Exploring thyroxine binding globulin structural changes and its release from human hepatoblastoma cells upon interaction with silica particles: A prelude to unrevealing the mechanism of thyroid hormone dysregulation
In conclusion, this study implies that SiO2 particles show the potential to result in inhibition of TBG release, TBG denaturation, and interfere with TBG binding affinity which may lead to dysregulation of the thyroid hormone transport and associated signaling pathways.PMID:37567530 | DOI:10.1016/j.ijbiomac.2023.126240 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - August 11, 2023 Category: Biochemistry Authors: Meiqi Wang Yu-Chen Wang Zhou-Lan Bai Yang Sui Detao Yin Hua Yin Source Type: research

Exploring thyroxine binding globulin structural changes and its release from human hepatoblastoma cells upon interaction with silica particles: A prelude to unrevealing the mechanism of thyroid hormone dysregulation
In conclusion, this study implies that SiO2 particles show the potential to result in inhibition of TBG release, TBG denaturation, and interfere with TBG binding affinity which may lead to dysregulation of the thyroid hormone transport and associated signaling pathways.PMID:37567530 | DOI:10.1016/j.ijbiomac.2023.126240 (Source: Mol Biol Cell)
Source: Mol Biol Cell - August 11, 2023 Category: Molecular Biology Authors: Meiqi Wang Yu-Chen Wang Zhou-Lan Bai Yang Sui Detao Yin Hua Yin Source Type: research

Anthropometric Outcomes in Survivors of Pediatric Solid Tumors
Nutr Cancer. 2023 Aug 6:1-8. doi: 10.1080/01635581.2023.2242104. Online ahead of print.ABSTRACTNutritional status is an important aspect of childhood cancer, with a bearing on the disease and subsequent survivorship. We sought to evaluate the long-term anthropometric outcomes in a cohort of pediatric solid tumor survivors treated between 1994 and 2016. Anthropometry was noted at the time of presentation, after completion of therapy, and at the last follow-up. The z-scores for weight-for-age, height-for-age, and BMI-for-age were calculated using WHO growth charts for ages <5 years and the Indian Academy of Pediatrics gro...
Source: Nutrition and Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Mehak Sehgal Vishesh Jain Sandeep Agarwala Anjan Dhua Prabudh Goel Devendra Kumar Yadav Sameer Bakhshi Mani Kalaivani Source Type: research

Anthropometric Outcomes in Survivors of Pediatric Solid Tumors
Nutr Cancer. 2023 Aug 6:1-8. doi: 10.1080/01635581.2023.2242104. Online ahead of print.ABSTRACTNutritional status is an important aspect of childhood cancer, with a bearing on the disease and subsequent survivorship. We sought to evaluate the long-term anthropometric outcomes in a cohort of pediatric solid tumor survivors treated between 1994 and 2016. Anthropometry was noted at the time of presentation, after completion of therapy, and at the last follow-up. The z-scores for weight-for-age, height-for-age, and BMI-for-age were calculated using WHO growth charts for ages <5 years and the Indian Academy of Pediatrics gro...
Source: Nutrition and Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Mehak Sehgal Vishesh Jain Sandeep Agarwala Anjan Dhua Prabudh Goel Devendra Kumar Yadav Sameer Bakhshi Mani Kalaivani Source Type: research

< em > TRMT61B < /em > rs4563180 G & gt;C variant reduces hepatoblastoma risk: a case-control study of seven medical centers
This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the TRMT61B rs4563180 G>C polymorphism among germline DNA samples from 313 cases and 1446 controls. The association of the rs4563180 G>C polymorphism with hepatoblastoma risk was estimated based on odds ratios (ORs) and 95% confidence intervals (CIs). We found that the TRMT61B rs4563180 G>C polymorphism correlated significantly with a reduction in hepatoblastoma risk (GC vs. GG: adjusted OR=0.65, 95% CI=0.49-0.85, P=0.002; GC/CC vs. GG: adjusted OR=0.66, 95% CI=0.51-0.85, P=0.002). In stratif...
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Dingyuan Zeng Jinhong Zhu Jingjing Li Fan Liao Zhonghua Yang Yong Li Jiao Zhang Jiwen Cheng Suhong Li Li Li Jing He Source Type: research

< em > TRMT61B < /em > rs4563180 G & gt;C variant reduces hepatoblastoma risk: a case-control study of seven medical centers
This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the TRMT61B rs4563180 G>C polymorphism among germline DNA samples from 313 cases and 1446 controls. The association of the rs4563180 G>C polymorphism with hepatoblastoma risk was estimated based on odds ratios (ORs) and 95% confidence intervals (CIs). We found that the TRMT61B rs4563180 G>C polymorphism correlated significantly with a reduction in hepatoblastoma risk (GC vs. GG: adjusted OR=0.65, 95% CI=0.49-0.85, P=0.002; GC/CC vs. GG: adjusted OR=0.66, 95% CI=0.51-0.85, P=0.002). In stratif...
Source: Aging - August 2, 2023 Category: Biomedical Science Authors: Dingyuan Zeng Jinhong Zhu Jingjing Li Fan Liao Zhonghua Yang Yong Li Jiao Zhang Jiwen Cheng Suhong Li Li Li Jing He Source Type: research

Genes, Vol. 14, Pages 1575: Correction: Li et al. m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK. Genes 2021, 12, 1747
n Fenyong Sun In the original publication [...] (Source: Genes)
Source: Genes - August 1, 2023 Category: Genetics & Stem Cells Authors: Guohui Li Liang Deng Nan Huang Zhongqi Cui Qi Wu Ji Ma Qiuhui Pan Fenyong Sun Tags: Correction Source Type: research

Cancers, Vol. 15, Pages 3921: Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience
Conclusions: Retreatment with cisplatin at the time of relapse may provide an advantage for some patients with hepatoblastoma. Multiply relapsed disease was not uncommon and not associated with a worse prognosis. Careful attention should be paid to cumulative therapy-induced toxicity while concurrently aiming to improve cure. (Source: Cancers)
Source: Cancers - August 1, 2023 Category: Cancer & Oncology Authors: Katherine M. Somers Rachel Bernstein Tabbouche Alexander Bondoc Alexander J. Towbin Sarangarajan Ranganathan Greg Tiao James I. Geller Tags: Article Source Type: research

Alternative splicing of lncRNAs from SNHG family alters snoRNA expression and induces chemoresistance in hepatoblastoma
CONCLUSIONS: Our findings revealed the role of intron retention in regulating snoRNA expression in hepatoblastoma, explained detailed regulatory mechanism between PABPN1 and the intron retention of SNHG RNAs, and provided insight into the development of new HB treatment options.PMID:37478905 | DOI:10.1016/j.jcmgh.2023.07.007 (Source: Molecular Medicine)
Source: Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Ni Zhen Jiabei Zhu Siwei Mao Qi Zhang Song Gu Ji Ma Yue Zhang Minzhi Yin Haojie Li Nan Huang Han Wu Fenyong Sun Binwu Ying Lin Zhou Qiuhui Pan Source Type: research

MRI-based deep learning model for differentiation of hepatic hemangioma and hepatoblastoma in early infancy
Conclusion:  The MRI-based integrated model, a noninvasive preoperative diagnostic tool, yielded favorable efficacy for differentiating HH and HBL in early infancy, which might reduce the patients ’ costs of repetitive and unnecessary examinations or over-treatment.Trial registration: ClinicalTrials.gov Identifier: NCT05170282.What is Known:• Hepatic hemangioma (HH) and hepatoblastoma (HBL) are common pediatric liver tumors and present with similar clinical manifestations with limited distinguishing value of serum AFP in early infancy.• Considering the rare incidence of infantile hepatic tumors, the distinguishing...
Source: European Journal of Pediatrics - July 18, 2023 Category: Pediatrics Source Type: research

Protocol to dissociate and isolate wide-diversity single cells by density gradient centrifugation from human hepatoblastoma tissue
We describe steps for tissue processing, enzymatic digestion, Percoll density gradient separation, cell lysis, cell suspension quality control, and scRNA library construction. We then detail sequencing and data analysis. This protocol is applicable to preparing single-cell suspensions from other human liver tissue samples.PMID:37459235 | DOI:10.1016/j.xpro.2023.102449 (Source: Cancer Control)
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Xianchao Zhou Mei Meng Yifan Wu Rui Gao Yuhua Shan Song Gu Jian He Source Type: research

Anabolic ‐androgenic anabolic steroids as a probable risk factor for hepatoblastoma in infants
Key Clinical MessageThe etiology of hepatoblastoma (HB) is still unknown; several risk factors have been identified. The only risk factor for the development of HB in presented case was the child's father using anabolic androgenic steroids. It may be a risk factor for developing HB in their children.AbstractHB is the most common primary liver cancer in children. Its etiology is still unclear. The patient's father's use of androgenic anabolic steroids could be a risk factor for developing HB in his child. A 14-month-old girl was hospitalized with intermittent fever, severe abdominal distention, and anorexia. On initial exam...
Source: Clinical Case Reports - July 10, 2023 Category: General Medicine Authors: Armen Malekiantaghi, Hosein Shabani ‐Mirzaee, MohammadAli Ehsani, Kambiz Eftekhari Tags: CASE REPORT Source Type: research

Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Biochimica et Biophysica Acta - July 10, 2023 Category: Biochemistry Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research

Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Mol Biol Cell - July 10, 2023 Category: Molecular Biology Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research

Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jul 8:159363. doi: 10.1016/j.bbalip.2023.159363. Online ahead of print.ABSTRACTProtective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist) was investigated. In vivo, after 21 days of fructose rich diet, we determined: glycemia, ins...
Source: Molecular Medicine - July 10, 2023 Category: Molecular Biology Authors: Mar ía Cecilia Castro Hern án Gonzalo Villagarcía Guillermo Schinella Mar ía Laura Massa Flavio Francini Source Type: research