Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients

CONCLUSION: This is the first study evaluating the role of miRNAs in colchicine resistant patients with FMF. Their differential expression may result in resistance to standard colchicine treatment by affecting the expression of genes that take place in drug absorption, distribution, metabolism, and excretion (ADME) or nuclear receptors that regulate ADME genes, thus potentially playing a role in both drug metabolism and inflammation.PMID:37844462 | DOI:10.1016/j.intimp.2023.111011
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research