Enhanced biocompatibility and improved osteogenesis of coralline hydroxyapatite modified by bone morphogenetic protein 2 incorporated into a biomimetic coating
ConclusionsThe biocompatibility of CHA granules (reduction of inflammation) was significantly improved by coating with a layer of OCP. Pure surface adsorption of BMP-2 to CHA also reduced inflammation. Incorporation of BMP-2 into the OCP coatings was associated with the highest volume and quality of bone, and the highest biocompatibility degree of the CHA granules.Clinical significanceHigher osteoinductivity and improved biocompatibility of CHA can be obtained when a layer of BMP-2 functionalized OCP is deposited on the surfaces of CHA granules. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 15, 2018 Category: Materials Science Source Type: research

Superparamagnetic hybrid microspheres affecting osteoblasts behaviour
Publication date: Available online 14 November 2018Source: Materials Science and Engineering: CAuthor(s): Tatiana M. Fernandes Patrício, Silvia Panseri, Monica Montesi, Michele Iafisco, Monica Sandri, Anna Tampieri, Simone SprioAbstractThe present work describes biomimetic hybrid microspheres made of collagen type I-like peptide matrix (RCP) mineralised with Fe2+/Fe3+ doping hydroxyapatite (RCPFeHA) by a bio-inspired process. Superparamagnetic RCPFeHA microspheres are obtained by emulsification of the hybrid slurries in the presence of citrate ions, to achieve a biomimetic surface functionalisation improving the bio...
Source: Materials Science and Engineering: C - November 15, 2018 Category: Materials Science Source Type: research

Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications
Publication date: March 2019Source: Materials Science and Engineering: C, Volume 96Author(s): M. Rasoulianboroujeni, F. Fahimipour, P. Shah, K. Khoshroo, M. Tahriri, H. Eslami, A. Yadegari, E. Dashtimoghadam, L. TayebiAbstractPorous scaffolds were 3D-printed using poly lactic-co-glycolic acid (PLGA)/TiO2 composite (10:1 weight ratio) for bone tissue engineering applications. Addition of TiO2 nanoparticles improved the compressive modulus of scaffolds. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed an increase in both glass transition temperature and thermal decomposition onset of the ...
Source: Materials Science and Engineering: C - November 15, 2018 Category: Materials Science Source Type: research

A novel label free electrochemiluminescent aptasensor for the detection of lysozyme
Publication date: Available online 13 November 2018Source: Materials Science and Engineering: CAuthor(s): Yasamin Nasiri Khonsari, Shiguo SunAbstractIn this paper we describe a novel ultrasensitive electrochemiluminescent (ECL) aptasensor based on the quenching effect of aptamer and lysozyme incubation on co-reactant ECL mechanism of nitrogen-doped graphene quantum dots and persulfate. Incorporation of gold nanoparticles let to enhancement of electron transfer process of co-reactant mechanism species. The electrochemical behavior of each step modification of aptasensor was investigated using electrochemical impedance spect...
Source: Materials Science and Engineering: C - November 14, 2018 Category: Materials Science Source Type: research

Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
This study shows that the physical and structural properties of core-shell Fe3O4/Au nanoparticles possess intrinsic properties of gold and magnetite. VSM revealed that the core-shell Fe3O4/Au have high saturation magnetization and low coercivity due to the magnetic properties. The core-shell nanoparticles show the inhibitory concentration (IC)50 of 235 μg/ml against a colorectal cancer cell line, HT-29. When tested against non-cancer cells, IC50 was not achieved even up to 500 μg/ml. This study highlights the magnetic properties and anticancer action of core-shell Fe3O4/Au nanoparticles. This compound can be idea...
Source: Materials Science and Engineering: C - November 14, 2018 Category: Materials Science Source Type: research

Effects of MgO, ZnO, SrO, and SiO2 in tricalcium phosphate scaffolds on in vitro gene expression and in vivo osteogenesis
This study shows beneficial effects of additives on osteoblastic viability and differentiation in vitro as well as osteogenesis in vivo, which is crucial towards the development of bone tissue engineering scaffolds. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 12, 2018 Category: Materials Science Source Type: research

Fabrication of three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity
Publication date: Available online 23 January 2007Source: Materials Science and Engineering: CAuthor(s): Shunji Yunoki, Toshiyuki Ikoma, Akira Monkawa, Kazushi Ohta, Masanori Kikuchi, Eriko Marukawa, Shinichi Sotome, Kenichi Shinomiya, Junzo Tanaka (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Pore shape and size dependence on cell growth into electrospun fiber scaffolds for tissue engineering: 2D and 3D analyses using SEM and FIB-SEM tomography
Publication date: Available online 19 August 2017Source: Materials Science and Engineering: CAuthor(s): Urszula Stachewicz, Piotr K. Szewczyk, Adam Kruk, Asa H. Barber, Aleksandra Czyrska-FilemonowiczAbstractElectrospun nanofibers have ability to boost cell proliferation in tissue engineered scaffolds as their structure remind cells extra cellular matrix of the native tissue. The complex architecture and network of nanofibrous scaffolds requires advanced characterization methods to understand interrelationship between cells and nanofibers. In our study, we used complementary 2D and 3D analyses of electrospun polylactide-co...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Influence of alginate backbone on efficacy of thermo-responsive alginate-g-P(NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery
This study was designed to produce the optimal Alg-g-P(NIPAAm) hydrogel with respect to localised delivery of DNA nanoparticles as a potential medical device for those with castrate resistant prostate cancer (CRPC). Given that CRPC typically disseminates to bone causing pain, morbidity and a plethora of skeletal related events, a copolymer based hydrogel was designed to for long term release of therapeutic DNA nanoparticles.The nanoparticles were comprised of plasmid DNA (pDNA), complexed with an amphipathic cell penetrating peptide termed RALA that is designed to enter cells with high efficiency. Alginate MW and M/G ratio...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Antiresorptive properties of strontium substituted and alendronate functionalized hydroxyapatite nanocrystals in an ovariectomized rat spinal arthrodesis model
ConclusionsResults of this study suggest that in spinal fusion the incorporation of bioactive ions or drugs as Sr and AL improves the biological performance of HA representing a promising strategy especially in osteoporosis patients with high risks of spinal fusion failure. Results also suggest the existence of a Sr and AL dose response effect and that HA containing the highest AL dose could be the candidate biomaterial for spinal fusion in osteoporotic subjects. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

X-ray physics-based CT-to-composition conversion applied to a tissue engineering scaffold, enabling multiscale simulation of its elastic behavior
Publication date: Available online 5 December 2017Source: Materials Science and Engineering: CAuthor(s): Karol Szlazak, Viktoria Vass, Patricia Hasslinger, Jakub Jaroszewicz, Alexander Dejaco, Joanna Idaszek, Stefan Scheiner, Christian Hellmich, Wojciech SwieszkowskiAbstractNowadays, the assessment of the mechanical competence of tissue engineering scaffolds based on computer simulations is a well-accepted technology. Typically, such simulations are performed by means of the Finite Element (FE) method, with the underlying structural model being created based on micro-computed tomography (microCT). Here, this analysis modal...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Corrosion and biocompatibility examination of multi-element modified calcium phosphate bioceramic layers
Publication date: Available online 31 January 2018Source: Materials Science and Engineering: CAuthor(s): Monika Furko, Elena Della Bella, Milena Fini, Csaba BalázsiAbstractMulti-ions doped bioactive calcium phosphate (dCaP) layers were developed by pulse current deposition onto surgical grade titanium alloy material (Ti6Al4V). The coatings were electrodeposited from base electrolyte containing adequate amounts of calcium nitrate and ammonium dihydrogen phosphate at 70 °C. After electrodeposition, the pure CaP layers were doped with different ions that possess bioactive and antimicrobial properties, such as Zn2...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Functionalization of phosphocalcic bioceramics for bone repair applications
Publication date: Available online 31 January 2018Source: Materials Science and Engineering: CAuthor(s): Chantal Damia, David Marchat, Charly Lemoine, Nathalie Douard, Vincent Chaleix, Vincent Sol, Nathanaël Larochette, Delphine Logeart-Avramoglou, Joël Brie, Eric ChampionAbstractThis work is devoted to the processing of bone morphogenetic protein (BMP-2) functionalized silicate substituted hydroxyapatite (SiHA) ceramic spheres. The motivation behind it is to develop injectable hydrogel/bioceramic composites for bone reconstruction applications. SiHA microspheres were shaped by spray drying and thoroughly charact...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Oxygen-distribution within 3-D collagen I hydrogels for bone tissue engineering
In this study, we intended to analyse the level of locally dissolved oxygen within 3-D cell-loaded collagen I gels in vitro. For the analysis of the oxygen levels in situ, we employed an optical fibre-based micro sensor setup, as well as a camera supported non-invasive optical sensor foil based technique. These complementary analytical tools enable the identification, localization, and temporal follow-up investigation of specified regions of interest within TE constructs. Human adipose-derived mesenchymal stem cells (hAdMSCs) cultured in collagen I gels under normoxic conditions were analysed periodically and kinetically u...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment
In this study, laser machining technology was employed in order to produce controlled regular micro-patterns on dense calcium phosphate surfaces, without any contamination. The choice of the source was directed towards a femtosecond pulsed laser in order to limit the thermal impact of such a process and thus to avoid the unwanted phase transformations potentially induced by the temperature elevation. Beta tricalcium phosphate substrates with perfectly controlled micro-patterning and without any secondary phase were obtained by optimization of the process parameters (laser power, scanning speed, pulse frequency). The micros...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Biphasic calcium phosphate scaffolds with controlled pore size distribution prepared by in-situ foaming
In this study, a reproducible method of fabricating hierarchically 3D porous scaffolds with high porosity and pore interconnectivity is reported. The method is based on in-situ foaming of a dispersion of diisocyanate, polyol, water and hydroxyapatite (HA) to form a hard foamed HA/polyurethane composite which after heat treatment provided a bi-phase calcium phosphate scaffold. This technique, combining the advantages of polymer sponge and direct foaming methods, provides a better control over the macrostructure of the scaffold. A modification of the multi-scaled porous macrostructure of scaffolds produced by changing the ra...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

The influence of chemical polishing of titanium scaffolds on their mechanical strength and in-vitro cell response
In this study, the influence of chemical polishing of SLM fabricated titanium scaffolds on their mechanical strength and in vitro cellular response was investigated. Scaffolds with bimodal pore size (200 μm core and 500 μm shell) were fabricated by SLM from commercially pure titanium powder and then chemically treated in HF/HNO3 solutions to remove unmelted powder particles. The cell viability and mechanical strength were compared between as-made and chemically-treated scaffolds. The chemical treatment was successful in the removal of unmelted powder particles from the titanium scaffold. The Young's modulus of th...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

PVP - CMC hydrogel: An excellent bioinspired and biocompatible scaffold for osseointegration
In conclusion, these three calcite filled hydrogel scaffolds are recommended and can be used for osseointegration.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Advanced materials and technologies for bone engineering
Publication date: Available online 10 September 2018Source: Materials Science and Engineering: CAuthor(s): Paola Palmero, Stéphane Hocquet (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Quaternized chitosan-stabilized copper sulfide nanoparticles for cancer therapy
In this study, we report a smart and green strategy to synthesize copper sulfide nanoparticles (CuS-NPs) for clinically translatable cancer treatment. For the first time, the preparation of CuS-NPs was developed by taking advantage of the copper-amine complex as the copper source and sodium sulfide as the sulfide source, in which the quaternized chitosan (QCS) was used as a biotemplate and stabilizing agent. The obtained QCS/CuS-NPs composites (CuS@QCS-NPs) were spherical and stable with an average diameter of 5.6 nm, and showed strong NIR absorbance for photothermal conversion. Moreover, in vitro and in vivo cancer ther...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Synthesis, characterization and application of Ag doped ZnO nanoparticles in a composite resin
Publication date: Available online 17 October 2018Source: Materials Science and Engineering: CAuthor(s): Hércules Bezerra Dias, Maria Inês Basso Bernardi, Valéria Spolon Marangoni, Adilson César de Abreu Bernardi, Alessandra Nara de Souza Rastelli, Antônio Carlos HernandesAbstractThe biofilm accumulation over the composite resin restorations can contribute to the formation of secondary caries. In this way, antibacterial restorative composite resins are highly desired. Then, the purpose of this study was to modify a composite resins using Ag doped ZnO nanoparticles (NPs), evaluate the antiba...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Preparation, characterization and evaluation of the zinc titanate and silver nitrate incorporated wipes for topical chemical and biological decontamination
Publication date: Available online 17 October 2018Source: Materials Science and Engineering: CAuthor(s): Navneet Sharma, Mamta Chaudhary, Bhupendra Singh Butola, Joseph Kingston Jeyabalaji, Dharm Pal Pathak, Rakesh Kumar SharmaAbstractChemical and biological warfare agents have detrimental effects on biological systems. These agents are rapidly absorbed through skin and hence warrant immediate decontamination. Zinc titanate (ZnTiO3), is a well-proven moiety used for neutralizing chemical warfare agents (CWA) and silver is widely used as an antibacterial agent. Spacer fabric sheet, due to its ability to hold large amount of...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Effects of MgO, ZnO, SrO, and SiO2 in tricalcium phosphate scaffolds on in vitro genes expression and in vivo osteogenesis
This study shows beneficial effects of additives on osteoblastic viability and differentiation in vitro as well as osteogenesis in vivo, which is crucial towards the development of bone tissue engineering scaffolds. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Development of 3D printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications
Publication date: Available online 23 October 2018Source: Materials Science and Engineering: CAuthor(s): M. Rasoulianboroujeni, F. Fahimipour, P. Shah, K. Khoshroo, M. Tahriri, H. Eslami, A. Yadegari, E. Dashtimoghadam, L. TayebiAbstractPorous scaffolds were 3D-printed using poly lactic-co-glycolic acid (PLGA)/TiO2 composite (10:1 weight ratio) for bone tissue engineering applications. Addition of TiO2 nanoparticles improved the compressive modulus of scaffolds. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed an increase in both glass transition temperature and thermal decomposition on...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Evaluation of reagents used to coat the hollow-fiber bioreactor membrane of the Quantum® Cell Expansion System for the culture of human mesenchymal stem cells
In this study, the efficacy of 8 potential coating reagents has been compared in terms of the doubling times of their cell populations, cell morphology, characterization via flow cytometry, and capacity for trilineage differentiation. Human fibronectin (FN), pooled human cryoprecipitate (CPPT), and recombinant human vitronectin (VN) were successful as coating reagents, and each product has advantages in different cell culture contexts. Mesenchymal stem cells harvested from Quantum cultured with each of these 3 compounds as coating reagents all met International Society for Cellular Therapy standards for plastic adherence, ...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Synthesis and biophysical characteristics of riboflavin/HSA protein system on silver nanoparticles
Publication date: Available online 30 October 2018Source: Materials Science and Engineering: CAuthor(s): M. Voicescu, S. Ionescu, V.S. Manoiu, M. Anastasescu, O. Craciunescu, L. MoldovanAbstractNovel l‑Arginine‑Dextran70 based-silver nanoparticles (SNPs) (SNPsArg), functionalized with Riboflavin (RF) and Human Serum Albumin (HSA) were characterized by UV–Vis absorption, Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), fluorescence and circular dichroism spectroscopy, chemiluminescence and Neutral red assays. TEM analysis showed the formed faceted particles, large clumps/fused aggregates, nan...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance
Publication date: Available online 1 November 2018Source: Materials Science and Engineering: CAuthor(s): Xi Yang, Yingjie Yu, Xing Huang, Qixian Chen, Hui Wu, Ran Wang, Ruogu Qi, Yifeng Miao, Yongming QiuAbstractDrug resistance induced by increasing intracellular levels of detoxifying agents for conventional platinum(II) drugs such as metallothioneins (MTs) and glutathione (GSH) are the major obstacles for widely used platinum-based chemotherapeutic cancer treatment. Here, we developed trans-geometry platinum (II) drugs with sterically hindered bulky ligands PyPt which is able to hind the GSH attack of platinum drug to ove...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Polydopamine doped reduced graphene oxide/mesoporous silica nanosheets for chemo-photothermal and enhanced photothermal therapy
Publication date: Available online 1 November 2018Source: Materials Science and Engineering: CAuthor(s): Rong Liu, Huicong Zhang, Fangrong Zhang, Xuandong Wang, Xiaolong Liu, Yun ZhangAbstractThe nanoplatform of synergistic chemo-photothermal therapy has superior advantages on antitumor. It is urgently needed to explore novel nanocarrier for improving photothermal performance in drug delivery process. Herein, we synthesized polydopamine doped mesoporous silica-coated reduced graphene oxide (rGO/MSN/PDA) by simply adding dopamine hydrochloride into the oil-water biphasic reaction system as a multifunctional drug carrier for...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Novel one step transformation method for Escherichia coli and Staphylococcus aureus using arginine-glucose functionalized hydroxyapatite nanoparticles
In this study, we have developed arginine-glucose functionalized hydroxyapatite nanoparticle (R-G-HAp NPs) mediated novel one step transformation method, effective for both Gram-positive and Gram-negative bacteria. R-G-HAp NPs served as carriers to deliver pDNA into Escherichia coli and Staphylococcus aureus at room temperature, without the need for preparation of competent cells. High transformation efficiency was achieved in Gram-positive, S. aureus (107 cfu/μg of pDNA) as well as Gram-negative, E. coli (109 cfu/μg of pDNA). This demonstrates the efficacy of R-G-HAp NPs as a nano-vehicle to achieve high plasmid...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Targeted delivery of etoposide, carmustine and doxorubicin to human glioblastoma cells using methoxy poly(ethylene glycol)‑poly(ε‑caprolactone) nanoparticles conjugated with wheat germ agglutinin and folic acid
Publication date: Available online 4 November 2018Source: Materials Science and Engineering: CAuthor(s): Yung-Chih Kuo, Yu-Hsuan Chang, Rajendiran RajeshAbstractWheat germ agglutinin (WGA) and folic acid (FA)-grafted methoxy poly(ethylene glycol) (MPEG)‑poly(ε‑caprolactone) (PCL) nanoparticles (WFNPs) were applied to transport anticancer drugs across the blood–brain barrier and treat glioblastoma multiforme (GBM). PCL was copolymerized with MPEG, and MPEG-PCL NPs were stabilized with pluronic F127 using a microemulsion-solvent evaporation technique and crosslinked with WGA and FA. The targeting ability of...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Revisiting the insights and applications of protein engineered hydrogels
Publication date: Available online 5 November 2018Source: Materials Science and Engineering: CAuthor(s): J. Brindha, Chanda Kaushik, M.M. BalamuraliAbstractUtilization of protein-protein interactions or protein-peptide interactions has led to new crosslinking chemistries, resulting into protein hydrogels. Enzyme catalyzed crosslinking of specific amino acids has also been used to generate crosslinked protein hydrogels. Weak, temporary, reversible or non-covalently crosslinked protein gels as well as strong, permanent, irreversible or covalently crosslinked protein gels with mechanical strengths of varying degrees are gener...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

High-performance non-enzymatic glucose sensor by hierarchical flower-like nickel(II)-based MOF/carbon nanotubes composite
Publication date: Available online 5 November 2018Source: Materials Science and Engineering: CAuthor(s): Feng Wang, Xiaoqian Chen, Lin Chen, Jialin Yang, Qingxiang WangAbstractA hierarchical three-dimensional flower-like nickel(II)-terephthalic acid (Ni(TPA)) metal-organic framework (MOF) was synthesized through a simple solvothermal method. Then the single-walled carbon nanotubes (SWCNT) were doped with the synthesized Ni(TPA) MOF by the ultrasonic method to improve the chemical stability and the electrochemical activity of the MOF. To explore the potential application of the nanocomposite, the Ni(TPA)-SWCNT modified glas...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin
Publication date: Available online 6 November 2018Source: Materials Science and Engineering: CAuthor(s): Kumbam Lingeshwar Reddy, Peeyush Kumar Sharma, Ashutosh Singh, Ajay Kumar, Konathala Ravi Shankar, Yashveer Singh, Neha Garg, Venkata KrishnanAbstractUpconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostic...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Green fabrication of biologically active magnetic core-shell Fe3O4/Au and their potential anticancer effect
This study shows that the physical and structural properties of core-shell Fe3O4/Au nanoparticles possess intrinsic properties of gold and magnetite. VSM revealed that the core-shell Fe3O4/Au have high saturation magnetization and low coercivity due to the magnetic properties. The core-shell nanoparticles show the inhibitory concentration (IC)50 of 235 μg/mL against a colorectal cancer cell line, HT-29. When tested against non-cancer cells, IC50 was not achieved even up to 500 μg/mL. This study highlights the magnetic properties and anticancer action of core-shell Fe3O4/Au nanoparticles. This compound can be idea...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Preparation and biomedical applications of silk fibroin-nanoparticles composites with enhanced properties - A review
Publication date: Available online 6 November 2018Source: Materials Science and Engineering: CAuthor(s): Zongpu Xu, Liyang Shi, Mingying Yang, Liangjun ZhuAbstractPolymer-nanoparticles composites have attracted considerable attention over the years, due to the superior combination performance from both materials. As a versatile natural polymer, silk fibroin has been combined with various nanoparticles. The introduction of nanoparticles brings many optimized and new functionalities to silk fibroin, such as mechanical, biological, thermal, electrical, florescent and magnetical properties. This review focuses on the preparati...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Study of synthesis, structural, optical and magnetic characterizations of iron/copper oxide nanocomposites: A promising novel inorganic antibiotic
Publication date: Available online 6 November 2018Source: Materials Science and Engineering: CAuthor(s): Mayank Bhushan, Yogesh Kumar, Latha Periyasamy, Annamraju Kasi ViswanathAbstractThis paper reports the development of inorganic nanoparticles based novel antibiotic. Inorganic nanoparticles have the potential of being used as bactericidal agent due to their effective antimicrobial activity, colloidal aqueous stability and comparatively low toxic profile. Among them, iron oxide and copper oxide were chosen for this study because of the nascent bactericidal properties of both iron and copper. In this work, along with the ...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Thinking small, doing big: Current success and future trends in drug delivery systems for improving cancer therapy with special focus on liver cancer
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): María J. Limeres, Marcela A. Moretton, Ezequiel Bernabeu, Diego A. Chiappetta, María L. CuestasAbstractNanotechnology has recently emerged as a promising tool in biomedicine research. An important branch of nanotechnology is drug delivery and drug targeting using a wide range of biomaterials with promising potential applications in cancer research. The aim of this review is to provide an overview of the evolution of nanotechnology in cancer therapy, exemplified by a myriad of applications in drug delivery,...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Plasmon enhanced photocatalytic and antimicrobial activities of Ag-TiO2 nanocomposites under visible light irradiation prepared by DBD cold plasma treatment
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): Peimei Dong, Fangfang Yang, Xudong Cheng, Zhengfeng Huang, Xiaoxiao Nie, Yonghong Xiao, Xiwen ZhangAbstractSilver nanoparticles (Ag NPs) have been deposited on powder P25 by a novel two-step method involving a precipitation reaction and atmospheric pressure dielectric barrier discharge (DBD) cold plasma treatment without the use of any environmentally and biologically hazardous reducing agents. The silver precursor is formed in the processing of precipitation reaction and then completely reduced to the metallic state by...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Development of solvent-casting particulate leaching (SCPL) polymer scaffolds as improved three-dimensional supports to mimic the bone marrow niche
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): Antonella Sola, Jessika Bertacchini, Daniele D'Avella, Laura Anselmi, Tullia Maraldi, Sandra Marmiroli, Massimo MessoriAbstractThe need for new approaches to investigate ex vivo the causes and effects of tumor and to achieve improved cancer treatments and medical therapies is particularly urgent for malignant pathologies such as lymphomas and leukemias, whose tissue initiator cells interact with the stroma creating a three-dimensional (3D) protective environment that conventional mono- and bi-dimensional (2D) models are...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Effect of surfactant concentration on textural characteristics and biomineralization behavior of mesoporous bioactive glasses
We report mesoporous bioactive glasses (MBGs) with different pore architecture synthesized using the supramolecular chemical approach using acid assisted sol-gel method followed by evaporation induced self-assembly (EISA) process. The surfactant of non-ionic block co-polymer used in the present work act as structure directing agent (SDA) with varying amount, which brings different textural properties. As prepared glasses possess wormhole-like mesostructure with different textural characteristics and it varies with surfactant concentrations. The pristine MBGs have been characterized by various analytical techniques before a...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Nanolayer coextrusion: An efficient and environmentally friendly micro/nanofiber fabrication technique
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): Junfeng Cheng, Hao Li, Zheng Cao, Dun Wu, Chunlin Liu, Hongting PuAbstractResearchers have developed many types of nanoscale materials with different properties. Among them, nanofibers have recently attracted increasing interest and attention due to their functional versatility and potential applications in diverse industries, including tapes, filtration, energy generation, and biomedical technologies. Nanolayer coextrusion, a novel polymer melt fiber processing technology, has gradually received attention due to its en...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Potential of niobium-based thin films as a protective and osteogenic coating for dental implants: The role of the nonmetal elements
Publication date: Available online 8 November 2018Source: Materials Science and Engineering: CAuthor(s): Zhengjiang Xu, Luis Yate, Yuan Qiu, Willian Aperador, Emerson Coy, Bin Jiang, Sergio Moya, Guocheng Wang, Haobo PanAbstractAn ideal dental implant coating should provide a highly protective interface and an osteogenic function. Inspired by the excellent biocompatibility and anti-corrosion of the Nb element, we produced Nb-based oxide, nitride and carbide films as well as the pure metal Nb film for surface enhancement of dental implants, and compare the impact of the nonmetal elements on the electrochemical, tribological...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: Skin permeation/penetration and efficacy in wound healing
Publication date: Available online 8 November 2018Source: Materials Science and Engineering: CAuthor(s): Aline Marquez Cardoso, Edilene Gadelha de Oliveira, Karine Coradini, Franciele Aline Bruinsmann, Tanira Aguirre, Ricardo Lorenzoni, Raquel Cristiane Silva Barcelos, Karine Roversi, Domenika Rubert Rossato, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Marilise Escobar Bürger, Ruy Carlos Ruver BeckAbstractAlthough phenytoin is an antiepileptic drug used in the oral treatment of epilepsy, its off-label use as a cutaneous healing agent has been studied in recent years due to the frequent reports...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Newly-designed collagen/polyurethane bioartificial blend as coating on bioactive glass-ceramics for bone tissue engineering applications
Publication date: Available online 10 November 2018Source: Materials Science and Engineering: CAuthor(s): Silvia Caddeo, Monica Mattioli-Belmonte, Claudio Cassino, Niccoletta Barbani, Manuela Dicarlo, Piergiorgio Gentile, Francesco Baino, Susanna Sartori, Chiara Vitale-Brovarone, Gianluca CiardelliAbstractIn the present work, a new combination of synthetic and natural biomaterials is proposed for bone tissue engineering (BTE) applications. In order to mimic the inorganic and organic phases of bone extracellular matrix (ECM), a bioactive glass-ceramic deriving from a SiO2–P2O5–CaO–MgO–Na2O–K2O ...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

d-Glucose recognition based on phenylboronic acid-functionalized polyoligomeric silsesquioxane fluorescent probe
We report a new strategy to synthesize hybrid fluorescent nanosensors consisting of phenylboronic acid-functionalized POSS (POSS–PBA) and diol-modified 8-anilino-1-naphthalenesulfonic acid (ANSA (a fluorescent dye)) for the detection of the biologically important d-glucose. The probe was characterized by FT-IR and 1H NMR analyses, and the photoluminescence intensity was measured under various conditions to confirm its glucose sensing ability. Our POSS-APBA-dye probe could detect glucose at concentrations of 0–20 mg/mL, with a good linear relationship even at low glucose concentrations of 0–1 mg/mL. Th...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Promoting osteoblast proliferation on polymer bone substitutes with bone-like structure by combining hydroxyapatite and bioactive glass
Publication date: March 2019Source: Materials Science and Engineering: C, Volume 96Author(s): Baisong Zhao, Haiping Xu, Ying Gao, Jia-Zhuang Xu, Hua-Mo Yin, Ling Xu, Zhong-Ming Li, Xingrong SongAbstractMimicking the structural features of natural bone has been demonstrated to bring pronounced advantages for mechanical reinforcement of polymeric orthopedic substitutes that are composed of bioinert polymer matrix and bioactive fillers. However, to trigger effective bone formation and implant integration, the bioactivity of bone substitutes plays a vital role. We hypothesized that the use of hydroxyapatite (HA) and bioactive ...
Source: Materials Science and Engineering: C - November 11, 2018 Category: Materials Science Source Type: research

Modification of in vitro degradation behavior of pure iron with ultrasonication treatment: Comparison of two different pseudo-physiological solutions
Publication date: 1 February 2019Source: Materials Science and Engineering: C, Volume 95Author(s): Juncen Zhou, Michael Fink, Mark Bruns, Yuyun Yang, Rainer Detsch, Aldo R. Boccaccini, Helmut Ermert, Sannakaisa VirtanenAbstractAn ultrasonication treatment is developed as an external method to control the degradation behavior of pure iron. Immersion tests (weight loss measurements) and electrochemical measurements were conducted in two different pseudo-physiological solutions, simulated body fluid (SBF) and Dulbecco's modified Eagle medium (DMEM) solution. By the comparison study in these two different solutions, more infor...
Source: Materials Science and Engineering: C - November 6, 2018 Category: Materials Science Source Type: research

Naftopidil-fumaric acid interaction in a solid dispersion system: Improving the dissolution rate and oral absorption of naftopidil in rats
In conclusion, fumaric acid is the major factor contributing to the TPGS-induced improvement of the dissolution rate of NAF in SD5 formulation, thereby increasing the oral absorption of NAF in rats.Graphical abstract (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - November 6, 2018 Category: Materials Science Source Type: research

Au-aided reduced graphene oxide-based nanohybrids for photo-chemotherapy
Publication date: 1 February 2019Source: Materials Science and Engineering: C, Volume 95Author(s): Weiqian Ma, Yanfang Hu, Huailin Yang, Yuandong Zhang, Jianxun Ding, Li ChenAbstractGraphene-based nanomaterials show great potential in photo-chemotherapy, but their photo-thermal effect is not very satisfactory. Herein, we presented a facile and low-cost strategy to grow Au clusters on the reduced graphene oxide (rGO) sheets aiming to improve photothermal effect. Au clusters with low-concentration was directly conjugated on the surface of rGO by electrostatic forces. To improve its biocompatibility, 3‑(3‑phenylureido) pr...
Source: Materials Science and Engineering: C - November 2, 2018 Category: Materials Science Source Type: research

Tuning the properties of magnesium phosphate-based bone cements: Effect of powder to liquid ratio and aqueous solution concentration
Publication date: 1 February 2019Source: Materials Science and Engineering: C, Volume 95Author(s): Rita Gelli, Laura Mati, Francesca Ridi, Piero BaglioniAbstractThe use of magnesium phosphate-based cements (MPCs) in the biomedical field has recently come under investigation in the scientific community, as these materials display many intriguing properties in the replacement and/or integration of calcium phosphate-based bone cements; however, the diverse preparation conditions reported in the literature make it difficult to evaluate how the modification of a specific parameter in the preparation of the paste affects the fin...
Source: Materials Science and Engineering: C - November 2, 2018 Category: Materials Science Source Type: research