Alternative splicing of lncRNAs from SNHG family alters snoRNA expression and induces chemoresistance in hepatoblastoma

CONCLUSIONS: Our findings revealed the role of intron retention in regulating snoRNA expression in hepatoblastoma, explained detailed regulatory mechanism between PABPN1 and the intron retention of SNHG RNAs, and provided insight into the development of new HB treatment options.PMID:37478905 | DOI:10.1016/j.jcmgh.2023.07.007

Source: Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Ni Zhen Jiabei Zhu Siwei Mao Qi Zhang Song Gu Ji Ma Yue Zhang Minzhi Yin Haojie Li Nan Huang Han Wu Fenyong Sun Binwu Ying Lin Zhou Qiuhui Pan Source Type: research