Smart electrospun nanofibers containing PCL/gelatin/graphene oxide for application in nerve tissue engineering
Publication date: Available online 20 May 2019Source: Materials Science and Engineering: CAuthor(s): Mina Heidari, S.Hajir. Bahrami, M. Ranjbar-Mohammadi, P.B. MilanAbstractCurrently graphene-doped electrospun scaffolds have been a matter of great interest to be exploited in biomedical fields such as tissue engineering and drug delivery applications. The main objective of this paper is to evaluate the effect of graphene on biological properties of PCL/gelatin nanofibrous mats. SEM analysis was conducted to investigate the morphology of the electrospun nanofibers. The in-vitro cellular proliferation of PC12 cells on nanofib...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Preparation of thermo-responsive PNIPAAm-MWCNT membranes and evaluation of its antifouling properties in dairy waste water
Publication date: Available online 20 May 2019Source: Materials Science and Engineering: CAuthor(s): Zeynab Yaghoubi, Jalal Basiri ParsaAbstractA novel MWCNT-PNIPAAm nanocomposite membrane was developed with an excellent cleaning efficiency of thermo-responsive surface. The thermo-responsive N-isopropyleacryleamide (NIPAAm) monomer was polymerized on the surface of MWCNT via free radical polymerization. The prepared MWCNT-PNIPAAm nanocomposite was characterized by FTIR, SEM and TGA analyses. Various amounts of the prepared nanocomposite were incorporated into the membrane matrix by the physical blending method. The resulta...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Preparation of hydrophilic polycaprolactone/modified ZIF-8 nanofibers as a wound dressing using hydrophilic surface modifying macromolecules
In this study, a simple one-step method was introduced to prepare suitable PCL wound dressing by using a small amount of hydrophilic surface modifying macromolecule (LSMM) with ends capped with Polyethylene glycol and aminated zeolitic imidazolate frameworks (MZIF-8) as a drug carrier for curcumin to accelerate the healing process while improve drug loading and controlled drug release. First, LSMM was synthesized and its chemical structure and average molecular weight were characterized by FTIR and gel permeation chromatography. Afterward, PCL nanofibers containing LSMM and curcumin loaded MZIF-8 were prepared and characte...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Dual effective core-shell electrospun scaffolds: Promoting osteoblast maturation and reducing bacteria activity
Publication date: Available online 21 May 2019Source: Materials Science and Engineering: CAuthor(s): Mirian Michelle Machado De-Paula, Samson Afewerki, Bartolomeu Cruz Viana, Thomas Jay Webster, Anderson Oliveira Lobo, Fernanda Roberta MarcianoAbstractHerein, we electrospun ultrathin core-shell fibers based on polycaprolactone (PCL), polyethylene glycol (PEG), gelatin and Osteogenic Growth Peptide (OGP), and evaluated their potential to upregulate human osteoblast cells (hFOB) and to reduce Gram-positive and Gram-negative bacteria. We also evaluated the fibers' morphology, chemical structure and peptide delivery efficacy. ...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency
Publication date: Available online 21 May 2019Source: Materials Science and Engineering: CAuthor(s): Jiang Pi, Ling Shen, Hongbo Shen, Enzhuo Yang, Wandang Wang, Richard Wang, Dan Huang, Bao-Shiang Lee, Chunmiao Hu, Crystal Chen, Hua Jin, Jiye Cai, Gucheng Zeng, Zheng W. ChenAbstractTuberculosis (TB), caused by M.tuberculosis (Mtb), has become a top killer among infectious diseases. Enhancing the ability of anti-TB drugs to kill intracellular Mtb in host cells remains a big challenge. Here, an innovative nano-system was developed to increase drug delivery and Mtb-killing efficacy in Mtb-infected macrophages. We employed ma...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

A novel biopolymer device fabricated by 3D printing for simplifying procedures of pancreaticojejunostomy
Publication date: Available online 21 May 2019Source: Materials Science and Engineering: CAuthor(s): Yuan-Yuan Yang, Chao-Qian Zhao, Lu-Sheng Wang, Jin-Xin Lin, Shun-Zhi Zhu, He-Guang HuangAbstractThe purpose of our research was to verify the feasibility and effectiveness of a novel three-dimensional printed biopolymer device (3DP-BPD) for duct-to-mucosa pancreaticojejunostomy (PJ) in minipigs. Polylactic acid (PLA) was selected as the raw materials for 3DP-BPD. Three components of a 3DP-BPD were designed and manufactured: hollow stent, supporting disk, and nut. A pancreatic duct dilation model was developed in six minipig...
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Preparation and in vitro evaluation of radiolabeled HA-PLGA nanoparticles as novel MTX delivery system for local treatment of rheumatoid arthritis
Conclusion: 177Lu-DOTA-HA-PLGA(MTX) was prepared as a biocompatible polymeric PLGA nanoparticle conjugated to HA for specific targeting. The therapeutic nanosystem is based on bi-modal mechanisms using MTX as a disease-modifying antirheumatic drug (DMARD) and 177Lu as a radiotherapeutic component. The 177Lu-DOTA-HA-PLGA(MTX) nanoparticles showed properties suitable for radiosynovectomy and further specific targeted anti-rheumatic therapy. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

Cellular organization of three germ layer cells on different types of noncovalent functionalized graphene substrates
This study highlights the extraordinary synergy between graphene and somatic cells, suggesting the discretionary use of extracellular matrix components for in vitro cultivation.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - May 21, 2019 Category: Materials Science Source Type: research

In vitro and in vivo evaluation of bioglass microspheres incorporated brushite cement for bone regeneration
In this study, an injectable bone substitute (IBS) system which utilizes bioglass microspheres incorporated into brushite based cement, was evaluated. The microspheres were synthesized with a simple and low sintering temperature process; there was no significant phase difference shown from the powder and good interactivity with cells was obtained. Furthermore, physical properties were optimized in microsphere incorporated brushite cement in order to investigate in vitro and in vivo performance. Accordingly, setting time and compressive strength were hardly altered until a microsphere content of 40% (v/v) was reached. The b...
Source: Materials Science and Engineering: C - May 20, 2019 Category: Materials Science Source Type: research

Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
Publication date: Available online 18 May 2019Source: Materials Science and Engineering: CAuthor(s): Muhammad Irfan, Masooma Irfan, Syed Mazhar Shah, Nadeem Baig, Tawfik A. Saleh, Mahmood Ahmed, Gul Naz, Naeem Akhtar, Nawshad Muhammad, Ani IdrisAbstractNon-covalent electrostatic interaction between amide nitrogen and carbonyl carbon of shorter chain length of polyvinylpyrrolidone (PVP-k25) was developed with in-house carboxylic oxidized multiwall carbon nanotubes (O-MWCNT) and then blended with Polyethersulfone (PES) polymer. FTIR analysis was utilized to confirm bonding nature of nano-composites (NCs) of O-MWCNT/PVP-k25 a...
Source: Materials Science and Engineering: C - May 20, 2019 Category: Materials Science Source Type: research

Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model
In conclusion, surface modification by Ag incorporation is a feasible approach to enhance the antibacterial activity of MBGN without significantly impacting morphology, polydispersity, and the apatite-forming ability of the nanoparticles. The prepared Ag-MBGN are attractive building blocks for the development of 3D antibacterial scaffolds for tissue engineering.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

Degradation behaviors of Mg alloy wires/PLA composite in the consistent and staged dynamic environments
Publication date: Available online 17 May 2019Source: Materials Science and Engineering: CAuthor(s): Xuan Li, Weidong Yu, Linyuan Han, Chenglin Chu, Bai Jing, Feng XueAbstractFully degradable poly lactic acid based composite reinforced with 20 vol% magnesium alloy wires (MAWs) is prepared for weight bearing bone fracture healing.The degradation behaviors of the composite in the consistent and staged dynamic environments are investigated. The results suggest that dynamic loading would overall accelerate the degradation of the composite. As the loading magnitude increases from 0.2 MPa to 1 MPa or frequency from 0.5 H...
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

Gellan gum incorporating titanium dioxide nanoparticles biofilm as wound dressing: Physicochemical, mechanical, antibacterial properties and wound healing studies
Publication date: Available online 18 May 2019Source: Materials Science and Engineering: CAuthor(s): Nur Arifah Ismail, Khairul Anuar Mat Amin, Fadzillah @. Adibah Abdul Majid, Mohd Hasmizam RazaliAbstractIn this work, the potential of titanium dioxide nanoparticles incorporated gellan gum (GG + TiO2-NPs) biofilm as wound dressing material was investigated. The GG + TiO2-NPs biofilm was prepared via evaporative casting technique and was characterized using FTIR, XRD, and SEM to study their physiochemical properties. The mechanical properties, swelling and water vapor transmission rate (WVTR) of biofilm was determin...
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

Preparation of graphene oxide-graphene quantum dots hybrid and its application in cancer theranostics
We report new synergistic properties of GO-PEI-GQDs such as stable fluorescence imaging, enhanced photothermal and cytotoxic activity on cancer cells. Composite materials made up of GO and GQDs combining diverse properties help to study 2D-0D heterosystems and improve specific therapeutic systems in theranostics.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

Characterization of polycaprolactone/rGO nanocomposite scaffolds obtained by electrospinning
Publication date: Available online 18 May 2019Source: Materials Science and Engineering: CAuthor(s): E. Correa, M.E. Moncada, O.D. Gutiérrez, C.A. Vargas, V.H. ZapataAbstractThe incorporation of nanoparticles inside polymeric matrices has led to the development of multifunctional composites necessary to repair human tissues. The addition of nanoparticles may improve the properties of the composite materials such as surface area, mechanical properties, flexibility, hydrophilicity, electrical conductivity, etc. These properties can help in cellular growth, proliferation and/or differentiation. In this work, scaffolds ...
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

A miniaturized device for biomembrane permeation analysis
In this study, we fabricated miniaturized multichannel devices (MCDs) by 3D printing, to minimize the use of skin and drug samples. The MCDs were compared with conventional static diffusion cells and achieved comparable drug permeation profiles. The finite element method-based simulation revealed the efficient carry-off of permeated ingredients by the multichannel devices, and a critical role of distance between the buffer stream and skin sample in determining the flow velocity inside the chamber. The results support these devices as qualified alternative to Franz cells for in vitro permeation studies using biomembranes, w...
Source: Materials Science and Engineering: C - May 18, 2019 Category: Materials Science Source Type: research

PreS1 peptide-functionalized gold nanostructures with SERRS tags for efficient liver cancer cell targeting
Publication date: Available online 16 May 2019Source: Materials Science and Engineering: CAuthor(s): Francesca Biscaglia, Santina Quarta, Gianmarco Villano, Cristian Turato, Alessandra Biasiolo, Lucio Litti, Maria Ruzzene, Moreno Meneghetti, Patrizia Pontisso, Marina GobboAbstractEarly detection is the most effective mean of improving prognosis for many fatal diseases such as cancer. In this context, the Surface Enhanced Resonance Raman Scattering (SERRS) technique is being proposed as alternative to fluorescent methods in detection of biomarkers, because SERRS nanostructures are bright as fluorescent tags but more stable ...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

From macroscopic mechanics to cell-effective stiffness within highly aligned macroporous collagen scaffolds
In this study we investigated how individual architectural features of highly aligned macroporous collagen scaffolds contribute to its mechanical properties on the macroscopic vs. the microscopic scale. Scaffolds were produced by controlled freezing and freeze-drying, a method frequently used for manufacturing of macroporous biomaterials. The individual architectural features of the biomaterial were carefully characterized to develop a finite element model (FE-model) that finally provided insights in the relation between the biomaterial's mechanical properties on the macro-scale and the properties on the micro-scale, as ex...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Dual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering
Publication date: Available online 17 May 2019Source: Materials Science and Engineering: CAuthor(s): Hilal Ahmad Rather, Dhwani Jhala, Rajesh VasitaAbstractBone fracture healing is a multistep and overlapping process of inflammation, angiogenesis and osteogenesis. It is initiated by inflammation, causing the release of various cytokines and growth factors. It leads to the recruitment of stem cells and formation of vasculature resulting in the functional bone formation. This combined phenomenon is used by bone tissue engineers from past few years to address the problem of vasculature and osteogenic differentiation during bo...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

In vitro and in vivo toxicity assessment of selenium nanoparticles with significant larvicidal and bacteriostatic properties
Publication date: Available online 17 May 2019Source: Materials Science and Engineering: CAuthor(s): Mariappan Yazhiniprabha, Baskaralingam VaseeharanAbstractIn the present study, we investigated the larvicidal and bacteriostatic activity of biosynthesized selenium nanoparticles using aqueous berry extract of Murraya koenigii (Mk-Se NPs). The synthesized Mk-Se NPs were characterized using UV–visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis. XRD analysis re...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Conductive nanostructured Si biomaterials enhance osteogeneration through electrical stimulation
Publication date: Available online 17 May 2019Source: Materials Science and Engineering: CAuthor(s): Yan Huang, Haokun Deng, Yubo Fan, Lisha Zheng, Jifei Che, Xiaoming Li, Katerina E. AifantisAbstractIt is well known that the differentiation of stem cells is affected by the cell culture medium, the scaffold surface and electrochemical signals. However, stimulation of patterned biomaterials seeded with stem cell cultures has not been explored. Herein the effect of electrical stimulation on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) cultured on solid and nanoporous micropyramid patt...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Poly(ε-caprolactone)/poly(glycerol sebacate) electrospun scaffolds for cardiac tissue engineering using benign solvents
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Lena Vogt, Laura Ramos Rivera, Liliana Liverani, Agnieszka Piegat, Miroslawa El Fray, Aldo R. BoccacciniAbstractElectrospun fibers based on combinations of poly(ε-caprolactone) (PCL) and poly(glycerol sebacate) (PGS) have been studied for applications in cardiac tissue engineering. The aim of the present study is to demonstrate the fabrication of PCL and PGS prepolymer or mildly crosslinked PGS by electrospinning using less toxic solvents, like acetic acid, as opposed to conventional solvents such as chloroform or dichl...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Low-temperature phyto-synthesis of copper oxide nanosheets: Its catalytic effect and application for colorimetric sensing
Publication date: Available online 15 May 2019Source: Materials Science and Engineering: CAuthor(s): Mojgan Kamali, Fayezeh Samari, Fatemeh SedaghatiAbstractThe last decade has seen a remarkable detonation in modifying chemical processes for nanomaterial synthesis to make them ‘green’. Owing to the unique properties of nanomaterial and with regard to environmental issues, in this study, a new alternative and fast eco-friendly approach for the synthesis of copper oxide nanosheets (CuO-NSs) using Terminalia catappa (Indian almond) leaf extract as a renewable and non-toxic reducing agent and efficient stabilizer w...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice
This study aimed to develop nanocapsules containing ketoprofen using rose hip oil (Keto-NC) as oil core, and to evaluate their anti-inflammatory activity in acute and chronic ear edema models in mice. Physicochemical characterization, drug release, photostability and cytotoxicity assays were performed for the developed Keto-NC formulations and compared to ketoprofen-loaded nanocapsules using medium chain triglycerides as oil core (Keto-MCT-NC). Anti-inflammatory activity of orally delivered KP (Ketoprofen-free; 10 mg.kg−1) or Keto-NC (2.5; 5; 10 mg.kg−1) was assessed in mouse acute and chronic ear edema ind...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
In this study, we have developed a novel, single-stage concept to support the weakened myocardial region post-MI by applying an elastic, biodegradable patch (SPREADS) via a minimal-invasive, closed chest intervention to the epicardial heart surface. We show a significant increase in %LVEF 14 days post-treatment when GS (clinical gold standard treatment) was compared to GS + SPREADS + Gel with and without cells (p ≤ 0.001). Furthermore, we did not find a significant difference in infarct quality or blood vessel density between any of the groups which suggests that neither infarct quality nor vascularization is ...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Co-incorporation of strontium and fluorine into diopside scaffolds: Bioactivity, biodegradation and cytocompatibility evaluations
This study focuses on the effect of Sr-, F-, and their co-doping on the structure, biodegradation, bioactivity and cytocompatibility of diopside-based scaffolds, using X-ray diffraction, Raman spectroscopy, field-emission scanning electron microscopy, Archimedes densitometry, inductively coupled plasma spectroscopy, pH-metry, and cell MTT assay. The structural characterization of the scaffolds confirmed the successful incorporation of the dopants into the ceramic. In addition, all the doped scaffolds presented higher apatite-forming ability levels in comparison to the undoped one, where the highest and the least impact of ...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Transition metal-doped cryogels as bioactive materials for wound healing applications
Publication date: Available online 16 May 2019Source: Materials Science and Engineering: CAuthor(s): Duong Luong, Abdulla A. Yergeshov, Mohamed Zoughaib, Farida R. Sadykova, Bulat I. Gareev, Irina N. Savina, Timur I. AbdullinAbstractTransition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble TM, such as Zn, Cu, Mn and Co, were stably incorporated into gelatin network during cryogelation. TM content in the resultant cryogels varied from 0.1 × 103 to...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Ni-free, built-in nanotubular drug eluting stents: Experimental and theoretical insights
In this study, a Ti-8Mn alloy was used to fabricate a nanostructured surface that can be used for drug eluting stents to overcome the hypersensitivity of metals that are currently used in stent making as well as introducing a new built-in nano-drug reservoir instead of polymer coatings. Two different systems were studied: titanium dioxide nanotubes (NTs) and Ti-8Mn oxides NTs. The materials were characterized using field emission electron microscope (FESEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), roughness, wettability and surface energy measurements. Na...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

“Effect of Zn content and aging temperature on the in-vitro properties of heat-treated and Ca/P ceramic-coated Mg-0.5%Ca-x%Zn alloys”
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Hamdy Ibrahim, Alan Luo, David Dean, Mohammad ElahiniaAbstractWhile potentially strong enough for load-bearing skeletal reconstruction applications, the corrosion (biodegradation) rate of biocompatible Mg-Zn-Ca-based alloys still presents. The present work reports on the use of heat treatment (strengthening and resorption delaying) and micro arc oxidation (MAO) coating (corrosion delaying) processes which were developed to induce desirable corrosion rates which are essential to maintaining the mechanical integrity of Mg-Zn-Ca-b...
Source: Materials Science and Engineering: C - May 17, 2019 Category: Materials Science Source Type: research

Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies
Publication date: Available online 3 May 2019Source: Materials Science and Engineering: CAuthor(s): Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Sainath Sindhikar, Dinesh K. MishraAbstractIn the twenty-first century, microneedles based drug delivery is drawing attention worldwide in the research due to current signs of progress in the controlled release drug delivery through microneedles. The microneedles represent a promising technology to deliver therapeutic compounds into the skin for chronic complications like osteoporosis, diabetes, cancer and induction of immune responses from protein and DNA vaccines. However, th...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Study on a biodegradable antibacterial Fe-Mn-C-Cu alloy as urinary implant material
This study was focused on the development of a new Fe-Mn-C-Cu alloy with antibacterial and anti-encrustation properties as a urinary implant material. The microstructure and mechanical properties of the alloy were studied. The degradation behavior, antibacterial and anti-encrustation properties were evaluated by immersion test, antibacterial test and encrustation test, respectively. The results showed that Fe-Mn-C-Cu alloy was a non-magnetic, biodegradable, anti-bacterial and anti-encrustation alloy that could inhibit the biofilm and stone formations on its surface through the dual effects of degradation and Cu ions releas...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Preparation and characterization of imprinted zeolite-Y for p-cresol removal in haemodialysis
Publication date: Available online 4 May 2019Source: Materials Science and Engineering: CAuthor(s): Yanuardi Raharjo, Ahmad Fauzi Ismail, Mohd Hafiz Dzarfan Othman, Nik Ahmad Nizam Nik Malek, Djoko SantosoAbstractIn this work, the novel imprinted zeolite (IZ) was synthesized, and its properties and performance in terms of adsorption of p-Cresol, which represent the protein-bounded uremic toxins in aqueous phase under phosphate buffer saline, were studied and compared with the synthesized zeolite-Y (ZeoY-S) and commercial CBV 100 zeolite-Y (ZeoY-C). The ZeoY-S was synthesized from sodium aluminate, NaOH, H2O and SiO2 under ...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Manufacturing and characterization of plates for fracture fixation of bone with biocomposities of poly (lactic acid-co-glycolic acid) (PLGA) with calcium phosphates biocermics
Publication date: Available online 8 May 2019Source: Materials Science and Engineering: CAuthor(s): Thaiane Maria Balestreri Knopf dos Santos, Claudia Merlini, Águedo Aragones, Márcio Celso FredelAbstractCommercially, there are several plates and screws for bone fracture fixation made with PLA, however, its long degradation time and lack of integration with bone structure, provides interest in research using polymers with faster degradation, such as PLGA, and together with bioceramics, in order to improve bioactivity in bone regeneration. Based on this, in this study, bone fracture fixation plates composed of...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Evaluating Ternary Metal Oxide (TMO) core-shell nanocomposites for the rapid determination of the anti-neoplastic drug Chlorambucil (Leukeran™) by electrochemical approaches
Publication date: Available online 8 May 2019Source: Materials Science and Engineering: CAuthor(s): Sakthivel Kogularasu, Muthumariappan Akilarasan, Shen-Ming Chen, Yi-Ling Li, Tse-Wei Chen, Mohammad Ajmal AliAbstractA functional ternary nanocomposite (MnO2@NiFe2O4) with hierarchically grown flower-like core-shell assembly has been prepared through a simple two-step hydrothermal methodology. The crystallographic information of the sample was obtained via X-ray diffraction. The morphological details of spherical NiFe2O4 (core) and flower-like MnO2 (shell) were examined over FE-SEM and TEM; finally, the XPS confirms the succ...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

TPGS-grafted and acid-responsive soy protein nanogels for efficient intracellular drug release, accumulation, penetration in 3D tumor spheroids of drug-resistant cancer cells
Publication date: Available online 9 May 2019Source: Materials Science and Engineering: CAuthor(s): Xu Cheng, Xiaoli Zeng, Dapeng Li, Xin Wang, Min Sun, Le He, Rupei TangAbstractThe frequent occurrence of multidrug resistance (MDR) in solid tumors is the major obstacle for nano-drug delivery systems (nDDS) to realize the successful cancer chemotherapy. Herein, we had prepared pH-responsive nanogels via cross-linking TPGS-grafted soy protein with an acid-labile ortho ester cross-linker (OEAM) to realize the efficient intracellular drugs release and accumulation, and subsequently enhance therapeutic effect in MDR tumor cells...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

A non-invasive monitoring of USPIO labeled silk fibroin/hydroxyapatite scaffold loaded DPSCs for dental pulp regeneration
Publication date: Available online 9 May 2019Source: Materials Science and Engineering: CAuthor(s): Wu Zhang, Yuanyuan Zheng, Haixia Liu, Xiao Zhu, Yongchun Gu, Yong Lan, Jiali Tan, Hao Xu, Rui GuoAbstractThe aim of this study was to prepare a promising biomaterial for dental pulp tissue repair and regeneration. The ultrasmall superparamagnetic iron oxide (USPIO)-labeled hydroxyapatite (HA)/silk fibroin (SF) scaffold loaded dental pulp stem cells (DPSCs) was designed. The odontogenic differentiation of DPSCs was investigated, and USPIO was used as magnetic resonance imaging (MRI) contrast agent. The results indicated that ...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Enhanced cellular uptake of near-infrared triggered targeted nanoparticles by cell-penetrating peptide TAT for combined chemo/photothermal/photodynamic therapy
Publication date: Available online 9 May 2019Source: Materials Science and Engineering: CAuthor(s): Hongshuai Wu, Chaoqun You, Fanghui Chen, Jia Jiao, Zhiguo Gao, Peijing An, Baiwang Sun, Renjie ChenAbstractRecently, the emergence of cell-penetrating peptides (CPPs) like TAT has greatly improved the efficiency of cancer therapy by enhancing cellular uptake of nanomaterials. Here, we designed a near-infrared (NIR) triggered TAT-based targeted nanoplatform (cRGD@TAT-DINPs), which co-delivered anticancer drug doxorubicin (DOX) and biocompatible dye indocyanine green (ICG) to realize combined chemo/photothermal/photodynamic th...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Synergistic effect of 2D material coated Pt nanoparticles with PEDOT polymer on electrode surface interface for a sensitive label free Helicobacter pylori CagA(Ag-Ab) immunosensing
Publication date: Available online 9 May 2019Source: Materials Science and Engineering: CAuthor(s): Shaivya Gupta, Ashutosh Tiwari, Utkarsh Jain, Nidhi ChauhanAbstractHelicobacter pylori (H. pylori) immunosensor based on platinum nanoparticles/poly(3,4-ethylenedioxythiophene)/reduced graphene oxide (Ptnano/PEDOT/red-GOx) modified gold electrode (Au-ET) was stepwise fabricated for the detection of cytotoxin-associated gene A antibodies (CagA antibody). H. pylori is a microaerophillic and a Gram-negative bacteria that causes gastric ulcer leading eventually to adenocarcinoma (gastric cancer) in the later stage. H. pylori col...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Enhanced cytotoxic and genotoxic effects of gadolinium-doped ZnO nanoparticles on irradiated lung cancer cells at megavoltage radiation energies
Publication date: Available online 9 May 2019Source: Materials Science and Engineering: CAuthor(s): Masoumeh Zangeneh, Hassan Ali Nedaei, Hossein Mozdarani, Aziz Mahmoudzadeh, Mahdieh SalimiAbstractThe purpose of this study was to investigate the radiation dose enhancement effects of gadolinium-doped zinc oxide nanoparticles (Gd-doped ZnO NPs) under the megavoltage (MV) X-ray irradiation. ZnO NPs have preferred photocatalytic properties under UV light for cancer killing. UV light has limited applications in cancer treatment and it is necessary to use X-ray photons with MV energies. In order to increase the absorption of ra...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Antimicrobial emulsions: Formulation of a triggered release reactive oxygen delivery system
This study aims to engineer a water-in-oil emulsion containing an engineered honey (SurgihoneyRO™) that is easy to administer topically and is controllably activated in-situ.Paraffin oil continuous emulsions formulated using the emulsifier polyglycerol polyricinoleate displayed shear-thinning characteristics. Viscosities between 1.4 and 19.3 Pa·s were achieved at a shear rate representative of post-mixing conditions (4.1 s−1) by changing the volume of the dispersed phase (30–60%). Notably, this wide viscosity range will be useful in tailoring future formulations for specific application mechani...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation
Publication date: Available online 10 May 2019Source: Materials Science and Engineering: CAuthor(s): Monika Yadav, Ana Guzman-Aranguez, Maria J. Perez de Lara, Mandeep Singh, Joga Singh, Indu Pal KaurAbstractPrimary treatment for glaucoma relies on chronic instillation (daily) of intraocular pressure (IOP) lowering eye drops. Present study tends to develop and assess a novel sustained release bimatoprost loaded nanovesicular (BMT-NV) - thermosensitive in-situ gelling implant (BMT-NV-GEL-IM), for subconjunctival delivery.BMT-NVs developed using novel composition and method of preparation, (IPA/700/DEL/2014) and industrially...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

3D printing of mesoporous bioactive glass/silk fibroin composite scaffolds for bone tissue engineering
In this study, a silk fibroin (SF) solution of 30 wt% was extracted from cocoons and combined with mesoporous bioactive glass (MBG) to fabricate MBG/SF composite scaffolds by 3D printing. The porosity, compressive strength, degradation and apatite forming ability were evaluated. The results illustrated that MBG/SF scaffolds had superior compressive strength (ca. 20 MPa) and good biocompatibility, and stimulated bone formation ability compared to mesoporous bioactive glass/polycaprolactone (MBG/PCL) scaffolds. We subcutaneously transplanted hBMSCs-loaded MBG/SF and MBG/PCL scaffolds into the back of nude mice to evaluat...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Polymer complexes. LXXV. Characterization of quinoline polymer complexes as potential bio-active and anti-corrosion agents
Publication date: Available online 10 May 2019Source: Materials Science and Engineering: CAuthor(s): M.I. Abou-Dobara, N.F. Omar, M.A. Diab, A.Z. El-Sonbati, Sh.M. Morgan, O.L. Salem, A.M. EldesokyAbstractThe Cu2+, Co2+, Ni2+ and UO22+ polymer complexes of 5-(2,3-dimethyl−1-phenylpyrazol-5-one azo)-8-hydroxyquinoline (HL) ligand were prepared and characterized. Elemental analyses, IR spectra, X-ray diffraction analysis and thermal analysis studies have been used to confirm the structure of the prepared polymer complexes. The chemical structure of metal chelates commensurate that the ligand acts as a neutral bis(biden...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Papaver somniferum L. mediated novel bioinspired lead oxide (PbO) and iron oxide (Fe2O3) nanoparticles: In-vitro biological applications, biocompatibility and their potential towards HepG2 cell line
Publication date: Available online 11 May 2019Source: Materials Science and Engineering: CAuthor(s): Wali Muhammad, Muhammad Aslam Khan, Munazza Nazir, Aisha Siddiquah, Sadaf Mushtaq, Syed Salman Hashmi, Bilal Haider AbbasiAbstractTo overcome the disadvantages of chemical and physical methods, phyto-fabricated nanoparticles attained great attention due to their multifarious applications. Here we successfully demonstrated Papaver somniferum L. mediated green synthesis of lead oxide (PbO) and iron oxide (Fe2O3) nanoparticles. Characterization of nanoparticles involved techniques including X-ray diffraction (XRD), Fourier tra...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Synergistic effects of ultrasound and photodynamic therapy leading to biofilm eradication on polyurethane catheter surfaces modified with hypericin nanoformulations
In this study polyurethane (PUR) surfaces were coated with hypericin nanoformulations, leading to 4.3 log10 reduction in bacterial growth in vitro. The effect could be enhanced by the application of ultrasound. The combination of PDT with ultrasound therapy led to a synergistic effect resulting in a 6.8 log10 reduction of viable counts. This minimal invasive method requires only an optical fibre inserted in the catheter lumen and an ultrasound device. Thus the implementation in daily clinical practice is very simple.Graphical abstractIllustration of in situ photo-triggered activation of hypericin in central venous catheter...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

PEI/NONOates-doped PLGA nanoparticles for eradicating methicillin-resistant Staphylococcus aureus biofilm in diabetic wounds via binding to the biofilm matrix
In this study, polyethylenimine/diazeniumdiolate (PEI/NONOate)-doped PLGA nanoparticles (PLGA-PEI/NO NPs) with an ability to bind to the biofilm matrix are developed to facilitate the NO delivery to MRSA biofilm-infected wound. In simulated wound fluid, PLGA-PEI/NO NPs show an extended NO release over 4 days. PLGA-PEI/NO NPs firmly bind to the MRSA biofilm matrix, resulting in a greatly enhanced anti-biofilm activity. Moreover, PLGA-PEI/NO NPs accelerate healing of MRSA biofilm-infected wounds in diabetic mice along with complete biofilm dispersal and reduced bacterial burden. These results suggest that the biofilm-bindi...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating
Publication date: Available online 14 May 2019Source: Materials Science and Engineering: CAuthor(s): Mehdi Fathi, Babak Akbari, Afshin TaheriazamAbstractBacterial infection, wide inflammation, and osteoporosis are the most common factors in the failure of orthopedic implants. The present study aims to design an orthopedic implant based on Titania nanotubes (TiO2-NTs) which not only have a high biocompatibility but also are characterized by anti-bacterial property. In order to improve the osseointegration of the TiO2-NTs structures (110–120 nm in diameter, 40 μm in length), they were used to coat the Titania im...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Au nanoparticle-decorated aragonite microdumbbells for enhanced antibacterial and anticancer activities
Publication date: Available online 15 May 2019Source: Materials Science and Engineering: CAuthor(s): Aniruddha Samanta, Soumik Podder, Murali Kumarasamy, Chandan Kumar Ghosh, Debrupa Lahiri, Partha Roy, Swarupananda Bhattacharjee, Jiten Ghosh, Anoop Kumar MukhopadhyayAbstractThe present work reports the very first hydrothermal synthesis of 100% triclinic phase pure aragonite (A1) with microdumbbell microstructural architecture and Au Nanoparticle-decorated (AuNP-decorated) aragonites (A2, A3 and A4) with spherical, pentagonal/hexagonal and agglomerated AuNP-decorated microdumbbells having triclinic aragonite phase as the m...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Design and preparation of mesoporous silica carriers with chiral structures for drug release differentiation
In this study, twisted rod-like chiral mesoporous silicas (CMSs) with discriminating chiral characteristics (D/L) were designed and biomimetic synthesized by using L- and d-alanine derivatives as templates, and employed as poorly water-soluble chiral drug ibuprofen (IBU) carriers. The morphology and mesoscopic characteristics of CMSs were determined by transmission electron microscope (TEM) and small-angle X-ray scattering (SAXS). Meanwhile, the physicochemical properties of CMSs before and after drug loading were systematically characterized by infrared spectroscopy (IR), nitrogen adsorption, X-ray diffraction (XRD), diff...
Source: Materials Science and Engineering: C - May 15, 2019 Category: Materials Science Source Type: research

Graphene/nickel oxide nanocomposites against isolated ESBL producing bacteria and A549 cancer cells
Publication date: September 2019Source: Materials Science and Engineering: C, Volume 102Author(s): Govindan Rajivgandhi, Muthuchamy Maruthupandy, Franck Quero, Wen-Jun LiAbstractThe synthesis of nickel oxide nanoparticles (NiO NPs) and graphene/nickel oxide nanocomposites (Gr/NiO NCs) was performed using a simple chemical reduction method. Powder X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were used to examine the crystalline nature and thermal stability of the synthesized NiO NPs and Gr/NiO NCs, respectively. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to ob...
Source: Materials Science and Engineering: C - May 11, 2019 Category: Materials Science Source Type: research