Congenital Hepatoblastoma and Beckwith-Wiedemann Syndrome
Following the discovery of a fetal hepatic tumor, labor was induced at 38 weeks, and a phenotypically normal female was delivered vaginally. A serum alpha-fetoprotein level at birth was 373,170 ng/mL. Postnatal magnetic resonance imaging confirmed a mass in the right lobe of the liver, and a percutaneous core biopsy revealed an epithelial type hepatoblastoma with predominantly embryonal histology. Methylation testing revealed hypomethylation at imprinting center 2, consistent with a diagnosis of Beckwith-Wiedemann syndrome. This case suggests that Beckwith-Wiedemann syndrome testing should be considered in all patie...
Source: Journal of Pediatric Hematology Oncology - October 23, 2020 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
In the article entitled, “The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans” (Volume 190, pages 1397–1413 of the July 2020 issue of The American Journal of Pathology; https://doi.org/10.1016/j.ajpath.2020.0 3.011), there was a copyediting error in the use of tafazzin and the expansion of TAZ. TAZ is the official gene symbol for tafazzin (transcriptional coactivator with PDZ-binding motif) however it is also an alias for WW Domain Containing Transcription Regulator 1 (WWTR1). (Source: Americ...
Source: American Journal of Pathology - October 16, 2020 Category: Pathology Tags: Correction Source Type: research
CircRNA CDR1as promotes hepatoblastoma proliferation and stemness by acting as a miR-7-5p sponge to upregulate KLF4 expression.
Abstract Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear. We found that the circRNA, CDR1as, was highly expressed in CSC-enriched populations of HB cell lines. Results from flow cytometric and sphere-forming assays revealed that CDR1as knockdown in HB cell lines decreased the proportion of stem cells. The Cell Counting Kit-8 (CCK-8) assay, colony ...
Source: Aging - October 14, 2020 Category: Biomedical Science Authors: Chen L, Shi J, Wu Y, Qiu R, Zeng L, Lou L, Su J, Liao M, Deng X Tags: Aging (Albany NY) Source Type: research
Identification of potential key genes and miRNAs involved in Hepatoblastoma pathogenesis and prognosis.
Abstract Hepatoblastoma (HB) is one of the most common liver malignancies in children, while the molecular basis of the disease is largely unknown. Therefore, this study aims to explore the key genes and molecular mechanisms of the pathogenesis of HB using a bioinformatics approach. The gene expression dataset GSE131329 was used to find differentially expressed genes (DEGs). Functional and enrichment analyses of the DEGs were performed by the EnrichR. Then, the protein-protein interaction (PPI) network of the up-regulated genes was constructed and visualized using STRING database and Cytoscape software, respective...
Source: Journal of Cell Communication and Signaling - October 13, 2020 Category: Molecular Biology Authors: Aghajanzadeh T, Tebbi K, Talkhabi M Tags: J Cell Commun Signal Source Type: research
Successful temporary resection of a ruptured hepatoblastoma without preoperative chemotherapy: A case report presenting a novel surgical strategy
Publication date: Available online 10 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Masaki Horiike, Maya Sogabe, Sinchul Jwa, Sadao Tokimasa, Shoji Kubo (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 11, 2020 Category: Surgery Source Type: research
Immunohistochemical Expression Analysis of EpCAM in Hepatoblastomas
The epithelial cell adhesion molecule (EpCAM) is involved in oncogenesis of hepatoblastomas (HBs). Prior genomic profiling studies showed higher EpCAM expression and worse prognosis in HBs containing primitive histotypes, however, this has not been fully addressed from an immunohistochemical perspective. Our goal is to characterize differential EpCAM immunohistochemistry (EpCAM-IHC) among HBs histotypes. We retrieved 62 HBs from 52 patients. EpCAM-IHC was performed (anti-MOC-31, 1:50 dilution; Cell Marque Corporation, Rocklin, CA) and graded in histotypes using the immunoreactive score. The median age of patients was 2 yea...
Source: Applied Immunohistochemistry and Molecular Morphology - October 1, 2020 Category: Chemistry Tags: Research Articles Source Type: research
Undifferentiated Embryonal Sarcoma of the Liver in the Pediatric Population: A National Cancer Database Analysis
Undifferentiated embryonal sarcoma of the liver (UESL) comprises approximately 10% of all pediatric liver malignancy after hepatoblastoma and hepatocellular carcinoma. We aimed to investigate the clinicopathologic characteristics and outcomes of pediatric UESL in the US during a contemporary era. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 30, 2020 Category: Surgery Authors: Ioannis A. Ziogas, Sophoclis P. Alexopoulos, Christina E. Bailey, Harold (Bo) N. Lovvorn, Irving J. Zamora Tags: Pediatric surgery Source Type: research
PIM Kinase Inhibitor, PIM447, Decreases Oncogenicity and Cancer Cell Stemness in a Human Hepatoblastoma Patient-Derived Xenograft
Despite recent advances, the prognosis for advanced stage hepatoblastoma remains poor, resulting in a desperate need for novel therapies. We have previously shown that Proviral Integration site for Moloney murine leukemia virus (PIM) kinases act as oncoproteins to promote cell survival in hepatoblastoma. In addition, PIM kinases promote the hepatoblastoma cancer stem cell phenotype, which may contribute to chemoresistance. We hypothesized that a novel PIM inhibitor, PIM447, would decrease oncogenicity and cancer cell stemness in a human hepatoblastoma, patient-derived xenograft (PDX) model. (Source: Journal of the American...
Source: Journal of the American College of Surgeons - September 30, 2020 Category: Surgery Authors: Nikita Wadhwani, Raoud Marayati, Colin H. Quinn, Laura V. Bownes, Jamie M. Aye, Jerry E. Stewart, Joseph T. Whitaker, Karina J. Yoon, Elizabeth A. Beierle Tags: Surgical oncology Source Type: research
Hepatocellular Malignant Neoplasm, NOS is a Unique Subtype of Hepatoblastoma Associated with Worse Outcomes
Hepatocellular malignant neoplasms, not otherwise specified (NOS) display histologic features of both hepatoblastoma (HPB) and hepatocellular carcinoma and may be associated with worse outcomes. We compared demographics, tumors characteristics, surgical management, and outcomes in patients with HBP vs those with NOS. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 30, 2020 Category: Surgery Authors: Caroline Lemoine, Riccardo A. Superina Tags: Pediatric Surgery Source Type: research
Sustained Remission After Maintenance Irinotecan in Patient With Multiply Relapsed Hepatoblastoma
Children with recurrent hepatoblastoma have a poor prognosis and limited treatment options. The authors describe a child with metastatic hepatoblastoma who had multiple relapses. He was treated with surgical resection and adjuvant chemotherapy at first relapse. At second relapse, he had progressive disease postresection. He was treated with ifosfamide/carboplatin/etoposide chemotherapy followed by maintenance irinotecan and achieved long-term disease-free survival. Irinotecan as maintenance should be explored in recurrent hepatoblastoma. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - September 29, 2020 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
A Novel Method for Observing Tumor Margin in Hepatoblastoma Based on Microstructure 3D Reconstruction.
Conclusions: Microstructure 3 D reconstruction is feasible for observing the pathological structure of the HB tumor margin. PMID: 32969743 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - September 26, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Stereotactic radiofrequency ablation of a variety of liver masses in children.
CONCLUSIONS: SRFA is an effective minimal-invasive treatment option in pediatric patients with liver tumors of different etiologies. PMID: 32954876 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 22, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Surgical Resection of Hepatoblastoma: Factors Affecting Local Recurrence
Conclusion Extracapsular tumor extension was a significant prognostic factor of local recurrence after surgical resection of HB. R1 margin does not necessarily require a second resection, and it could achieve accepted results when combined with adjuvant platinum-based chemotherapy. However, patients who are not eligible for surgical resection must be transferred for primary transplantation to obtain favorable outcome. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 18, 2020 Category: Surgery Authors: Younes, Alaa Elgendy, Ahmed Fadel, Sayed Romeih, Marwa Elwakeel, Madeeha Salama, Asmaa Azer, Magda Ahmed, Gehad Tags: Original Article Source Type: research
Cancers, Vol. 12, Pages 2668: A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing
s Sanford Simon Hepatoblastoma is the most common childhood liver cancer. Although survival has improved significantly over the past few decades, there remains a group of children with aggressive disease who do not respond to current treatment regimens. There is a critical need for novel models to study aggressive hepatoblastoma as research to find new treatments is hampered by the small number of laboratory models of the disease. Organoids have emerged as robust models for many diseases, including cancer. We have generated and characterized a novel organoid model of aggressive hepatoblastoma directly from freshly re...
Source: Cancers - September 17, 2020 Category: Cancer & Oncology Authors: James A. Saltsman William J. Hammond Nicole J. C. Narayan David Requena Helmuth Gehart Gadi Lalazar Michael P. LaQuaglia Hans Clevers Sanford Simon Tags: Article Source Type: research
Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
k D Abstract 1,2-unsaturated pyrrolizidine alkaloids (PAs) are natural plant constituents comprising more than 600 different structures. A major source of human exposure is thought to be cross-contamination of food, feed and phytomedicines with PA plants. In humans, laboratory and farm animals, certain PAs exert pronounced liver toxicity and can induce malignant liver tumors in rodents. Here, we investigated the cytotoxicity and genotoxicity of eleven PAs belonging to different structural classes. Although all PAs were negative in the fluctuation Ames test in Salmonella, they were cytotoxic and induced micronuclei...
Source: Archives of Toxicology - September 9, 2020 Category: Toxicology Authors: Rutz L, Gao L, Küpper JH, Schrenk D Tags: Arch Toxicol Source Type: research
A Case of Congenital Hepatoblastoma Coexisting with Pulmonary Hypertension.
Conclusion: HBL is an embryonal tumor which can develop early in the intrauterine period. Although the mechanism is not known, it may cause PHT which would affect the prognosis negatively. PMID: 32979909 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - August 31, 2020 Category: Middle East Health Authors: Özdemir ZC, Çakıl Sağlık A, Düzenli Kar Y, Köşger P, Arık D, Tekin AN, Bör Ö Tags: Arch Iran Med Source Type: research
Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway
Conclusion: Huaier extract inhibits proliferation, and induces cell apoptosis and cell cycle arrest via the MEK-ERK pathway in hepatoblastoma cells. Huaier extract may act as a complementary agent for treating hepatoblastoma. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: XU, D.-Q., YUAN, X.-J., HIRAYAMA, M., TOYODA, H. Tags: Experimental Studies Source Type: research
Focal nodular hyperplasia masquerading as malignancy in an infant with elevated alpha-fetoprotein: A case report with literature review
We describe a unique case of focal nodular hyperplasia (FNH) in a 6-month-old-girl with elevated alpha-fetoprotein (AFP). Given the patient's age and elevated AFP, a diagnosis of hepatoblastoma was presumed. However, the histopathologic assessment of the lesion was typical for focal nodular hyperplasia. This was further corroborated using hepatobiliary contrast agent to exclude the possibility of a collision or a composite liver tumor. (Source: Clinical Imaging)
Source: Clinical Imaging - August 25, 2020 Category: Radiology Authors: Hassan Aboughalia, Karen M. Chisholm, Ramesh S. Iyer Tags: Pediatric Radiology Source Type: research
Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis
ConclusionThis report shows that it is feasible to measure AUCs for both drugs and to individualize the dose of these drugs according to the PK results and clinical parameters. Our advice for future cases would be to calculate the starting dose of carboplatin using the (pediatric) Calvert formula, assuming a dialytic clearance of zero, and to adjust the dose if required, based on therapeutic drug monitoring. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - August 19, 2020 Category: Cancer & Oncology Source Type: research
Hepatic resection using clamp-crush technique for pediatric hepatoblastoma
Publication date: October 2020Source: Journal of Pediatric Surgery Case Reports, Volume 61Author(s): Shabrina Rizky Putri, Asri D. Rachmawati, Ahmad Yani, Adianto Nugroho (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - August 18, 2020 Category: Surgery Source Type: research
Cancers, Vol. 12, Pages 2294: SP8 Promotes an Aggressive Phenotype in Hepatoblastoma via FGF8 Activation
einitz Kappler Hepatoblastoma (HB) is the most common malignant liver tumor in childhood and it generally has a good prognosis. However, if associated with aggressive metastatic disease, outcome is still poor. The molecular mechanisms leading to metastatic spread in HB patients are still unknown. By combining RNA-sequencing and a genome-wide methylome analysis, we identified the transcription factor SP8 and the growth factor FGF8 among the most strongly upregulated genes in metastatic HB cases, with a concomitant robust demethylation of the respective promoter regions. Of note, high expression of both candidates was...
Source: Cancers - August 14, 2020 Category: Cancer & Oncology Authors: Wagner Schwarzmayr H äberle Vokuhl Schmid Schweinitz Kappler Tags: Article Source Type: research
Liver Transplant for Posthepatectomy Liver Failure in Hepatoblastoma.
CONCLUSIONS: When the predictive remnant liver volume by computed tomography-volumetry before extended hepatectomy for patients with hepatoblastoma is less than 40%, the possibility of posthepatectomy liver failure should be recognized. PMID: 32799783 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 14, 2020 Category: Transplant Surgery Authors: Hirata Y, Sanada Y, Omameuda T, Katano T, Miyahara G, Yamada N, Okada N, Onishi Y, Sakuma Y, Sata N Tags: Exp Clin Transplant Source Type: research
Corrigendum to "Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1" [Biomed. Pharmacother. 101 (2018) 14-23].
Corrigendum to "Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1" [Biomed. Pharmacother. 101 (2018) 14-23]. Biomed Pharmacother. 2020 Aug 12;:110598 Authors: Zhang Z, Liu F, Yang F, Liu Y PMID: 32800378 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 11, 2020 Category: Drugs & Pharmacology Authors: Zhang Z, Liu F, Yang F, Liu Y Tags: Biomed Pharmacother Source Type: research
DNA methylation in Hepatoblastoma-a literature review
Hepatoblastoma (HB) is the most common malignant liver tumor in children. Abnormal activation of the Wnt/ β-catenin signaling pathway plays an important role in the formation and development of HB. Genes in HB ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - August 5, 2020 Category: Pediatrics Authors: Gang Shen, Hongyu Shen, Jing Zhang, Qingtao Yan and Huixian Liu Tags: Review Source Type: research
DNA methylation in Hepatoblastoma-a literature review
This article reviews the hypermethylation changes in several TSGs, such as RASSF1A , SOCS1, APC, HHIP, and P16, and analyzes the pathways and mechanisms of TSGs regulating gene expression. The role of the methylation-regulating enzymes DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) family members enzymes in the methylation changes of HB was analyzed, and it was speculated that the occurrence of HB is partly due to the obstruction of liver differentiation in the early stage of differentiation. The origin cells may be incompletely differentiated hepatocytes remaining in the liver of children after birth. T...
Source: Italian Journal of Pediatrics - August 4, 2020 Category: Pediatrics Source Type: research
The peptide encoded by a novel putative lncRNA HBVPTPAP inducing the apoptosis of hepatocellular carcinoma cells by modulating JAK/STAT signaling pathways.
Abstract When the hepatitis B virus (HBV) enters target cells, there are complex trans-regulatory mechanisms involved in the interactions between the virus and the target cells. In the present study, a new gene screened from the hepatoblastoma cell line HepG2 using suppression subtractive hybridization, referred to as lncRNA HBVPTPAP, was used to study the trans-regulation of HBV DNA polymerase. According to the structural characteristics of the full-length sequences, it was classified as long non-coding RNA. However, a unique and complete open reading frame (ORF) was still present. Therefore, to further identify ...
Source: Virus Research - August 1, 2020 Category: Virology Authors: Lun YZ, Pan ZP, Liu SA, Sun J, Han M, Liu B, Dong W, Pan LH, Cheng J Tags: Virus Res Source Type: research
Computed tomography imaging and clinical features of congenital hepatoblastoma: A retrospective analysis
Congenital hepatoblastoma (CHB) is the most common hepatic malignant tumor of fetus or neonates, but few studies focusing on the radiological characteristics of CHB have been reported to date. To investigate the characteristic clinical and computed tomography (CT) findings of CHB to facilitate recognition and noninvasive diagnosis. Medical records of 7 patients with CHB were retrospectively reviewed. The demographic, clinical, and laboratory data were extracted from the electronic medical records. Two pediatric radiologists evaluated the abdominal CT examinations for the hepatic tumor location, size, enhancement characte...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma
Conclusions: CQ treatment inhibits cell survival in cell models of aggressive HB, presumably by perturbing NAD+ levels, impairing aspartate bioavailability, and inhibiting PARP expression. CQ thus holds potential as a new agent in the management of HB. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - July 16, 2020 Category: Cancer & Oncology Source Type: research
Hepatoblastoma with multiple tumors in a school ‐aged child
Clinicians need to consider hepatoblastoma in the differential even in school ‐aged children or adolescents presenting with multiple liver tumors. AbstractClinicians need to consider hepatoblastoma in the differential even in school ‐aged children or adolescents presenting with multiple liver tumors. (Source: Clinical Case Reports)
Source: Clinical Case Reports - July 16, 2020 Category: General Medicine Authors: Yugo Takaki, Takahiro Yamashita, Natsumi Kataoka, Satomi Yokoyama, Tadashi Anan, Kimitoshi Nakamura, Kazuhiko Yoshimoto, Shintaro Hayashida, Hirotoshi Yamamoto, Taizo Hibi, Masahiro Migita Tags: CLINICAL IMAGE Source Type: research
Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation.
In conclusion, PRDX4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation. It can be adopted as an important marker for HB prognosis and a potential treatment target. PMID: 32655804 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - July 15, 2020 Category: Research Tags: Am J Transl Res Source Type: research
Upregulation of human endogenous retrovirus-K (HML-2) mRNAs in hepatoblastoma: Identification of potential new immunotherapeutic targets and biomarkers
Hepatoblastoma is the most common liver malignancy in children. In order to advance therapy against hepatoblastoma, novel immunologic targets and biomarkers are needed. Our purpose in this investigation is to examine hepatoblastoma transcriptomes for the expression of a class of genomic elements known as Human Endogenous Retrovirus (HERVs). HERVs are abundant in the human genome and are biologically active elements that have been associated with multiple malignancies and proposed as immunologic targets in a subset of tumors. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - July 14, 2020 Category: Surgery Authors: David F Grabski, Aakrosh Ratan, Laurie R Gray, Stefan Bekiranov, David Rekosh, Marie-Louise Hammarskjold, Sara K Rasmussen Source Type: research
Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.
CONCLUSION: Overall, this meta-analysis has demonstrated for the first time that LINC00673 rs11655237 could increase susceptibility to cancer. PMID: 32650095 [PubMed - as supplied by publisher] (Source: Genomics)
Source: Genomics - July 6, 2020 Category: Genetics & Stem Cells Authors: Li N, Cui Z, Huang D, Gao M, Li S, Song M, Wang Y, Tong L, Yin Z Tags: Genomics Source Type: research
LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children
Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma. To detect the association between LIN28B gene polymorphisms and hepatoblastoma risk in Chinese children, we conducted a five-center case-control study of 275 hepatoblastoma patients and 1018 cancer-free controls. Four potentially functional polymorphisms were genotyped using the Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were u...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhonghua Yang, Yuyao Deng, Keren Zhang, Yuzuo Bai, Jinhong Zhu, Jiao Zhang, Yijuan Xin, Li Li, Jing He, Weilin Wang Tags: Research Paper Source Type: research
YTHDF1 rs6090311 A > G polymorphism reduces Hepatoblastoma risk: Evidence from a seven-center case-control study
In conclusion, our results indicate that the rs6090311 A>G in the YTHDF1 gene is related to decreased hepatoblastoma risk. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhendong Luo, Guoyuan Li, Mi Wang, Jinhong Zhu, Zhonghua Yang, Yong Li, Jiao Zhang, Yijuan Xin, Suhong Li, Li Li, Zhenjian Zhuo, Jing He Tags: Research Paper Source Type: research
Challenges Faced During the Ventilation of a Child With Bronchobiliary Fistula: A Case Report
We present a case report that describes the associated anesthetic challenges that we encountered for the treatment of this pathology. (Source: A&A Case Reports)
Source: A&A Case Reports - July 1, 2020 Category: Anesthesiology Tags: Case Report Source Type: research
Liver biopsy for hepatoblastoma: a single institution ’s experience
ConclusionPercutaneous liver biopsy is safe and effective for diagnosing hepatoblastoma, and its complication rate is very low. Collecting>3 pieces of tissue is preferred.Level of evidenceIII. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - June 24, 2020 Category: Surgery Source Type: research
Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2
Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - June 3, 2020 Category: Cancer & Oncology Authors: Yanfeng Liu, Jianping Song, Yu Liu, Zhipeng Zhou and Xianqiang Wang Tags: Research Source Type: research
18. Two distinct cell lines in one hepatoblastoma tissue block
The patient was a 4 year old male diagnosed with hepatoblastoma. DNA was extracted from paraffin embedded tumor sections and analyzed using the OncoScan CNV assay. Tissue from the same block was independently analyzed on the a targeted DNA hybrid capture NGS platform. Initial microarray results indicated a copy number gain at 1q32.1 (PIK3C2B, MDM4), copy number gains on Chromosome 20 and multiple regions of loss of heterozygosity. In contrast, data from the NGS assay indicated whole chromosome gains of 2, 5, 10 and 17 along with the copy number gain at 1q32.1 (PIK3C2B, MDM4). (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Leslie Grimmett, Joanna Plunkitt, Tamara Restrepo, Alanna Church, Sanda Alexandrescu, Marian Harris Source Type: research
Precocious pseudopuberty, a paraneoplastic manifestation: a report of 2 cases.
We describe 2 young children with β-hCG-secreting tumors presenting with signs of pubertal activation. In the first patient, a 16-month-old boy with hepatoblastoma, only initial signs of PPP at presentation were identifiable, with concomitant high levels of β-hCG. Although the tumor had good response to therapy, β-hCG levels were fluctuant until the tumor was resected surgically. The second patient, an 18-month-old boy with intracranial germ cell tumor, presented with clear signs of pubertal activation and genitalia enlargement with no initial alteration of sex hormones. In both cases, the oncologic response...
Source: Tumori - May 30, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research
Mesohepatectomy for recurrent hepatoblastoma in a nine year old boy
Publication date: Available online 28 May 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Fadi Rayya (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - May 30, 2020 Category: Surgery Source Type: research
GSE151347 SP8 promotes an aggressive phenotype in hepatoblastoma via FGF8 activation
Contributor : Roland KapplerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: Despite an overall good outcome of hepatoblastoma patients, prognosis is still poor if associated with metastatic disease. Transcriptomic profiling enables a global view on deregulated cellular pathways. The goal of this study was to compare RNAseq data of metastasized and non-metastasized specimens to identify new molecular players for high-risk hepatoblastoma patients. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 29, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cost-effectiveness Analysis of Screening Extremely Low Birthweight Children for Hepatoblastoma Using Serum Alpha-fetoprotein
To evaluate the cost-effectiveness of screening children born at extremely low birth weight (ELBW) for hepatoblastoma using serial serum alpha-fetoprotein (AFP) measurements. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 25, 2020 Category: Pediatrics Authors: Rebecca MacDonell-Yilmaz, Kelly Anderson, Bradley DeNardo, Philippa Sprinz, William V. Padula Tags: Original Articles Source Type: research
New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulata.
Abstract Biotransformation of ent-kaur-16-en-19-oic acid using fungus Cunninghamella echinulata resulted in two novel hydroxylated metabolites together with five known compounds. Their structures were elucidated by means of extensive NMR and HR-ESI-MS data analysis. The eight compounds were measured for their cytotoxicity against the human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines. Seven compounds showed no cytotoxicity to the two cell lines. One compound displayed moderate cytotoxicity against HepG-2 and MCF-7 with the IC50 values of 12.6 and 27.1 μM, respectively. PMID: 3245...
Source: Chemistry and Biodiversity - May 25, 2020 Category: Biochemistry Authors: Song C, Liu J, Wang H, Li X, Liu B, Zhang M, Shan X, Li H, Gao J, Qin J Tags: Chem Biodivers Source Type: research
Cost-effectiveness Analysis of Screening Extremely Low Birth Weight Children for Hepatoblastoma Using Serum Alpha-fetoprotein
To evaluate the cost-effectiveness of screening children born at extremely low birth weight (ELBW) for hepatoblastoma using serial serum alpha-fetoprotein measurements. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 25, 2020 Category: Pediatrics Authors: Rebecca MacDonell-Yilmaz, Kelly Anderson, Bradley DeNardo, Philippa Sprinz, William V. Padula Tags: Original Articles Source Type: research
The association of hepatoblastoma, prematurity and cerebral palsy: Case reports.
CONCLUSIONS: Hepatoblastoma is the most common primary liver tumor in children and has an increased incidence in children with a history of prematurity and very low birth weight. Providers who frequently care for the very low birth weight and premature children with CP should be aware of this correlation and include hepatoblastoma in the differential when managing patients with suddenly worsening constipation or abdominal distension. Pediatric physiatrists and other providers for these patients could be a source of referrals and diagnosis leading to timely treatment. PMID: 32444576 [PubMed - as supplied by publisher] (...
Source: Journal of Pediatric Rehabilitation Medicine - May 25, 2020 Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference
Liver transplantation (LT) for unresectable colorectal liver metastases has long been abandoned because of dismal prognoses. After the dark ages, advances in chemotherapy and diagnostic imaging have enabled strict patient selection, and the pioneering study from the Oslo group has contributed to the substantial progress in this field. For unresectable neuroendocrine liver metastases, LT for patients who met the Milan criteria was able to achieve excellent long-term outcomes. The guidelines further adopted in the United States and Europe were based on these criteria. For hepatoblastoma, patients with unresectable and border...
Source: Transplantation - May 22, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research
Metabolomics study of the metabolic changes in hepatoblastoma cells in response to NTCP/SLC10A1 overexpression.
In this study, we found that NTCP (SLC10A1) expression was downregulated in HB cells and tissues, and it was demonstrated that NTCP (SLC10A1) reduced cell viability, promoted cell cycle arrest and induced apoptosis of HB cells. The metabolic profiles of HB cells with NTCP (SLC10A1) overexpression were further examined to determine their biochemical alterations and deepen our understanding on the metabolic regulation of NTCP (SLC10A1) overexpression. The metabolomics study based on ultra performance liquid chromatography-mass spectrometry revealed alterations in the metabolites of HB cells following NTCP (SLC10A1) overexpre...
Source: The International Journal of Biochemistry and Cell Biology - May 21, 2020 Category: Biochemistry Authors: Wang J, Tian R, Shan Y, Li J, Gao H, Xie C, Ma Y, Wu Y, Ji B, Gu S, Xu M Tags: Int J Biochem Cell Biol Source Type: research
Intracellular localization of beta-catenin expression plays a possible prognostic role on the outcome of hepatoblastoma patients
ConclusionAlthough the numbers are limited in our series, the intracellular localization of BC expression has been found to be a promising determining factor for hepatoblastoma prognosis. With larger patient series, more reliable results can be achieved. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - May 19, 2020 Category: Surgery Source Type: research
Feasibility of Nonanatomical Liver Resection in Diligently Selected Patients with Hepatoblastoma and Comparison of Outcomes with Anatomic Resection
Conclusion NAR is feasible with clear margins in carefully selected patients. It is not associated with more complications and outcomes are not inferior to AR. NAR is associated with lesser blood loss and operative time. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 17, 2020 Category: Surgery Authors: Qureshi, Sajid S. Kembhavi, Seema A. Kazi, Mufaddal Smriti, Vasundhara Baheti, Akshay Vora, Tushar Chinnaswamy, Girish Prasad, Maya Amin, Nayana Ramadwar, Mukta Khanna, Nehal Laskar, Sidharth Tags: Original Article Source Type: research
Histopathologic correlation with 68Ga PSMA PET/CT in Non Prostate Tumors.
Conclusions: Of the solid tumors and metastatic sites evaluated, a high detection rate was observed (39/47 non-prostatic tumors showed focal uptake). These findings correlate with the series of cases reported in the literature. Although our population has heterogeneous diagnoses, renal tumors showed greater avidity of the radiotracer. With these findings, the expression of PSMA in a variety of non-prostatic malignancies, gives us the potential theragnostic application. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Vargas, J., Garcia Perez, F., Gomez, E., Pitalua, Q., Ornelas, M., Ignacio, E., Campuzano, M., Lemus, F. Tags: PSMA and DCFPyL Source Type: research