PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
ConclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.Trial registrationClinical Trials, NCT03645655. Registered 20 August 2018,https://www.clinicaltrials.gov/ct2/show/NCT03645655. (Source: Hepatology International)
Source: Hepatology International - April 16, 2024 Category: Infectious Diseases Source Type: research
Genes, Vol. 15, Pages 463: Therapeutic Management and Outcomes of Hepatoblastoma in a Pediatric Patient with Mosaic Edwards Syndrome
andowska
The mosaic form of Edwards syndrome affects 5% of all children with Edwards syndrome. The clinical phenotype is highly variable, ranging from the full spectrum of trisomy 18 to the normal phenotype. The purpose of this publication was to present the therapeutic process in an 18-month-old girl with the mosaic form of Edwards syndrome and hepatoblastoma, against the background of other cases of simultaneous occurrence of this syndrome and hepatoblastoma described so far. It appears that this particular group of patients with hepatoblastoma and Edwards syndrome can have good outcomes, provided they do not have li...
Source: Genes - April 7, 2024 Category: Genetics & Stem Cells Authors: Patrycja Sosnowska-Sienkiewicz Alicja Kami ńska Iwona Anderko Gabriela Telman-Ko łodziejczyk Przemys ław Mańkowski Danuta Januszkiewicz-Lewandowska Tags: Case Report Source Type: research
Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications
Liver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cancer progression remain largely elusive. N6-methyladenosine (m6A) modification, as the most prevalent and abundant internal RNA modification in eukaryotic RNAs, plays an essential role in regulating RNA metabolism including RNA splicing, stability, translation, degradation. To date, there is mounting evidence showing that m6A dysre...
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity
In conclusion, SBSGL had immunomodulatory effects and regulated the malignancy and autophagy of HB by regulating the O-GlcNAcylation of RACK1. These findings suggest that SBSGL holds promise as a potential anticancer drug for HB treatment.PMID:38451046 | DOI:10.1111/jcmm.18223 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 7, 2024 Category: Molecular Biology Authors: Rui Shen Yang Ge Yunpeng Qin Hang Gao Hongyan Yu Huazhang Wu Hang Song Source Type: research
Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity
In conclusion, SBSGL had immunomodulatory effects and regulated the malignancy and autophagy of HB by regulating the O-GlcNAcylation of RACK1. These findings suggest that SBSGL holds promise as a potential anticancer drug for HB treatment.PMID:38451046 | DOI:10.1111/jcmm.18223 (Source: Molecular Medicine)
Source: Molecular Medicine - March 7, 2024 Category: Molecular Biology Authors: Rui Shen Yang Ge Yunpeng Qin Hang Gao Hongyan Yu Huazhang Wu Hang Song Source Type: research
Use of modern three-dimensional imaging models to guide surgical planning for local control of pediatric extracranial solid tumors
CONCLUSION: Our institutional series demonstrates a wide spectrum of clinical application for 3D modeling and printing technology within pediatric surgical oncology. This technology may aid in surgical planning for both resection and reconstruction, can be applied to a diverse breadth of diagnoses, and may potentially augment patient and/or family education about their condition.PMID:38430473 | DOI:10.1002/pbc.30933 (Source: Cancer Control)
Source: Cancer Control - March 2, 2024 Category: Cancer & Oncology Authors: Nikhil R Shah William J Weadock Keyonna M Williams Rebecca Moreci Tammy Stoll Aparna Joshi Robin Petroze Erika A Newman Source Type: research
Intratumoral CXCR4hi neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma
In this study, through bulk RNA sequencing for sorted blood and tumor-infiltrated neutrophils and comparison of neutrophils in tumor and para-tumor tissue by single-cell sequencing, we found that intratumoral neutrophils were composed of heterogenous functional populations at different development stages. Our study showed that terminally differentiated neutrophils with active ferroptosis prevailed in tumor tissue, whereas, in para-tumor, pre-fate naïve neutrophils were dominant and ferroptotic neutrophils dispersed in a broad spectrum of cell maturation. Gene profiling and in vitro T-cell coculture experiment confirmed th...
Source: Frontiers in Immunology - February 29, 2024 Category: Allergy & Immunology Source Type: research
Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity
DiscussionThis work aims to highlight an effective method for delivering bioactive compounds extracted from brown algae and emphasize its future therapeutic prospects. The potential of Selenium-Zinc oxide nanoparticles is of great interest due to the biocompatibility and low toxicity aspects of selenium combined with the cost-effectiveness and sustainability of zinc metal. The presence of bioactive compounds contributed to the stability of the nanoparticles and acted as capping properties. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 26, 2024 Category: Microbiology Source Type: research
Histopathologic and immunophenotypic characterization of patient-derived pediatric malignant hepatocellular tumor xenografts (PDXs)
Pathol Res Pract. 2024 Feb 1;255:155163. doi: 10.1016/j.prp.2024.155163. Online ahead of print.ABSTRACTAdvances in targeted therapies for pediatric hepatocellular tumors have been limited due to a paucity of clinically relevant models. Establishment and validation of intrahepatic patient-derived xenograft (PDX) models would help bridging this gap. The aim of this study is to compare the histomorphologic and immunophenotypic fidelity of patient tumors and their corresponding intrahepatic PDX models. Murine PDX models were established by intrahepatic implantation of patient tumors. Pathology slides from both patients and the...
Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: Kalyani R Patel Andres F Espinoza Martin Urbicain Roma H Patel Angela Major Stephen F Sarabia Dolores Lopez-Terrada Sanjeev A Vasudevan Sarah E Woodfield Source Type: research
Nur77 inhibition of β-catenin expression mediates Hepatoblastoma progression and enhances cisplatin's therapeutic effect
This study found that Nur77 was downregulated in HB tumors, compared with paracancer tissue. Knockout or overexpression of Nur77 in HB tumor cell line HepG2 and HuH6 could significantly enhance or inhibit the proliferation, migration and invasion of tumor cells both in vitro and in vivo. Further studies illustrated that Nur77 regulated the proliferation of tumor cells by affecting the expression of β-catenin. Nur77 agonist Csn-B effectively enhanced the therapeutic effect of cisplatin on HB tumors both in vitro and in vivo. This study confirms that Nur77 may act as an oncogene in HB tumors and mediate the progression of H...
Source: Gene - February 18, 2024 Category: Genetics & Stem Cells Authors: Jianfeng Zhou Xingyu Liu Hanjun Yin Yong Zhou Zhongya Xu Kai Zhou Tao Li Yongjun Fang Qiyang Shen Source Type: research
Nur77 inhibition of β-catenin expression mediates Hepatoblastoma progression and enhances cisplatin's therapeutic effect
This study found that Nur77 was downregulated in HB tumors, compared with paracancer tissue. Knockout or overexpression of Nur77 in HB tumor cell line HepG2 and HuH6 could significantly enhance or inhibit the proliferation, migration and invasion of tumor cells both in vitro and in vivo. Further studies illustrated that Nur77 regulated the proliferation of tumor cells by affecting the expression of β-catenin. Nur77 agonist Csn-B effectively enhanced the therapeutic effect of cisplatin on HB tumors both in vitro and in vivo. This study confirms that Nur77 may act as an oncogene in HB tumors and mediate the progression of H...
Source: Gene - February 18, 2024 Category: Genetics & Stem Cells Authors: Jianfeng Zhou Xingyu Liu Hanjun Yin Yong Zhou Zhongya Xu Kai Zhou Tao Li Yongjun Fang Qiyang Shen Source Type: research
Association of Sociodemographic Factors with Surgical Management of Hepatoblastoma and Hepatocellular Carcinoma in Children
To evaluate for disparities in surgical care among US children with hepatoblastoma (HB) and hepatocellular carcinoma (HCC). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 16, 2024 Category: Pediatrics Authors: Ioannis A. Ziogas, Jonathan P. Roach, Shannon N. Acker, Kristine S. Corkum, Jose L. Diaz-Miron, Ann M. Kulungowski, Ankush Gosain, Jonathan L. Hills-Dunlap Tags: Original Articles Source Type: research
The expression analysis of SerpinB9 in hepatoblastoma microenvironment
ConclusionIn hepatoblastoma, SerpinB9 is thought to be more highly expressed in macrophages and enhanced by interaction with hepatoblastoma cell. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 12, 2024 Category: Surgery Source Type: research
Digital medicine and Minimally invasive surgery in pediatric Hepatoblastoma surgery: An update
This article provides a comprehensive review of the recent advancements in surgical treatment of HB, focusing on digital surgery and minimally invasive techniques.PMID:38331610 | DOI:10.1016/j.asjsur.2024.01.134 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 8, 2024 Category: Surgery Authors: Jie Liu Wenli Xiu Guangqi Duan Bao Wang Nannan Jiang Qian Dong Nan Xia Aiqin Lin Source Type: research
