An update on diagnosis and treatment of hepatoblastoma
Biosci Trends. 2024 Jan 30;17(6):445-457. doi: 10.5582/bst.2023.01311. Epub 2023 Dec 23.ABSTRACTHepatoblastoma (HB) remains the most common paediatric liver tumour and survival in children with hepatoblastoma has improved considerably since the advent of sequential surgical regimens of chemotherapy based on platinum-based chemotherapeutic agents in the 1980s. With the advent of modern diagnostic imaging and pathology techniques, new preoperative chemotherapy regimens and the maturation of surgical techniques, new diagnostic and treatment options for patients with hepatoblastoma have emerged and international collaborations...
Source: BioScience Trends - December 24, 2023 Category: Biomedical Science Authors: Yinbiao Cao Shurui Wu Haowen Tang Source Type: research
Cancers, Vol. 16, Pages 38: Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children & mdash;A Single-Centre Experience
Conclusions: From the available literature and data presented here, we propose that (bi)segmentectomy can become a viable surgical option in carefully selected paediatric patients and is sufficient to achieve a cure. Further studies evaluating the impact of parenchymal preservation surgery on surgical and oncological outcome should be conducted with a larger dataset. (Source: Cancers)
Source: Cancers - December 20, 2023 Category: Cancer & Oncology Authors: Maciej Murawski Hanna Garnier Joanna Stefanowicz Katarzyna Sinacka Ewa Izycka-Swieszewska Malgorzata Sawicka-Zukowska Pawel Wawrykow Grazyna Wrobel Agnieszka Mizia-Malarz Patrycja Marciniak-Stepak Piotr Czauderna Tags: Article Source Type: research
Nutritional status associated with clinical outcomes in children with solid tumors: A retrospective cohort study from China
ConclusionThere is a considerable prevalence of malnutrition in children with solid tumors. Malnutrition is related to adverse clinical outcomes and increases in total hospital expenses and antibiotic costs. (Source: Cancer Medicine)
Source: Cancer Medicine - December 19, 2023 Category: Cancer & Oncology Authors: Yongzhen Li,
Zhongying Lu,
Ao Ma,
Wei Yao,
Rui Dong,
Kai Li,
Min Wu,
Kuiran Dong,
Tian Qian Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 16, Pages 12: Quantitative ctDNA Detection in Hepatoblastoma: Implications for Precision Medicine
in
Jonathan Karpelowsky
Hepatoblastoma is characterized by driver mutations in CTNNB1, making it an attractive biomarker for a liquid biopsy approach utilizing circulating tumor DNA (ctDNA). This prospective observational study sought to ascertain the feasibility of ctDNA detection in patients with hepatoblastoma and explore its associations with established clinical indicators and biomarkers, including serum Alpha-fetoprotein (AFP). We obtained 38 plasma samples and 17 tumor samples from 20 patients with hepatoblastoma. These samples were collected at various stages: 10 at initial diagnosis, 17 during neoadjuvant ch...
Source: Cancers - December 19, 2023 Category: Cancer & Oncology Authors: Smadar Kahana-Edwin James Torpy Lucy E. Cain Anna Mullins Geoffrey McCowage Sarah E. Woodfield Sanjeev A. Vasudevan Dan P. T. Shea Andre E. Minoche Andres F. Espinoza Sarah Kummerfeld Leonard D. Goldstein Jonathan Karpelowsky Tags: Article Source Type: research
Molecular analysis of the human cytoglobin mRNA isoforms
J Inorg Biochem. 2023 Nov 15;251:112422. doi: 10.1016/j.jinorgbio.2023.112422. Online ahead of print.ABSTRACTMultiple functions have been proposed for the ubiquitously expressed vertebrate globin cytoglobin (Cygb), including nitric oxide (NO) metabolism, lipid peroxidation/signalling, superoxide dismutase activity, reactive oxygen/nitrogen species (RONS) scavenging, regulation of blood pressure, antifibrosis, and both tumour suppressor and oncogenic effects. Since alternative splicing can expand the biological roles of a gene, we investigated whether this mechanism contributes to the functional diversity of Cygb. By mining...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Elena Porto Paraskevi Loula Susanne Strand Thomas Hankeln Source Type: research
Molecular analysis of the human cytoglobin mRNA isoforms
J Inorg Biochem. 2023 Nov 15;251:112422. doi: 10.1016/j.jinorgbio.2023.112422. Online ahead of print.ABSTRACTMultiple functions have been proposed for the ubiquitously expressed vertebrate globin cytoglobin (Cygb), including nitric oxide (NO) metabolism, lipid peroxidation/signalling, superoxide dismutase activity, reactive oxygen/nitrogen species (RONS) scavenging, regulation of blood pressure, antifibrosis, and both tumour suppressor and oncogenic effects. Since alternative splicing can expand the biological roles of a gene, we investigated whether this mechanism contributes to the functional diversity of Cygb. By mining...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Elena Porto Paraskevi Loula Susanne Strand Thomas Hankeln Source Type: research
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
CONCLUSIONS: We applied an ASEE-mediated approach to silence TERT allele specifically. Our results show that the concept of dominant oncogene inactivation by allele-specific epigenome editing can be successfully translated into cancer models. This new strategy may have important advantages in comparison with existing therapeutic approaches, e.g., targeting telomerase, especially with regard to reducing adverse side effects.PMID:37993930 | DOI:10.1186/s13148-023-01599-2 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 23, 2023 Category: Cancer & Oncology Authors: Alexandra G Kouroukli Nivethika Rajaram Pavel Bashtrykov Helene Kretzmer Reiner Siebert Albert Jeltsch Susanne Bens Source Type: research
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
CONCLUSIONS: We applied an ASEE-mediated approach to silence TERT allele specifically. Our results show that the concept of dominant oncogene inactivation by allele-specific epigenome editing can be successfully translated into cancer models. This new strategy may have important advantages in comparison with existing therapeutic approaches, e.g., targeting telomerase, especially with regard to reducing adverse side effects.PMID:37993930 | PMC:PMC10666398 | DOI:10.1186/s13148-023-01599-2 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 23, 2023 Category: Cancer & Oncology Authors: Alexandra G Kouroukli Nivethika Rajaram Pavel Bashtrykov Helene Kretzmer Reiner Siebert Albert Jeltsch Susanne Bens Source Type: research
Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy
ConclusionsThis radiomics-based cluster system may have the potential to facilitate the precise treatment of hepatoblastoma. In addition, this study further demonstrated the feasibility of using unsupervised machine learning in a disease without a proper imaging classification system.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - November 20, 2023 Category: Radiology Source Type: research
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma
CONCLUSIONS: Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.PMID:37975379 | DOI:10.26355/eurrev_202311_34333 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 17, 2023 Category: Drugs & Pharmacology Authors: Y-B Lin S-H Huang S Liu Source Type: research
