Alternative splicing of lncRNAs from SNHG family alters snoRNA expression and induces chemoresistance in hepatoblastoma
CONCLUSIONS: Our findings revealed the role of intron retention in regulating snoRNA expression in hepatoblastoma, explained detailed regulatory mechanism between PABPN1 and the intron retention of SNHG RNAs, and provided insight into the development of new HB treatment options.PMID:37478905 | DOI:10.1016/j.jcmgh.2023.07.007 (Source: Molecular Medicine)
Source: Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Ni Zhen Jiabei Zhu Siwei Mao Qi Zhang Song Gu Ji Ma Yue Zhang Minzhi Yin Haojie Li Nan Huang Han Wu Fenyong Sun Binwu Ying Lin Zhou Qiuhui Pan Source Type: research
MRI-based deep learning model for differentiation of hepatic hemangioma and hepatoblastoma in early infancy
Conclusion: The MRI-based integrated model, a noninvasive preoperative diagnostic tool, yielded favorable efficacy for differentiating HH and HBL in early infancy, which might reduce the patients ’ costs of repetitive and unnecessary examinations or over-treatment.Trial registration: ClinicalTrials.gov Identifier: NCT05170282.What is Known:• Hepatic hemangioma (HH) and hepatoblastoma (HBL) are common pediatric liver tumors and present with similar clinical manifestations with limited distinguishing value of serum AFP in early infancy.• Considering the rare incidence of infantile hepatic tumors, the distinguishing...
Source: European Journal of Pediatrics - July 18, 2023 Category: Pediatrics Source Type: research
Protocol to dissociate and isolate wide-diversity single cells by density gradient centrifugation from human hepatoblastoma tissue
We describe steps for tissue processing, enzymatic digestion, Percoll density gradient separation, cell lysis, cell suspension quality control, and scRNA library construction. We then detail sequencing and data analysis. This protocol is applicable to preparing single-cell suspensions from other human liver tissue samples.PMID:37459235 | DOI:10.1016/j.xpro.2023.102449 (Source: Cancer Control)
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Xianchao Zhou Mei Meng Yifan Wu Rui Gao Yuhua Shan Song Gu Jian He Source Type: research
Anabolic ‐androgenic anabolic steroids as a probable risk factor for hepatoblastoma in infants
Key Clinical MessageThe etiology of hepatoblastoma (HB) is still unknown; several risk factors have been identified. The only risk factor for the development of HB in presented case was the child's father using anabolic androgenic steroids. It may be a risk factor for developing HB in their children.AbstractHB is the most common primary liver cancer in children. Its etiology is still unclear. The patient's father's use of androgenic anabolic steroids could be a risk factor for developing HB in his child. A 14-month-old girl was hospitalized with intermittent fever, severe abdominal distention, and anorexia. On initial exam...
Source: Clinical Case Reports - July 10, 2023 Category: General Medicine Authors: Armen Malekiantaghi,
Hosein Shabani ‐Mirzaee,
MohammadAli Ehsani,
Kambiz Eftekhari Tags: CASE REPORT Source Type: research
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Biochimica et Biophysica Acta - July 10, 2023 Category: Biochemistry Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Mol Biol Cell - July 10, 2023 Category: Molecular Biology Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Molecular Medicine - July 10, 2023 Category: Molecular Biology Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Biochimica et Biophysica Acta - July 10, 2023 Category: Biochemistry Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Mol Biol Cell - July 10, 2023 Category: Molecular Biology Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11: 2186-2197
FEBS Open Bio. 2023 Aug;13(8):1540. doi: 10.1002/2211-5463.13664. Epub 2023 Jul 6.ABSTRACThttps://doi.org/10.1002/2211-5463.13221 The above article, published online on 08 June 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-9]. Thus, the editors c...
Source: Genetics and Molecular Research - July 6, 2023 Category: Genetics & Stem Cells Source Type: research
