2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
Whole-genome Sequencing and RNA Sequencing Analysis Reveals Novel Risk Genes and Differential Expression Patterns in Hepatoblastoma
Gene. 2023 Nov 14:147991. doi: 10.1016/j.gene.2023.147991. Online ahead of print.ABSTRACTHepatoblastoma (HB) is an uncommon malignant liver cancer primarily affecting infants and children, characterized by the presence of tissue that resembling fetal hepatocytes, mature liver cells or bile duct cells. The primary symptom in affected children is abdominal lumps. HB constitutes approximately 28% of all liver tumors and two-thirds of liver malignancies in the pediatric and adolescent population. Despite its high prevalence, the underlying mechanism of HB pathogenesis remain largely unknown. To reveal the genetic alternations ...
Source: Gene - November 16, 2023 Category: Genetics & Stem Cells Authors: Wuqian Wang Na Zhang Luan Chen Xianglong Zhao Yuhua Shan Fan Yang Bo Wang Hongxiang Gao Min Xu Ping Tang Shengying Qin Song Gu Source Type: research
Whole-genome Sequencing and RNA Sequencing Analysis Reveals Novel Risk Genes and Differential Expression Patterns in Hepatoblastoma
Gene. 2023 Nov 14:147991. doi: 10.1016/j.gene.2023.147991. Online ahead of print.ABSTRACTHepatoblastoma (HB) is an uncommon malignant liver cancer primarily affecting infants and children, characterized by the presence of tissue that resembling fetal hepatocytes, mature liver cells or bile duct cells. The primary symptom in affected children is abdominal lumps. HB constitutes approximately 28% of all liver tumors and two-thirds of liver malignancies in the pediatric and adolescent population. Despite its high prevalence, the underlying mechanism of HB pathogenesis remain largely unknown. To reveal the genetic alternations ...
Source: Gene - November 16, 2023 Category: Genetics & Stem Cells Authors: Wuqian Wang Na Zhang Luan Chen Xianglong Zhao Yuhua Shan Fan Yang Bo Wang Hongxiang Gao Min Xu Ping Tang Shengying Qin Song Gu Source Type: research
GSE235202 EZH2 is a key component of Hepatoblastoma tumor cell growth
Contributors : Kathryn Glaser ; Rebekah KarnsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo understand molecular mechanisms driving HB pathogenesis, we hypothesize that pathologic activation of Enhancer of Zeste Homolog 2 contributes to hepatoblastoma propagation. Here we demonstrate that EZH2 promotes proliferation in HB cell lines through interaction with β-catenin, the most frequently mutated gene in HB. We demonstrate that canonical and noncanonical EZH2 signaling occur in HB tumor cells, likely driven by aberrant EZH2 expression. We use comparison groups of liver cancer, h...
Source: GEO: Gene Expression Omnibus - November 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy
ConclusionsThis study demonstrates that PRETEXT IV staging is an independent predictor of relapsed disease. The most common relapsed histology was epithelial, suggesting a potential selection or resistance of this component. Surgical resection is a critical component of multimodal therapy for relapsed HB. (Source: Cancer Medicine)
Source: Cancer Medicine - November 14, 2023 Category: Cancer & Oncology Authors: Andres F. Espinoza,
Kalyani R. Patel,
Priya B. Shetty,
Richard S. Whitlock,
Pavel Sumazin,
Xinjian Yu,
Stephen F. Sarabia,
Martin Urbicain,
Andras Heczey,
Prakash Masand,
Sarah E. Woodfield,
Dolores H. L ópez‐Terrada,
Sanjeev A. Vasudevan Tags: RESEARCH ARTICLE Source Type: research
SGLT2 is upregulated to acquire cisplatin resistance and SGLT2 inhibition reduces cisplatin resistance in hepatoblastoma
ConclusionsCisplatin-resistant hepatoblastoma cells exhibited upregulated SGLT2 expression and activated glucose uptake to survive under cisplatin stress. SGLT2 inhibition decreased cellular resistance to cisplatin. SGLT2 inhibition with cisplatin therapy could be a novel therapeutic strategy for cisplatin-resistant hepatoblastoma patients. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - November 6, 2023 Category: Gastroenterology Authors: Sunao Fujiyoshi,
Shohei Honda,
Momoko Ara,
Takafumi Kondo,
Nozomi Kobayashi,
Akinobu Taketomi Tags: ORIGINAL ARTICLE Source Type: research
