SGLT2 is upregulated to acquire cisplatin resistance and SGLT2 inhibition reduces cisplatin resistance in hepatoblastoma
ConclusionsCisplatin-resistant hepatoblastoma cells exhibited upregulated SGLT2 expression and activated glucose uptake to survive under cisplatin stress. SGLT2 inhibition decreased cellular resistance to cisplatin. SGLT2 inhibition with cisplatin therapy could be a novel therapeutic strategy for cisplatin-resistant hepatoblastoma patients. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - November 6, 2023 Category: Gastroenterology Authors: Sunao Fujiyoshi,
Shohei Honda,
Momoko Ara,
Takafumi Kondo,
Nozomi Kobayashi,
Akinobu Taketomi Tags: ORIGINAL ARTICLE Source Type: research
Looking beyond toxicities: Other health-related morbidities noted in childhood solid tumor survivors
Conclusions: A high prevalence of medically or surgically manageable conditions makes it imperative to keep these children under follow-up to address any health-related conditions they may subsequently develop. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - November 2, 2023 Category: Surgery Authors: Mehak Sehgal Vishesh Jain Sandeep Agarwala Anjan Dhua Prabudh Goel Devendra Kumar Yadav Sameer Bakhshi Mani Kalaivani Source Type: research
GSE160939 LIM homeobox-2 suppresses hallmarks of adult and pediatric liver cancers by controlling MAPK/ERK and Wnt/beta-catenin pathways
Contributors : Christophe F Grosset ; Nicola Mosca ; Fatma-Zohra Khoubai ; Philippe Veschambre ; Sandrine Fedou ; Emeric Dubois ; Christophe Avignon ; Juan Carrillo-Reixach ; Stefano Caruso ; Carolina Armengol ; Jessica Zucman-Rossi ; Catherine Guettier ; Charlotte Mussini ; Pierre Thi ébaudSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) and Hepatoblastoma (HB) are two liver cancers characterized by high gene deregulation, chromosomal rearrangements and typical mutations in genes related to the Wnt/ β-catenin (Wnt) pathway. LHX2, a transcr...
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 15, Pages 5182: Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)
This study demonstrates that the metabolomic landscape of HB is distinct from that of non-tumour (NT) liver tissue, with 35 differentially abundant metabolites mapping onto pathways such as fatty acid transport, glycolysis, the tricarboxylic acid (TCA) cycle, branched-chain amino acid degradation and glutathione synthesis. Targeted metabolomics demonstrated reduced short-chain acylcarnitines and a relative accumulation of branched-chain amino acids. Medium- and long-chain acylcarnitines in HB were similar to those in NT. The metabolomic changes reported are consistent with previously reported transcriptomic data from tumou...
Source: Cancers - October 28, 2023 Category: Cancer & Oncology Authors: Alison Whitby Pardeep Pabla Bhoomi Shastri Laudina Amugi Álvaro Del Río-Álvarez Dong-Hyun Kim Laura Royo Carolina Armengol Madhumita Dandapani Tags: Article Source Type: research
Retracted: Exploration of Potential Biomarkers and Immune Landscape for Hepatoblastoma: Evidence from Machine Learning Algorithm
Evid Based Complement Alternat Med. 2023 Oct 18;2023:9893765. doi: 10.1155/2023/9893765. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/2417134.].PMID:37886423 | PMC:PMC10599939 | DOI:10.1155/2023/9893765 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 27, 2023 Category: Complementary Medicine Authors: Evidence-Based Complementary And Alternative Medicine Source Type: research
Protective efficacy of Toxoplasma gondii infected cells-derived exosomes against chronic murine toxoplasmosis
Acta Trop. 2023 Oct 17:107041. doi: 10.1016/j.actatropica.2023.107041. Online ahead of print.ABSTRACTExosomes were isolated from T. gondii infected human hepatoblastoma cells using the exosome isolation kit and characterized by electron microscopy and Western blotting. Exosomes adsorbed to alum adjuvant were evaluated as a potential immunizing agent against murine chronic toxoplasmosis compared to excretory secretory antigens (ESA)-alum. Mice were immunized at days 1, 15 and 29. The levels of IgG, IFN-γ, IL-4 and IL-10, CD4+ and CD8+ T cells were determined using sandwich enzyme-linked immunosorbent assay (sandwich ELISA)...
Source: Acta Tropica - October 20, 2023 Category: Infectious Diseases Authors: Gihan M Tawfeek Iman F Abou-El-Naga Eman Mohamed Elsayed Hassan Dina Sabry Rasha Abdallah Meselhey Salwa Samy Younis Source Type: research
Protective efficacy of Toxoplasma gondii infected cells-derived exosomes against chronic murine toxoplasmosis
Acta Trop. 2023 Oct 17:107041. doi: 10.1016/j.actatropica.2023.107041. Online ahead of print.ABSTRACTExosomes were isolated from T. gondii infected human hepatoblastoma cells using the exosome isolation kit and characterized by electron microscopy and Western blotting. Exosomes adsorbed to alum adjuvant were evaluated as a potential immunizing agent against murine chronic toxoplasmosis compared to excretory secretory antigens (ESA)-alum. Mice were immunized at days 1, 15 and 29. The levels of IgG, IFN-γ, IL-4 and IL-10, CD4+ and CD8+ T cells were determined using sandwich enzyme-linked immunosorbent assay (sandwich ELISA)...
Source: Acta Tropica - October 20, 2023 Category: Infectious Diseases Authors: Gihan M Tawfeek Iman F Abou-El-Naga Eman Mohamed Elsayed Hassan Dina Sabry Rasha Abdallah Meselhey Salwa Samy Younis Source Type: research
Protective efficacy of Toxoplasma gondii infected cells-derived exosomes against chronic murine toxoplasmosis
Acta Trop. 2023 Oct 17;248:107041. doi: 10.1016/j.actatropica.2023.107041. Online ahead of print.ABSTRACTExosomes were isolated from T. gondii infected human hepatoblastoma cells using the exosome isolation kit and characterized by electron microscopy and Western blotting. Exosomes adsorbed to alum adjuvant were evaluated as a potential immunizing agent against murine chronic toxoplasmosis compared to excretory secretory antigens (ESA)-alum. Mice were immunized at days 1, 15 and 29. The levels of IgG, IFN-γ, IL-4 and IL-10, CD4+ and CD8+ T cells were determined using sandwich enzyme-linked immunosorbent assay (sandwich EL...
Source: Acta Tropica - October 20, 2023 Category: Infectious Diseases Authors: Gihan M Tawfeek Iman F Abou-El-Naga Eman Mohamed Elsayed Hassan Dina Sabry Rasha Abdallah Meselhey Salwa Sami Younis Source Type: research
Identification of hepatoblastoma susceptibility loci in the TRMT6 gene from a seven-center case-control study
In conclusion, we identified three susceptibility loci in the TRMT6 gene for hepatoblastoma. Our findings warrant further validation by extensive case-control studies across different ethnicities.PMID:37850543 | DOI:10.1111/jcmm.18006 (Source: Cancer Control)
Source: Cancer Control - October 18, 2023 Category: Cancer & Oncology Authors: Lin Ma Jinhong Zhu Jiao Zhang Wenli Zhang Yong Li Zhonghua Yang Suhong Li Jiwen Cheng Li Li Jing He Peng Liu Source Type: research
Identification of hepatoblastoma susceptibility loci in the TRMT6 gene from a seven-center case-control study
In conclusion, we identified three susceptibility loci in the TRMT6 gene for hepatoblastoma. Our findings warrant further validation by extensive case-control studies across different ethnicities.PMID:37850543 | DOI:10.1111/jcmm.18006 (Source: J Cell Mol Med)
Source: J Cell Mol Med - October 18, 2023 Category: Molecular Biology Authors: Lin Ma Jinhong Zhu Jiao Zhang Wenli Zhang Yong Li Zhonghua Yang Suhong Li Jiwen Cheng Li Li Jing He Peng Liu Source Type: research
Identification of hepatoblastoma susceptibility loci in the TRMT6 gene from a seven-center case-control study
In conclusion, we identified three susceptibility loci in the TRMT6 gene for hepatoblastoma. Our findings warrant further validation by extensive case-control studies across different ethnicities.PMID:37850543 | DOI:10.1111/jcmm.18006 (Source: Molecular Medicine)
Source: Molecular Medicine - October 18, 2023 Category: Molecular Biology Authors: Lin Ma Jinhong Zhu Jiao Zhang Wenli Zhang Yong Li Zhonghua Yang Suhong Li Jiwen Cheng Li Li Jing He Peng Liu Source Type: research
Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients
CONCLUSION: This is the first study evaluating the role of miRNAs in colchicine resistant patients with FMF. Their differential expression may result in resistance to standard colchicine treatment by affecting the expression of genes that take place in drug absorption, distribution, metabolism, and excretion (ADME) or nuclear receptors that regulate ADME genes, thus potentially playing a role in both drug metabolism and inflammation.PMID:37844462 | DOI:10.1016/j.intimp.2023.111011 (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 16, 2023 Category: Allergy & Immunology Authors: Bilgesu Şafak Tümerdem Tayfun Hilmi Akbaba Ezgi Deniz Batu Yeliz Z Akkaya-Ulum Pelin Mutlu Seza Ozen Banu Balci-Peynircio ğlu Source Type: research
Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients
CONCLUSION: This is the first study evaluating the role of miRNAs in colchicine resistant patients with FMF. Their differential expression may result in resistance to standard colchicine treatment by affecting the expression of genes that take place in drug absorption, distribution, metabolism, and excretion (ADME) or nuclear receptors that regulate ADME genes, thus potentially playing a role in both drug metabolism and inflammation.PMID:37844462 | DOI:10.1016/j.intimp.2023.111011 (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 16, 2023 Category: Allergy & Immunology Authors: Bilgesu Şafak Tümerdem Tayfun Hilmi Akbaba Ezgi Deniz Batu Yeliz Z Akkaya-Ulum Pelin Mutlu Seza Ozen Banu Balci-Peynircio ğlu Source Type: research
