Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial, The Lancet Respiratory Medicine
In patients ≥40 with Covid-19 and ≥1 high-risk characteristic (n=4488), colchicine (0.5mg twice daily for 3 days, then once daily for 27 days) was not associated with a statistically significant reduction in death or Covid-19 hospital admission (4.7% v 5.8% placebo; p=0.081). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2021 Category: Consumer Health News Source Type: news

Managing COVID-19 [NG191], NICE (updated 27th May 2021)
New recommendations have been added on colchicine to treat COVID-19 and existing recommendations on remdesivir for COVID-19 pneumonia have been updated. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 28, 2021 Category: Consumer Health News Source Type: news

Results of the COLCORONA study published in The Lancet Respiratory Medicine
(University of Montreal) Colchicine could be considered as a treatment for non-hospitalized patients diagnosed with COVID-19 by PCR test and at risk of complications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2021 Category: International Medicine & Public Health Source Type: news

Management of severe covid-19: progress and promise, BMJ
This BMJ editorial outlines the current therapeutic approaches noting there is no evidence to support vitamins C and D, zinc, lopinavir-ritonavir, colchicine, interferons, fluvoxamine, ivermectin, and convalescent plasma; and survival benefit only reported with glucocorticoids. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 11, 2021 Category: Consumer Health News Source Type: news

Case report: colchicine toxicokinetic analysis in a poisoned child requiring extracorporeal life support - P érez Marín M, Prod'hom S, de Villiers SF, Ferry T, Amiet V, Natterer J, Perez MH, Buclin T, Chtioui H, Longchamp D.
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine eliminat... (Source: SafetyLit)
Source: SafetyLit - April 28, 2021 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Colchicine for Secondary Prevention in Coronary Disease Colchicine for Secondary Prevention in Coronary Disease
Two new studies provide evidence supporting the cardiovascular benefits of once-daily colchicine in coronary disease.European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2021 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19, Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial
Preliminary analysis found no significant difference in 28-day mortality (20% colchicine vs. 19% usual care alone; risk ratio 1.02 [95% CI 0.94-1.11]; p=0.63). On the advice of the independent Data Monitoring Committee, recruitment to this arm of the study has closed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 9, 2021 Category: Consumer Health News Source Type: news

RECOVERY Trial of COVID Treatments Stops Colchicine Arm RECOVERY Trial of COVID Treatments Stops Colchicine Arm
Recruitment was halted for lack of efficacy in patients hospitalized with the disease.Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - March 5, 2021 Category: Intensive Care Tags: Cardiology News Source Type: news

Scientists will test whether gout drug helps infected adults beat Covid symptoms
Oxford University researchers have begun trials on 30p pill colchicine today to examine whether it can reduce recovery time from Covid and prevent the need for hospital admission. (Source: the Mail online | Health)
Source: the Mail online | Health - March 3, 2021 Category: Consumer Health News Source Type: news

Colchicine in the Management of COVID-19 (SARS-CoV 2) Positive Patients, MHRA
Colchicine should not be used in the management of COVID-19 positive patients other than in the context of a trial, or unless there is an additional licensed indication for its use. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 16, 2021 Category: Consumer Health News Source Type: news

Covid-19 Therapeutic Alert: Colchicine in the Management of COVID-19 (SARS-CoV 2) Positive Patients - Trial Use Only, MHRA (published 12th February 2021)
Colchicine should NOT be used in the management of COVID-19 positive patients other than in the context of a trial, or unless there is an additional licensed indication for its use. Although early trial data is potentially promising, further evaluation of study data is needed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 15, 2021 Category: Consumer Health News Source Type: news

Colchicine Post-MI: Close but No Cigar Colchicine Post-MI: Close but No Cigar
The inflammatory hypothesis of coronary artery disease has gained traction, but prescribing drugs with anti-inflammatory effects has yet to take off. Could recent data on colchicine change that?theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 11, 2021 Category: Consumer Health News Tags: Cardiology Expert Column Source Type: news

ColCORONA: More Questions Than Answers for Colchicine in COVID-19 ColCORONA: More Questions Than Answers for Colchicine in COVID-19
Millions of dollars and thousands of patients later, the phase 3 study highlights the challenges of COVID-19-related preprint studies without peer review.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 8, 2021 Category: Consumer Health News Tags: Cardiology News Source Type: news

Experience sharing on treatment of an acute colchicine poisoning patient - Jiang Q, Li S, Yang Z, Liu F, Wang P, Wang J, Zhao H.
Colchicine is mainly used in the treatment of acute gout attack, acute attack of chronic gout and other diseases in clinic. But the drug has high toxicity (highly toxic), the therapeutic dose is very close to the toxic dose, and there is no special effect ... (Source: SafetyLit)
Source: SafetyLit - February 8, 2021 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Small Study Tests Colchicine for Moderate-to-Severe COVID-19
FRIDAY, Feb. 5, 2021 -- For patients with moderate-to-severe COVID-19, colchicine reduces the length of supplemental oxygen therapy and hospitalization, according to a study published online Feb. 4 in RMD Open. Maria Isabel Lopes, from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 5, 2021 Category: Pharmaceuticals Source Type: news

Little evidence that colchicine benefits COVID-19 patients, Quebec advisory panel finds
Quebec government clinical experts say there isn't enough evidence to recommend widespread use of the popular gout medication to treat COVID-19 patients, dampening hopes the drug could be a short-term tool to reduce hospitalizations and deaths. (Source: CBC | Health)
Source: CBC | Health - February 5, 2021 Category: Consumer Health News Tags: News/Canada/Montreal Source Type: news

Gout can be used to cut hospital times for coronavirus by reducing the need for oxygen therapy
Brazilian researchers found colchicine, which is used to treat gout, helped reduce the need for oxygen therapy by more than a third in hospital coronavirus cases in a 75-patient study. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2021 Category: Consumer Health News Source Type: news

Drug vignettes: Colchicine, CEBM
Colchicine is an alkaloid present in all parts of the autumn crocus, Colchicum autumnale. It has been used therapeutically since the first half of the 19th century. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 4, 2021 Category: Consumer Health News Source Type: news

The Sooner, the Better: Anti-inflammation in Acute MI The Sooner, the Better: Anti-inflammation in Acute MI
Should we be using colchicine in the very early phase of ACS to reduce major coronary events? This commentary explores the benefits and possible caveats.European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2021 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

ColCORONA: Colchicine Reduces Complications in Outpatient COVID-19 ColCORONA: Colchicine Reduces Complications in Outpatient COVID-19
The primary endpoint was not significant in the overall population, but in those with PCR-confirmed COVID, treatment reduced hospitalization, need for ventilation, and death, top-line results show.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 25, 2021 Category: Cancer & Oncology Tags: Cardiology News Source Type: news

Quebec researchers say they have found an effective drug to fight COVID-19
A team of researchers from the Montreal Heart Institute believes they have found an effective weapon against COVID-19: colchicine, an... (Source: Reuters: Health)
Source: Reuters: Health - January 24, 2021 Category: Consumer Health News Source Type: news

Drug treatments for covid-19: living systematic review and network meta-analysis (update), BMJ
Updated review includes results for new interventions (azithromycin, colchicine, interferons, rhG-CSF, tocilizumab) and evidence remdesivir may not reduce mortality or time to symptom resolution; glucocorticoids probably reduce length of ICU stay and increase ventilator-free days BMJ2020; 370 doi: 2 External 0 0 0 https://doi.org/10.1136/bmj.m2980 false https://doi.org/10.1136/bmj.m2980 true false%> (Published 30 July 2020). Cite this as: BMJ 2020;370:m2980. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 21, 2020 Category: Consumer Health News Source Type: news

Colchicine a Case Study for What's Wrong With US Drug Pricing Colchicine a Case Study for What's Wrong With US Drug Pricing
A Medicare/Medicaid analysis shows a prolonged public-spending burden, despite generics available outside the United States for pennies a pill. Meanwhile, use widens from gout to MI, even COVID-19.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - December 2, 2020 Category: Drugs & Pharmacology Tags: Cardiology News Source Type: news

Gout drug Colchicine to be tested as COVID-19 treatment in UK trial, Reuters
The RECOVERY trial, which is world's largest clinical trial of treatments for patients hospitalised with COVID-19, will randomly allocate at least 2,500 patients recruited to receive the anti-inflammatory colchicine, as inflammation is considered to play a major role in COVID-19. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 30, 2020 Category: Consumer Health News Source Type: news

Accidental poisoning with autumn crocus (Colchicum autumnale): a case series - Razinger G, Kozelj G, Gorjup V, Grenc D, Brvar M.
In this study, we retros... (Source: SafetyLit)
Source: SafetyLit - November 11, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

ESC 2020 Highlights: Drugs Old and New ESC 2020 Highlights: Drugs Old and New
Top trials from the virtual ESC 2020 featured old drugs such as aspirin and colchicine as well as the new SGLT2 inhibitors.theheart.org on Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 12, 2020 Category: Cardiology Tags: Cardiology Commentary Source Type: news

The Earlier the Better for Colchicine Post-MI: COLCOT The Earlier the Better for Colchicine Post-MI: COLCOT
One substudy supported in-hospital initiation of colchicine and a second offered clues as to who may respond or experience tell-tale GI events.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 9, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Colchicine overdose: a South African experience, a case report - Essame J, Grossberg S, Mahomed A.
Introduction Colchicine overdose is uncommon but is associated with a high mortality rate. It has a narrow therapeutic index and has been described to have a 100% mortality with ingestion of>0.8  mg/kg (Finkelstein et al., 2010; Herran-Monge et al., 2013... (Source: SafetyLit)
Source: SafetyLit - September 1, 2020 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

LoDoCo2: Added Steam for Colchicine as Secondary Prevention LoDoCo2: Added Steam for Colchicine as Secondary Prevention
The benefits emerged early and continued to accrue through the trial, with no suggestion of attenuation during up to 5 years of treatment.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - September 1, 2020 Category: Internal Medicine Tags: Cardiology News Source Type: news

Common medicine used to treat gout found to prevent progression of coronary disease
(Harry Perkins Institute of Medical Research) A major clinical trial involving 5,500 patients in Australia and the Netherlands found heart attacks and the need for coronary stenting or bypass surgery reduced by 30% in patients taking low dose colchicine, an old and widely available drug commonly used to treat gout. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 31, 2020 Category: International Medicine & Public Health Source Type: news

Colchicine Promising in COVID-19 Treatment? Colchicine Promising in COVID-19 Treatment?
Colchicine, an anti-inflammatory drug used to treat gout and rheumatic disease, may be a promising treatment for COVID-19, a randomized, open-label trial suggests.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - June 30, 2020 Category: Allergy & Immunology Tags: Cardiology News Source Type: news

Colchicine May Improve Time to Clinical Deterioration in COVID-19
FRIDAY, June 26, 2020 -- Hospitalized patients with COVID-19 receiving colchicine have significantly improved time to clinical deterioration, according to a study published online June 24 in JAMA Network Open. Spyridon G. Deftereos, M.D., Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 26, 2020 Category: Pharmaceuticals Source Type: news

Could an old gout drug help treat coronavirus? Study suggests colchicine can fight inflammation
A new study from the University of Athens in Greece found that 14% of coronavirus patients in a control group died compared to 1.8% in the group receiving colchicine, an old gout drug. (Source: the Mail online | Health)
Source: the Mail online | Health - June 24, 2020 Category: Consumer Health News Source Type: news

A 2000-year-old medicine might find its thunder amidst Covid scare
The trial involved 105 Greek patients hospitalised with Covid-19. The results suggest a significant clinical benefit from colchicine in patients who are hospitalised with Covid-19. Doctors in India say that the drug is commonly available in India and is also used in some heart conditions. (Source: The Economic Times)
Source: The Economic Times - June 24, 2020 Category: Consumer Health News Source Type: news

In Early Trial, an Ancient Drug, Colchicine, Shows Promise Against Severe COVID-19
WEDNESDAY, June 24, 2020 -- There's new evidence that a 2,000-year-old medicine might offer hope against a modern scourge: COVID-19. The medication, called colchicine, is an anti-inflammatory taken as a pill. It's long been prescribed for gout, a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 24, 2020 Category: General Medicine Source Type: news

Effect of colchicine on biomarkers and clinical outcomes in patients hospitalized with COVID-19
(JAMA Network) This randomized clinical trial evaluates the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 24, 2020 Category: Infectious Diseases Source Type: news

Could an Ancient Drug Help Fight Severe COVID-19?
WEDNESDAY, April 22, 2020 -- As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place. The medication, called colchicine, is an oral... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 22, 2020 Category: General Medicine Source Type: news

Could Gout Drug Colchicine Help Fight Severe COVID-19?
WEDNESDAY, April 22, 2020 -- As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place. The medication, called colchicine, is an oral... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 22, 2020 Category: General Medicine Source Type: news

New trial will send drug to COVID-19 patients' home to see if it can prevent serious complications
A new international clinical trial will examine if colchicine, a drug most often used to treat gout, can can reduce rates of hospitalization and death caused by the novel coronavirus. (Source: the Mail online | Health)
Source: the Mail online | Health - April 21, 2020 Category: Consumer Health News Source Type: news

Adverse Events During Oral Colchicine Use Adverse Events During Oral Colchicine Use
Colchicine is commonly used in the treatment of inflammatory diseases, but what do we know about the potential adverse events associated with its use?Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 7, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Could Colchicine Be the New Aspirin? Could Colchicine Be the New Aspirin?
Michel Zeitouni talks to Jean-Claude Tardif about the COLCOT series of clinical trials testing colchicine, an anti-inflammatory gout drug, for the prevention and treatment of cardiovascular disease.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2020 Category: Consumer Health News Tags: Cardiology Expert Interview Source Type: news

What Is the Classic Clinical Presentation of Pericarditis?
Discussion The pericardium is a bi-layered membrane that envelops the heart and provides a barrier to prevent disease and also decreases friction as the heart moves. Pericarditis is the inflammation of pericardium. The incidence is underreported as asymptomatic or mild disease may go unrecognized. From hospitalized patient data, 0.2-5% of patients with various cardiac disease had pericarditis. An incidence rate for hospitalizations of 3.32 per 100,000 person years has been cited. Percarditis occurs more often in adolescent males. Treatment of the underlying cause or suspected cause is important, along with close monitorin...
Source: PediatricEducation.org - January 13, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Drug used to treat gout cuts odds of new heart attack, stroke in heart attack survivors
The inflammation-fighting drug colchicine, already a treatment for gout, dramatically reduces the odds of future cardiovascular problems in people who have just survived a heart attack, a large new study by a Montreal researcher has concluded. (Source: CBC | Health)
Source: CBC | Health - November 18, 2019 Category: Consumer Health News Tags: News/Health Source Type: news

Colchicine cuts odds of new heart attack, stroke in heart attack survivors
(Reuters Health) - The inflammation-fighting drug colchicine, already a treatment for gout, dramatically reduces the odds of future cardiovascular problems in people who have just survived a heart attack, a large new study has concluded. (Source: Reuters: Health)
Source: Reuters: Health - November 18, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Cheap, Older Gout Drug Could Be a Lifesaver After Heart Attack
In the new trial, colchicine reduced by as much as 34% a heart attack survivor's combined risk of either dying from heart disease or having cardiac arrest, a heart attack, a stroke or angioplasty. (Source: WebMD Health)
Source: WebMD Health - November 18, 2019 Category: Consumer Health News Source Type: news

AHA: Risk for Ischemic CV Events Lower With Colchicine After MI
MONDAY, Nov. 18, 2019 -- Patients with recent myocardial infarction have a lower risk for ischemic cardiovascular events with colchicine versus placebo, according to a study published online Nov. 16 in the New England Journal of Medicine to coincide... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2019 Category: Pharmaceuticals Source Type: news

Colchicine Before PCI Cuts Inflammatory Markers but Not MACE Colchicine Before PCI Cuts Inflammatory Markers but Not MACE
Although colchicine did not significantly reduce major adverse cardiovascular events after PCI, the researchers are encouraged by significant decreases in markers of inflammation vs placebo.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 18, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Older Gout Drug Colchicine Could Be a Lifesaver After Heart Attack
SUNDAY, Nov. 17, 2019 -- A cheap drug that's been around for centuries as a gout treatment might also shield heart attack survivors from future heart crises, new trial results show. The drug, colchicine, is derived from a plant called the autumn... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 17, 2019 Category: General Medicine Source Type: news

COLCOT: Colchicine Shows Promise to Reduce Events After MI COLCOT: Colchicine Shows Promise to Reduce Events After MI
A widely available anti-inflammatory agent used to treat pericarditis and gout may have value in secondary prevention after myocardial infarction, new trial results suggest.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 16, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Rapid identification of Gloriosa superba and Colchicum autumnale by melting curve analysis: application to a suicide case involving massive ingestion of G. superba - Sakurada M, Yoshioka N, Kuse A, Nakagawa K, Morichika M, Takahashi M, Kondo T, Asano M, Ueno Y.
The plant species Gloriosa superba and Colchicum autumnale produce extremely poisonous colchicine as a major toxic metabolite. Almost all previous studies on colchicine poisoning have focused on drug analysis and clinical and pathological aspects. In this ... (Source: SafetyLit)
Source: SafetyLit - May 2, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news