B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults
Conditions: Pediatric Solid Tumor; Germ Cell Tumor; Retinoblastoma; Hepatoblastoma; Wilms Tumor; Rhabdoid Tumor; Carcinoma; Osteosarcoma; Ewing Sarcoma; Rhabdomyosarcoma; Synovial Sarcoma; Clear Cell Sarcoma; Malignant Peripheral Nerve Sheath Tumors; Desm oplastic Small Round Cell Tumor; Soft Tissue Sarcoma; Neuroblastoma; Melanoma Interventions: Biological: second generation 4-1BBζ B7H3-EGFRt-DH...
Source: ClinicalTrials.gov - July 23, 2020 Category: Research Source Type: clinical trials
A Randomized Multi-institutional Study of Sodium Thiosulfate as Auditory Protection for Children With Hepatoblastoma
Condition: Hepatoblastoma Intervention: Drug: Sodium Thiosulfate Injection Sponsors: Shanghai Children's Medical Center; Children's Hospital of Fudan University; Shanghai Children's Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 20, 2020 Category: Research Source Type: clinical trials
Flavored, Oral Irinotecan (VAL-413) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
Conditions: Solid Tumors; Neuroblastoma; Rhabdomyosarcoma; Ewing Sarcoma; Hepatoblastoma; Medulloblastoma Interventions: Drug: VAL-413; Drug: Temozolomide Sponsor: Valent Technologies, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 7, 2020 Category: Research Source Type: clinical trials
Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Recurrent Ependymoma; Recurrent Ewing Sarcoma; Recurrent Hepatoblastoma; Recurrent Histiocytic and Dendritic Cell Neoplasm; Recurrent Langerhans Cell Histiocytosis; Recurrent Lymphoma; Recurrent Malignant Germ Cel l Tumor; Recurrent Malignant Glioma; Recurrent Malignant Solid Neoplasm; Recurrent Medulloblastoma; Recurrent Neuroblastoma; Recurr...
Source: ClinicalTrials.gov - March 25, 2020 Category: Research Source Type: clinical trials
Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors
Conditions: Hepatoblastoma; Hepatocellular Carcinoma; Rhabdoid Tumor of Liver; Undifferentiated (Embryonal) Sarcoma of the Liver; Pediatric Liver Cancer; Liver Tumors Interventions: Behavioral: Quality of Life Assessment; Radiation: Transarterial Radioembolization Sponsors: Nemours Children's Clinic; Alfred I. duPont Hospital for Children Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2020 Category: Research Source Type: clinical trials