realize imprinting, Cu(II) ions were used to provide interaction between E. coli cell wall and amine functionalized AuNPs forming cavities on the surface of nanosensor. E. coli surface imprinted AuNPs nanosen...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

Synthesis and characterization of TPP/chitosan nanoparticles: Colloidal mechanism of reaction and antifungal effect on C. albicans biofilm formation
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Fabiola Galbiatti de Carvalho, Taís Chaves Magalhães, Natália Moreira Teixeira, Brenna Louise Cavalcanti Gondim, Hugo Lemes Carlo, Rogério Lacerda dos Santos, Alan Reis de Oliveira, Ângelo Marcio Leite DenadaiAbstractIn the present study chitosan (Chit) nanoparticles were synthetized by the ionic gelation process, using tripolyphosphate (TPP) as crosslinking agent. The TPP/Chit nanoparticle formation was evaluated by titrations, measuring electrical conductivity (k), zeta potential (ZP), hydro...
Source: Materials Science and Engineering: C - June 20, 2019 Category: Materials Science Source Type: research

PEGylated graphene oxide-capped gold nanorods/silica nanoparticles as multifunctional drug delivery platform with enhanced near-infrared responsiveness
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Zeer Qi, Jun Shi, Zheng Zhang, Yuchan Cao, Jingguo Li, Shaokui CaoAbstractIn this paper, near infrared (NIR)-responsive core-shell gold nanorods/mesoporous silica nanoparticles capped with PEGylated graphene oxide (GNRs/SiO2/GO-PEG) were prepared via electrostatic and physical absorption interactions. Hybrid nanoparticles display distinct photothermal stability in physiological environment and acidic media because of the introduction of biocompatible GO-PEG. In addition, due to the high specific surface area of GO-PEG and syne...
Source: Materials Science and Engineering: C - June 18, 2019 Category: Materials Science Source Type: research

Evaluation of cationic core-shell thermoresponsive poly(N-vinylcaprolactam)-based microgels as potential drug delivery nanocarriers
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Laura Etchenausia, Eva Villar-Alvarez, Jacqueline Forcada, Maud Save, Pablo TaboadaAbstractThe present work investigates the potentiality of poly(N-vinyl caprolactam) (PVCL)-based thermoresponsive microgels decorated with cationic polymer brushes as drug delivery carriers. The effect of physico-chemical features of the colloids on cell viability response have to be carefully investigated to establish the range of suitable hydrodynamic diameters, crosslinking densities, lengths and ratios of the cationic polyelectrolyte shell w...
Source: Materials Science and Engineering: C - June 18, 2019 Category: Materials Science Source Type: research

Evaluation of osseointegration of staged or simultaneously placed dental implants with nanocomposite fibrous scaffolds in rabbit mandibular defect
In this study, we have developed a nanocomposite fibrous scaffold [silica coated nanoHA-gelatin reinforced with electrospun poly(L-lactic acid) (PLLA) nanoyarns] and evaluated its efficacy to promote osseointegration in rabbit mandibular defect in comparison to the scaffold without fibers and commercial nanoHA-collagen graft. For this, critical sized bilateral defect (10 mm length, 3 mm depth and 3 mm width) was created in rabbit mandible and dental implantation was done in two manners. In strategy 1, Ti dental implant was placed along with the scaffold and in strategy 2, the scaffold was implanted for 3 months to ...
Source: Materials Science and Engineering: C - June 18, 2019 Category: Materials Science Source Type: research

Nanocrystalline Zn2+ and SO42− binary doped fluorohydroxyapatite: A novel biomaterial with enhanced osteoconductive and osteoinconductive properties
In this study, we have successfully doped hydroxyapatite (HA) with zinc (Zn2+), sulphate (SO42−) and fluoride (F−) ions to develop a new composition of bioceramic, Ca10-x Znx(PO4)6-y(SO4)y(OH)2-z-yFz(SO4)y, (x = 0, 0.2, 0.6, 1.0, y = 0, 0.5 and z = 0,1.0 mol), using wet precipitation method. The obtained materials were analysed using XRD, FTIR, FESEM, and XPS techniques to investigate the phase purity, particle morphology and elemental composition, respectively. A model anticancer drug (Doxorubicin, DOX) was loaded onto the surface of the Zn/SO4-FHA materials. About 100% loading of DOX with a cont...
Source: Materials Science and Engineering: C - June 18, 2019 Category: Materials Science Source Type: research

In vitro antimicrobial and anticancer properties of TiO2 blow-spun nanofibers containing silver nanoparticles
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Roberta Ferreti Bonan, Mariaugusta Ferreira Mota, Rosiane Maria da Costa Farias, Sabrina Daniela da Silva, Paulo Rogério Ferreti Bonan, Luciana Diesel, Romualdo Rodrigues Menezes, Danyel Elias da Cruz PerezAbstractNanosilver immobilized on TiO2 nanometric fibers (Ag/TiO2) was produced by solution blow spinning and characterized using scanning electron microscopy, transmission electron microscopy, N2 adsorption/desorption, X-ray diffraction, X-ray photoelectron spectroscopy, water contact angle, and inductively coupled p...
Source: Materials Science and Engineering: C - June 16, 2019 Category: Materials Science Source Type: research

Comparative assessment of the interface between poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and fish scales in composites: Preparation, characterization, and applications
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Chin-San WuAbstractPoly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) composites containing fish scales (FSs) were prepared and used in the fabrication of three-dimensional printing filaments. Maleic anhydride (MA)-grafted polyhydroxyalkanoate (PHBV-g-MA) and FS were used to improve the compatibility of FS within a PHBV matrix. Mechanical and morphological characterization indicated that improved adhesion between FS and PHBV-g-MA enhanced the tensile strength of the composite compared with that of PHBV/FS. The PHBV-g-MA/FS c...
Source: Materials Science and Engineering: C - June 16, 2019 Category: Materials Science Source Type: research

A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Jingjunjiao Long, Alaitz Etxabide Etxeberria, Ashveen V. Nand, Craig R. Bunt, Sudip Ray, Ali SeyfoddinAbstractA chitosan-pectin (CS-PEC) biopolymeric hydrogel wound dressing was investigated for lidocaine delivery. Here we demonstrate for the first time the feasibility of three-dimensional (3D) printed CS-PEC hydrogel incorporating the local anaesthetic drug lidocaine hydrochloride (LDC) as a potential wound dressing candidate. The hydrogels were prepared by physical crosslinking of CS and PEC polysaccharides. The scaffolds we...
Source: Materials Science and Engineering: C - June 16, 2019 Category: Materials Science Source Type: research

Improved antioxidant activity and oxidative stability of spray dried European eel (Anguilla anguilla) oil microcapsules: Effect of emulsification process and eel protein isolate concentration
The objective of this study was to prepare European eel oil (EO) microcapsules using European eel protein isolate (EPI) as a wall material and investigate its oxidative stability. The EPI emulsions were obtained at different EO: EPI ratios (1:1, 1:2 and 1:4, w/w) and using two emulsification procedures: Homogenization (H) and homogenization followed by ultrasonication (HU) treatments. The microcapsules prepared by combining the two emulsification processes (HU) and at core and wall ratio of was 1:4 presented the smallest particles size and the greatest encapsulation efficiency (68.50%) and oxidative stability. Scanning ele...
Source: Materials Science and Engineering: C - June 16, 2019 Category: Materials Science Source Type: research

An injectable cationic hydrogel electrostatically interacted with BMP2 to enhance in vivo osteogenic differentiation of human turbinate mesenchymal stem cells
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Mal Geum Kim, Tae Woong Kang, Joon Yeong Park, Seung Hun Park, Yun Bae Ji, Hyeon Jin Ju, Doo Yeon Kwon, Young Sik Kim, Sung Won Kim, Bong Lee, Hak Soo Choi, Hai Bang Lee, Jae Ho Kim, Bun Yeoul Lee, Byoung Hyun Min, Moon Suk KimAbstractWe have designed and characterized an injectable, electrostatically bonded, in situ–forming hydrogel system consisting of a cationic polyelectrolyte [(methoxy)polyethylene glycol-b-(poly(ε-caprolactone)-ran-poly(L-lactic acid)] (MP) copolymer derivatized with an amine group (MP-NH2) ...
Source: Materials Science and Engineering: C - June 15, 2019 Category: Materials Science Source Type: research

Rational design of gelatin/nanohydroxyapatite cryogel scaffolds for bone regeneration by introducing chemical and physical cues to enhance osteogenesis of bone marrow mesenchymal stem cells
In this study, we engineered different gelatin-based cryogels and studied the effect of nanohydroxyapatite (nHAP) and crosslinking agents on scaffold properties and its osteogenic response towards bone marrow stem cells (BMSCs). The cryogels examined are 5% gelatin and 5% gelatin/2.5% nHAP, crosslinked either with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) or glutaraldehyde (GA). We confirmed that nHAP or the crosslinking agent has no effects on scaffold pore size and porosity. Nonetheless, incorporation of nHAP increased mechanical strength, swelling ratio and degree of crosslinking, but decreased degradation ra...
Source: Materials Science and Engineering: C - June 15, 2019 Category: Materials Science Source Type: research

Shape-controlled assemblies of graphitic carbon nitride polymer for efficient sterilization therapies of water microbial contamination via 2D g-C3N4 under visible light illumination
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Nam Su Heo, Shruti Shukla, Seo Yeong Oh, Vivek K. Bajpai, Sun Uk Lee, Hye-Jin Cho, Suji Kim, Yeonho Kim, Hae Jin Kim, Sang Yup Lee, Young-Si Jun, Mi-Wha Oh, Young-Kyu Han, Seung Min Yoo, Yun Suk HuhAbstractBacterial pathogens of water origin have potential public threats thus suggesting the need of developing efficient and sustainable water disinfection strategies from waterborne pathogens. We set out to synthesize different controlled morphologies of graphitic carbon nitride (g-C3N4) polymer, evaluate their comparative effect...
Source: Materials Science and Engineering: C - June 15, 2019 Category: Materials Science Source Type: research

Design of colloidal drug carriers of celecoxib for use in treatment of breast cancer and leukemia
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Melike Üner, Gülgün Yener, Mine ErgüvenAbstractInflammation develops initiation and pathological process of cancer. Nanoscale drug carriers are required to be investigated for delivery of actives at cellular level for treatment of various cancer types. Solid lipid nanoparticles (CLX-SLN), nanostructured lipid carriers (CLX-NLC) and a nanoemulsion (CLX-NE) of celecoxib (CLX), a selective cyclooxygenase-2 inhibitor, were formulated for use in remedy of breast cancer and acute promyelocytic leukemia. The hot hi...
Source: Materials Science and Engineering: C - June 14, 2019 Category: Materials Science Source Type: research

Effect of structure in ionised albumin based nanoparticle: Characterisation, Emodin interaction, and in vitro cytotoxicity
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Macarena Siri, Maria Julieta Fernandez Ruocco, Estefanía Achilli, Malvina Pizzuto, Juan F. Delgado, Jean-Marie Ruysschaert, Mariano Grasselli, Silvia del V. AlonsoAbstractA γ–irradiated bovine albumin serum-based nanoparticle was characterised structurally, and functionally. The nanoparticle was characterised by A.F.M., D.L.S, zeta potential, T.E.M., gel-electrophoresis, and spectroscopy. We studied the stability of the nanoparticle at different pH values and against time, by fluorescence spectroscopy followi...
Source: Materials Science and Engineering: C - June 14, 2019 Category: Materials Science Source Type: research

The antimicrobial efficacy of zinc doped phosphate-based glass for treating catheter associated urinary tract infections
In this study, a series of phosphate-based glasses; (P2O5)50(Na2O)20(CaO)30-x (ZnO)x were prepared with increasing concentration of zinc oxide to determine the antimicrobial effect against clinically relevant microorganisms. The addition of 1 and 3 mol% zinc oxide decreased glass degradation however a higher dissolution rate was observed for 5 and 10 mol% ZnO. The antimicrobial results showed a concentration dependent effect on the viability of microorganisms. When in direct contact zinc doped glasses showed a complete kill, within 24 h, against Escherichia coli and a significant (p 
Source: Materials Science and Engineering: C - June 14, 2019 Category: Materials Science Source Type: research

Development of chitosan/glycerophosphate/collagen thermo-sensitive hydrogel for endoscopic treatment of mucosectomy-induced ulcer
In this study, we developed the chitosan/β-glycerophosphate/collagen (CS/GP/Col) thermo-sensitive systems to satisfy the requirements for the endoscopic treatment for ESD-induced ulcer. The results indicated that the addition of collagen to CS/GP system did not lead to remarkable changes on the physicochemical properties of the systems, which can transform from solution to hydrogels under physiological temperature within 90s, technically makes it suitable to be applied through catheter to gastric ulcer during ESD operation. Besides, hydrogels with high collagen concentration showed better biocompatibility, effectively...
Source: Materials Science and Engineering: C - June 14, 2019 Category: Materials Science Source Type: research

Multipotency expression of human adipose stem cells in filament-like alginate and gelatin derivative hydrogel fabricated through visible light-initiated crosslinking
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Mehdi Khanmohammadi, Sorour Nemati, Jafar Ai, Farzaneh KhademiAbstractHydrogel fibers are structurally and biologically useful devices for differentiation of stem cells and fabrication of filament-like tissues. We established cell-laden degradable hydrogel fibers through visible light-initiated crosslinking to differentiate stem cells and fabricate filament-like tissue. Human adipose stem cell (hADSC)-laden fibers were fabricated by cross-linking phenolic-substituted alginate and gelatin (Alg-Ph and Gela-Ph respectively) in an ...
Source: Materials Science and Engineering: C - June 14, 2019 Category: Materials Science Source Type: research

Graphene oxide as a polymeric N-halamine carrier and release platform: Highly-efficient, sustained-release antibacterial property and great storage stability
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Nengyu Pan, Yingfeng Wang, Xuehong Ren, Tung-Shi Huang, Ick Soo KimAbstractN-halamine compounds have been applied as antibacterial agents owing to the oxidative chlorine. In this work, graphene oxide (GO) as carrier was used to load N-halamine compounds for the sustained-release of chlorine in order to maintain long-term biocidal efficacies. 3‑(3′‑Acrylic acid propylester)‑5,5‑dimethylhydantoin (APDMH) was synthesized using 5,5‑dimethylhydantoin as a heterocyclic precursor and attached on the surface of GO nanos...
Source: Materials Science and Engineering: C - June 13, 2019 Category: Materials Science Source Type: research

Microwrinkled pH-sensitive hydrogel films and their role on the cell adhesion/proliferation
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Carmen M. González-Henríquez, Susan C. Galleguillos-Guzmán, Mauricio A. Sarabia-Vallejos, Ana Santos-Coquillat, Enrique Martínez-Campos, Juan Rodríguez-HernándezAbstractIn this work, hydrogels based on HEMA and DMAEMA (pH-sensitive monomer) were used to form biocompatible films which present microwrinkled patterns in their surface, with the focus of exploring the role of chemical composition on cell adhesion and proliferation. Three different pH (5.4, 7.4, and 8.3) were employed to prep...
Source: Materials Science and Engineering: C - June 13, 2019 Category: Materials Science Source Type: research

Diselenide linkage containing triblock copolymer nanoparticles based on Bi(methoxyl poly(ethylene glycol))-poly(ε-carprolactone): Selective intracellular drug delivery in cancer cells
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Balkew Zewge Hailemeskel, Wei-Hsin Hsu, Kefyalew Dagnew Addisu, Abegaz Tizazu Andrgie, Hsiao-Ying Chou, Juin-Yih Lai, Hsieh-Chih TsaiAbstractRedox-responsive diselenide bond containing triblock copolymer Bi(mPEG-SeSe)-PCL,Bi(mPEG-SeSe)-PCL was developed for specific drug release in cancer cells. Initially, ditosylated polycaprolactone was prepared via the reaction between polycaprolactone diol (PCL-diol) and tosyl chloride (TsCl). Next, Bi(mPEG-SeSe)-PCL was synthesized via the reaction between ditosylated polycaprolactone and ...
Source: Materials Science and Engineering: C - June 12, 2019 Category: Materials Science Source Type: research

NIR/pH dual-responsive polysaccharide-encapsulated gold nanorods for enhanced chemo-photothermal therapy of breast cancer
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Weijun Xu, Jinlei Wang, Junmin Qian, Guanghui Hou, Yaping Wang, Lijie Ji, Aili SuoAbstractCombination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepa...
Source: Materials Science and Engineering: C - June 12, 2019 Category: Materials Science Source Type: research

Biodegradable cross-linked chitosan nanoparticles improve anti-Candida and anti-biofilm activity of TistH, a peptide identified in the venom gland of the Tityus stigmurus scorpion
In this study, distinct entrapment methods of TistH in chitosan nanoparticles was tested using its incorporation (CN-TistH-Inc) or adsorption (CN-TistH-Ads) methods by ionotropic gelification. Physico-chemical properties as well as biocompatibility and antifungal efficacy were assessed for different samples. Atomic force microscopy and field emission gun scanning electronic microscopy images associated with particle size measurements demonstrated that the two methods induced cationic spherical, small (
Source: Materials Science and Engineering: C - June 12, 2019 Category: Materials Science Source Type: research

Extracellular matrix electrospun membranes for mimicking natural renal filtration barriers
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Rita Sobreiro-Almeida, Diana R. Fonseca, Nuno M. NevesAbstractKidney diseases are recognized as a major health problem, which affect 10% of the population. Because currently available therapies have many limitations, some tissue engineering strategies have been emerging as promising approaches in this field.In this work, porcine kidneys were decellularized to obtain decellularized kidney extracellular matrix (dKECM).1 Our results demonstrate a successful protocol of decellularization characterized by the removal of nucleic acid...
Source: Materials Science and Engineering: C - June 12, 2019 Category: Materials Science Source Type: research

Injectable dicalcium phosphate bone cement prepared from biphasic calcium phosphate extracted from lamb bone
This study reports the preparation of injectable bone cement by using biphasic calcium phosphate (BCP) extracted from femur lamb bone by calcination at 1450 °C. EDX analysis infers the presence of Mg and Na ions as trace elements in BCP. X-ray diffraction patterns of the prepared cement confirmed the formation of brushite (DCPD) along with monetite (DCPA) as a minor phase. DCPA phase diminished gradually with a decrease in powder to liquid ratio (PLR). Initial and final setting time of 5.3 ± 0.5 and 14.67 ± 0.5 min respectively are obtained and within the acceptable recommended range for ortho...
Source: Materials Science and Engineering: C - June 12, 2019 Category: Materials Science Source Type: research

A new nanocomposite scaffold based on polyurethane and clay nanoplates for osteogenic differentiation of human mesenchymal stem cells in vitro
In conclusion, our results revealed that these biocompatible nanocomposites porous scaffolds with proper cell adhesion and proliferation as well as effective osteogenic differentiation and which are able to provide a new and useful matrix for bone tissue engineering purposes.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Physicochemical and structural features of heat treated silver-silica nanocomposite and their impact on biological properties
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): M. Dulski, J. Peszke, J. Włodarczyk, S. Sułowicz, Z. Piotrowska-Seget, K. Dudek, J. Podwórny, K. Malarz, A. Mrozek-Wilczkiewicz, M. Zubko, A. NowakAbstractIn the last few decades, many nanostructures with varying properties and possible applications have been developed. These materials have been intended to work in various environmental temperature conditions. In this context, the main challenge has been to comprehend the impact of synergic interaction between individual elements included in non-annealed materials in r...
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Anticancer potential of zinc oxide nanoparticles against cervical carcinoma cells synthesized via biogenic route using aqueous extract of Gracilaria edulis
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Mohamed Asik R., Gowdhami B., Mohamed Jaabir M.S., Archunan G., Suganthy N.AbstractDevelopment of novel approach for cancer therapy, sparing healthy normal cells overcoming the limitation of available therapies is of prime importance for cervical cancer treatment. Recently metal oxide based chemotherapeutics has emanated as a promising approach for cancer therapy. Hence, the present study was carried out to assess the anticancer potential of zinc oxide nanoparticles (ZnONPs) synthesized using biogenic source, aqueous extract of...
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Fibroin/peptide co-functionalized calcium titanate nanorods improve osteoinductivity of titanium via mimicking osteogenic niche
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Yimin Sun, Cheng Hu, Yuanyi Yang, Bin Dong, Yi DengAbstractThe surface-inspirable biomaterials have captured extensive attention in simulating microenvironments by mimicking nanoscale architectures and signal molecules in the extracellular matrix (ECM). To activate osteogenic differentiation through biomimetic nanostructures, osteoid-like calcium titanate nanorods (CT) were fabricated via anodization and hydrothermal treatment. SEM, EDS, and XPS were employed to confirm the morphology and chemical composition. The functional fi...
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Simple and rapid method for synthesis of porous gold nanoparticles and its application in improving DNA loading capacity
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Fatemeh Hakimian, Hedayatollah GhourchianAbstractPorous gold nanoparticles (GNPs) attracted considerable attention due to their remarkable properties. The porous GNPs due to the high surface area-to-volume ratio have potential applications in areas such as drug delivery, biosensors, and fuel cells. The most frequently used method for synthesis of porous GNPs is the de-alloying approach. Despite the benefits of this approach, the nanoparticles synthesized by this method were not very stable. Nevertheless, we report herein a nove...
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Patterned iridium oxide film as neural electrode interface: Biocompatibility and improved neurite outgrowth with electrical stimulation
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Cen Chen, Shichao Ruan, Xue Bai, Chenming Lin, Chungang Xie, In-Seop LeeAbstractIridium (Ir) thin film was deposited on patterned titanium substrate by direct-current (DC) magnetron sputtering, and then activated in sulfuric acid (H2SO4) through repetitive potential sweeps to form iridium oxide (IrOx) as neural electrode interface. The resultant IrOx film showed a porous and open morphology with aligned microstructure, exhibited superior electrochemical performance and excellent stability. The IrOx film supported neural stem ce...
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research

Incorporation of multi-walled carbon nanotubes to PMMA bone cement improves cytocompatibility and osseointegration
In conclusion, cytocompatibility and osseointegration of the bone cements can be controlled by adjusting the MWCNT loading. The whole collection of the present results suggests that MWCNT-incorporated PMMA bone cement may have promise for use in certain orthopedic applications.Graphical abstractThe osteogenic differentiation of cells in vitro and the osseointegration degree between the cements and bone tissue in vivo are enhanced significantly with the increase of MWCNT loading. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - June 11, 2019 Category: Materials Science Source Type: research